4.3 Review

Suicidality and montelukast

Journal

EXPERT OPINION ON DRUG SAFETY
Volume 8, Issue 3, Pages 273-282

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1517/14740330902932688

Keywords

allergic rhinitis; allergy; anxiety; asthma; leukotriene antagonists; montelukast (Singulair (R)); mood disorders; self-harm; suicidal attempt; suicidal behavior; suicidal ideation; suicidality; suicide; suicide risk factors

Funding

  1. NIH [R01MH074891]
  2. NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH074891] Funding Source: NIH RePORTER

Ask authors/readers for more resources

Background: Suicide is a serious public health problem. Prevention of suicide depends to a great degree on identification and mitigation of its risk factors. Allergy has been associated with mood and anxiety disorders, risk factors for suicidality. Antiallergic medication could modulate or mediate these predictive associations. Recently, the FDA issued a warning raising concerns about the suicidality potential of montelukast and other leukotriene (LT) antagonists. Objective: The purpose of this review is to integrate the emerging interpretations of the link between suicidality, suicide risk factors, allergy and treatment of allergy in particular, with LT antagonists. Methods: We reviewed the available reports on the possible relationships between montelukast, allergy, suicide, suicidality and suicide risk factors. We also present the positions of the FDA, manufacturer, and national organizations of allergists and immunologists on the possible role of montelukast in suicidality. Conclusion: At present, there is insufficient data to prove that there is a link between montelukast and suicidality. Inquiring about mood changes and suicidal ideation should be integrated in general medical practice.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.3
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Review Construction & Building Technology

A brief review on the mental health for select elements of the built environment

Cody J. Beemer, Kelly A. Stearns-Yoder, Steven J. Schuldt, Kerry A. Kinney, Christopher A. Lowry, Teodor T. Postolache, Lisa A. Brenner, Andrew J. Hoisington

Summary: The impact of the built environment on mental health is significant, with factors such as connection to nature, personal control, and indoor air quality playing crucial roles. Architectural designs that include urban greenspace, personalized temperature control, and building ventilation can improve occupant mental health. Interdisciplinary research utilizing controlled experiments is needed to confirm causality and further understand the mechanisms underlying the association between the built environment and mental health.

INDOOR AND BUILT ENVIRONMENT (2021)

Review Neurosciences

Inflammation in Traumatic Brain Injury

Teodor T. Postolache, Abhishek Wadhawana, Adem Can, Christopher A. Lowry, Margaret Woodbury, Hina Makkar, Andrew J. Hoisington, Alison J. Scott, Eileen Potocki, Michael E. Benros, John W. Stiller

JOURNAL OF ALZHEIMERS DISEASE (2020)

Article Public, Environmental & Occupational Health

Parkinson's Disease-Related Motor and Nonmotor Symptoms in the Lancaster Amish

Michael D. F. Goldenberg, Xuemei Huang, Honglei Chen, Lan Kong, Teodor T. Postolache, John W. Stiller, Katherine A. Ryan, Mary Pavlovich, Toni Pollin, Alan R. Shuldiner, Richard B. Mailman, Braxton D. Mitchell

NEUROEPIDEMIOLOGY (2020)

Article Environmental Sciences

Daily and Seasonal Variation in Light Exposure among the Old Order Amish

Ellen E. Lee, Ameya Amritwar, L. Elliot Hong, Iqra Mohyuddin, Timothy Brown, Teodor T. Postolache

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

Editorial Material Psychiatry

Targetable Biological Mechanisms Implicated in Emergent Psychiatric Conditions Associated With SARS-CoV-2 Infection

Teodor T. Postolache, Michael E. Benros, Lisa A. Brenner

Summary: This viewpoint discusses the targetable biological mechanisms involved in emergent psychiatric conditions associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

JAMA PSYCHIATRY (2021)

Article Clinical Neurology

Microbial Diversity and Community Structures Among Those With Moderate to Severe TBI: A United States-Veteran Microbiome Project Study

Lisa A. Brenner, Christopher E. Stamper, Andrew J. Hoisington, Kelly A. Stearns-Yoder, Maggie A. Stanislawksi, Diana P. Brostow, Claire A. Hoffmire, Jeri E. Forster, Alexandra L. Schneider, Teodor T. Postolache, Christopher A. Lowry

JOURNAL OF HEAD TRAUMA REHABILITATION (2020)

Article Clinical Neurology

Evaluation of an Immunomodulatory Probiotic Intervention for Veterans With Co-occurring Mild Traumatic Brain Injury and Posttraumatic Stress Disorder: A Pilot Study

Lisa A. Brenner, Jeri E. Forster, Kelly A. Stearns-Yoder, Christopher E. Stamper, Andrew J. Hoisington, Diana P. Brostow, Meredith Mealer, Hal S. Wortzel, Teodor T. Postolache, Christopher A. Lowry

