Development of aldose reductase inhibitors for the treatment of inflammatory disorders

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

(2013) Umesh C. S. Yadav et al.   PLoS One

Deletion of Aldose Reductase from Mice Inhibits Diabetes-Induced Retinal Capillary Degeneration and Superoxide Generation

(2013) Jie Tang et al.   PLoS One

A New Approach to Control the Enigmatic Activity of Aldose Reductase

(2013) Antonella Del-Corso et al.   PLoS One

Aldose Reductase Inhibition Prevents Colon Cancer Growth by Restoring Phosphatase and Tensin Homolog Through Modulation of miR-21 and FOXO3a

(2012) Ashish Saxena et al.   ANTIOXIDANTS & REDOX SIGNALING

Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues

(2012) Kun-Che Chang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Targeting Aldose Reductase for the Treatment of Cancer

(2012) R. Tammali et al.   CURRENT CANCER DRUG TARGETS

Current Prospective of Aldose Reductase Inhibition in the Therapy of Allergic Airway Inflammation in Asthma

(2012) K.V. Ramana et al.   CURRENT MOLECULAR MEDICINE

Molecular Link Mechanisms between Inflammation and Cancer

(2012) D. B. Vendramini-Costa et al.   CURRENT PHARMACEUTICAL DESIGN

A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases

(2012) Saumya Pandey et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Novel aldose reductase inhibitors: a patent survey (2006 – present)

(2012) Maria Chatzopoulou et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Protective role of D-saccharic acid-1,4-lactone in alloxan induced oxidative stress in the spleen tissue of diabetic rats is mediated by suppressing mitochondria dependent apoptotic pathway

(2012) Kahkashan Rashid et al.   FREE RADICAL RESEARCH

The inhibition of aldose reductase on mucus production induced by interleukin-13 in the human bronchial epithelial cells

(2012) Depeng Jiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats

(2012) Ayman M. Mahmoud et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Osmotic stress induced oxidative damage: Possible mechanism of cataract formation in diabetes

(2012) Zehra Hashim et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Inflammation and Cancer: Chemical Approaches to Mechanisms, Imaging, and Treatment

(2012) Lawrence J. Marnett   JOURNAL OF ORGANIC CHEMISTRY

Hesperidin Prevents Retinal and Plasma Abnormalities in Streptozotocin-Induced Diabetic Rats

(2012) Xiupu Shi et al.   MOLECULES

Amelioration of Acute Kidney Injury in Lipopolysaccharide-Induced Systemic Inflammatory Response Syndrome by an Aldose Reductase Inhibitor, Fidarestat

(2012) Kazunori Takahashi et al.   PLoS One

The Isolation and Characterization of β-Glucogallin as a Novel Aldose Reductase Inhibitor from Emblica officinalis

(2012) Muthenna Puppala et al.   PLoS One

d-Saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-κB and PKC signaling

(2012) Semantee Bhattacharya et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The prostaglandin F synthase activity of the human aldose reductase AKR1B1 brings new lenses to look at pathologic conditions

(2012) Eva Bresson   Frontiers in Pharmacology

Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo

(2011) Ravinder Tammali et al.   ANGIOGENESIS

Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2–Keap1 signaling

(2011) P. Palsamy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aldose reductase inhibition suppresses airway inflammation

(2011) Umesh C.S. Yadav et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders

(2011) Satish K. Srivastava et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aldose Reductase / Polyol Inhibitors for Diabetic Retinopathy

(2011) Irina G. Obrosova et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase

(2011) Xuehua Zheng et al.   FEBS LETTERS

Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages

(2011) Mohammad Shoeb et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aldose Reductase Inhibition Prevents Hypoxia-induced Increase in Hypoxia-inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor (VEGF) by Regulating 26 S Proteasome-mediated Protein Degradation in Human Colon Cancer Cells

(2011) Ravinder Tammali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane

(2011) Wai Ho Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

(Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl4-induced liver injury

(2011) Zhen-ling Wang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids

(2011) Elena Vladykovskaya et al.   JOURNAL OF LIPID RESEARCH

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

(2011) Lien Dejager et al.   TRENDS IN MICROBIOLOGY

Leukocyte Adhesion Molecules in Diabetic Retinopathy

(2011) Kousuke Noda et al.   Journal of Ophthalmology

Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells

(2010) Umesh C.S. Yadav et al.   EXPERIMENTAL EYE RESEARCH

Inflammatory Markers Are Increased in Youth with Type 1 Diabetes: The SEARCH Case-Control Study

(2010) Janet K. Snell-Bergeon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Efficacy of Structurally Diverse Aldose Reductase Inhibitors on Experimental Periodontitis in Rats

(2010) Peter F. Kador et al.   JOURNAL OF PERIODONTOLOGY

Inhibition of Aldose Reductase Prevents Growth Factor–Induced G1-S Phase Transition through the AKT/Phosphoinositide 3-Kinase/E2F-1 Pathway in Human Colon Cancer Cells

(2010) Kota V. Ramana et al.   MOLECULAR CANCER THERAPEUTICS

Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells

(2010) Umesh C. S. Yadav et al.   PLoS One

The Role of Oxidative Stress in the Pathogenesis of Asthma

(2010) You Sook Cho et al.   Allergy Asthma & Immunology Research

Aldose Reductase Enzyme and its Implication to Major Health Problems of the 21st Century

(2009) Polyxeni Alexiou et al.   CURRENT MEDICINAL CHEMISTRY

Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis

(2009) Aramati B.M. Reddy et al.   CYTOKINE

The Transforming Growth Factor-  Pathway Is a Common Target of Drugs That Prevent Experimental Diabetic Retinopathy

(2009) C. Gerhardinger et al.   DIABETES

Aldose reductase: A novel therapeutic target for inflammatory pathologies

(2009) Kota V. Ramana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Airway glutathione homeostasis is altered in children with severe asthma: Evidence for oxidant stress

(2009) Anne M. Fitzpatrick et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Novel Role for Aldose Reductase in Mediating Acute Inflammatory Responses in the Lung

(2009) T. M. Ravindranath et al.   JOURNAL OF IMMUNOLOGY

Aldose Reductase Inhibition Suppresses the Expression of Th2 Cytokines and Airway Inflammation in Ovalbumin-Induced Asthma in Mice

(2009) U. C. S. Yadav et al.   JOURNAL OF IMMUNOLOGY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of aldose reductase in TGF-β1-induced fibronectin synthesis in human mesangial cells

(2009) Yuejuan Zhang et al.   MOLECULAR BIOLOGY REPORTS

Chronic inflammation and asthma

(2009) Jenna R. Murdoch et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Inhibition of Aldose Reductase Prevents Experimental Allergic Airway Inflammation in Mice

(2009) Umesh C. S. Yadav et al.   PLoS One

Advanced Glycation End Products and Receptor–Oxidative Stress System in Diabetic Vascular Complications

(2009) Sho-ichi Yamagishi   THERAPEUTIC APHERESIS AND DIALYSIS

Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation

(2008) R. Tammali et al.   CARCINOGENESIS

Aldose Reductase, Still a Compelling Target for Diabetic Neuropathy

(2008) Peter Oates   CURRENT DRUG TARGETS

From a Dull Enzyme to Something Else: Facts and Perspectives Regarding Aldose Reductase

(2008) A. Corso et al.   CURRENT MEDICINAL CHEMISTRY

Islet Inflammation in Type 2 Diabetes: From metabolic stress to therapy

(2008) M. Y. Donath et al.   DIABETES CARE

The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification

(2008) Oleg A. Barski et al.   DRUG METABOLISM REVIEWS

Ranirestat as a therapeutic aldose reductase inhibitor for diabetic complications

(2008) Nick Giannoukakis   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Merging the Binding Sites of Aldose and Aldehyde Reductase for Detection of Inhibitor Selectivity-determining Features

(2008) Holger Steuber et al.   JOURNAL OF MOLECULAR BIOLOGY