Therapeutic targeting of platelet-derived growth factor receptors in solid tumors

Prognostic Significance in Breast Cancer of a Gene Signature Capturing Stromal PDGF Signaling

(2013) Oliver Frings et al.   AMERICAN JOURNAL OF PATHOLOGY

Distinct Effects of Ligand-Induced PDGFR  and PDGFR  Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments

(2013) M. Ehnman et al.   CANCER RESEARCH

Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma

(2013) A. Broniscer et al.   CLINICAL CANCER RESEARCH

Imatinib and prostate cancer: lessons learned from targeting the platelet-derived growth factor receptor

(2013) Aaron Rosenberg et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

The role of tumour–stromal interactions in modifying drug response: challenges and opportunities

(2013) Douglas W. McMillin et al.   NATURE REVIEWS DRUG DISCOVERY

Imatinib Ameliorates Neuroinflammation in a Rat Model of Multiple Sclerosis by Enhancing Blood-Brain Barrier Integrity and by Modulating the Peripheral Immune Response

(2013) Milena Z. Adzemovic et al.   PLoS One

Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis

(2013) Kayoko Hosaka et al.   Nature Communications

De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients

(2013) David Akhavan et al.   Cancer Discovery

Fibroblasts as architects of cancer pathogenesis

(2012) Timothy Marsh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

(2012) Vesselina G. Cooke et al.   CANCER CELL

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

(2012) C. Pena et al.   CANCER RESEARCH

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Converting Cancer Therapies into Cures: Lessons from Infectious Diseases

(2012) Michael S. Glickman et al.   CELL

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

(2012) James S. Duncan et al.   CELL

Crenolanib Inhibits the Drug-Resistant PDGFRA D842V Mutation Associated with Imatinib-Resistant Gastrointestinal Stromal Tumors

(2012) M. C. Heinrich et al.   CLINICAL CANCER RESEARCH

Dermatofibrosarcoma protruberans treatment with platelet-derived growth factor receptor inhibitor

(2012) Binu Malhotra et al.   CURRENT OPINION IN ONCOLOGY

Adjuvant Therapy for High-Risk Gastrointestinal Stromal Tumour

(2012) Heikki Joensuu   DRUGS

One vs Three Years of Adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor

(2012) Heikki Joensuu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Phase II Study of Imatinib in Advanced Chordoma

(2012) Silvia Stacchiotti et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinically Used Breast Cancer Markers Such As Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Are Unstable Throughout Tumor Progression

(2012) Linda Sofie Lindström et al.   JOURNAL OF CLINICAL ONCOLOGY

Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial

(2012) Winette TA van der Graaf et al.   LANCET

Stromal Platelet-Derived Growth Factor Receptor   (PDGFR ) Provides a Therapeutic Target Independent of Tumor Cell PDGFR  Expression in Lung Cancer Xenografts

(2012) D. E. Gerber et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

The tumor microenvironment controls drug sensitivity

(2012) Arne Östman   NATURE MEDICINE

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas

(2012) Stephanie Puget et al.   PLoS One

Effects of Sorafenib on Intra-Tumoral Interstitial Fluid Pressure and Circulating Biomarkers in Patients with Refractory Sarcomas (NCI Protocol 6948)

(2012) Chandrajit P. Raut et al.   PLoS One

Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis

(2012) Carina Strell et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

PDGF and PDGF receptors in glioma

(2012) Inga Nazarenko et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Increased Vascular Delivery and Efficacy of Chemotherapy after Inhibition of Platelet-Derived Growth Factor-B

(2011) Beverly L. Falcon et al.   AMERICAN JOURNAL OF PATHOLOGY

PTEN Regulates PDGF Ligand Switch for β-PDGFR Signaling in Prostate Cancer

(2011) M. Katie Conley-LaComb et al.   AMERICAN JOURNAL OF PATHOLOGY

Prognostic value of KIT/PDGFRA mutations in gastrointestinal stromal tumours (GIST): Polish Clinical GIST Registry experience

(2011) A. Wozniak et al.   ANNALS OF ONCOLOGY

The angiogenic process as a therapeutic target in cancer

(2011) Esther M. Bridges et al.   BIOCHEMICAL PHARMACOLOGY

Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor β In Vivo

(2011) M. Lindborg et al.   JOURNAL OF MOLECULAR BIOLOGY

PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells

(2011) Yuan Xue et al.   NATURE MEDICINE

Cediranib inhibits both the intraosseous growth of PDGF D-Positive prostate cancer cells and the associated bone reaction

(2011) Abdo J. Najy et al.   PROSTATE

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

A Novel Signaling Axis of Matriptase/PDGF-D/ -PDGFR in Human Prostate Cancer

(2010) C. V. Ustach et al.   CANCER RESEARCH

Targeting the   Receptor for Platelet-Derived Growth Factor as a Primary or Combination Therapy in a Preclinical Model of Prostate Cancer Skeletal Metastasis

(2010) M. R. Russell et al.   CLINICAL CANCER RESEARCH

Efficacy of Imatinib in Aggressive Fibromatosis: Results of a Phase II Multicenter Sarcoma Alliance for Research through Collaboration (SARC) Trial

(2010) R. Chugh et al.   CLINICAL CANCER RESEARCH

Phase II study of oral masitinib mesilate in imatinib-naïve patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST)

(2010) Axel Le Cesne et al.   EUROPEAN JOURNAL OF CANCER

Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma

(2010) Janna Paulsson et al.   INTERNATIONAL JOURNAL OF CANCER

Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease

(2010) Barbara S. Paugh et al.   JOURNAL OF CLINICAL ONCOLOGY

Multicenter Phase II trial assessing effectiveness of imatinib mesylate on relapsed or refractory KIT-positive or PDGFR-positive sarcoma

(2010) Hideshi Sugiura et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

Stromal PDGFRβ Expression in Prostate Tumors and Non-Malignant Prostate Tissue Predicts Prostate Cancer Survival

(2010) Christina Hägglöf et al.   PLoS One

Platelet-Derived Growth Factor Receptor Expression and Activation in Choroid Plexus Tumors

(2009) Björn Koos et al.   AMERICAN JOURNAL OF PATHOLOGY

Prognostic Significance of Stromal Platelet-Derived Growth Factor β-Receptor Expression in Human Breast Cancer

(2009) Janna Paulsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Fibroblast Hepatocyte Growth Factor Promotes Invasion of Human Mammary Ductal Carcinoma In situ

(2009) C. Jedeszko et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Phase I Study of the Safety, Tolerability, and Pharmacokinetics of Oral CP-868,596, a Highly Specific Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor in Patients With Advanced Cancers

(2009) Nancy L. Lewis et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model

(2009) Rashmi Chugh et al.   JOURNAL OF CLINICAL ONCOLOGY

Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide

(2009) Gregor Dresemann et al.   JOURNAL OF NEURO-ONCOLOGY

Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

(2009) F van Zijl et al.   ONCOGENE

Activity of Dasatinib, a Dual SRC/ABL Kinase Inhibitor, and IPI-504, a Heat Shock Protein 90 Inhibitor, against Gastrointestinal Stromal Tumor-Associated PDGFRAD842V Mutation

(2008) B. Dewaele et al.   CLINICAL CANCER RESEARCH

Role of platelet-derived growth factors in physiology and medicine

(2008) J. Andrae et al.   GENES & DEVELOPMENT

Long-Term Results From a Randomized Phase II Trial of Standard- Versus Higher-Dose Imatinib Mesylate for Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing KIT

(2008) Charles D. Blanke et al.   JOURNAL OF CLINICAL ONCOLOGY

Correlation of Kinase Genotype and Clinical Outcome in the North American Intergroup Phase III Trial of Imatinib Mesylate for Treatment of Advanced Gastrointestinal Stromal Tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group

(2008) Michael C. Heinrich et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

(2008) Enming J Su et al.   NATURE MEDICINE

The uPA/uPAR system regulates the bioavailability of PDGF-DD: implications for tumour growth

(2008) M Ehnman et al.   ONCOGENE