Natural compounds to overcome cancer chemoresistance: toxicological and clinical issues

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

(2016) Marco Demaria et al.   Aging-US

Nucleotide excision repair: Why is it not used to predict response to platinum-based chemotherapy?

(2014) Nikola A. Bowden   CANCER LETTERS

Curcumin-enhanced chemosensitivity of FDA-approved platinum (II)-based anti-cancer drugs involves downregulation of nuclear endonuclease G and NF-κB as well as induction of apoptosis and G2/M arrest

(2014) Ying-Ti Wang et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Curcumin induces apoptosis and inhibits growth of orthotopic human non-small cell lung cancer xenografts

(2014) Shahar Lev-Ari et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin-induced Aurora-A suppression not only causes mitotic defect and cell cycle arrest but also alters chemosensitivity to anticancer drugs

(2014) Ching-Shiun Ke et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures

(2014) Mehdi Shakibaei et al.   PLoS One

The Natural Chemopreventive Agent Sulforaphane Inhibits STAT5 Activity

(2014) Sophia Pinz et al.   PLoS One

Activation of Nrf2 Protects against Triptolide-Induced Hepatotoxicity

(2014) Jia Li et al.   PLoS One

Modulation of cisplatin sensitivity in human ovarian carcinoma A2780 and SKOV3 cell lines by sulforaphane

(2014) Luba Hunakova et al.   TOXICOLOGY LETTERS

Curcumin Promotes Apoptosis, Increases Chemosensitivity, and Inhibits Nuclear Factor κB in Esophageal Adenocarcinoma

(2014) Wibisono Hartojo et al.   Translational Oncology

Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation

(2014) Y Fu et al.   Cell Death & Disease

Hitting the Golden TORget: Curcumin’s Effects on mTOR Signaling

(2013) Christopher Beevers et al.   Anti-Cancer Agents in Medicinal Chemistry

Silencing of the STAT3 signaling pathway reverses the inherent and induced chemoresistance of human ovarian cancer cells

(2013) Zhiqiang Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of curcumin action: Signal transduction

(2013) Adeeb Shehzad et al.   BIOFACTORS

Exploring the effects of isothiocyanates on chemotherapeutic drugs

(2013) Anna Minarini et al.   Expert Opinion on Drug Metabolism & Toxicology

Cisplatin: an old drug with a newfound efficacy – from mechanisms of action to cytotoxicity

(2013) Antonio Macciò et al.   EXPERT OPINION ON PHARMACOTHERAPY

Sulforaphane induces reactive oxygen species-mediated mitotic arrest and subsequent apoptosis in human bladder cancer 5637 cells

(2013) Hyun Soo Park et al.   FOOD AND CHEMICAL TOXICOLOGY

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Curcumin Enhances the Effect of Chemotherapy against Colorectal Cancer Cells by Inhibition of NF-κB and Src Protein Kinase Signaling Pathways

(2013) Mehdi Shakibaei et al.   PLoS One

Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin

(2013) Bin Sun et al.   TOXICOLOGY IN VITRO

Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil

(2013) B S Vinod et al.   Cell Death & Disease

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Chemotherapy in gastroenteropancreatic (GEP) neuroendocrine carcinomas (NEC): A critical view

(2012) Nicola Fazio et al.   CANCER TREATMENT REVIEWS

Apoptosis-Modulating Drugs for Improved Cancer Therapy

(2012) M. Ocker et al.   EUROPEAN SURGICAL RESEARCH

In vitro cytogenetic and genotoxic effects of curcumin on human peripheral blood lymphocytes

(2012) Natividad Sebastià et al.   FOOD AND CHEMICAL TOXICOLOGY

Sulforaphane Induces Cell Cycle Arrest and Apoptosis in Acute Lymphoblastic Leukemia Cells

(2012) Koramit Suppipat et al.   PLoS One

Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation

(2012) Sanjica Rak et al.   TOXICOLOGY IN VITRO

Nrf2: control of sensitivity to carcinogens

(2011) Stephen L. Slocum et al.   ARCHIVES OF TOXICOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Discovery of curcumin, a component of golden spice, and its miraculous biological activities

(2011) Subash C Gupta et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

(2011) John D. Clarke et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Natural isothiocyanates: Genotoxic potential versus chemoprevention

(2011) Carmela Fimognari et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Plant Polyphenol Curcumin Significantly Affects CYP1A2 and CYP2A6 Activity in Healthy, Male Chinese Volunteers

(2010) Y. Chen et al.   ANNALS OF PHARMACOTHERAPY

Curcumin in Cancer Chemoprevention: Molecular Targets, Pharmacokinetics, Bioavailability, and Clinical Trials

(2010) Adeeb Shehzad et al.   ARCHIV DER PHARMAZIE

Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death

(2010) Bettina M. Kaminski et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer

(2010) Masashi Kanai et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway

(2010) L.-h. Wang et al.   CANCER RESEARCH

Early reduction of glucose uptake after cisplatin treatment is a marker of cisplatin sensitivity in ovarian cancer

(2010) Tomomi Egawa-Takata et al.   CANCER SCIENCE

Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism

(2010) Nataly Shulga et al.   CELL CYCLE

Anti-angiogenic effect of resveratrol or curcumin in Ehrlich ascites carcinoma-bearing mice

(2010) Mona El-Azab et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo

(2010) Lynne M. Howells et al.   INTERNATIONAL JOURNAL OF CANCER

Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in vitro anticancer activity by induction of apoptosis

(2010) Rohit S. Mulik et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

(2010) Jianhui Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and Prostate

(2010) Georgios Kallifatidis et al.   MOLECULAR THERAPY

Sulforaphane induces DNA single strand breaks in cultured human cells

(2010) Piero Sestili et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention

(2009) Ka Lung Cheung et al.   AAPS Journal

Curcumin Sensitizes Lung Cancer Cells to Cisplatin-Induced Apoptosis Through Superoxide Anion-Mediated Bcl-2 Degradation

(2009) Pithi Chanvorachote et al.   CANCER INVESTIGATION

Cell-cycle inhibition and apoptosis induced by curcumin and cisplatin or oxaliplatin in human ovarian carcinoma cells

(2009) M. Montopoli et al.   CELL PROLIFERATION

Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells

(2009) Hanane Akhdar et al.   EUROPEAN JOURNAL OF CANCER

Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model

(2009) Ajaikumar B. Kunnumakkara et al.   INTERNATIONAL JOURNAL OF CANCER

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dichloroacetate induces apoptosis in endometrial cancer cells

(2008) Jason Y.Y. Wong et al.   GYNECOLOGIC ONCOLOGY

SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism

(2008) X.-J. Liang et al.   MOLECULAR CANCER RESEARCH

5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

(2008) Ning Zhang et al.   MOLECULES

Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma

(2008) Xiao-Feng Wang et al.   PHYTOTHERAPY RESEARCH

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY

Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment, membrane rigidification and apoptosis in rat liver

(2007) N. M. Martins et al.   JOURNAL OF APPLIED TOXICOLOGY