FRONTIERS IN NEUROLOGY (2020)

Article Public, Environmental & Occupational Health

Risk factors for Toxoplasma gondii seropositivity in the Old Order Amish

A. O. Markon, K. A. Ryan, A. Wadhawan, M. Pavlovich, M. W. Groer, C. Punzalan, K. Gensheimer, J. L. Jones, M. L. Daue, A. Dagdag, P. Donnelly, X. Peng, T. I. Pollin, B. D. Mitchell, T. T. Postolache

EPIDEMIOLOGY AND INFECTION (2020)

Article Genetics & Heredity

Genetic versus stress and mood determinants of sleep in the Amish

Heather A. Bruce, Peter Kochunov, Joshua Chiappelli, Anya Savransky, Kathleen Carino, Jessica Sewell, Wyatt Marshall, Mark Kvarta, Francis J. McMahon, Seth A. Ament, Teodor T. Postolache, Jeff O'Connell, Alan Shuldiner, Braxton Mitchell, L. Elliot Hong

Summary: Sleep is essential and regulated by genetics, but also influenced by health, environment, stress, and mood. The study found that genetics play a significant role in sleep features, but stress, mood disorder, and environmental factors can also impact sleep quality, highlighting the complexity of genetic studies of sleep.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2021)

Article Environmental Sciences

A framework for estimating the United States depression burden attributable to indoor fine particulate matter exposure

William L. Taylor, Steven J. Schuldt, Justin D. Delorit, Christopher M. Chini, Teodor T. Postolache, Christopher A. Lowry, Lisa A. Brenner, Andrew J. Hoisington

Summary: Exploratory studies suggest a potential link between indoor PM2.5 exposure and major depressive disorder. Modifying input parameters can estimate the burden of major depressive disorder in the US due to indoor PM2.5 exposure, with findings indicating that improving HVAC filter efficiency may slightly reduce depressive disorders.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Review Psychiatry

Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19

Boris N. Tizenberg, Lisa A. Brenner, Christopher A. Lowry, Olaoluwa O. Okusaga, David R. Benavides, Andrew J. Hoisington, Michael E. Benros, John W. Stiller, Ronald C. Kessler, Teodor T. Postolache

Summary: This study discusses the biological and psychological factors related to psychiatric manifestations of SARS-CoV-2, as well as its effects on the nervous and immune systems. It found that preexisting mental illness in COVID-19 patients can lead to worse clinical outcomes, and that the virus can be detected in brain tissue.

CURRENT PSYCHIATRY REPORTS (2021)

Article Biochemistry & Molecular Biology

Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression

Mutaz Amin, Jurg Ott, Rongling Wu, Teodor T. Postolache, Claudia Gragnoli

Summary: Melanocortin receptor genes are associated with the risk of major depressive disorder (MDD) and type 2 diabetes (T2D). This study found that MC2R and MC5R genes are associated with MDD, while MC1R, MC2R, MC3R, and MC4R genes are associated with T2D. These findings provide important insights into the role of melanocortin receptor genes in the comorbidity of MDD and T2D.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression

Mutaz Amin, Jurg Ott, Derek Gordon, Rongling Wu, Teodor T. Postolache, Michael Vergare, Claudia Gragnoli

Summary: Variants of the CRHR2 gene are associated with the risk of depression and type 2 diabetes. This study identified novel risk variants related to depression and type 2 diabetes in 212 Italian families. The findings suggest that CRHR2 plays a stronger role in the risk of depression than in the risk of type 2 diabetes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Familial Linkage and Association of the NR3C1 Gene with Type 2 Diabetes and Depression Comorbidity

Mutaz Amin, Shumail Syed, Rongling Wu, Teodor Tudorel Postolache, Claudia Gragnoli

Summary: Impairment in the HPA axis and cortisol pathway may contribute to the development of major depressive disorders and type 2 diabetes. Variants in the NR3C1 gene are associated with the risk of T2D-MDD comorbidity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Medicine, Research & Experimental

Rationale, design, and methods: A randomized placebo-controlled trial of an immunomodulatory probiotic intervention for Veterans with PTSD

Lisa A. Brenner, Kelly A. Stearns-Yoder, Christopher E. Stamper, Andrew J. Hoisington, Diana P. Brostow, Claire A. Hoffmire, Jeri E. Forster, Meghan L. Donovan, Arthur T. Ryan, Teodor T. Postolache, Christopher A. Lowry

Summary: This article describes the rationale, design, and methods of a randomized placebo-controlled trial of Lactobacillus rhoosus GG for posttraumatic stress disorder (PTSD) in United States military Veterans. The trial aims to reduce inflammation and alleviate symptoms of PTSD through the use of immunoregulatory/antiinflammatory probiotics, providing evidence for this innovative intervention strategy.

CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS (2022)

No Data Available