Emerging drugs in sepsis

Ghrelin Protects against Experimental Sepsis by Inhibiting High-Mobility Group Box 1 Release and by Killing Bacteria

(2014) A. Chorny et al.   JOURNAL OF IMMUNOLOGY

Statin Therapy Is Associated with Decreased Mortality in Patients with Infection

(2009) Michael W. Donnino et al.   ACADEMIC EMERGENCY MEDICINE

MitoQ administration prevents endotoxin-induced cardiac dysfunction

(2009) G. S. Supinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effectiveness of Treatments for Severe Sepsis

(2009) Ricard Ferrer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Population Pharmacokinetic Analysis of Colistin Methanesulfonate and Colistin after Intravenous Administration in Critically Ill Patients with Infections Caused by Gram-Negative Bacteria

(2009) D. Plachouras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Statins for the Prevention and Treatment of Infections

(2009) Imad M. Tleyjeh   ARCHIVES OF INTERNAL MEDICINE

Doripenem

(2009) David L. Paterson et al.   CLINICAL INFECTIOUS DISEASES

Statins for sepsis: a critical and updated review

(2009) P. Kopterides et al.   CLINICAL MICROBIOLOGY AND INFECTION

Activated protein C for the treatment of severe sepsis

(2009) G. Houston et al.   CLINICAL MICROBIOLOGY AND INFECTION

Non-antibiotic treatment for bacterial infections: how to validate chance findings

(2009) L. Leibovici   CLINICAL MICROBIOLOGY AND INFECTION

Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock

(2009) Dianne P. Stephens et al.   CRITICAL CARE MEDICINE

Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: A multicenter, randomized study*

(2009) Jean Chastre et al.   CRITICAL CARE MEDICINE

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

EF6265, a novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor, protects against sepsis-induced organ dysfunction in rats*

(2009) Yuko Muto et al.   CRITICAL CARE MEDICINE

Effects of an angiotensin-converting enzyme inhibitor on the inflammatory response in in vivo and in vitro models*

(2009) Satoshi Hagiwara et al.   CRITICAL CARE MEDICINE

Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)*

(2009) Fabián Jaimes et al.   CRITICAL CARE MEDICINE

Efficacy and safety of a phospholipid emulsion (GR270773) in Gram-negative severe sepsis: Results of a phase II multicenter, randomized, placebo-controlled, dose-finding clinical trial

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Antioxidant Therapy in Critically Septic Patients

(2009) S. Rinaldi et al.   CURRENT DRUG TARGETS

Critically elucidating the role of selenium

(2009) Jean-Louis Vincent et al.   Current Opinion in Anesthesiology

Early goal-directed therapy in severe sepsis and septic shock: a contemporary review of the literature

(2009) Emanuel P Rivers et al.   Current Opinion in Anesthesiology

Poly(ADP-ribose) polymerase: a new therapeutic target?

(2009) Domokos Gerö et al.   Current Opinion in Anesthesiology

Ceftaroline

(2009) George G. Zhanel et al.   DRUGS

Ceftobiprole: a new broad spectrum cephalosporin

(2009) Ali A El Solh   EXPERT OPINION ON PHARMACOTHERAPY

Management of complicated infections in the era of antimicrobial resistance: the role of tigecycline

(2009) David P Nicolau   EXPERT OPINION ON PHARMACOTHERAPY

Cost-Effectiveness of Linezolid vs Vancomycin in Suspected Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia in Germany

(2009) E. De Cock et al.   INFECTION

The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial

(2009) Victor Novack et al.   INTENSIVE CARE MEDICINE

Activity of the new cephalosporin ceftaroline against bacteraemia isolates from patients with community-acquired pneumonia

(2009) Ian Morrissey et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Cost-effectiveness analysis of linezolid vs. vancomycin in treating methicillin-resistantStaphylococcus aureuscomplicated skin and soft tissue infections using a decision analytic model

(2009) M. Bounthavong et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock

(2009) Dinna N. Cruz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Update on the treatment of Pseudomonas aeruginosa pneumonia

(2009) A. A. El Solh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Involvement of central angiotensin II type 1 receptors in LPS-induced systemic vasopressin release and blood pressure regulation in rats

(2009) Fumihiro Shimizu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Reduction in Mortality Associated with Statin Therapy in Patients with Severe Sepsis

(2009) Paul P Dobesh et al.   PHARMACOTHERAPY

Inhaled colistin as monotherapy for multidrug-resistant gram (−) nosocomial pneumonia: A case series

(2009) Matthew E. Falagas et al.   RESPIRATORY MEDICINE

ENOXAPARIN ATTENUATES ENDOTHELIAL DAMAGE WITH LESS BLEEDING COMPARED WITH UNFRACTIONATED HEPARIN IN ENDOTOXEMIC RATS

(2009) Toshiaki Iba et al.   SHOCK

LOSARTAN PREVENTS SEPSIS-INDUCED ACUTE LUNG INJURY AND DECREASES ACTIVATION OF NUCLEAR FACTORκB AND MITOGEN-ACTIVATED PROTEIN KINASES

(2009) Lihan Shen et al.   SHOCK

β2 Adrenoreceptor blockade attenuates the hyperinflammatory response induced by traumatic injury

(2009) James Rough et al.   SURGERY

β-Adrenergic Blockade Exacerbates Sepsis-Induced Changes in Tumor Necrosis Factor α and Interleukin-6 in Skeletal Muscle and is Associated With Impaired Translation Initiation

(2009) Charles H. Lang et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

In Vitro Evaluation of the Antimicrobial Activity of Ceftaroline against Cephalosporin-Resistant Isolates of Streptococcus pneumoniae

(2008) L. McGee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activities of Ceftobiprole, Linezolid, Vancomycin, and Daptomycin against Community-Associated and Hospital-Associated Methicillin-Resistant Staphylococcus aureus

(2008) S. N. Leonard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Preadmission Use of Statins and Outcomes After Hospitalization With Pneumonia

(2008) Reimar W. Thomsen et al.   ARCHIVES OF INTERNAL MEDICINE

Predictors of 30-Day Mortality and Hospital Costs in Patients With Ventilator-Associated Pneumonia Attributed to Potentially Antibiotic-Resistant Gram-Negative Bacteria

(2008) Katherine E. Kollef et al.   CHEST

Complicated Skin and Skin‐Structure Infections and Catheter‐Related Bloodstream Infections: Noninferiority of Linezolid in a Phase 3 Study

(2008) Mark H. Wilcox et al.   CLINICAL INFECTIOUS DISEASES

New developments in carbapenems

(2008) J.N. Kattan et al.   CLINICAL MICROBIOLOGY AND INFECTION

Colistin serum concentrations after intravenous administration in critically ill patients with serious multidrug-resistant, gram-negative bacilli infections: A prospective, open-label, uncontrolled study

(2008) Nikolaos Markou et al.   CLINICAL THERAPEUTICS

Cellular Dysfunction in Sepsis

(2008) Mervyn Singer   CLINICS IN CHEST MEDICINE

Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?

(2008) Alex Dyson et al.   CRITICAL CARE MEDICINE

How to break the vicious circle of antibiotic resistances?

(2008) Marc Leone et al.   Current Opinion in Critical Care

The Epidemiology of Sepsis

(2008) Katherine Hodgin et al.   CURRENT PHARMACEUTICAL DESIGN

Use of ACE inhibitors and risk of community-acquired pneumonia: a review

(2008) Petros I. Rafailidis et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Cytomegalovirus Reactivation in Critically Ill Immunocompetent Patients

(2008)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Efficacy and safety of high-dose ampicillin/sulbactam vs. colistin as monotherapy for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia

(2008) Alex P. Betrosian et al.   JOURNAL OF INFECTION

Hydrocortisone Therapy for Patients with Septic Shock

(2008) Charles L. Sprung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of angiotensin-converting enzyme gene polymorphisms in children with sepsis and septic shock

(2008) Ozgur Cogulu et al.   PEDIATRICS INTERNATIONAL

Plasticity of the Systemic Inflammatory Response to Acute Infection during Critical Illness: Development of the Riboleukogram

(2008) Jonathan E. McDunn et al.   PLoS One

EXPERIMENTAL MODELS OF SEPSIS AND THEIR CLINICAL RELEVANCE

(2008) Luiz F. Poli-de-Figueiredo et al.   SHOCK

Losartan Attenuates Ventilator-Induced Lung Injury

(2007) Shanglong Yao et al.   JOURNAL OF SURGICAL RESEARCH

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES