The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification

Catalytic Mechanism and Substrate Specificity of the β-Subunit of the Voltage-Gated Potassium Channel†

(2008) Srinivas M. Tipparaju et al.   BIOCHEMISTRY

Inhibition of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors

(2008) Urmi Dhagat et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Quantification of Urinary Aflatoxin B1Dialdehyde Metabolites Formed by Aflatoxin Aldehyde Reductase Using Isotope Dilution Tandem Mass Spectrometry

(2008) Denise N. Johnson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers

(2008) Malkhey Verma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of Nitric Oxide in Regulating Aldose Reductase Activation in the Ischemic Heart

(2008) Karin Kaiserova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selectivity Determinants of Inhibitor Binding to Human 20α-Hydroxysteroid Dehydrogenase: Crystal Structure of the Enzyme in Ternary Complex with Coenzyme and the Potent Inhibitor 3,5-Dichlorosalicylic Acid†

(2008) Urmi Dhagat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Merging the Binding Sites of Aldose and Aldehyde Reductase for Detection of Inhibitor Selectivity-determining Features

(2008) Holger Steuber et al.   JOURNAL OF MOLECULAR BIOLOGY

Ranirestat (AS-3201), a Potent Aldose Reductase Inhibitor, Reduces Sorbitol Levels and Improves Motor Nerve Conduction Velocity in Streptozotocin-Diabetic Rats

(2008) Takafumi Matsumoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Human Δ4-3-oxosteroid 5β-reductase (AKR1D1) deficiency and steroid metabolism

(2008) Mario Palermo et al.   STEROIDS

An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies

(2007) Michael C. Byrns et al.   BIOCHEMICAL PHARMACOLOGY

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors

(2007) A Negre-Salvayre et al.   BRITISH JOURNAL OF PHARMACOLOGY

Short-chain dehydrogenase/reductase (SDR) relationships: A large family with eight clusters common to human, animal, and plant genomes

(2002) Yvonne Kallberg et al.   PROTEIN SCIENCE