Safety and tolerability profile of new antiepileptic drug treatment in children with epilepsy

Specific Patient Features Affect Antiepileptic Drug Therapy Decisions: Focus on Gender, Age, and Psychiatric Comorbidities

(2018) Laura Rosa Pisani et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of adjunctive eslicarbazepine acetate on neurocognitive functioning in children with refractory focal-onset seizures

(2018) Sergiusz Jóźwiak et al.   EPILEPSY & BEHAVIOR

Long-term effects of adjunctive perampanel on cognition in adolescents with partial seizures

(2018) Jesus E. Piña-Garza et al.   EPILEPSY & BEHAVIOR

Association Between HLA genotypes and Oxcarbazepine-induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-Analysis

(2018) Wimonchat Tangamornsuksan et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Pharmacogenomics in epilepsy

(2018) Simona Balestrini et al.   NEUROSCIENCE LETTERS

Mechanisms of epileptogenesis and preclinical approach to antiepileptogenic therapies

(2018) Krzysztof Łukawski et al.   Pharmacological Reports

The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs

(2017) Noel Frey et al.   EPILEPSIA

Effect of vigabatrin on seizure control and safety profile in different subgroups of children with epilepsy

(2017) Michele C. Jackson et al.   EPILEPSIA

Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII)

(2017) Meir Bialer et al.   EPILEPSIA

A two-year retrospective evaluation of perampanel in patients with highly drug-resistant epilepsy and cognitive impairment

(2017) Bernd Huber et al.   EPILEPSY & BEHAVIOR

Evaluation of perampanel in patients with intellectual disability and epilepsy

(2017) Francesca M. Snoeijen-Schouwenaars et al.   EPILEPSY & BEHAVIOR

Research Review: Childhood chronic physical illness and adult emotional health - a systematic review and meta-analysis

(2017) Ekin Secinti et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Levetiracetam-induced rhabdomyolysis: Analysis of reports from the Food and Drug Administration's Adverse Event Reporting System database

(2017) Carla Carnovale et al.   MUSCLE & NERVE

HLA-A*24:02 as a common risk factor for antiepileptic drug–induced cutaneous adverse reactions

(2017) Yi-Wu Shi et al.   NEUROLOGY

Trends in Antiepileptic Drug Use in Children and Adolescents With Epilepsy

(2017) Xinyue Liu et al.   PEDIATRIC NEUROLOGY

Effect of CYP Inducers/Inhibitors on Topiramate Concentration

(2017) Yoshiaki Yamamoto et al.   THERAPEUTIC DRUG MONITORING

Cognitive and Behavioral Comorbidities: An Unwanted Effect of Antiepileptic Drugs in Children

(2017) Adriana Ulate-Campos et al.   Seminars in Pediatric Neurology

Perampanel as add-on treatment in refractory focal epilepsy. The Dianalund experience

(2016) S. Juhl et al.   ACTA NEUROLOGICA SCANDINAVICA

Lamotrigine monotherapy for newly diagnosed typical absence seizures in children: A multi-center, uncontrolled, open-label study

(2016) Sawa Yasumoto et al.   BRAIN & DEVELOPMENT

Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation

(2016) Ian Wadsworth et al.   CNS DRUGS

Tolerability and efficacy of perampanel in children with refractory epilepsy

(2016) Eli Heyman et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Cognitive effects of adjunctive perampanel for partial-onset seizures: A randomized trial

(2016) Kimford J. Meador et al.   EPILEPSIA

Adjunctive perampanel in adolescents with inadequately controlled partial-onset seizures: A randomized study evaluating behavior, efficacy, and safety

(2016) Lieven Lagae et al.   EPILEPSIA

HLA-B*40:02 and DRB1*04:03 are risk factors for oxcarbazepine-induced maculopapular eruption

(2016) Jangsup Moon et al.   EPILEPSIA

Evaluating the safety and efficacy of felbamate in the context of a black box warning: A single center experience

(2016) Yash D. Shah et al.   EPILEPSY & BEHAVIOR

Long-term safety and seizure outcome in Japanese patients with Lennox–Gastaut syndrome receiving adjunctive rufinamide therapy: An open-label study following a randomized clinical trial

(2016) Yoko Ohtsuka et al.   EPILEPSY RESEARCH

The efficacy and safety of rufinamide in drug-resistant epilepsy: A meta-analysis of double-blind, randomized, placebo controlled trials

(2016) Zhenghao Xu et al.   EPILEPSY RESEARCH

Safety, efficacy and outcome-related factors of perampanel over 12 months in a real-world setting: The FYDATA study

(2016) V. Villanueva et al.   EPILEPSY RESEARCH

Effectiveness and tolerability of perampanel in children and adolescents with refractory epilepsies—An Italian observational multicenter study

(2016) P. De Liso et al.   EPILEPSY RESEARCH

Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study

(2016) Alexis Arzimanoglou et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research

(2016) U. Damar et al.   Expert Review of Neurotherapeutics

Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study

(2016) Jacqueline A French et al.   LANCET

Intravenous Lacosamide in Pediatric Status Epilepticus: An Open-Label Efficacy and Safety Study

(2016) Karan Poddar et al.   PEDIATRIC NEUROLOGY

Safety of Levetiracetam in Paediatrics: A Systematic Review

(2016) Oluwaseun Egunsola et al.   PLoS One

The efficacy, tolerability and safety of levetiracetam therapy in a pediatric population

(2016) Hasan Tekgül et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research

(2016) U. Damar et al.   Expert Review of Neurotherapeutics

Lacosamide cardiac safety: clinical trials in patients with partial-onset seizures

(2015) G. D. Rudd et al.   ACTA NEUROLOGICA SCANDINAVICA

Zonisamide: Review of Recent Clinical Evidence for Treatment of Epilepsy

(2015) Shang-Yeong Kwan et al.   CNS Neuroscience & Therapeutics

Psychiatric and behavioral adverse events in randomized clinical studies of the noncompetitive AMPA receptor antagonist perampanel

(2015) Alan B. Ettinger et al.   EPILEPSIA

Summary of recommendations for the management of infantile seizures: Task Force Report for the ILAE Commission of Pediatrics

(2015) Jo M. Wilmshurst et al.   EPILEPSIA

Clobazam is equally safe and efficacious for seizures associated with Lennox–Gastaut syndrome across different age groups: Post hoc analyses of short- and long-term clinical trial results

(2015) Yu-Tze Ng et al.   EPILEPSY & BEHAVIOR

Efficacy and safety of perampanel in adolescent patients with drug-resistant partial seizures in three double-blind, placebo-controlled, phase III randomized clinical studies and a combined extension study

(2015) William Rosenfeld et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Drugs Commonly Associated With Weight Change: A Systematic Review and Meta-analysis

(2015) Juan Pablo Domecq et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999–2014

(2015) Xiang-qing Wang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Effectiveness and Tolerability of Perampanel in Children and Adolescents with Refractory Epilepsies: First Experiences

(2015) Ulrich Stephani et al.   NEUROPEDIATRICS

Toxic Epidermal Necrolysis Triggered by Clobazam: A Case Report in a 13-Year-Old Girl

(2015) Chuong D. Dang et al.   PEDIATRIC DERMATOLOGY

Mechanistic Target of Rapamycin (mTOR) in Tuberous Sclerosis Complex-Associated Epilepsy

(2015) Paolo Curatolo   PEDIATRIC NEUROLOGY

Clinical utility of eslicarbazepine: current evidence

(2015) Gaetano Zaccara et al.   Drug Design Development and Therapy

Comparison of Drug Utilization Patterns in Observational Data: Antiepileptic Drugs in Pediatric Patients

(2015) Florence T. Bourgeois et al.   PEDIATRIC DRUGS

A prospective study of adverse drug reactions to antiepileptic drugs in children

(2015) M. Anderson et al.   BMJ Open

Safety of lamotrigine in paediatrics: a systematic review

(2015) O. Egunsola et al.   BMJ Open

Population Pharmacokinetics Analysis of Vigabatrin in Adults and Children with Epilepsy and Children with Infantile Spasms

(2014) Jace C. Nielsen et al.   CLINICAL PHARMACOKINETICS

Changes in the ERG d-wave with vigabatrin treatment in a pediatric cohort

(2014) Rachel Dragas et al.   DOCUMENTA OPHTHALMOLOGICA

Safety and retention rate of rufinamide in 300 patients: A single pediatric epilepsy center experience

(2014) Sigride Thome-Souza et al.   EPILEPSIA

Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years

(2014) Joan A. Conry et al.   EPILEPSIA

Adjunctive zonisamide therapy in the long-term treatment of children with partial epilepsy: Results of an open-label extension study of a phase III, randomized, double-blind, placebo-controlled trial

(2014) Renzo Guerrini et al.   EPILEPSIA

The clinical pharmacology profile of the new antiepileptic drug perampanel: A novel noncompetitive AMPA receptor antagonist

(2014) Philip N. Patsalos   EPILEPSIA

Safety and efficacy of adjunctive lacosamide among patients with partial-onset seizures in a long-term open-label extension trial of up to 8years

(2014) William Rosenfeld et al.   EPILEPSY & BEHAVIOR

Rufinamide as an adjunctive therapy for Lennox–Gastaut syndrome: A randomized double-blind placebo-controlled trial in Japan

(2014) Yoko Ohtsuka et al.   EPILEPSY RESEARCH

Rufinamide for the treatment of refractory epilepsy secondary to neuronal migration disorders

(2014) Raffaella Cusmai et al.   EPILEPSY RESEARCH

Safety and tolerability of zonisamide in paediatric patients with epilepsy

(2014) J. Helen Cross et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Efficacy and safety of felbamate in children with refractory epilepsy

(2014) Eli Heyman et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Zonisamide: Pharmacokinetics, Efficacy, and Adverse Events in Children with Epilepsy

(2014) Inger Ohman et al.   NEUROPEDIATRICS

Clobazam: Effect on Frequency of Seizures and Safety Profile in Different Subgroups of Children With Epilepsy

(2014) Jacquelyn Klehm et al.   PEDIATRIC NEUROLOGY

Basic mechanisms of antiepileptic drugs and their pharmacokinetic/pharmacodynamic interactions: an update

(2014) Władysław Lasoń et al.   Pharmacological Reports

Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist

(2013) M. A. Rogawski et al.   ACTA NEUROLOGICA SCANDINAVICA

The association between oxcarbazepine-induced maculopapular eruption and HLA-B alleles in a Northern Han Chinese population

(2013) Yu-Dan Lv et al.   BMC Neurology

Lacosamide as an adjunctive therapy in pediatric patients with refractory focal epilepsy

(2013) Jon Soo Kim et al.   BRAIN & DEVELOPMENT

E-pharmacovigilance: development and implementation of a computable knowledge base to identify adverse drug reactions

(2013) Antje Neubert et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Comparative efficacy and tolerability of anti-epileptic drugs for refractory focal epilepsy: systematic review and network meta-analysis reveals the need for long term comparator trials

(2013) Pritesh N. Bodalia et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 2: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs and Drugs Used to Treat Non-Epilepsy Disorders

(2013) Philip N. Patsalos   CLINICAL PHARMACOKINETICS

Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 1: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs

(2013) Philip N. Patsalos   CLINICAL PHARMACOKINETICS

Pharmacotherapy of Focal Epilepsy in Children: A Systematic Review of Approved Agents

(2013) Ravindra Arya et al.   CNS DRUGS

A Revisited Strategy for Antiepileptic Drug Development in Children

(2013) Catherine Chiron et al.   CNS DRUGS

Erythropoietin: A Neuroprotective Agent in Cerebral Hypoxia, Neurodegeneration, and Epilepsy

(2013) Amalia Merelli et al.   CURRENT PHARMACEUTICAL DESIGN

Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: A pooled analysis of three phase III studies

(2013) Bernhard J. Steinhoff et al.   EPILEPSIA

Stiripentol in Dravet syndrome: Results of a retrospective U.S. study

(2013) Elaine C. Wirrell et al.   EPILEPSIA

Tiagabine in clinical practice: effects on seizure control and behavior

(2013) David G. Vossler et al.   EPILEPSY & BEHAVIOR

The adverse event profile of perampanel: meta-analysis of randomized controlled trials

(2013) G. Zaccara et al.   EUROPEAN JOURNAL OF NEUROLOGY

Long-term effect of everolimus on epilepsy and growth in children under 3 years of age treated for subependymal giant cell astrocytoma associated with tuberous sclerosis complex

(2013) Katarzyna Kotulska et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Efficacy and safety of lacosamide in infants and young children with refractory focal epilepsy

(2013) Salvatore Grosso et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

A Pharmacokinetic Study and Correlation with Clinical Response of Rufinamide in Infants with Epileptic Encephalopathies

(2013) Giancarlo la Marca et al.   PHARMACOLOGY

Lacosamide in pediatric and adult patients: Comparison of efficacy and safety

(2013) Alberto Verrotti et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Efficacy and Tolerability of Lacosamide in the Concomitant Treatment of 130 Patients Under 16 Years of Age with Refractory Epilepsy

(2013) Carlos Casas-Fernández et al.   Drugs in research & development

When EMA and FDA decisions conflict: differences in patients or in regulation?

(2013) S. M. Wolfe   BMJ-British Medical Journal

Use of Topiramate and Risk of Glaucoma: A Case-Control Study

(2012) Mahyar Etminan et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Safety and Tolerability of Antiepileptic Drug Treatment in Children with Epilepsy

(2012) Renzo Guerrini et al.   DRUG SAFETY

Pharmacokinetics and safety of adjunctive topiramate in infants (1-24 months) with refractory partial-onset seizures: A randomized, multicenter, open-label phase 1 study

(2012) Prasarn Manitpisitkul et al.   EPILEPSIA

Dramatic weight loss with rufinamide

(2012) Isabelle Mourand et al.   EPILEPSIA

Pharmacokinetics and drug interactions of eslicarbazepine acetate

(2012) Meir Bialer et al.   EPILEPSIA

Rufinamide efficacy and safety as adjunctive treatment in children with focal drug resistant epilepsy: The first Italian prospective study

(2012) Romina Moavero et al.   EPILEPSY RESEARCH

Clobazam for treatment of epilepsy

(2012) Melissa Giarratano et al.   EXPERT OPINION ON PHARMACOTHERAPY

Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide

(2012) Rainer Schimpf et al.   HEART RHYTHM

Lamotrigine and aseptic meningitis

(2012) K. M. Simms et al.   NEUROLOGY

Stevens–Johnson syndrome induced by levetiracetam

(2012) Li-Ping Zou et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Levetiracetam-associated aggravation of myoclonic seizure in children

(2012) Yong-Hong Liu et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Rufinamide for refractory focal seizures: An open-label, multicenter European study

(2012) Giangennaro Coppola et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Concentrations of Stiripentol in Children and Adults With Epilepsy

(2012) Theodor W. May et al.   THERAPEUTIC DRUG MONITORING

Mechanism of action of vigabatrin: correcting misperceptions

(2011) E. Ben-Menachem   ACTA NEUROLOGICA SCANDINAVICA

Retinal nerve fiber layer thickness in Vigabatrin-exposed patients

(2011) Lisa M. Clayton et al.   ANNALS OF NEUROLOGY

Worsening of negative myoclonus by lamotrigine in a case of idiopathic focal epilepsy of children with long-term follow-up

(2011) Philippe Gélisse et al.   BRAIN & DEVELOPMENT

Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy

(2011) Ahmad Nizam et al.   EPILEPSIA

The effects of stiripentol on GABAA receptors

(2011) Janet L. Fisher   EPILEPSIA

Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy

(2011) Takahisa Hanada et al.   EPILEPSIA

Aggravation of absence seizure related to levetiracetam

(2011) Stéphane Auvin et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Preliminary efficacy and safety of lacosamide in children with refractory epilepsy

(2011) Eli Heyman et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Paediatric post-marketing pharmacovigilance: comparison of the adverse event profile of vigabatrin prescribed to children and adults

(2011) Beate Aurich-Barrera et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Rufinamide for Pediatric Patients with Lennox-Gastaut Syndrome

(2011) Heather Ann Wier et al.   PEDIATRIC DRUGS

Adjunctive rufinamide in Lennox-Gastaut syndrome: a long-term, open-label extension study

(2010) G. Kluger et al.   ACTA NEUROLOGICA SCANDINAVICA

Prevalence of visual field loss following exposure to vigabatrin therapy: A systematic review

(2010) Melissa J. Maguire et al.   EPILEPSIA

Vigabatrin-associated reversible MRI signal changes in patients with infantile spasms

(2010) Aphrodite Dracopoulos et al.   EPILEPSIA

Atrial flutter/atrial fibrillation associated with lacosamide for partial seizures

(2010) Christopher M. DeGiorgio   EPILEPSY & BEHAVIOR

Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy

(2010) E. Ben-Menachem et al.   EPILEPSY RESEARCH

A 24-week multicenter, randomized, double-blind, parallel-group, dose-ranging study of rufinamide in adults and adolescents with inadequately controlled partial seizures

(2010) Christian E. Elger et al.   EPILEPSY RESEARCH

Anticonvulsant Medications and the Risk of Suicide, Attempted Suicide, or Violent Death

(2010) Elisabetta Patorno   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Vigabatrin for the Treatment of Infantile Spasms: Final Report of a Randomized Trial

(2010) Roy D. Elterman et al.   JOURNAL OF CHILD NEUROLOGY

Zonisamide discontinuation due to psychiatric and cognitive adverse events: A case-control study

(2010) J. R. White et al.   NEUROLOGY

New Drugs for Pediatric Epilepsy

(2010) Catherine J. Chu-Shore et al.   Seminars in Pediatric Neurology

Efficacy and tolerability of adjunctive therapy with zonisamide in childhood intractable epilepsy

(2009) Yun Jin Lee et al.   BRAIN & DEVELOPMENT

Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives

(2009) Rashmi R Shah   BRITISH JOURNAL OF PHARMACOLOGY

Lacosamide

(2009) Giulia Curia et al.   CNS DRUGS

Antiepileptic Drug Development in Children

(2009) Catherine Chiron et al.   DRUGS

Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: A randomized, double-blind, placebo-controlled, parallel-group phase III study

(2009) Christian Elger et al.   EPILEPSIA

Vigabatrin: 2008 Update

(2009) L. James Willmore et al.   EPILEPSIA

A multicenter, outpatient, open-label study to evaluate the dosing, effectiveness, and safety of topiramate as monotherapy in the treatment of epilepsy in clinical practice

(2009) Raman Sankar et al.   EPILEPSY & BEHAVIOR

Effectiveness and tolerability of zonisamide in children with epilepsy: A retrospective review

(2009) Hui Jeen Tan et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Vigabatrin in the treatment of childhood epilepsy: A retrospective chart review of efficacy and safety profile

(2008) Susana E. Camposano et al.   EPILEPSIA

Rufinamide: Clinical pharmacokinetics and concentrationresponse relationships in patients with epilepsy

(2008) Emilio Perucca et al.   EPILEPSIA

Efficacy and safety of felbamate in children under 4 years of age: a retrospective chart review

(2008) S. Grosso et al.   EUROPEAN JOURNAL OF NEUROLOGY

Efficacy and safety of lamotrigine monotherapy in children and adolescents with epilepsy

(2008) Ignacio Valencia et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy

(2008) Shlomo Shinnar et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome

(2008) T. Glauser et al.   NEUROLOGY

Long-term use of zonisamide in refractory childhood-onset epilepsy

(2007) Gerhard Kluger et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY