Recent development in high-throughput bioanalytical support forin vitroADMET profiling

High Throughput Screening of Physicochemical Properties and In Vitro ADME Profiling in Drug Discovery

(2009) Hong Wan et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Critical comparison of performances of superficially porous particles and sub-2μm particles under optimized ultra-high pressure conditions

(2009) Yu Zhang et al.   JOURNAL OF CHROMATOGRAPHY A

A liquid chromatography‐tandem mass spectrometry method for the simultaneous determination of exemestane and its metabolite 17‐dihydroexemestane in human plasma

(2009) Giuseppe Corona et al.   JOURNAL OF MASS SPECTROMETRY

A high-throughput LC–MS/MS method for the quantitation of posaconazole in human plasma: Implementing fused core silica liquid chromatography

(2009) Jennifer M. Cunliffe et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Quantitative-qualitative data acquisition using a benchtop orbitrap mass spectrometer

(2009) Kevin P. Bateman et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Quantitation of small molecules using high-resolution accurate mass spectrometers - a different approach for analysis of biological samples

(2009) Nanyan Rena Zhang et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen

(2009) Kasia Kieltyka et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Semi-automated tandem mass spectrometric (MS/MS) triple quadrupole operating parameter optimization for high-throughput MS/MS detection workflows

(2009) Kristin Geddes et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Bioanalysis without Sample Cleanup or Chromatography: The Evaluation and Initial Implementation of Direct Analysis in Real Time Ionization Mass Spectrometry for the Quantification of Drugs in Biological Matrixes

(2008) Shaoxia Yu et al.   ANALYTICAL CHEMISTRY

Recent Advances in High Throughput Screening for ADME Properties

(2008) Timothy Carlson et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Artificial Membrane Assays to Assess Permeability

(2008) Bernard Faller   CURRENT DRUG METABOLISM

Editorial [Hot Topic: High Throughput In Vitro ADME/Tox Profiling for Drug Discovery(Guest Editor: Edward H. Kerns)]

(2008) Edward Kerns   CURRENT DRUG METABOLISM

Plasma / Serum Protein Binding Determinations

(2008) Michael Banker et al.   CURRENT DRUG METABOLISM

Permeability – In Vitro Assays for Assessing Drug Transporter Activity

(2008) Hong Jin et al.   CURRENT DRUG METABOLISM

Perspectives on Bioanalytical Mass Spectrometry and Automation in Drug Discovery

(2008) John Janiszewski et al.   CURRENT DRUG METABOLISM

High Throughput ADME Screening: Practical Considerations, Impact on the Portfolio and Enabler of In Silico ADME Models

(2008) Cornelis Hop et al.   CURRENT DRUG METABOLISM

The Role of Genetic Toxicology in Drug Discovery and Optimization

(2008) L. Custer et al.   CURRENT DRUG METABOLISM

hERG (KCNH2 or Kv11.1) K+ Channels: Screening for Cardiac Arrhythmia Risk

(2008) Mark Bowlby et al.   CURRENT DRUG METABOLISM

In Vitro Cytochrome P450 Inhibition and Induction

(2008) Robert Walsky et al.   CURRENT DRUG METABOLISM

Permeability for Intestinal Absorption: Caco-2 Assay and Related Issues

(2008) Barry Press et al.   CURRENT DRUG METABOLISM

Case study: impact of technology investment on lead discovery at Bristol–Myers Squibb, 1998–2006

(2008) J HOUSTON   DRUG DISCOVERY TODAY

Ultra-fast quantitation of saquinavir in human plasma by matrix-assisted laser desorption/ionization and selected reaction monitoring mode detection

(2008) Michel Wagner et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC–MS/MS end-point

(2008) Kuresh A. Youdim et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The use of partially porous particle columns for the routine, generic analysis of biological samples for pharmacokinetic studies in drug discovery by reversed-phase ultra-high performance liquid chromatography–tandem mass spectrometry

(2008) David N. Mallett et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Addressing the analytical throughput challenges in ADME screening using rapid ultra-performance liquid chromatography/tandem mass spectrometry methodologies

(2008) Robert S. Plumb et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Quantitative analysis of small molecules by desorption electrospray ionization mass spectrometry from polytetrafluoroethylene surfaces

(2008) Demian R. Ifa et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Sub one minute inhibition assays for the major cytochrome P450 enzymes utilizing ultra-performance liquid chromatography/tandem mass spectrometry

(2008) Paul D. Rainville et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a ‘first-line’ approach for metabolite identification studies

(2008) Philip R. Tiller et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Quantification of small molecules in plasma with direct analysis in real time tandem mass spectrometry, without sample preparation and liquid chromatographic separation

(2008) Yeping Zhao et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Ambient desorption ionization mass spectrometry

(2008) Andre Venter et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY