AMPA receptor positive allosteric modulators: a patent review

A Translational Approach to Evaluate the Efficacy and Safety of the Novel AMPA Receptor Positive Allosteric Modulator Org 26576 in Adult Attention-Deficit/Hyperactivity Disorder

(2012) Lenard A. Adler et al.   BIOLOGICAL PSYCHIATRY

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

(2011) Christian Krintel et al.   BIOCHEMICAL JOURNAL

Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators

(2011) Rudolf Mueller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted benzoxazinones as potent positive allosteric AMPA receptor modulators: Part II

(2011) Rudolf Mueller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzoxazinones as potent positive allosteric AMPA receptor modulators: Part I

(2011) Rudolf Mueller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5-Arylbenzothiadiazine Type Compounds as Positive Allosteric Modulators of AMPA/Kainate Receptors

(2011) Umberto M. Battisti et al.   ACS Medicinal Chemistry Letters

A novel series of positive modulators of the AMPA receptor: Discovery and structure based hit-to-lead studies

(2010) Craig Jamieson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization

(2010) Craig Jamieson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators

(2010) Kevin M. Thewlis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure based evolution of a novel series of positive modulators of the AMPA receptor

(2010) Craig Jamieson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Challenges for and current status of research into positive modulators of AMPA receptors

(2010) Simon E Ward et al.   BRITISH JOURNAL OF PHARMACOLOGY

Recent Advances in the Discovery of Selective AMPA Receptor Positive Allosteric Modulators

(2010) Simon E. Ward et al.   CURRENT MEDICINAL CHEMISTRY

Ring-Fused Thiadiazines as Core Structures for the Development of Potent AMPA Receptor Potentiators

(2010) B. Pirotte et al.   CURRENT MEDICINAL CHEMISTRY

The AMPA receptor as a therapeutic target: current perspectives and emerging possibilities

(2010) Ian R Mellor   Future Medicinal Chemistry

New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors

(2010) Pierre Francotte et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery ofN-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a Novel Clinical AMPA Receptor Positive Modulator

(2010) Simon E. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Positive Allosteric Modulators of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor

(2010) Simon J. A. Grove et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators

(2010) Simon E. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging role of glutamate in the pathophysiology of major depressive disorder

(2009) Kenji Hashimoto   BRAIN RESEARCH REVIEWS

The Role of AMPA receptor modulation in the treatment of neuropsychiatric diseases

(2008) Carlos A. Zarate et al.   EXPERIMENTAL NEUROLOGY

The quest for treatment of cognitive impairment: AMPA and mGlu5 receptor modulators

(2008) Miao-Kun Sun   EXPERT OPINION ON THERAPEUTIC PATENTS

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

(2008) Gerard Sanacora et al.   NATURE REVIEWS DRUG DISCOVERY

Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression

(2008) J.C. Lauterborn et al.   NEUROSCIENCE