Shikonin and its derivatives: a patent review

Naturally Occurring Isohexenylnaphthazarins and Wound Healing: Experimental Study in Dogs

(2015) Maria Karayannopoulou et al.   JOURNAL OF CUTANEOUS MEDICINE AND SURGERY

Synthesis and human telomeric G-quadruplex DNA-binding activity of glucosaminosides of shikonin/alkannin

(2012) Hao He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An Efficient Multigram Synthesis of Alkannin and Shikonin

(2012) Rubing Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A novel and efficient total synthesis of shikonin

(2012) Rubing Wang et al.   TETRAHEDRON LETTERS

Tigloylshikonin, a New Minor Shikonin Derivative, from the Roots and the Commercial Root Extract of Lithospermum erythrorhizon

(2011) Yusai Ito et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Cancer Therapeutic Agents Targeting Hypoxia-Inducible Factor-1

(2011) R. Wang et al.   CURRENT MEDICINAL CHEMISTRY

Semi-synthesis and antitumor activity of 6-isomers of 5, 8-O-dimethyl acylshikonin derivatives

(2011) Wen Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antitumour activity of β-hydroxyisovalerylshikonin analogues

(2011) Zhen Rao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition

(2011) Li Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

DNA damage induced by shikonin in the presence of Cu(II) ions: potential mechanism of its activity to apoptotic cell death

(2011) Hong-Ming Cheng et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

General and Highly α-Regioselective Zinc-Mediated Prenylation of Aldehydes and Ketones

(2011) Li-Ming Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells

(2010) I-Chang Chang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Semi-synthesis and anti-tumor activity of 5,8-O-dimethyl acylshikonin derivatives

(2010) Wen Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-radical scavenging activity relationship of alkannin/shikonin derivatives

(2010) Stella A. Ordoudi et al.   FOOD CHEMISTRY

Cytotoxic Naphthoquinones fromAlkanna cappadocica⊥

(2010) Canan Sevimli-Gur et al.   JOURNAL OF NATURAL PRODUCTS

Shikonin inhibits tumor invasion via down-regulation of NF-κB-mediated MMP-9 expression in human ACC-M cells

(2010) R Min et al.   ORAL DISEASES

An efficient synthesis of 2-formyl-1,4,5,8-tetramethoxynaphthalene

(2010) Rubing Wang et al.   JOURNAL OF CHEMICAL RESEARCH

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Synthesis and biological activity of novel shikonin analogues

(2008) Wenjing Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Naturally-occurring shikonin analogues – A class of necroptotic inducers that circumvent cancer drug resistance

(2008) Yanyan Xuan et al.   CANCER LETTERS

Modulation of Orphan Nuclear Receptor Nur77-Mediated Apoptotic Pathway by Acetylshikonin and Analogues

(2008) Jie Liu et al.   CANCER RESEARCH

Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells

(2008) Xin Mao et al.   CELL RESEARCH

Alkannins and Shikonins: A New Class of Wound Healing Agents

(2008) V. Papageorgiou et al.   CURRENT MEDICINAL CHEMISTRY

RETRACTED: β-Hydroxyisovalerylshikonin has a profound anti-growth activity in human endometrial and ovarian cancer cells

(2008) Noriyuki Takai et al.   GYNECOLOGIC ONCOLOGY

Shikonin exerts antitumor activityviaproteasome inhibition and cell death inductionin vitroandin vivo

(2008) Huanjie Yang et al.   INTERNATIONAL JOURNAL OF CANCER

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain

(2008) Jennifer Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Concise Formal Synthesis of (±)-Shikonin Via a Highly α-Regioselective Prenylation of 1, 4, 5, 8-Tetramethoxynaphthalene-2-Carbaldehyde

(2008) Li-Ming Zhao et al.   LETTERS IN ORGANIC CHEMISTRY

Shikonin, Acetylshikonin, and Isobutyroylshikonin Inhibit VEGF-induced Angiogenesis and Suppress Tumor Growth in Lewis Lung Carcinoma-bearing Mice

(2008) Hyo-Jung LEE et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN