Latest advances in the discovery of fatty acid amide hydrolase inhibitors
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Latest advances in the discovery of fatty acid amide hydrolase inhibitors
Authors
Keywords
-
Journal
Expert Opinion on Drug Discovery
Volume 8, Issue 5, Pages 509-522
Publisher
Informa Healthcare
Online
2013-03-14
DOI
10.1517/17460441.2013.780021
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Alternative Targets Within the Endocannabinoid System for Future Treatment of Gastrointestinal Diseases
- (2016) Rudolf Schicho et al. CANADIAN JOURNAL OF GASTROENTEROLOGY
- Rat and human fatty acid amide hydrolases: Overt similarities and hidden differences
- (2012) Almerinda Di Venere et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites
- (2012) Mark S. Tichenor et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The Endocannabinoid System and Pain
- (2012) Josee Guindon et al. CNS & Neurological Disorders-Drug Targets
- Evidence for Bidirectional Endocannabinoid Transport across Cell Membranes
- (2012) Andrea Chicca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases
- (2012) Stefania Butini et al. JOURNAL OF MEDICINAL CHEMISTRY
- Sulfonyl Fluoride Inhibitors of Fatty Acid Amide Hydrolase
- (2012) Shakiru O. Alapafuja et al. JOURNAL OF MEDICINAL CHEMISTRY
- An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee
- (2012) John P. Huggins et al. PAIN
- Discovery of Prostamide F2α and Its Role in Inflammatory Pain and Dorsal Horn Nociceptive Neuron Hyperexcitability
- (2012) Luisa Gatta et al. PLoS One
- α-Ketoheterocycle-Based Inhibitors of Fatty Acid Amide Hydrolase (FAAH)
- (2011) Katerina Otrubova et al. ACS Chemical Neuroscience
- Mechanism of Inhibition of Fatty Acid Amide Hydrolase by Sulfonamide-Containing Benzothiazoles: Long Residence Time Derived from Increased Kinetic Barrier and Not Exclusively from Thermodynamic Potency
- (2011) Gaochao Tian et al. BIOCHEMISTRY
- Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors
- (2011) Darin J. Gustin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects
- (2011) Gai Ling Li et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice
- (2011) M Bashashati et al. BRITISH JOURNAL OF PHARMACOLOGY
- Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling
- (2011) Alessio Lodola et al. CHEMICAL COMMUNICATIONS
- Endocannabinoid Oxygenation by Cyclooxygenases, Lipoxygenases, and Cytochromes P450: Cross-Talk between the Eicosanoid and Endocannabinoid Signaling Pathways
- (2011) Carol A. Rouzer et al. CHEMICAL REVIEWS
- The Endocannabinoid System in the Cancer Therapy: An Overview
- (2011) C. Grimaldi et al. CURRENT MEDICINAL CHEMISTRY
- Covalent Inhibitors of Fatty Acid Amide Hydrolase: A Rationale for the Activity of Piperidine and Piperazine Aryl Ureas
- (2011) Giulia Palermo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain
- (2011) K. Ahn et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Endocannabinoids and the cardiovascular response to stress
- (2011) Saoirse E O’Sullivan et al. JOURNAL OF PSYCHOPHARMACOLOGY
- The major central endocannabinoid directly acts at GABAA receptors
- (2011) E. Sigel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase
- (2010) Sonia Gattinoni et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Inactivation of Lipid Glyceryl Ester Metabolism in Human THP1 Monocytes/Macrophages by Activated Organophosphorus Insecticides: Role of Carboxylesterases 1 and 2
- (2010) Shuqi Xie et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System
- (2010) Sonia Gattinoni et al. ChemMedChem
- Endocannabinoids as Regulators of Transient Receptor Potential (TRP)Channels: a Further Opportunity to Develop New Endocannabinoid-Based Therapeutic Drugs
- (2010) V. Marzo et al. CURRENT MEDICINAL CHEMISTRY
- Endocannabinoid biosynthesis and inactivation, from simple to complex
- (2010) Giulio G. Muccioli DRUG DISCOVERY TODAY
- Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice
- (2010) Y. Gao et al. JOURNAL OF NEUROSCIENCE
- DAG Lipase Involvement in Depolarization-Induced Suppression of Inhibition: Does Endocannabinoid Biosynthesis Always Meet the Demand?
- (2010) Rogier Min et al. NEUROSCIENTIST
- Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications
- (2010) N. T. Snider et al. PHARMACOLOGICAL REVIEWS
- N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA)
- (2010) Natsuo Ueda et al. PROGRESS IN LIPID RESEARCH
- Intracellular trafficking of anandamide: new concepts for signaling
- (2010) Mauro Maccarrone et al. TRENDS IN BIOCHEMICAL SCIENCES
- Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor
- (2010) Douglas S. Johnson et al. ACS Medicinal Chemistry Letters
- Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas
- (2009) Terance Hart et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Oxime Carbamate—Discovery of a series of novel FAAH inhibitors
- (2009) S.Y. Sit et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain
- (2009) Kay Ahn et al. CHEMISTRY & BIOLOGY
- X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase
- (2009) Mauro Mileni et al. JOURNAL OF MEDICINAL CHEMISTRY
- Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain
- (2009) S. G. Kinsey et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures
- (2009) Mauro Mileni et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase
- (2008) Mark J. Karbarz et al. ANESTHESIA AND ANALGESIA
- Discovery of Boronic Acids as Novel and Potent Inhibitors of Fatty Acid Amide Hydrolase
- (2008) Anna Minkkilä et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors
- (2008) Xueqing Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors
- (2008) Martin A. Storr et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Endogenous Cannabinoids: Structure and Metabolism
- (2008) T. Bisogno JOURNAL OF NEUROENDOCRINOLOGY
- Targeting the endocannabinoid system: to enhance or reduce?
- (2008) Vincenzo Di Marzo NATURE REVIEWS DRUG DISCOVERY
- Structure-guided inhibitor design for human FAAH by interspecies active site conversion
- (2008) M. Mileni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling
- (2007) Alessio Lodola et al. CHEMICAL COMMUNICATIONS
- The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition
- (2007) Maria Scherma et al. NEUROPHARMACOLOGY
- Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
- (2007) Fabricio A. Moreira et al. NEUROPHARMACOLOGY
- Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms
- (2006) Leon Chang et al. BRITISH JOURNAL OF PHARMACOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More