PTEN modulators: a patent review

The RhoA-ROCK-PTEN pathway as a molecular switch for anchorage dependent cell behavior

(2012) Seungwon Yang et al.   BIOMATERIALS

Abstract 2048: Phosphorylation and regulation of PTEN by Polo-like kinase 1

(2012) Byeong Hyeok Choi et al.   CANCER RESEARCH

Gene of the month: PTEN: Figure 1

(2012) Dhirendra Govender et al.   JOURNAL OF CLINICAL PATHOLOGY

PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance

(2012) Amit Gupta et al.   MOLECULAR BIOLOGY OF THE CELL

SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT

(2012) Praveen Bhoopathi et al.   PLoS One

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate

(2012) Anette Hübner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins

(2011) A. Yoshimi et al.   BLOOD

Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition

(2011) Alexey Goltsov et al.   CELLULAR SIGNALLING

Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins

(2011) Evelyne Lima-Fernandes et al.   EMBO JOURNAL

Microsomal Prostaglandin E Synthase-1 Inhibits PTEN and Promotes Experimental Cholangiocarcinogenesis and Tumor Progression

(2011) Dongdong Lu et al.   GASTROENTEROLOGY

GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen receptor and by androgen-independent suppression of PTEN transcription in breast cancer

(2011) Yu Wang et al.   HUMAN MOLECULAR GENETICS

Insulin-Like Growth Factor–Type 1 Receptor Inhibitor NVP-AEW541 Enhances Radiosensitivity of PTEN Wild-Type but Not PTEN-Deficient Human Prostate Cancer Cells

(2011) Sofie F. Isebaert et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Opposite Effects of HIV-1 p17 Variants on PTEN Activation and Cell Growth in B Cells

(2011) Cinzia Giagulli et al.   PLoS One

α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells

(2011) Lizhi He et al.   Nature Communications

Recombinant Human Erythropoietin Antagonizes Trastuzumab Treatment of Breast Cancer Cells via Jak2-Mediated Src Activation and PTEN Inactivation

(2010) Ke Liang et al.   CANCER CELL

Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth

(2010) Nayana Ghosh-Choudhury et al.   CELLULAR SIGNALLING

Semaphorin 4D/Plexin-B1 Stimulates PTEN Activity through R-Ras GTPase-activating Protein Activity, Inducing Growth Cone Collapse in Hippocampal Neurons

(2010) Izumi Oinuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shank-interacting protein–like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells

(2010) Lizhi He et al.   JOURNAL OF CLINICAL INVESTIGATION

Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells

(2010) Thamara J. Abouantoun et al.   JOURNAL OF NEURO-ONCOLOGY

A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons

(2010) Ana Luisa Perdigoto et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

(2009) S. Vemula et al.   BLOOD

Rak Functions as a Tumor Suppressor by Regulating PTEN Protein Stability and Function

(2009) Eun-Kyoung Yim et al.   CANCER CELL

PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR

(2009) M. L. Sos et al.   CANCER RESEARCH

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+Channels

(2009) Ke Ning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium Selenite Increases the Activity of the Tumor Suppressor Protein, PTEN, in DU-145 Prostate Cancer Cells

(2009) Margareta Berggren et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

(2009) B. Fine et al.   SCIENCE

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

(2008) G. Y. Oudit et al.   CARDIOVASCULAR RESEARCH

Tissue Transglutaminase Regulates Focal Adhesion Kinase/AKT Activation by Modulating PTEN Expression in Pancreatic Cancer Cells

(2008) A. Verma et al.   CLINICAL CANCER RESEARCH

Temporal PTEN inactivation causes proliferation of saphenous vein smooth muscle cells of human CABG conduits

(2008) Amit K. Mitra et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of cell cycle entry by PTEN in smooth muscle cell proliferation of human coronary artery bypass conduits

(2008) Guanghong Jia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis

(2008) M. Escriva et al.   MOLECULAR AND CELLULAR BIOLOGY

CSIG Inhibits PTEN Translation in Replicative Senescence

(2008) L. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY