Recent developments in clopidogrel pharmacology and their relation to clinical outcomes

Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel

(2008) Jolanta M. Siller-Matula et al.   AMERICAN HEART JOURNAL

Dynamics of Platelet Functional Recovery Following a Clopidogrel Loading Dose in Healthy Volunteers

(2008) Matthew J. Price et al.   AMERICAN JOURNAL OF CARDIOLOGY

Relation of Low Response to Clopidogrel Assessed With Point-of-Care Assay to Periprocedural Myonecrosis in Patients Undergoing Elective Coronary Stenting for Stable Angina Pectoris

(2008) Thomas Cuisset et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effect of Cytochrome P450 Polymorphisms on Platelet Reactivity After Treatment With Clopidogrel in Acute Coronary Syndrome

(2008) Corinne Frere et al.   AMERICAN JOURNAL OF CARDIOLOGY

Antiplatelet Drugs

(2008) Carlo Patrono et al.   CHEST

The Effect of CYP2C19 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Clopidogrel: A Possible Mechanism for Clopidogrel Resistance

(2008) KA Kim et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2

(2008) E. T. Williams et al.   DRUG METABOLISM AND DISPOSITION

The Antiplatelet Effect of Higher Loading and Maintenance Dose Regimens of Clopidogrel

(2008) Patrick Gladding et al.   JACC-Cardiovascular Interventions

Incidence of Death and Acute Myocardial Infarction Associated With Stopping Clopidogrel After Acute Coronary Syndrome

(2008) P. Michael Ho   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of the Proton Pump Inhibitor Lansoprazole on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel

(2008) David S. Small et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Smoking behaviour modulates pharmacokinetics of orally administered clopidogrel

(2008) A.-M. Yousef et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Population pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in aspirin-treated patients with stable coronary artery disease

(2008) C. Steven Ernest et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Incidence and Clinical Impact of Dual Nonresponsiveness to Aspirin and Clopidogrel in Patients With Drug-Eluting Stents

(2008) Anna Maria Gori et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adjusted Clopidogrel Loading Doses According to Vasodilator-Stimulated Phosphoprotein Phosphorylation Index Decrease Rate of Major Adverse Cardiovascular Events in Patients With Clopidogrel Resistance

(2008) Laurent Bonello et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Initial Assessment of Clinical Impact of a Drug Interaction Between Clopidogrel and Proton Pump Inhibitors

(2008) Edmund Pezalla et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Patients With Poor Responsiveness to Thienopyridine Treatment or With Diabetes Have Lower Levels of Circulating Active Metabolite, but Their Platelets Respond Normally to Active Metabolite Added Ex Vivo

(2008) David Erlinge et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Influence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin

(2008) Martine Gilard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Calcium-Channel Blockers Reduce the Antiplatelet Effect of Clopidogrel

(2008) Jolanta M. Siller-Matula et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents

(2008) Dietmar Trenk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Association of Cigarette Smoking With Enhanced Platelet Inhibition by Clopidogrel

(2008) Kevin P. Bliden et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The reversible P2Y12antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function

(2008) N. L. DOVLATOVA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

(2008) Jean-Philippe Collet et al.   LANCET

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

(2008) Jessica L. Mega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

(2008) Tabassome Simon et al.   NEW ENGLAND JOURNAL OF MEDICINE

CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation

(2008) Tobias Geisler et al.   PHARMACOGENOMICS

Effect of Atorvastatin on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel in Healthy Subjects

(2008) Nagy A Farid et al.   PHARMACOTHERAPY

The active metabolite of prasugrel effectively blocks the platelet P2Y12receptor and inhibits procoagulant and pro-inflammatory platelet responses

(2008) Heather M. Judge et al.   PLATELETS

Platelet reactivity to adenosine diphosphate and long-term ischemic event occurrence following percutaneous coronary intervention: A potential antiplatelet therapeutic target

(2008) Paul A. Gurbel et al.   PLATELETS