Vorapaxar: a novel protease-activated receptor-1 inhibitor

Randomized Trial of Atopaxar in the Treatment of Patients With Coronary Artery Disease

(2011) Stephen D. Wiviott et al.   CIRCULATION

Safety and Tolerability of Atopaxar in the Treatment of Patients With Acute Coronary Syndromes

(2011) Michelle L. O'Donoghue et al.   CIRCULATION

Safety and Exploratory Efficacy of the Novel Thrombin Receptor (PAR-1) Antagonist SCH530348 for Non-ST-Segment Elevation Acute Coronary Syndrome

(2011) Shinya Goto et al.   Journal of Atherosclerosis and Thrombosis

SCH 602539, a Protease-Activated Receptor-1 Antagonist, Inhibits Thrombosis Alone and in Combination With Cangrelor in a Folts Model of Arterial Thrombosis in Cynomolgus Monkeys

(2010) Madhu Chintala et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Combination Antithrombotic Therapies

(2010) Paul A. Gurbel et al.   CIRCULATION

Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P)-TIMI 50 trial

(2009) David A. Morrow et al.   AMERICAN HEART JOURNAL

The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA•CER) trial: study design and rationale

(2009) The TRA•CER Executive and Steering Committees   AMERICAN HEART JOURNAL

Recent developments in clopidogrel pharmacology and their relation to clinical outcomes

(2009) Paul A Gurbel et al.   Expert Opinion on Drug Metabolism & Toxicology

Bivalirudin and Clopidogrel With and Without Eptifibatide for Elective Stenting: Effects on Platelet Function, Thrombelastographic Indexes, and Their Relation to Periprocedural Infarction

(2009) Paul A. Gurbel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study

(2009) Richard C Becker et al.   LANCET

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet protease-activated receptor 1 and membrane expression of P-selectin in pulmonary arterial hypertension

(2009) Nair Y. Maeda et al.   THROMBOSIS RESEARCH

2008 ATVB Oral Presentations

(2008)   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity

(2008) Samuel Chackalamannil et al.   JOURNAL OF MEDICINAL CHEMISTRY

Basic and Translational Research on Proteinase-Activated Receptors: Antagonism of the Proteinase-Activated Receptor 1 for Thrombin, a Novel Approach to Antiplatelet Therapy for Atherothrombotic Disease

(2008) Madhu Chintala et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES