Advances in iron chelation: an update

Propargylamine Containing Compounds as Modulators of Proteolytic Cleavage of Amyloid Protein Precursor: Involvement of MAPK and PKC Activation

(2017) Orit Bar-Am et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Iron Metabolism and Its Role in Neurodegeneration

(2017) Maxx P. Horowitz et al.   JOURNAL OF ALZHEIMERS DISEASE

The Effects of Deferiprone and Deferasirox on the Structure and Function of β-Thalassemia Hemoglobin

(2012) A. A. Moosavi-Movahedi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

HIF-1α dysfunction in diabetes

(2011) Hariharan Thangarajah et al.   CELL CYCLE

Hepcidin in β-thalassemia

(2010) Elizabeta Nemeth   Annals of the New York Academy of Sciences

Hepcidin and Hfe in iron overload in β-thalassemia

(2010) Sara Gardenghi et al.   Annals of the New York Academy of Sciences

Deferasirox-current knowledge and future challenges

(2010) John B. Porter   Annals of the New York Academy of Sciences

Deferiprone

(2010) Antonio Piga et al.   Annals of the New York Academy of Sciences

Cardiovascular MRI in thalassemia major

(2010) John C Wood et al.   Annals of the New York Academy of Sciences

Combined iron chelation therapy

(2010) Renzo Galanello et al.   Annals of the New York Academy of Sciences

The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia

(2010) Eitan Fibach et al.   Annals of the New York Academy of Sciences

Monitoring the efficiency of iron chelation therapy: the potential of nontransferrin-bound iron

(2010) R.C. Hider et al.   Annals of the New York Academy of Sciences

Thalassemia as a global health problem: recent progress toward its control in the developing countries

(2010) D.J. Weatherall   Annals of the New York Academy of Sciences

Neuroprotective Multifunctional Iron Chelators: From Redox-Sensitive Process to Novel Therapeutic Opportunities

(2010) Orly Weinreb et al.   ANTIOXIDANTS & REDOX SIGNALING

Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases

(2010) Myong Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The universal mechanism for iron translocation to the ferroxidase site in ferritin, which is mediated by the well conserved transit site

(2010) Taro Masuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Siderophore uptake in bacteria and the battle for iron with the host; a bird’s eye view

(2010) Byron C. Chu et al.   BIOMETALS

The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages

(2010) A Rossi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comparison of Clinically Used and Experimental Iron Chelators for Protection against Oxidative Stress-Induced Cellular Injury

(2010) Petra Bendova et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The transition metals copper and iron in neurodegenerative diseases

(2010) Susana Rivera-Mancía et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Up-Regulation of Hypoxia-Inducible Factor (HIF)-1α and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30

(2010) Y. Avramovich-Tirosh et al.   Current Alzheimer Research

Antifungal therapy in invasive fungal infections

(2010) Sharon C-A Chen et al.   CURRENT OPINION IN PHARMACOLOGY

Pharmacokinetics, Metabolism, and Disposition of Deferasirox in  -Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State

(2010) F. Waldmeier et al.   DRUG METABOLISM AND DISPOSITION

In vitro time-kill activities of ciprofloxacin alone and in combination with the iron chelator deferasirox against Vibrio vulnificus

(2010) G. P. Neupane et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Reduction of body iron stores to normal range levels in thalassaemia by using a deferiprone/deferoxamine combination and their maintenance thereafter by deferiprone monotherapy

(2010) Annita Kolnagou et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

New quinolone antibiotics: a survey of the literature from 2005 to 2010

(2010) Jason A Wiles et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity

(2010) Pavlína Hašková et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hereditary Hemochromatosis: Pathogenesis, Diagnosis, and Treatment

(2010) Antonello Pietrangelo   GASTROENTEROLOGY

The 18th ICOC Proceedings in Athens, Greece: New Breakthrough in Thalassemia Leading to the Complete Treatment of Iron Overload and to Hundreds of Patients Achieving and Maintaining Normal Body Iron Stores. Ethical Questions on Chelation Therapy

(2010) George J. Kontoghiorghes   HEMOGLOBIN

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study

(2010) Patric J. Jansson et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Multifunctional Antioxidants for the Treatment of Age-Related Diseases

(2010) Hongxia Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glucosylated Deferiprone and Its Brain Uptake: Implications for Developing Glucosylated Hydroxypyridinone Analogues Intended to Cross the Blood−Brain Barrier

(2010) Sourav Roy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acquired Proximal Renal Tubular Dysfunction in β-Thalassemia Patients Treated With Deferasirox

(2010) Joanne Yacobovich et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

The Safety, Tolerability, and Efficacy of a Liquid Formulation of Deferiprone in Young Children With Transfusional Iron Overload

(2010) Moshen El Alfy et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

The Novel Multifunctional, Iron-Chelating Drugs M30 and HLA20 Protect Pancreatic  -Cell Lines from Oxidative Stress Damage

(2010) D. Mechlovich et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium

(2010) Sofia Sousa Fernandes et al.   MICROBES AND INFECTION

Chemistry and biology of siderophores

(2010) Robert C. Hider et al.   NATURAL PRODUCT REPORTS

Protective hemoglobinopathies and Plasmodium falciparum transmission

(2010) Geoffrey Pasvol   NATURE GENETICS

Periodontal Disease Mechanisms: Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases

(2010) RJ Waddington et al.   ORAL DISEASES

Causes for Hospitalization and Death in Iranian Patients with β-Thalassemia Major

(2010) Masood Bazrgar et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

The iron-regulatory peptide hepcidin is upregulated in the ischemic and in the remote myocardium after myocardial infarction

(2010) Gregor Simonis et al.   PEPTIDES

Mechanisms of Anthracycline Cardiac Injury: Can We Identify Strategies for Cardioprotection?

(2010) Douglas B. Sawyer et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Design and synthesis of fluorine-substituted 3-hydroxypyridin-4-ones

(2010) Yong Min Ma et al.   TETRAHEDRON LETTERS

Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone

(2010) Patricia Evans et al.   Translational Research

Role of T2* Magnetic Resonance in Monitoring Iron Chelation Therapy

(2009) John-Paul Carpenter et al.   ACTA HAEMATOLOGICA

Deferiprone Chelation Therapy for Thalassemia Major

(2009) R. Galanello et al.   ACTA HAEMATOLOGICA

Iron Metabolism and Iron Chelation in Sickle Cell Disease

(2009) Patrick B. Walter et al.   ACTA HAEMATOLOGICA

Deferasirox (Exjade®) for the Treatment of Iron Overload

(2009) M.D. Cappellini et al.   ACTA HAEMATOLOGICA

Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic β-cells

(2009) David M. Hudson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma

(2009) C. M. Nutting et al.   ANNALS OF ONCOLOGY

Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase

(2009) Lijun Zhu et al.   BIOCHEMICAL PHARMACOLOGY

Siderophores as drug delivery agents: application of the “Trojan Horse” strategy

(2009) Ute Möllmann et al.   BIOMETALS

Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic conjugates

(2009) Timothy A. Wencewicz et al.   BIOMETALS

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

(2009) Y. Eberhard et al.   BLOOD

Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease

(2009) Lauren E. Scott et al.   CHEMICAL REVIEWS

Desferrioxamine as Immunomodulatory Agent During Microorganism Infection

(2009) A. Williams et al.   CURRENT PHARMACEUTICAL DESIGN

Malaria and iron: history and review

(2009) Eugene D. Weinberg et al.   DRUG METABOLISM REVIEWS

Imidazo[2,1-b]thiazoles and their use as pharmaceuticals

(2009) K Karimian   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthetic and natural iron chelators: therapeutic potential and clinical use

(2009) Heather C Hatcher et al.   Future Medicinal Chemistry

Les hémochromatoses. Nouvelle compréhension, nouveaux traitements

(2009) P. Brissot   GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE

Effects of Chelators (Deferoxamine, Deferiprone and Deferasirox) on the Growth ofKlebsiella PneumoniaeandAeromonas HydrophilaIsolated from Transfusion-Dependent Thalassemia Patients

(2009) Godfrey Chi-Fung Chan et al.   HEMOGLOBIN

A phase II trial of Triapine® (NSC# 663249) and gemcitabine as second line treatment of advanced non-small cell lung cancer: Eastern Cooperative Oncology Group Study 1503

(2009) Anne M. Traynor et al.   INVESTIGATIONAL NEW DRUGS

Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective−Neurorestorative Moieties for Alzheimer’s Therapy

(2009) Hailin Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors

(2009) Yu Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The ins and outs of mitochondrial iron-loading: the metabolic defect in Friedreich’s ataxia

(2009) Des R. Richardson et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice

(2009) Xing Shen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Restoration of Nigrostriatal Dopamine Neurons in Post-MPTP Treatment by the Novel Multifunctional Brain-Permeable Iron Chelator-Monoamine Oxidase Inhibitor Drug, M30

(2009) Shunit Gal et al.   NEUROTOXICITY RESEARCH

Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center

(2009) V. V. Vu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A

(2009) Mainul Hoque et al.   Retrovirology

The effect of lactoferrin on oral bacterial attachment

(2009) S. Y. Arslan et al.   Oral microbiology and immunology

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

(2008) Johanna Myllyharju   ANNALS OF MEDICINE

Iron chelation as a potential therapy for neurodegenerative disease

(2008) Robert C. Hider et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of Dcytb in iron metabolism: an update

(2008) Andrew T. McKie   BIOCHEMICAL SOCIETY TRANSACTIONS

Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia

(2008) J. E. Farrar et al.   BLOOD

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

(2008) T Šimůnek et al.   BRITISH JOURNAL OF PHARMACOLOGY

Leishmania donovanidepletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth

(2008) Nupur Kanti Das et al.   CELLULAR MICROBIOLOGY

The use of dexrazoxane for the prevention of anthracycline extravasation injury

(2008) Brian B Hasinoff   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Polyol pathway mediates iron-induced oxidative injury in ischemic–reperfused rat heart

(2008) Wai Ho Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Unusually Frequent β-Thalassemia Mutation in an Iranian Province

(2008) Peyman Eshghi et al.   HEMOGLOBIN

Anthracycline Cardiotoxicity: From Bench to Bedside

(2008) Luca Gianni et al.   JOURNAL OF CLINICAL ONCOLOGY

Design, Synthesis, and Testing of Non-Nephrotoxic Desazadesferrithiocin Polyether Analogues

(2008) Raymond J. Bergeron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chelation of Mitochondrial Iron Prevents Seizure-Induced Mitochondrial Dysfunction and Neuronal Injury

(2008) L.-P. Liang et al.   JOURNAL OF NEUROSCIENCE

Deferiprone Does Not Protect against Chronic Anthracycline Cardiotoxicity in Vivo

(2008) O. Popelova et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Post-hypoxic cellular disintegration in glycine-preserved renal tubules is attenuated by hydroxyl radical scavengers and iron chelators

(2008) Mohammed R. Moussavian et al.   LANGENBECKS ARCHIVES OF SURGERY

Protection against Hydrogen Peroxide-Mediated Cytotoxicity in Friedreich's Ataxia Fibroblasts Using Novel Iron Chelators of the 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone Class

(2008) C. K. Lim et al.   MOLECULAR PHARMACOLOGY

Reflecting on a quarter century of HIV research

(2008) Andrew E Armitage et al.   NATURE IMMUNOLOGY

The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

(2008) Jon O. Lundberg et al.   NATURE REVIEWS DRUG DISCOVERY

Viral infection and iron metabolism

(2008) Hal Drakesmith et al.   NATURE REVIEWS MICROBIOLOGY

Multifunctional neuroprotective derivatives of rasagiline as anti-alzheimer’s disease drugs

(2008) Orly Weinreb et al.   Neurotherapeutics

Design and synthesis of a novel protected mixed ligand siderophore

(2008) Pingyu Ding et al.   TETRAHEDRON LETTERS

Electrocatalytic oxidation and determination of deferasirox and deferiprone on a nickel oxyhydroxide-modified electrode

(2007) M. Hajjizadeh et al.   ANALYTICAL BIOCHEMISTRY

Design and synthesis of a siderophore conjugate as a potent PSMA inhibitor and potential diagnostic agent for prostate cancer

(2007) Pingyu Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Electrocatalytic oxidation of deferiprone and its determination on a carbon nanotube-modified glassy carbon electrode

(2007) H. Yadegari et al.   ELECTROCHIMICA ACTA

Targeting multiple Alzheimer’s disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

(2007) Tamar Amit et al.   FASEB JOURNAL

Potentiometric, spectrophotometric and calorimetric study on iron(III) and copper(II) complexes with 1,2-dimethyl-3-hydroxy-4-pyridinone

(2007) Valeria M. Nurchi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY