Investigational agents for Crohn's disease

Meta-analysis: remission and response from control arms of randomized trials of biological therapies for active luminal Crohn’s disease

(2010) F. TINÈ et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Golimumab, a new human anti-tumor necrosis factor α antibody, administered intravenously in patients with active rheumatoid arthritis: Forty-eight-week efficacy and safety results of a phase III randomized, double-blind, placebo-controlled study

(2010) Joel Kremer et al.   ARTHRITIS AND RHEUMATISM

The Probiotic Preparation, VSL#3 Induces Remission in Patients With Mild-to-Moderately Active Ulcerative Colitis

(2009) Ajit Sood et al.   Clinical Gastroenterology and Hepatology

Biological Therapies for Inflammatory Bowel Diseases

(2009) Paul Rutgeerts et al.   GASTROENTEROLOGY

Steroid-sparing properties of sargramostim in patients with corticosteroid-dependent Crohn's disease: a randomised, double-blind, placebo-controlled, phase 2 study

(2009) J F Valentine et al.   GUT

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

Fontolizumab in moderate to severe Crohnʼs disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study

(2009) Walter Reinisch et al.   INFLAMMATORY BOWEL DISEASES

Innate antimicrobial host defense in small intestinal Crohn's disease

(2009) Maureen J. Koslowski et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Sargramostim in patients with Crohn’s disease: results of a phase 1–2 study

(2009) Masakazu Takazoe et al.   JOURNAL OF GASTROENTEROLOGY

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of the Immunomodulatory Properties of Three Probiotic Strains of Lactobacilli Using Complex Culture Systems: Prediction for In Vivo Efficacy

(2009) Erika Mileti et al.   PLoS One

Development of recombinant vaccines against IL-12/IL-23 p40 and in vivo evaluation of their effects in the downregulation of intestinal inflammation in murine colitis

(2009) Qingdong Guan et al.   VACCINE

Clinical trial: a multicentre, randomized, double-blind, placebo-controlled, dose-finding, phase II study of subcutaneous interferon-β-1a in moderately active ulcerative colitis

(2008) C. PENA-ROSSI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A Multicenter, Randomized, Double-Blind Trial of EverolimusVersusAzathioprine and Placebo to Maintain Steroid-Induced Remission in Patients With Moderate-to-Severe Active Crohn's Disease

(2008) Walter Reinisch et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Treatment of Active Crohn's Disease With MLN0002, a Humanized Antibody to the α4β7 Integrin

(2008) Brian G. Feagan et al.   Clinical Gastroenterology and Hepatology

Efficacy and Safety of Tumor Necrosis Factor Antagonists in Crohn's Disease: Meta-Analysis of Placebo-Controlled Trials

(2008) Laurent Peyrin–Biroulet et al.   Clinical Gastroenterology and Hepatology

A Meta-Analysis on the Efficacy of Probiotics for Maintenance of Remission and Prevention of Clinical and Endoscopic Relapse in Crohn’s Disease

(2008) Roja Rahimi et al.   DIGESTIVE DISEASES AND SCIENCES

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

Infliximab Prevents Crohn's Disease Recurrence After Ileal Resection

(2008) Miguel Regueiro et al.   GASTROENTEROLOGY

A component of polysaccharide peptidoglycan complex onLactobacillusinduced an improvement of murine model of inflammatory bowel disease and colitis-associated cancer

(2008) S. Matsumoto et al.   IMMUNOLOGY

Clinical use of E. coli Nissle 1917 in inflammatory bowel disease

(2008) Michael Schultz   INFLAMMATORY BOWEL DISEASES

Mechanisms of action of probiotics: Recent advances

(2008) S. C. Ng et al.   INFLAMMATORY BOWEL DISEASES