Neutrophil elastase inhibitors

Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease

(2016) Caroline Owen   International Journal of Chronic Obstructive Pulmonary Disease

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Treatment of Chronic Obstructive Pulmonary Disease with Roflumilast, a New Phosphodiesterase 4 Inhibitor

(2010) Nicholas J. Gross et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Airway inflammation in chronic obstructive pulmonary disease

(2010) Katarzyna Górska et al.   CURRENT OPINION IN PULMONARY MEDICINE

Biologic and pharmacologic therapies in clinical development for the inflammatory response in COPD

(2010) Jaymin B. Morjaria et al.   DRUG DISCOVERY TODAY

Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats

(2010) Pei-Wen Hsieh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

(2010) Guijia He et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats

(2010) Sumiko Yoshikawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway

(2010) A Boutten et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Ziconotide for treatment of severe chronic pain

(2010) Achim Schmidtko et al.   LANCET

New Therapies for Chronic Obstructive Pulmonary Disease

(2010) Peter J. Barnes   MEDICAL PRINCIPLES AND PRACTICE

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

A human surfactant peptide-elastase inhibitor construct as a treatment for emphysema

(2010) F. Guarnieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

(2009) Tirumalai Rangasamy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury

(2009) Yasunao Inoue et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S′ subsite binding

(2009) Yi Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase

(2009) Kevin R. Shreder et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

(2009) Katharine H Banner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Human Leukocyte Elastase by Brunsvicamides A-C: Cyanobacterial Cyclic Peptides

(2009) Mihiret T. Sisay et al.   ChemMedChem

α1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

(2009) Ugo I. Ekeowa et al.   CLINICAL SCIENCE

Emerging drugs in chronic obstructive pulmonary disease

(2009) Carola Seifart et al.   EXPERT OPINION ON EMERGING DRUGS

Neutrophil-derived serine proteases modulate innate immune responses

(2009) Ulf Meyer-Hoffert   Frontiers in Bioscience-Landmark

Potent Inhibitors of β-Tryptase and Human Leukocyte Elastase Based on the MCoTI-II Scaffold

(2009) Panumart Thongyoo et al.   JOURNAL OF MEDICINAL CHEMISTRY

4-Oxo-β-lactams (Azetidine-2,4-diones) Are Potent and Selective Inhibitors of Human Leukocyte Elastase

(2009) Jalmira Mulchande et al.   JOURNAL OF MEDICINAL CHEMISTRY

SIVELESTAT (SELECTIVE NEUTROPHIL ELASTASE INHIBITOR) IMPROVES THE MORTALITY RATE OF SEPSIS ASSOCIATED WITH BOTH ACUTE RESPIRATORY DISTRESS SYNDROME AND DISSEMINATED INTRAVASCULAR COAGULATION PATIENTS

(2009) Mineji Hayakawa et al.   SHOCK

Mechanisms of cigarette smoke-induced COPD: insights from animal models

(2008) Andrew Churg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Chronic Obstructive Pulmonary Disease

(2008) Antonello Punturieri et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents

(2008) Qingliang Yang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke

(2008) C Le Quément et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting neutrophil elastase in cystic fibrosis

(2008) Emer Kelly et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cystatins: Biochemical and structural properties, and medical relevance

(2008) ">Vito Turk   Frontiers in Bioscience-Landmark

Proteases and cystic fibrosis

(2008) J VOYNOW et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeted Induction of Lung Endothelial Cell Apoptosis Causes Emphysema-like Changes in the Mouse

(2008) Ricardo J. Giordano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular pathogenesis of emphysema

(2008) Laimute Taraseviciene-Stewart et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of proteases and amide hydrolases that employ an α-ketoheterocycle as a key enabling functionality

(2007) Bruce E. Maryanoff et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neutrophil serine proteases fine-tune the inflammatory response

(2007) C PHAM   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY