Article
Chemistry, Inorganic & Nuclear
Dameng Sun, Xin Huang, Ruojun Man, Xinjie Jia, Xinluan Song, Sihan Wang, Xingyong Xue, Hongming Liu, Zhen Ma
Summary: A series of Fe(ii) complexes were synthesized using modified terpyridine ligands, and they exhibited high antiproliferation activities against human cancer cell lines with low toxicity to normal cells. The carboxyl-modified complex showed significant selectivity in killing hepatoma cancer cells. These Fe(ii) complexes have potential as anticancer drugs against hepatoma cancer.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Giulia Breveglieri, Nicoletta Bianchi, Ilaria Lampronti, Jessica Gasparello, Chiara Scapoli, Monica Borgatti, Alessia Finotti, Roberto Gambari
Summary: The human homologue of mouse Ly-1 antibody reactive clone protein (LYAR) is a potential regulator of gamma-globin gene transcription. The LYAR rs368698783 (G > A) polymorphism is present in beta-thalassemia patients and reduces the LYAR binding efficiency to the A gamma-globin gene. This study aimed to stratify beta-thalassemia patients based on the rs368698783 (G > A) polymorphism and investigate their erythroid precursor cells' response to selected HbF inducers in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Rajeswari Rethinaswamy DivakarJose, C. G. Delhikumar, G. Ram Kumar
Summary: The study aimed to evaluate the efficacy and safety of dual oral iron chelation therapy in reducing iron overload in transfusion-dependent thalassemic children. The results showed a significant decrease in serum ferritin levels with the combination therapy, while liver and myocardial iron concentrations did not change significantly. Adverse effects such as red color urine and transient elevation in creatinine and liver enzymes were observed during the study period.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Review
Medicine, General & Internal
Fangfang Wang, Ling Ling, Duonan Yu
Summary: Beta-thalassemia is a lethal inherited disease that requires regular blood transfusions, but other interventions like iron chelation, stem cell transplantation, and gene therapy have improved quality of life. Certain microRNAs play important roles in regulating globin expression and can potentially serve as biomarkers for diagnosing and predicting outcomes of beta-thalassemia.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Thunwarat Suriyun, Pranee Winichagoon, Suthat Fucharoen, Orapan Sripichai
Summary: This study investigated the characteristics of erythroid maturation in patients with β(0)-thalassemia/HbE and found delayed maturation and impaired mitochondrial clearance. The study also revealed increased transcript levels of BNIP3L and PINK1, genes related to erythroid mitophagy, in erythroblasts of these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Hematology
Paola Quarello, Ugo Ramenghi, Franca Fagioli
Summary: This report provides guidance and management of deferiprone in transfusion-dependent DBA patients, but deferiprone may lead to agranulocytosis in DBA patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrea Bellelli, Jeremy R. H. Tame
Summary: The oxygen demands of the human body rely on the constant circulation of blood with a high concentration of hemoglobin. The transport of oxygen not only depends on the amount of hemoglobin but also on its affinity for the gas, which can be modified through changes in the concentration of certain effectors. Certain pathological conditions affecting hemoglobin may be treated with drugs that alter its properties or oxygen affinity. This review explores the pharmacology of hemoglobin and its potential uses.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Gufran Ahmed Siddiqui, Aabgeena Naeem
Summary: The crowded cellular environment can affect protein structure and lead to neurodegenerative diseases. This study found that bioflavonoids derived from food and plants can protect hemoglobin from aggregation caused by crowding. These bioflavonoids stabilize hemoglobin structure and have the potential to be used as future treatments for neurodegenerative diseases.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Medicine, Research & Experimental
Qinzi Xu, Jason J. Rose, Xiukai Chen, Ling Wang, Anthony W. DeMartino, Matthew R. Dent, Sagarika Tiwari, Kaitlin Bocian, Xueyin N. Huang, Qin Tong, Charles F. McTiernan, Lanping Guo, Elmira Alipour, Trevor C. Jones, K. Burak Ucer, Daniel B. Kim-Shapiro, Jesus Tejero, Mark T. Gladwin
Summary: This study evaluates different hemoproteins and finds that 2,3-diphosphoglycerate stripped human hemoglobin (StHb) and N-ethylmaleimide modified hemoglobin (NEMHb) have high CO binding affinities and efficiently scavenge CO from erythrocytes, suggesting their potential therapeutic role in CO poisoning.
Article
Biophysics
Priyanka Tiwari, Neha S. Ekal, Binny A. Rudani, Pratap Bahadur, Sanjay Tiwari
Summary: This study investigates the impact of surface oxygen groups on the ability of graphene oxide (GO) sheets to suppress the fibrillation of lysozyme (LYZ). GO sheets were produced by oxidizing graphite with different amounts of KMnO4. The particulate characteristics of the sheets were analyzed, and their interaction with LYZ was examined using circular dichroism spectroscopy. The results showed that the fibrillation of dispersed protein can be prevented by adding GO sheets, and the inhibitory effect is attributed to the binding of LYZ to the sheets via noncovalent forces.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Medicinal
Zheng-Sheng Lai, Teng-Kuang Yeh, Yu-Chi Chou, Tsu Hsu, Cheng-Tai Lu, Fang-Chun Kung, Ming-Yen Hsieh, Chun-Hung Lin, Chiung-Tong Chen, Che-Kun James Shen, Weir-Torn Jiaang
Summary: A more potent inducer, compound 13a, was discovered in this study, which can efficiently induce gamma-globin gene expression at non-cytotoxic concentrations and ameliorate anemia and related symptoms in SCD mice through oral administration.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Zhengjie Hu, Zhiying Chen, Xuwei Chen
Summary: Adsorbents for protein enrichment are crucial in proteomic applications. The construction of tunable metal-organic framework (MOF) through rational selection of metal nodes and organic linkers has gained special interest in the field of protein enrichment. This study successfully prepared a nickel-based MOF (NiBPDC) and demonstrated its attractive adsorption efficiency and selectivity for hemoglobin (Hb) through strong metal affinity and pi stacking interaction.
ANALYTICAL LETTERS
(2022)
Article
Cardiac & Cardiovascular Systems
Kobina Dufu, Alexander T. Williams, Cynthia R. Muller, Cynthia M. Walser, Alfredo Lucas, Allyn M. Eaker, Carsten Alt, Brian E. Cathers, Donna Oksenberg, Pedro Cabrales
Summary: The study suggests that increasing hemoglobin affinity for oxygen can improve the survival rate and brain tissue oxygenation of SCD mice under hypoxic conditions.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physics, Multidisciplinary
Dongsheng Song, Rafal E. Dunin-Borkowski
Summary: This study presents a method for three-dimensional magnetic measurement at atomic scale using EMCD technology, which allows for obtaining signals related to magnetization in three Cartesian directions by using a subangstrom convergent electron beam in STEM. Atomic resolution EMCD signals from all three directions can be separately acquired by moving the detector, and signal enhancement can be achieved by using a defocused electron beam.
PHYSICAL REVIEW LETTERS
(2021)
Article
Medicine, Research & Experimental
Noppawan Phumala Morales, Supot Rodrat, Pannaree Piromkraipak, Paveena Yamanont, Kittiphong Paiboonsukwong, Suthat Fucharoen
Summary: Treatment with deferiprone significantly improved the oxidative status in β-thalassemia/hemoglobin E patients, reducing the risk of oxidative-related complications and improving red blood cell quality. This improvement may partially be attributed to the reduction of redox active iron and enhancement of antioxidant enzyme activity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Anas Shamsi, Taj Mohammad, Saleha Anwar, Khalida Nasreen, Md Imtaiyaz Hassan, Faizan Ahmad, Asimul Islam
Summary: This study investigated the binding of alpha-crystallin and PEG-400 using various spectroscopic techniques and molecular modeling. The results suggest a strong binding between alpha-crystallin and PEG-400, driven by van der Waals forces and hydrogen bonding. Molecular docking further confirmed the binding site of PEG-400 in alpha-crystallin.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Abdullah Naiyer, Bushra Khan, Asimul Islam, Md Imtaiyaz Hassan, Monica Sundd, Faizan Ahmad
Summary: The structure, stability, and dynamics properties of horse cytochrome c and its M80G mutant have been investigated. The effect of the M80G mutation on the protein's structure and stability was examined, and the dynamic behavior of the WT cyt c and its M80G mutant was measured. The results showed that the mutation caused partial loss of structure but slightly increased overall stability, and the mutant had increased stability and flexibility compared to the wild-type.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Sogand Sasan Moghadam, Maryam Ghahramani, Kazem Khoshaman, Ahmad Oryan, Ali Akbar Moosavi-Movahedi, Boris Kurganov, Reza Yousefi
Summary: This study evaluated the impact of peroxynitrite (PON) and methylglyoxal (MGO) on alpha A-crystallin (alpha A-Cry) and found that the reaction of these compounds led to the formation of new chromophores, changes in protein structure, reduction in oligomer size, and increased chaperone activity of alpha A-Cry. Ascorbic acid and glutathione were able to reverse these effects. The results suggest that the lens antioxidant defense system, particularly glutathione, can provide strong protection against diabetic cataract.
BIOCHEMISTRY-MOSCOW
(2022)
Article
Neurosciences
Sajjad Shojai, Seyed-Ali Haeri Rohani, Ali Akbar Moosavi-Movahedi, Mehran Habibi-Rezaei
Summary: Serum albumin plays important roles in the body, including carrying substances, protecting other proteins, and functioning as an antioxidant. The decrease in serum albumin concentration is associated with cognitive deterioration in the elderly and various neurodegenerative diseases.
REVIEWS IN THE NEUROSCIENCES
(2022)
Article
Environmental Sciences
Zahra Khoshkam, Mehran Habibi-Rezaei, Mohammad Sadegh Hassanvand, Younes Aftabi, Ensiyeh Seyedrezazadeh, Amir Amiri-Sadeghan, Habib Zarredar, Leila Roshangar, Akbar Gholampour, Ali A. Moosavi-Movahedi
Summary: The study compared a multi-solvent extraction approach with a conventional aqueous extraction method for PM2.5 extraction, finding that the multi-solvent extraction method showed higher extraction efficiency and reduced compositional biases.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Minoo Qafary, Fatemeh Rashno, Khosro Khajeh, Mohammad Khaledi, Ali A. Moosavi-Movahedi
Summary: Insulin and its homologous play a crucial role in diabetic patients' treatment and can form amyloid-like fibrils. Therefore, understanding the fibrillation mechanism and developing effective inhibitors are important in the pharmaceutical industry. There are various inhibitors that can stabilize the native structure of the protein, inhibit formation of partially folded species, hinder different steps in the fibrillation process, and even dissociate pre-existing fibrils.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hossein Lanjanian, Shadi Hosseini, Zahra Narimani, Sogol Meknatkhah, Gholam Hossein Riazi
Summary: The study aimed to develop a pipeline to identify potential protein-protein interaction inhibitors by screening phytochemicals from Middle Eastern antiviral herbs. A series of simulations were performed to determine candidate molecules for inhibiting PPIs involved in COVID-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Multidisciplinary
Manizheh Poodat, Adeleh Divsalar, Behafarid Ghalandari, Ramezanali Khavarinezhad
Summary: This study aims to develop a new drug delivery system using green synthetic and modified iron oxide nanoparticles (IONPs) combined with the methanolic extract of Artemisia Persica loaded with cisplatin. The synthesized IONPs showed no cytotoxicity on normal cells but exhibited significant cytotoxicity on cancer cells. Additionally, the interaction between the nanoparticles and DNA did not cause any structural changes, indicating good biocompatibility. The IONP complexed cisplatin holds promise as a potential candidate in overcoming challenges of conventional chemotherapy for breast cancer treatment.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Sedigheh Abedanzadeh, Babak Karimi, Zainab Moosavi-Movahedi, Omid Pourshiani, Alireza Badiei, Ali A. Moosavi-Movahedi
Summary: Artificial enzymes resembling natural enzymes were developed using a rational design approach to simulate the coordination sphere around the iron active center. Periodic mesoporous organosilica (PMO) materials were used as supports due to their unique properties, and a new peroxidase-like nanozyme was fabricated. The biomimetic pathways used in this study showed potential for the development of nanozymes with excellent thermal stability and long-term storage stability.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Chemistry, Physical
Sarvenaz Moradi Taklimi, Adeleh Divsalar, Behafarid Ghalandari, Xianting Ding, Maria Luisa Di Gioia, Karzan A. Omar, Ali Akbar Saboury
Summary: Since their introduction in 2003, deep eutectic solvents (DESs) have gained attention in various technological fields, especially biocatalysis, due to their unique properties such as low melting points, safety, low cost of raw materials, availability, sustainability, and biodegradability. Recent research has shown that enzymes can maintain and even improve their activity and stability when used in DES-based media. Therefore, DESs have emerged as promising alternatives to conventional organic solvents. This study reviews the effects of different DESs on the function and stability of various enzymes.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Farhad Sanginabadi, Nematollah Gheibi, Adeleh Divsalar, Ali Akbar Saboury, Parichehreh Yaghmaei, Morteza Sadeghi
Summary: In this study, the inhibitory ability and mechanism of omega 3-nicotinic acid (omega 3-NA) and omega 3-Picolinic acid (omega 3-PA) complexes on mushroom tyrosinase (MT) activity were investigated. The complexes showed significant inhibition on MT activity, with K-i values of 5.2 mM and 5.1 mM for omega 3-NA and omega 3-PA, respectively. Fluorescence quenching experiments confirmed the interaction between omega 3-NA, omega 3-PA, and MT. Molecular docking and dynamics simulations revealed that hydrogen bonding with Trp136, His263, and Val299 residues is involved in the formation of ligand-MT complexes. These findings suggest that omega 3-NA and omega 3-PA have the potential to be used as MT inhibitors for treating hyperpigmentation.
Article
Chemistry, Physical
Mahdie Rahban, Parviz Norouzi, Zainab Moosavi-Movahedi, Ali A. Moosavi-Movahedi
Summary: This study introduces a new method, FFTCCV, for determining the reversibility of catalase activation upon injection of different concentrations of hydrogen peroxide (H2O2). The results show that catalase can rapidly decompose H2O2 at concentrations below 40 mM, but its activity gradually decreases at higher concentrations. The irreversibility of catalase is triggered at a concentration of 80 mM, and the catalase activity can be recovered at lower concentrations of H2O2 after multiple injections.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Physical
Mohammad Reza Abolhassan, Adeleh Divsalar, Farideh Badalkhani-Khamseh, Nejat Kheiripour, Mahboubeh Eslami-Moghadam, Hamed Mirzaei
Summary: The present study investigated the interaction of new Schiff base-platinum complexes with human serum albumin and their toxicity effects on cancer cell lines. Fluorescence and circular dichroism spectroscopy revealed the quenching mechanisms and structural changes of the albumin caused by the complexes. Molecular docking and molecular dynamics simulations identified the main interactions between the complexes and albumin. The IC50 values of the complexes on the cancer cell lines demonstrated their anti-cancer activities.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Liana Ghasemi, Maryam Hasanzadeh Esfahani, Unes Sahebi, Adeleh Divsalar, Alireza Abbasi, Mahdi Behzad
Summary: This study synthesized and characterized a series of new mixed-ligand Cu(II) complexes, and investigated their anticancer activity. Through experimental and computational analysis, the complexes showed potent cytotoxic effects on three human carcinoma cell lines. The highest cytotoxicity was observed in complex (2), making it a promising candidate for developing new anticancer drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Education & Educational Research
Faizan Ahmad, Luo Zongwei, Zeeshan Ahmed, Sara Muneeb
Summary: This paper presents an empirical study on the experiences of players during brain games play, analyzing correlations among different types of experiences and identifying similarities and differences among different age groups. The observations provide insights to predict players' behavioral trends and simplify the user feedback process.
INTERACTIVE LEARNING ENVIRONMENTS
(2023)