Emerging drugs which target the renin–angiotensin–aldosterone system

Renin Release: Sites, Mechanisms, and Control

(2011) Armin Kurtz   Annual Review of Physiology

Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide

(2011) Mohd Akif et al.   BIOCHEMICAL JOURNAL

An Oral Formulation of Angiotensin-(1-7) Produces Cardioprotective Effects in Infarcted and Isoproterenol-Treated Rats

(2011) Fúlvia D. Marques et al.   HYPERTENSION

Does renin-angiotensin system blockade have a role in preventing diabetic retinopathy? A clinical review

(2011) A. K. Sjølie et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

SM-368229, a Novel Selective and Potent Non-steroidal Mineralocorticoid Receptor Antagonist With Strong Urinary Na+ Excretion Activity

(2011) Tetsuro Nariai et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism

(2011) J. P. Habashi et al.   SCIENCE

Effect of eplerenone versus spironolactone on cortisol and hemoglobin A1c levels in patients with chronic heart failure

(2010) Masayuki Yamaji et al.   AMERICAN HEART JOURNAL

Bradykinin B2 Receptor Agonism: A Novel Therapeutic Strategy for Myocardial Infarction?

(2010) J. Duchene et al.   AMERICAN JOURNAL OF HYPERTENSION

Angiotensin-Converting Enzyme Inhibitor Associated Cough: Deceptive Information from the Physicians' Desk Reference

(2010) Sripal Bangalore et al.   AMERICAN JOURNAL OF MEDICINE

Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy

(2010) Michael Bader   Annual Review of Pharmacology and Toxicology

Renin, (pro)renin and receptor: an update

(2010) Genevieve Nguyen   CLINICAL SCIENCE

Non-peptide AT2-receptor agonists

(2010) U Muscha Steckelings et al.   CURRENT OPINION IN PHARMACOLOGY

Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones

(2010) Koichiro Kuwahara et al.   ENDOCRINE JOURNAL

Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases

(2010) Anderson J. Ferreira et al.   EXPERIMENTAL PHYSIOLOGY

Vascular Relaxation, Antihypertensive Effect, and Cardioprotection of a Novel Peptide Agonist of the Mas Receptor

(2010) Silvia Quintão Savergnini et al.   HYPERTENSION

Aldosterone Synthase Inhibition With LCI699

(2010) Laurence Amar et al.   HYPERTENSION

A Global Perspective on Blood Pressure Treatment and Control in a Referred Cohort of Hypertensive Patients

(2010) Peter Bramlage et al.   Journal of Clinical Hypertension

Selectively Engaging  -Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

(2010) J. D. Violin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Physiology of the (pro)renin receptor: Wnt of change?

(2010) Gabin Sihn et al.   KIDNEY INTERNATIONAL

Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial

(2010)   LANCET

Novel therapeutic targets for hypertension

(2010) Ludovit Paulis et al.   Nature Reviews Cardiology

LCZ696, a novel dual inhibitor of neprilysin and the angiotensin II receptor, shows promise in phase II trial

(2010) Baldo Lucchese   Nature Reviews Nephrology

New Function for an Old Enzyme: NEP Deficient Mice Develop Late-Onset Obesity

(2010) Matthias Becker et al.   PLoS One

Aldosterone and Mineralocorticoid Receptors in the Cardiovascular System

(2010) John W. Funder   PROGRESS IN CARDIOVASCULAR DISEASES

Are There Effects of Renin–Angiotensin System Antagonists Beyond Blood Pressure Control?

(2009) George Bakris   AMERICAN JOURNAL OF CARDIOLOGY

Pharmacodynamic Hybrids Coupling Established Cardiovascular Mechanisms of Action with Additional Nitric Oxide Releasing Properties

(2009) Alma Martelli et al.   CURRENT PHARMACEUTICAL DESIGN

The clinical pharmacology of eplerenone

(2009) James AS Muldowney III et al.   Expert Opinion on Drug Metabolism & Toxicology

Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage

(2009) Heiko Funke-Kaiser et al.   HYPERTENSION RESEARCH

Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

(2009) Jessie Gu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Phosphinic Tripeptides as Dual Angiotensin-Converting Enzyme C-Domain and Endothelin-Converting Enzyme-1 Inhibitors

(2009) Nicolas Jullien et al.   JOURNAL OF MEDICINAL CHEMISTRY

The past, present and future of angiotensin II type 2 receptor stimulation

(2009) U. Muscha Steckelings et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt

(2009) William B. Lea et al.   KIDNEY INTERNATIONAL

Success and failure of vaccines against renin–angiotensin system components

(2009) Morris J. Brown   Nature Reviews Cardiology

A Comparison of the Aldosterone-blocking Agents Eplerenone and Spironolactone

(2008) Allan Struthers et al.   CLINICAL CARDIOLOGY

Telmisartan, ramipril, or both in patients at high risk for vascular events

(2008) Donald G. Vidt   CURRENT HYPERTENSION REPORTS

Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone

(2008) P. Mulder et al.   EUROPEAN HEART JOURNAL

Renin/prorenin receptor, (P)RR, in end-organ damage: current issues in 2007

(2008) Tadashi Inagami et al.   Journal of the American Society of Hypertension

Thrombolytics for PE and right ventricular dysfunction

(2008) Syed Wamique Yusuf et al.   LANCET

Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study

(2008) Alain C Tissot et al.   LANCET

Aliskiren: the first renin inhibitor for clinical treatment

(2008) Chris Jensen et al.   NATURE REVIEWS DRUG DISCOVERY

Genetically altered animal models for Mas and angiotensin-(1-7)

(2007) Natalia Alenina et al.   EXPERIMENTAL PHYSIOLOGY