Advances in the role of microRNAs in lipid metabolism-related anti-atherosclerotic drug discovery

MicroRNA-155 Silencing Enhances Inflammatory Response and Lipid Uptake in Oxidized Low-Density Lipoprotein-Stimulated Human THP-1 Macrophages

(2016) Ri-sheng Huang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

MicroRNA-126, -145, and -155

(2013) Yuanyuan Wei et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNAs 185, 96, and 223 Repress Selective High-Density Lipoprotein Cholesterol Uptake through Posttranscriptional Inhibition

(2013) L. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Sequence-specific inhibition of Dicer measured with a force-based microarray for RNA ligands

(2013) Katja Limmer et al.   NUCLEIC ACIDS RESEARCH

MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice

(2013) Takahiro Horie et al.   Journal of the American Heart Association

Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing

(2012) Glen F. Deleavey et al.   CHEMISTRY & BIOLOGY

Gut Microbiota Metabolism of Anthocyanin Promotes Reverse Cholesterol Transport in Mice Via Repressing miRNA-10b

(2012) Dongliang Wang et al.   CIRCULATION RESEARCH

MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7

(2012) Dongsheng Sun et al.   FEBS LETTERS

Discovering the first microRNA-targeted drug

(2012) Morten Lindow et al.   JOURNAL OF CELL BIOLOGY

Novel Insights of Structure-Based Modeling for RNA-Targeted Drug Discovery

(2012) Lu Chen et al.   Journal of Chemical Information and Modeling

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

(2012) Shu-hao Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

(2012) Wei-Chih Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNAs 125a and 455 Repress Lipoprotein-Supported Steroidogenesis by Targeting Scavenger Receptor Class B Type I in Steroidogenic Cells

(2012) Z. Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

Passenger strand miRNA miR-31∗ regulates the phenotypes of oral cancer cells by targeting RhoA

(2012) Kuo-Wei Chang et al.   ORAL ONCOLOGY

microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans

(2012) Bernd Denecke et al.   THROMBOSIS AND HAEMOSTASIS

MicroRNAs and Diabetic Complications

(2012) Rama Natarajan et al.   Journal of Cardiovascular Translational Research

Small Molecule Inhibition of RISC Loading

(2011) Grace S. Tan et al.   ACS Chemical Biology

The Tuberculosis Drug Streptomycin as a Potential Cancer Therapeutic: Inhibition of miR-21 Function by Directly Targeting Its Precursor

(2011) Debojit Bose et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MicroRNA-758 Regulates Cholesterol Efflux Through Posttranscriptional Repression of ATP-Binding Cassette Transporter A1

(2011) Cristina M. Ramirez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cyanidin-3-O-β-glucoside with the aid of its metabolite protocatechuic acid, reduces monocyte infiltration in apolipoprotein E-deficient mice

(2011) Dongliang Wang et al.   BIOCHEMICAL PHARMACOLOGY

miRNA cassettes in viral vectors: Problems and solutions

(2011) Ying Poi Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Macrophage development from HSCs requires PU.1-coordinated microRNA expression

(2011) S. Ghani et al.   BLOOD

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

(2011) Lin Zhang et al.   CELL RESEARCH

miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression

(2011) Jaekwang Kim et al.   EXPERIMENTAL NEUROLOGY

MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4

(2011) Ke Yang et al.   FEBS LETTERS

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

(2011) Katey J. Rayner et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA Modulation in Obesity and Periodontitis

(2011) R. Perri et al.   JOURNAL OF DENTAL RESEARCH

Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI

(2011) Ailing Ji et al.   JOURNAL OF LIPID RESEARCH

Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice

(2011) Menno Hoekstra et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

MicroRNA hsa-miR-613 Targets the HumanLXRα Gene and Mediates a Feedback Loop of LXRα Autoregulation

(2011) Zhimin Ou et al.   MOLECULAR ENDOCRINOLOGY

Pervasive roles of microRNAs in cardiovascular biology

(2011) Eric M. Small et al.   NATURE

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Silencing of microRNA families by seed-targeting tiny LNAs

(2011) Susanna Obad et al.   NATURE GENETICS

Hepato-specific microRNA-122 facilitates accumulation of newly synthesized miRNA through regulating PRKRA

(2011) Shuai Li et al.   NUCLEIC ACIDS RESEARCH

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

(2011) A. Davalos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

(2011) M. Kurowska-Stolarska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Future Therapeutic Directions in Reverse Cholesterol Transport

(2010) Amit V. Khera et al.   Current Atherosclerosis Reports

How can high-throughput screening deliver drugs to treat atherosclerosis?

(2010) Yuan Yang et al.   Expert Opinion on Drug Discovery

Mechanical Stretch Up-regulates MicroRNA-26a and Induces Human Airway Smooth Muscle Hypertrophy by Suppressing Glycogen Synthase Kinase-3β

(2010) Junaith S. Mohamed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism

(2010) Dimitrios Iliopoulos et al.   JOURNAL OF LIPID RESEARCH

CLINICAL TRIALS AND TRANSLATIONAL MEDICINE COMMENTARY: Drug Delivery Trends in Clinical Trials and Translational Medicine: Challenges and Opportunities in the Delivery of Nucleic Acid-Based Therapeutics

(2010) Long Xu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

(2010) Douglas D. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing

(2010) Chanseok Shin et al.   MOLECULAR CELL

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Targeting microRNAs in cancer: rationale, strategies and challenges

(2010) Ramiro Garzon et al.   NATURE REVIEWS DRUG DISCOVERY

miRBase: integrating microRNA annotation and deep-sequencing data

(2010) A. Kozomara et al.   NUCLEIC ACIDS RESEARCH

miR-33 links SREBP-2 induction to repression of sterol transporters

(2010) T. J. Marquart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo

(2010) T. Horie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA sponges: Progress and possibilities

(2010) M. S. Ebert et al.   RNA

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

(2010) S. H. Najafi-Shoushtari et al.   SCIENCE

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages

(2009) Ting Chen et al.   CARDIOVASCULAR RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding

(2009) Tomoko Kawamata et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Discovering ligands for a microRNA precursor with peptoid microarrays

(2009) Sara Chirayil et al.   NUCLEIC ACIDS RESEARCH

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Small-Molecule Inhibitors of MicroRNA miR-21 Function

(2008) Kiranmai Gumireddy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhancement of RNAi by a small molecule antibiotic enoxacin

(2008) Qiangzhe Zhang et al.   CELL RESEARCH

Control of protein synthesis and mRNA degradation by microRNAs

(2008) Jidong Liu   CURRENT OPINION IN CELL BIOLOGY

An efficient method to enhance gene silencing by using precursor microRNA designed small hairpin RNAs

(2008) Zhixin Shan et al.   MOLECULAR BIOLOGY REPORTS

The seeds of silence

(2008) Zissimos Mourelatos   NATURE

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

Widespread Translational Inhibition by Plant miRNAs and siRNAs

(2008) P. Brodersen et al.   SCIENCE

A fluorescence probe for assaying micro RNA maturation

(2007) Brian P. Davies et al.   BIOORGANIC & MEDICINAL CHEMISTRY