Article
Pediatrics
Emile Simard, Christophe Morin, David Coquerel, Frederic Chagnon, Charlene Nadeau, Nathalie Samson, Jean-Paul Praud, Olivier Lesur, Etienne Fortin-Pellerin
Summary: This study aimed to assess the hemodynamic impacts of Apelin-13 in a neonatal lamb septic shock model. The results showed that Apelin-13 increased mean arterial pressure but also increased systemic vascular resistances.
PEDIATRIC RESEARCH
(2023)
Review
Medicine, General & Internal
Stephen Macdonald, Sandra L. Peake, Alasdair R. Corfield, Anthony Delaney
Summary: Intravenous fluid resuscitation is recommended as the first-line treatment for sepsis-associated hypotension and/or hypoperfusion, but there is limited high-level evidence to support this practice. Recent studies have found potential harms associated with large volume fluid resuscitation, leading to recommendations for a more conservative approach and earlier use of vasopressors. However, there is currently uncertainty and variation in practice regarding the choice between fluids or vasopressors for initial resuscitation in septic shock.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Chang Liu, Heyi Li, Zhiyong Peng, Bo Hu, Yue Dong, Xiaolan Gao, Ryan D. Frank, Rahul Kashyap, Ognjen Gajic, Kianoush B. Kashani
Summary: The study demonstrates that the use of albumin during the initial 6 hours of resuscitation in septic patients does not provide benefits in clinical outcomes.
Article
Medicine, General & Internal
Maximilian Dietrich, Tobias Hoelle, Lazar Detelinov Lalev, Martin Loos, Felix Carl Fabian Schmitt, Mascha Onida Fiedler, Thilo Hackert, Daniel Christoph Richter, Markus Alexander Weigand, Dania Fischer
Summary: This study analyzed the indication for and effect of fresh frozen plasma (FFP) transfusion in patients with septic shock. The results showed that early FFP administration did not have significant harm or associated benefit in septic shock, and plasma should only be used in patients with a strong indication according to current recommendations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Gianluca Tullo, Marcello Candelli, Irene Gasparrini, Sara Micci, Francesco Franceschi
Summary: Sepsis and septic shock are leading causes of in-hospital mortality worldwide, with significant burden on healthcare systems. Ultrasound has been used as an adjunctive tool for the diagnosis and treatment of these conditions, providing valuable information for clinicians. Further research is needed to determine the impact of ultrasound on patient survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Daun Jeong, Gun Tak Lee, Jong Eun Park, Tae Gun Shin, Kyunga Kim, Doeun Jang, Won Young Kim, You Hwan Jo, Sung Phil Chung, Jin Ho Beom, Sung-Hyuk Choi, Woon Yong Kwon, Gil Joon Suh, Byuk Sung Ko, Kap Su Han, Jong Hwan Shin, Hanjin Cho, Sung Yeon Hwang
Summary: This study investigated the impact of changes in emergency department practices due to the COVID-19 pandemic on the clinical outcomes and management of patients with septic shock. Although there were delays in sepsis-related interventions during the pandemic, there was no significant difference in in-hospital mortality between the pre- and post-COVID-19 groups.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Anesthesiology
Marina Garcia-de-Acilu, Jaume Mesquida, Guillem Gruartmoner, Ricard Ferrer
Summary: Resuscitation should be personalized and based on global and regional markers of tissue hypoxia as well as the fluid responsiveness indices. The beneficial effect of multimode approach with different types of vasopressors, remains to be determined.
CURRENT OPINION IN ANESTHESIOLOGY
(2021)
Article
Anesthesiology
Lohith H. N. Kumar, Swagata Tripathy, Prasanta Kumar Das
Summary: The study found that goal-directed therapy guided by DCO2 did not improve organ function, but it did reduce ICU stay. More evidence is needed to determine the routine use of DCO2 in sicker patients.
ANESTHESIA AND ANALGESIA
(2022)
Article
Emergency Medicine
Gun Tak Lee, Sung Yeon Hwang, Jong Eun Park, Ik Joon Jo, Won Young Kim, Sung Phil Chung, You Hwan Jo, Gil Joon Suh, Sung-Hyuk Choi, Tae Gun Shin
Summary: The study aimed to investigate the diagnostic accuracy of post-fluid resuscitation lactate levels in predicting 28-day mortality in suspected septic shock patients. The results showed that post-fluid resuscitation lactate levels were more accurate than initial lactate levels in predicting mortality.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Chanu Rhee, Kathleen Chiotos, Sara E. Cosgrove, Emily L. Heil, Sameer S. Kadri, Andre C. Kalil, David N. Gilbert, Henry Masur, Edward J. Septimus, Daniel A. Sweeney, Jeffrey R. Strich, Dean L. Winslow, Michael Klompas
Summary: The Infectious Diseases Society of America (IDSA) is concerned about the potential for antibiotic overuse due to the SEP-1 measure and has outlined recommendations to limit its application to patients with septic shock. The IDSA believes that managing possible sepsis without shock should be guided by more appropriate guidelines that allow for individualized patient care.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Veterinary Sciences
Havva Suleymanoglu, Kursad Turgut, Merve Ertan, Mehmet Ege Ince, Amir Naseri
Summary: The aim of this study was to evaluate the changes in macrovascular and microvascular parameters in survivors and non-survivors dogs with severe sepsis and septic shock in response to goal-directed hemodynamic optimization at the ICU. The effectiveness of norepinephrine and dobutamine applications for predicting death was also evaluated. The results showed that there were no major differences in macrovascular and microvascular characteristics and dobutamine applications between the survivor and non-survivor groups, but non-survivors received a greater amount of norepinephrine. Further research is needed to provide evidence-based guidelines for dogs with severe sepsis and septic shock.
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
(2023)
Article
Medicine, General & Internal
T. S. Meyhoff, P. B. Hjortrup, J. Wetterslev, P. Sivapalan, J. H. Laake, M. Cronhjort, S. M. Jakob, M. Cecconi, M. Nalos, M. Ostermann, M. Malbrain, V Pettila, M. H. Moller, M-B N. Kjaer, T. Lange, C. Overgaard-Steensen, B. A. Brand, M. Winther-Olesen, J. O. White, L. Quist, B. Westergaard, A. B. Jonsson, C. J. S. Hjortso, N. Meier, T. S. Jensen, J. Engstrom, L. Nebrich, N. C. Andersen-Ranberg, J. Jensen, N. A. Joseph, L. M. Poulsen, L. S. Herlov, C. G. Solling, S. K. Pedersen, K. K. Knudsen, T. S. Straarup, M. L. Vang, H. Bundgaard, B. S. Rasmussen, S. R. Aagaard, T. Hildebrandt, L. Russell, M. H. Bestle, M. Schonemann-Lund, A. C. Brochner, C. F. Elvander, S. K. L. Hoffmann, M. L. Rasmussen, Y. K. Martin, F. F. Friberg, H. Seter, T. N. Aslam, S. Adnoy, P. Seidel, K. Strand, B. Johnstad, E. Joelsson-Alm, J. Christensen, C. Ahlstedt, C. A. Pfortmueller, M. Siegemund, M. Greco, J. Radej, M. Kriz, D. W. Gould, K. M. Rowan, P. R. Mouncey, A. Perner
Summary: The study found that restricting intravenous fluid therapy in adult patients with septic shock in the ICU did not lead to fewer deaths at 90 days compared to standard intravenous fluid therapy. Other survival indicators during ICU stay and at 90 days were similar in both groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Fang Feng, Huyong Yang, Weiwei Yang, Yu Chen
Summary: The main objective of our research was to explore the effectiveness and underlying pathophysiological principles of metabolic resuscitation therapy in critically ill patients with sepsis and septic shock. We found that metabolic resuscitation therapy is beneficial for these patients, as it reduces the length of ICU stay, decreases the duration of vasopressor use, and lowers the ICU mortality rate. However, it does not have a significant impact on the overall hospital mortality rate.
Article
Immunology
Marcela Hortova-Kohoutkova, Monika Skotakova, Isaac G. Onyango, Miriam Slezakova, Roman Panovsky, Lukas Opatril, Peter Slanina, Marco De Zuani, Ondrej Mrkva, Ivana Andrejcinova, Petra Laznickova, Martina Dvoncova, Alexandra Mytnikova, Vaughn Ostland, Michal Sitina, Gorazd B. Stokin, Vladimir Sramek, Marcela Vlkova, Martin Helan, Jan Fric
Summary: This study investigated the dynamics of iron regulation in different clinical settings and determined the suitability of hepcidin and/or ferritin levels as biomarkers of inflammatory disease severity. The results showed that hepcidin levels reflect overall immune cell activation driven by intrinsic stimuli, while ferritin levels are more strongly influenced by pathogen-induced inflammation. Furthermore, the hepcidin-to-ferritin ratio has the ability to predict mortality in septic shock.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Critical Care Medicine
John A. Kellum, Claudio Ronco
Summary: Septic shock, caused by bacterial toxins like endotoxin, is a severe disease that can lead to organ failure. It is important to note that endotoxin may play a role in all types of septic shock, including non-bacterial causes such as COVID-19. Diagnosis relies on measuring endotoxin activity in addition to clinical assessment. Treatment options are limited, with immune modulating therapies and extracorporeal blood purification still being investigated.