Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

Molecular Mechanism of Flop Selectivity and Subsite Recognition for an AMPA Receptor Allosteric Modulator: Structures of GluA2 and GluA3 in Complexes with PEPA

(2010) Ahmed H. Ahmed et al.   BIOCHEMISTRY

A novel series of positive modulators of the AMPA receptor: Discovery and structure based hit-to-lead studies

(2010) Craig Jamieson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ring-Fused Thiadiazines as Core Structures for the Development of Potent AMPA Receptor Potentiators

(2010) B. Pirotte et al.   CURRENT MEDICINAL CHEMISTRY

Discovery ofN-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a Novel Clinical AMPA Receptor Positive Modulator

(2010) Simon E. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Piracetam Defines a New Binding Site for Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors

(2010) Ahmed H. Ahmed et al.   JOURNAL OF MEDICINAL CHEMISTRY

Probing the Allosteric Modulator Binding Site of GluR2 with Thiazide Derivatives

(2009) Christopher P. Ptak et al.   BIOCHEMISTRY

Distinct Structural Features of Cyclothiazide Are Responsible for Effects on Peak Current Amplitude and Desensitization Kinetics at iGluR2

(2009) Helle Hald et al.   JOURNAL OF MOLECULAR BIOLOGY

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators

(2008) Pierre Francotte et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ionotropic Glutamate Receptors & CNS Disorders

(2008) Derek Bowie   CNS & Neurological Disorders-Drug Targets

Do enthalpy and entropy distinguish first in class from best in class?

(2008) E FREIRE   DRUG DISCOVERY TODAY

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols