Article
Multidisciplinary Sciences
Philip G. Ferstl, Natalie Filmann, Eva-Maria Heilgenthal, Andreas A. Schnitzbauer, Wolf O. Bechstein, Volkhard A. J. Kempf, David Villinger, Tilman G. Schultze, Michael Hogardt, Christoph Stephan, Haitham Mutlak, Nina Weiler, Marcus M. Muecke, Jonel Trebicka, Stefan Zeuzem, Oliver Waidmann, Martin-Walter Welker
Summary: The prevalence of multidrug-resistant organisms is a major health concern for liver cirrhosis patients. This study found that MDRO colonization in liver transplant candidates and recipients is associated with increased mortality on the waiting list, especially with CRGN colonization.
Article
Immunology
Karim Khader, Alun Thomas, W. Charles Huskins, Vanessa Stevens, Lindsay T. Keegan, Lindsay Visnovsky, Matthew H. Samore
Summary: The study found limited evidence that contact precautions implemented in ICUs reduced transmission of MRSA or VRE, with significant differences in transmission dynamics and clearance rates between the two pathogens. ICU-level factors were not found to be associated with the effects of contact precautions.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Elvira Aguglia, Eleonora Chines, Stefania Stefani, Viviana Cafiso
Summary: This study compares VISA CA-MRSA with its VSSA CA-MRSA parent in a hospitalized patient undergoing glycopeptide treatment and identifies mutational and transcriptomic adaptations in genes involved in the biosynthesis of the glycopeptide target and pathways supporting glycopeptide resistance. These adaptations include key genes responsible for the biosynthesis of peptidoglycan precursors, as well as accessory genes involved in transport and transcription.
Article
Chemistry, Medicinal
Anish Parmar, Rajamani Lakshminarayanan, Abhishek Iyer, Eunice Tze Leng Goh, Tsz Ying To, Joey Kuok Hoong Yam, Liang Yang, Enas Newire, Maria C. Robertson, Stephen H. Prior, Eefjan Breukink, Annemieke Madder, Ishwar Singh
Summary: Teixobactin analogues with simplified structures, consisting of commercially available hydrophobic amino acid residues and various combinations of arginines, showed potent antibacterial activity against a broad range of Gram-positive bacteria, including MRSA and VRE strains. These analogues also demonstrated strong antibiofilm activity against Staphylococcus species associated with chronic infections, providing insights for the synthesis of highly potent Teixobactin analogues to combat resistant bacterial infections and biofilms.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Environmental Sciences
Christiane Schreiber, Nicole Zacharias, Sarah M. Essert, Felix Wasser, Heike Mueller, Esther Sib, Tabea Precht, Marijo Parcina, Gabriele Bierbaum, Ricarda M. Schmithausen, Thomas Kistemann, Martin Exner
Summary: The emergence of antibiotic-resistant clinically relevant facultative pathogenic bacteria in the environment has become a major global health challenge, with standardized methods for detection limited to clinical investigations. By proposing standardized cultivation methods, this study achieved effective detection of clinically-relevant antibiotic resistant bacteria in aquatic environmental samples, enhancing accuracy and efficiency in detection.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Infectious Diseases
Evan J. Zasowski, Maryam Ali, Ada Anugo, Nayle Ibragimova, Kierra M. Dotson, Bradley T. Endres, Khurshida Begum, M. Jahangir Alam, Kevin W. Garey
Summary: This study aimed to develop predictive indices for multidrug-resistant organism (MDRO) gut colonization in patients with Clostridioides difficile infection (CDI). They compared the predictive performance of a regression-based risk score with two other simplified risk stratification approaches. The results showed that a simplified approach using prior healthcare exposure and receipt of prior antibiotics was as effective as individual patient/antibiotic risk modeling in identifying patients at risk for MDRO gut colonization.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Microbiology
Cecilia G. Carvalhaes, Helio S. Sader, Jennifer M. Streit, Mariana Castanheira, Rodrigo E. Mendes
Summary: According to data from a 10-year study, oritavancin has shown strong activity against Gram-positive pathogens that cause bloodstream infections, and has demonstrated good efficacy against resistant strains of MRSA and Enterococcus.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Warren Rose, Cecilia Volk, Thomas J. Dilworth, George Sakoulas
Summary: This perspective highlights the continued use of vancomycin as the standard antibiotic for serious MRSA infections despite its complexity. However, vancomycin treatment failure and potential nephrotoxicity pose challenges, and the cost and complexity of vancomycin care are often overlooked in a time when alternative antibiotics are becoming more cost-effective.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Anders Skyrud Danielsen, Petter Elstrom, Hanne-Merete Eriksen-Volle, Solveig Hofvind, David W. Eyre, Oliver Kacelnik, Jorgen Vildershoj Bjornholt
Summary: Surveillance has shown an increase in multidrug-resistant organisms (MDROs), even in low-prevalent settings like Norway, including among individuals with cancer. This study aimed to describe the epidemiology of MDROs in cancer patients in Norway from 2008 to 2018 by combining existing data sources. The findings highlight the need for effective infection control and surveillance, as there was an unfavorable trend in the incidence and resistance of Gram-negative bacteria.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Review
Chemistry, Medicinal
Yujie Gao, Yuan Chen, Yubin Cao, Anchun Mo, Qiang Peng
Summary: The abuse of antibiotics has led to the emergence of drug-resistant pathogens, such as MRSA, which presents a significant challenge in treatment. Nanotechnology offers a promising solution, utilizing functional nanomaterials as drug carriers or antibacterial agents for therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Infectious Diseases
Pavlina Lena, Spyridon A. Karageorgos, Panayiota Loutsiou, Annita Poupazi, Demetris Lamnisos, Panagiotis Papageorgis, Constantinos Tsioutis
Summary: This study aimed to evaluate the presence of multidrug-resistant bacteria (MDRB) on healthcare worker (HCW) uniforms in Cyprus. The study found that HCW uniforms harbored MDRB, and identified long-term care facilities as an important area for interventions. Factors associated with HCW practices, characteristics, and attire laundering practices were also identified as areas for improvement.
Article
Biochemistry & Molecular Biology
Ibrahim S. Alkhaibari, Hansa Raj Kc, Subrata Roy, Mohd. K. Abu-gazleh, David F. Gilmore, Mohammad A. Alam
Summary: This study reports the design, synthesis, and antimicrobial studies of 30 novel pyrazole derivatives, most of which are potent growth inhibitors of planktonic Gram-positive bacteria. Several lead compounds were identified to be bactericidal and effective against MRSA persisters, as well as S. aureus biofilms.
Review
Microbiology
Kelly A. Cairns, Andrew A. Udy, Trisha N. Peel, Iain J. Abbott, Michael J. Dooley, Anton Y. Peleg
Summary: Vancomycin-resistant enterococci (VRE) are a common cause of bloodstream infections (BSIs) with high morbidity and mortality rates. The management of VRE BSI presents significant challenges, including drug dosing, resistance emergence, and optimal treatment strategies. Therapeutic drug monitoring (TDM) shows promise in predicting drug toxicity for VRE-active agents, but there is limited evidence for predicting antimicrobial efficacy for VRE BSIs. This article provides an overview of treatment options, the role of TDM in clinical infection management, and future challenges and perspectives.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Sachin Kumar, Haris M. Khan, Fohad Mabood Husain, Rafiq Ahmad, Faizan Abul Qais, Mo Ahamad Khan, Mohammad Jalal, Uzma Tayyaba, Syed Ghazanfar Ali, Amardeep Singh, Mohammad Shahid, Byeong-Il Lee
Summary: Infectious diseases are a major concern for human health, and the emergence of multidrug-resistant bacteria has made this issue even more complex. In this study, silver nanoparticles synthesized using the leaf extract of a medicinal plant showed robust antibacterial and antibiofilm activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) bacteria. Electron microscopy revealed that these nanoparticles had a deleterious impact on bacterial morphology.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Microbiology
Manav Jain, Gideon Stitt, Luke Son, Elena Y. Enioutina
Summary: Antibiotic resistance is a major global health problem, particularly in treating MRSA and VRE infections. Probiotics and antimicrobial peptides are promising approaches that can inhibit pathogen growth and enhance the host immune system, potentially providing new strategies against antibiotic-resistant bacteria.
Article
Microbiology
Suzanne L. Parker, Frantzeska Frantzeskaki, Steven C. Wallis, Chryssa Diakaki, Helen Giamarellou, Despoina Koulenti, Ilias Karaiskos, Jeffrey Lipman, George Dimopoulos, Jason A. Roberts
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Microbiology
Ilias Karaiskos, Lena E. Friberg, Konstantinos Pontikis, Konstantinos Ioannidis, Vasiliki Tsagkari, Lamprini Galani, Eirini Kostakou, Fotini Baziaka, Charalambos Paskalis, Antonia Koutsoukou, Helen Giamarellou
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Critical Care Medicine
Mirjam J. D. Dautzenberg, Ann N. Wekesa, Marek Gniadkowski, Anastasia Antoniadou, Helen Giamarellou, George L. Petrikkos, Anna Skiada, Christian Brun-Buisson, Marc J. M. Bonten, Lennie P. G. Derde
CRITICAL CARE MEDICINE
(2015)
Article
Pharmacology & Pharmacy
Ilias Karaiskos, Maria Souli, Helen Giamarellou
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2015)
Letter
Infectious Diseases
Christina Routsi, Stelios Kokkoris, Evangelia Douka, Foteini Ekonomidou, Ilias Karaiskos, Helen Giamarellou
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2015)
Article
Infectious Diseases
D. J. Hetem, L. P. G. Derde, J. Empel, A. Mroczkowska, M. Orczykowska-Kotyna, A. Kozinska, W. Hryniewicz, H. Goossens, M. J. M. Bonten
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2016)
Article
Infectious Diseases
Maria Souli, Ilias Karaiskos, Lambrini Galani, Sofia Maraki, Efstathia Perivolioti, Athina Argyropoulou, Athina Charissiadou, Levantia Zachariadou, Sofia Tsiplakou, Vassiliki Papaioannou, Helen Tsorlini, Helen Katsifa, Vasiliki Baka, Paraskevi Pantazi, Angeliki Paschali, Anna Kyratsa, Eleftheria Trikka-Graphakos, Panagiota Giannopoulou, Evangelos Vogiatzakis, Helen Moraitou, Helen Papadogeorgaki, Helen Avgerinou, Theofano Panagea, Angeliki Pantazatou, Efthymia Petinaki, Giannoula Stamatopoulou, Marina Toutouza, Ioanna Karatzoglou, Konstantina Kontopoulou, Maria Orfanidou, Irene Karantani, Panteleimon Fytas, Konstantina Tzanetou, Evangelia Platsouka, Polyzo Kazila, Anastasia Chli, Ntina Statiri, Helen Giamarellou
INFECTIOUS DISEASES
(2016)
Article
Infectious Diseases
Ilias Karaiskos, Lena E. Friberg, Lambrini Galani, Konstantinos Ioannidis, Emmanouela Katsouda, Zoe Athanassa, Harris Paskalis, Helen Giamarellou
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2016)
Article
Infectious Diseases
Helen Giamarellou
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2016)
Article
Infectious Diseases
Efthymia Giannitsioti, Sofia Athanasia, Diamantis Plachouras, Stavroula Kanellaki, Fani Bobota, Georgia Tzepetzi, Helen Giamarellou
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2016)
Review
Infectious Diseases
Ilias Karaiskos, Anastasia Antoniadou, Helen Giamarellou
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2017)
Review
Biochemistry & Molecular Biology
Ilias Karaiskos, Irene Galani, Maria Souli, Helen Giamarellou
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2019)
Article
Infectious Diseases
Irene Galani, Ilias Karaiskos, Evdokia Angelidis, Vassiliki Papoutsaki, Lamprini Galani, Maria Souli, Anastasia Antoniadou, Helen Giamarellou
Summary: Three ceftazidime-avibactam-resistant KPC-2-producing Klebsiella pneumoniae strains of ST39 were isolated in Greece, with two strains corresponding to KPC-33 and KPC-57, and the third strain corresponding to KPC-44.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Irene Galani, Ilias Karaiskos, Helen Giamarellou
Summary: Multi-drug-resistant Klebsiella pneumoniae is a major concern in bacterial resistance, with reports of strains developing resistance to Ceftazidime-Avibactam during treatment. Understanding the mechanisms of resistance can help improve the efficacy of current antimicrobials and guide the design of novel therapeutic agents that can overcome resistance mechanisms.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Review
Infectious Diseases
Ilias Karaiskos, Irene Galani, Vassiliki Papoutsaki, Lamprini Galani, Helen Giamarellou
Summary: The emergence of carbapenemase resistant Gram-negative bacteria is a major public health concern. The review highlights new treatments for infections caused by carbapenemase producing Klebsiella pneumoniae, with a focus on novel antibiotics and beta-lactamase inhibitors. Approvals and developments of new antimicrobial agents show promising outcomes in combating CPKP infections, with potential for improved efficacy and safety profiles in future therapeutic strategies against multidrug-resistant K. pneumoniae.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
