Alternatives to the carcinogenicity bioassay for toxicity prediction: are we there yet?

The tissue organization field theory of cancer: A testable replacement for the somatic mutation theory

(2011) Ana M. Soto et al.   BIOESSAYS

Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for Predictive Toxicology

(2011) Romualdo Benigni et al.   CHEMICAL REVIEWS

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

(2011) W. Patrick Walters et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs

(2011) S. Creton et al.   MUTAGENESIS

Alternative strategies for carcinogenicity assessment: an efficient and simplified approach based on in vitro mutagenicity and cell transformation assays

(2011) R. Benigni et al.   MUTAGENESIS

The new ISSMIC database on in vivo micronucleus and its role in assessing genotoxicity testing strategies

(2011) R. Benigni et al.   MUTAGENESIS

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Research on Early-Stage Carcinogenesis: Are We Approaching Paradigm Instability?

(2010) Stuart G. Baker et al.   JOURNAL OF CLINICAL ONCOLOGY

Exploring In Vitro/In Vivo Correlation: Lessons Learned from Analyzing Phase I Results of the US EPA's ToxCast Project

(2010) ROMUALDO BENIGNI et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Toxic and genotoxic effects of oral administration of furan in mouse liver

(2010) E. Cordelli et al.   MUTAGENESIS

A Medium-Term, Rapid Rat Bioassay Model for the Detection of Carcinogenic Potential of Chemicals

(2010) Hiroyuki Tsuda et al.   TOXICOLOGIC PATHOLOGY

Chromosomes in Leukemia and Beyond: From Irrelevant to Central Players

(2009) Janet D. Rowley   Annual Review of Genomics and Human Genetics

New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome

(2009) Narasimhulu Shakunthala   Expert Opinion on Drug Metabolism & Toxicology

Assessment of in vivo genotoxicity of the rodent carcinogen furan: evaluation of DNA damage and induction of micronuclei in mouse splenocytes

(2009) P. Leopardi et al.   MUTAGENESIS

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

(2009) Lya G. Hernández et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Using chemical categories to fill data gaps in hazard assessment

(2009) K. van Leeuwen et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Current and Future Application of Genetic Toxicity Assays: The Role and Value of In Vitro Mammalian Assays

(2009) Rosalie K. Elespuru et al.   TOXICOLOGICAL SCIENCES

Toxicity Testing in the 21st Century: A View from the Pharmaceutical Industry

(2009) James S. MacDonald et al.   TOXICOLOGICAL SCIENCES

Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

(2008) Jordi Alcaraz et al.   EMBO JOURNAL

Predictivity of QSAR

(2008) Romualdo Benigni et al.   Journal of Chemical Information and Modeling

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Structure alerts for carcinogenicity, and the Salmonella assay system: A novel insight through the chemical relational databases technology

(2008) R BENIGNI et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

(2008) Robert J. Kavlock et al.   RISK ANALYSIS

More Toxin Tests Needed

(2008) J. Huff   SCIENCE