Peptide fusion inhibitors targeting the HIV-1 gp41: a patent review (2009 – 2014)

The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance

(2014) Huihui Chong et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Two M-T hook residues greatly improve the antiviral activity and resistance profile of the HIV-1 fusion inhibitor SC29EK

(2014) Huihui Chong et al.   Retrovirology

A Rationally Engineered Anti-HIV Peptide Fusion Inhibitor with Greatly Reduced Immunogenicity

(2012) F. Brauer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

(2012) Weiguo Shi et al.   CHEMICAL COMMUNICATIONS

Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1

(2012) Avraham Ashkenazi et al.   FASEB JOURNAL

Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1

(2012) Huihui Chong et al.   FASEB JOURNAL

Discovery of Critical Residues for Viral Entry and Inhibition through Structural Insight of HIV-1 Fusion Inhibitor CP621–652

(2012) Huihui Chong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broad Antiviral Activity and Crystal Structure of HIV-1 Fusion Inhibitor Sifuvirtide

(2012) Xue Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The M-T Hook Structure Is Critical for Design of HIV-1 Fusion Inhibitors

(2012) Huihui Chong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biophysical Property and Broad Anti-HIV Activity of Albuvirtide, a 3-Maleimimidopropionic Acid-Modified Peptide Fusion Inhibitor

(2012) Huihui Chong et al.   PLoS One

A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

(2012) Lu Lu et al.   Retrovirology

A Novel Chimeric Protein-based HIV-1 Fusion Inhibitor Targeting gp41 Glycoprotein with High Potency and Stability

(2011) Chungen Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unravelling the molecular basis of the selectivity of the HIV-1 fusion inhibitor sifuvirtide towards phosphatidylcholine-rich rigid membranes

(2010) Henri G. Franquelim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Discovery of Entry Inhibitors for HIV-1 via a New De Novo Protein Design Framework

(2010) M.L. Bellows et al.   BIOPHYSICAL JOURNAL

Novel Recombinant Engineered gp41 N-terminal Heptad Repeat Trimers and Their Potential as Anti-HIV-1 Therapeutics or Microbicides

(2010) Xi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Biological Activity of Novel 5-((Arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 Fusion Inhibitors Targeting gp41

(2010) Shibo Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synergistic efficacy of combination of enfuvirtide and sifuvirtide, the first- and next-generation HIV-fusion inhibitors

(2009) Chungen Pan et al.   AIDS

An Albumin-Conjugated Peptide Exhibits Potent Anti-HIV Activity and Long In Vivo Half-Life

(2009) D. Xie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, Synthesis, and Structure−Activity Relationship of a Novel Series of 2-Aryl 5-(4-Oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 Entry Inhibitors⊥

(2009) Alan R. Katritzky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency

(2009) P. Ingallinella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel anti-HIV peptides containing multiple copies of artificially designed heptad repeat motifs

(2008) Weiguo Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rationally Designed Anti-HIV Peptides Containing Multifunctional Domains as Molecule Probes for Studying the Mechanisms of Action of the First and Second Generation HIV Fusion Inhibitors

(2008) Zhi Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Evaluation of Sifuvirtide, a Novel HIV-1 Fusion Inhibitor

(2008) Yuxian He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Critical Motif for the Human Immunodeficiency Virus Type 1 (HIV-1) gp41 Core Structure: Implications for Designing Novel Anti-HIV Fusion Inhibitors

(2008) Y. He et al.   JOURNAL OF VIROLOGY

Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains

(2008) Y. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA