Review
Gastroenterology & Hepatology
Sudheer Kumar Vuyyuru, Virginia Solitano, Malcolm Hogan, John K. MacDonald, Alexa Zayadi, Claire E. Parker, Bruce E. Sands, Remo Panaccione, Neeraj Narula, Brian G. Feagan, Siddharth Singh, Vipul Jairath, Christopher Ma
Summary: This systematic review and meta-analysis evaluated the efficacy and safety of selective IL-23p19 and IL-12/23p40 inhibitors in patients with moderate-to-severe CD. The results demonstrated that targeting IL-23 is effective and safe for inducing and maintaining clinical and endoscopic remission.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Bram Verstockt, Azucena Salas, Bruce E. Sands, Clara Abraham, Haim Leibovitzh, Markus Neurath, Niels Vande Casteele
Summary: IL-12 and IL-23 play a crucial role in intestinal homeostasis and inflammation, and are implicated in the pathogenesis of inflammatory bowel disease. Monoclonal antibodies targeting IL-12 and/or IL-23 have been developed for the treatment of Crohn's disease and ulcerative colitis. This Review summarizes the biological characteristics of IL-12 and IL-23, discusses their role in intestinal homeostasis and inflammation, and highlights the development of drugs targeting IL-12 and/or IL-23.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Rong Xu, Kaijing Liu, Xiaoli Wang, Chuangnian Zhang, Yajing Zhang, Jing Yang
Summary: In this study, a synergistic therapy strategy of cytokine and dendritic cell vaccine was developed by chemically conjugating cytokine-loaded SiO2 onto the plasma membrane of dendritic cells. The SiO2 had high cytokine loading capacity and entrapment efficiency, and was stably attached to the dendritic cell surface without affecting cell viability and membrane integrity. This strategy avoids the systemic toxicity of cytokines and improves the ability of dendritic cells to target lymph nodes, providing long-term anti-tumor protection.
Article
Nanoscience & Nanotechnology
Anjali Barnwal, Surajit Ganguly, Jayanta Bhattacharyya
Summary: In this study, Interleukin-12 (IL-12) was encapsulated in extracellular vesicles derived from activated dendritic cells (DEVs) with tumor antigens. The DEV-IL delayed the growth of murine glioblastoma by recruiting immune cells, depleting immunosuppressive cells, and inhibiting angiogenesis. It also enhanced systemic immunity by increasing CTL activity and proinflammatory cytokines levels in the spleen.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jin-Qing Liu, Chengxiang Zhang, Xinfu Zhang, Jingyue Yan, Chunxi Zeng, Fatemeh Talebian, Kimberly Lynch, Weiyu Zhao, Xucheng Hou, Shi Du, Diana D. Kang, Binbin Deng, David W. McComb, Xue-Feng Bai, Yizhou Dong
Summary: Localized therapy that delivers immune stimulatory cytokines directly to tumors improves therapeutic efficacy without causing systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Aurelie Fantou, Eric Lagrue, Thomas Laurent, Laurence Delbos, Stephanie Blandin, Anne Jarry, Gaelle Beriou, Cecile Braudeau, Nina Salabert, Eros Marin, Aurelie Moreau, Juliette Podevin, Arnaud Bourreille, Regis Josien, Jerome C. Martin
Summary: This research further characterizes the production and distribution of IL-22BP in Crohn's disease (CD) tissues. IL-22BP levels were found to be higher in inflamed ileums than colons. Mononuclear phagocytes and eosinophils expressed the highest levels of IL-22BP among T cell sources. Inflamed colons showed increased IL-22/IL-22BP ratios and a strong correlation between IL-22BP and CCL24. Monocyte-derived dendritic cells (moDC) were identified as a cellular subtype co-expressing both IL-22BP and IL-22, and retinoic acid induced the secretion of IL-22BP and CCL24 by moDC. Higher IL-22BP levels were also observed in active smokers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
S. Elizabeth Franks, Ginette S. Santiago-Sanchez, Kellsye P. Fabian, Kristen Solocinski, Paul L. Chariou, Duane H. Hamilton, Joshua T. Kowalczyk, Michelle R. Padget, Sofia R. Gameiro, Jeffrey Schlom, James W. Hodge
Summary: Chemotherapy can induce tumor necrosis, allowing targeted delivery of immuno-oncology agents into the tumor microenvironment. Combining docetaxel and NHS-IL-12 provides significant antitumor benefits and prolonged survival in murine tumor models.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Geriatrics & Gerontology
Youn-Kwan Jung, Sangyeob Lee, Jun-Il Yoo, Kyung-Wan Baek
Summary: This study found that treatment with IL-12/23 p40 neutralizing antibody can alleviate inflammation and improve muscle mass and function in an experimental colitis model.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Oncology
Bing Feng, Banzhou Pan, Jiayuan Huang, Yuxin Du, Xin Wang, Jianzhong Wu, Rong Ma, Bo Shen, Guichun Huang, Jifeng Feng
Summary: Through bioinformatics screening, we identified PDE4D as a gene related to immunotherapy efficacy. We discovered a functional PDE4D/cAMP/IL-23 axis in a co-culture system of lung adenocarcinoma cells and tumor-specific CD8+ T cells. Our findings from fluorescent multiplex immunohistochemistry analysis and transcriptome sequencing revealed that IL-23 up-regulates IL-9 expression in CTLs via activating the NF-kappa B signaling pathway, leading to enhanced antitumor immunotherapy efficacy. Additionally, we uncovered an autocrine loop of IL-9 during this process.
Article
Dermatology
Tiago Torres, Luis Puig, Ron Vender, Charles Lynde, Stefano Piaserico, Jose M. Carrascosa, Paolo Gisondi, Esteban Dauden, Curdin Conrad, Pedro Mendes-Bastos, Paulo Ferreira, Luiz Leite, Justin D. Lu, J. Valerio, M. Bruni, F. Messina, A. Nidegger, M. Llamas-Velasco, E. del Alcazar, A. Mufti, Kyra White, G. Caldarola, Laetitia Teixeira, Paolo Romanelli, K. Desai, Spyridon Gkalpakiotis, Marco Romanelli, Jensen Yeung, Miguel Nogueira, Andrea Chiricozzi
Summary: In this study, drug survival analysis of the most recent biologic agents approved for the treatment of psoriasis was conducted. Factors such as female sex, higher BMI, and prior exposure to biologic agents were found to significantly increase the risk of drug discontinuation. The study also showed that the drug survival of guselkumab and risankizumab was higher than that of ustekinumab, while secukinumab had a lower drug survival rate.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Caleb R. Glassman, Yamuna Kalyani Mathiharan, Kevin M. Jude, Leon Su, Ouliana Panova, Patrick J. Lupardus, Jamie B. Spangler, Lauren K. Ely, Christoph Thomas, Georgios Skiniotis, K. Christopher Garcia
Summary: The structural mechanism of receptor sharing used by IL-12 family cytokines can be utilized to tune the cytokine axis for therapeutics, as demonstrated by the design of IL-12 partial agonists that elicited anti-tumor immunity in vivo.
Article
Multidisciplinary Sciences
Mary Jo Rademacher, Anahi Cruz, Mary Faber, Robyn A. A. Oldham, Dandan Wang, Jeffrey A. Medin, Nathan J. Schloemer
Summary: Lentiviral transduction of sarcoma cells to express IL-12 can induce high-level expression of IL-12 and elicit specific immune responses in murine models, particularly mature human NK cells. IL-12 immunomodulation through autologous tumor transduction and reintroduction shows promise for sarcoma treatment and warrants further exploration.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Matias Tellado, Mariangela De Robertis, Daniela Montagna, Daniela Giovannini, Sergio Salgado, Sebastian Michinski, Emanuela Signori, Felipe Maglietti
Summary: This retrospective cohort study evaluated the addition of canine IL-2 gene electrotransfer (GET) peritumorally and IL-12 intramuscularly in inoperable canine oral malignant melanoma. The results showed that ECT+GET using IL-2 and IL-12 significantly improved progression-free survival in advanced stages of canine oral malignant melanoma.
Review
Oncology
Bhalchandra Mirlekar, Yuliya Pylayeva-Gupta
Summary: The IL-12 family cytokines are crucial in regulating tumor immune contexture and activating anti-tumor immune responses. Different family members have distinct roles, encompassing both promoting effector responses and inhibitory functions. These cytokines hold promise as candidates for developing immunomodulatory therapeutic approaches.
Article
Multidisciplinary Sciences
Jardin A. Leleux, Tina C. Albershardt, Rebecca Reeves, Reice James, Jordan Krull, Andrea J. Parsons, Jan ter Meulen, Peter Berglund
Summary: The study introduces two IL12-expressing vector platforms that can overcome the limitations of previous systemic IL12 therapies and achieve complete remission of tumors in murine models. Combining vectorized IL12 with a TLR4 agonist induces systemic memory T cell responses, enhancing protection against tumor rechallenge.
Meeting Abstract
Cardiac & Cardiovascular Systems
Maya M. Jeyaraman, Rasheda Rabbani, Leslie Copstein, Wasan Sulaiman, Farnaz Farshidfar, Hessam Kashani, Sheikh M. Z. Qadar, Qingdong Guan, Becky Skidmore, Elissavet Kardami, John Ducas, Samer Mansour, Ryan Zarychanski, Ahmed M. Abou-Setta
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2017)
Editorial Material
Cell Biology
Qingdong Guan, Xiaoling Gao, Junhui Wang, Yu Sun, Sudhanshu Shekhar
MEDIATORS OF INFLAMMATION
(2017)
Review
Cell Biology
Qingdong Guan, Jiguo Zhang
MEDIATORS OF INFLAMMATION
(2017)
Article
Biochemical Research Methods
Qingdong Guan, Peyman Ezzati, Victor Spicer, Oleg Krokhin, Donna Wall, John A. Wilkins
CLINICAL PROTEOMICS
(2017)
Article
Cell & Tissue Engineering
Qingdong Guan, Yun Li, Tanner Shpiruk, Swaroop Bhagwat, Donna A. Wall
Article
Gastroenterology & Hepatology
Qingdong Guan, Carolyn R. Weiss, Shuhe Wang, Gefei Qing, Xi Yang, Richard J. Warrington, Charles N. Bernstein, Zhikang Peng
INFLAMMATORY BOWEL DISEASES
(2018)
Editorial Material
Cell Biology
Qingdong Guan, Cheng Xiao, Minggang Zhang
MEDIATORS OF INFLAMMATION
(2018)
Editorial Material
Immunology
Cheng Xiao, Qingdong Guan, Yong Tan, Lifei Hou, Wuxiang Xie
JOURNAL OF IMMUNOLOGY RESEARCH
(2018)
Article
Hematology
Ahmed Y. Ali, Qingdong Guan, Xun Wu, Sen Hou, Versha Banerji, James B. Johnston, Donna Wall, David Szwajcer, Spencer B. Gibson, Aaron J. Marshall
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Allergy
Qingdong Guan, Bin Yang, Richard J. Warrington, Steven Mink, Chrystyna Kalicinsky, Allan B. Becker, Elinor Simons, Zhikang Peng
Editorial Material
Cell Biology
Qingdong Guan, Cheng Xiao, Minggang Zhang
MEDIATORS OF INFLAMMATION
(2019)
Review
Immunology
Qingdong Guan
JOURNAL OF IMMUNOLOGY RESEARCH
(2019)
Article
Medicine, Research & Experimental
Qingdong Guan, Richard Warrington, Sem Moreno, Gefei Qing, Carolyn Weiss, Zhikang Peng
Review
Cardiac & Cardiovascular Systems
Maya M. Jeyaraman, Rasheda Rabbani, Leslie Copstein, Wasan Sulaiman, Farnaz Farshidfar, Hessam H. Kashani, Sheikh M. Z. Qadar, Qingdong Guan, Becky Skidmore, Elissavet Kardami, John Ducas, Samer Mansour, Ryan Zarychanski, Ahmed M. Abou-Setta
CANADIAN JOURNAL OF CARDIOLOGY
(2017)
Article
Medicine, Research & Experimental
Sabine Ivison, Mehrnoush Malek, Rosa Garcia, Raewyn Broady, Anne Halpin, Manon Richaud, Rollin F. Brant, Szu- Wang, Mathieu Goupil, Qingdong Guan, Peter Ashton, Jason Warren, Amr Rajab, Simon Urschel, Deepali Kumar, Mathias Streitz, Birgit Sawitzki, Stephan Schlickeiser, Janetta J. Bijl, Donna A. Wall, Jean-Sebastien Delisle, Lori J. West, Ryan R. Brinkman, Megan K. Levings