Modular pharmacology: the next paradigm in drug discovery

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

(2011) Tomas Malinauskas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identifying and Characterizing Nodes Important to Community Structure Using the Spectrum of the Graph

(2011) Yang Wang et al.   PLoS One

Network-Based Tools for the Identification of Novel Drug Targets

(2011) I. J. Farkas et al.   Science Signaling

Allo-network drugs: harnessing allostery in cellular networks

(2011) Ruth Nussinov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

From protoplasmic theory to cellular systems biology: a 150-year reflection

(2010) G. Rickey Welch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PathWave: discovering patterns of differentially regulated enzymes in metabolic pathways

(2010) Gunnar Schramm et al.   BIOINFORMATICS

Biology-driven cancer drug development: back to the future

(2010) Christopher J Lord et al.   BMC BIOLOGY

Pathway Analysis of Breast Cancer Genome-Wide Association Study Highlights Three Pathways and One Canonical Signaling Cascade

(2010) Idan Menashe et al.   CANCER RESEARCH

Network Systems Biology for Drug Discovery

(2010) D K Arrell et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Complementarity in biology

(2010) Fulvio Mazzocchi   EMBO REPORTS

Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia

(2010) A. Torkamani et al.   GENOME RESEARCH

An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer: Figure 1.

(2010) Mark Asquith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pulmonary dendritic cells: thinking globally, acting locally: Figure 1.

(2010) Troy D. Randall   JOURNAL OF EXPERIMENTAL MEDICINE

Combination therapy in multiple sclerosis

(2010) Devon Conway et al.   LANCET NEUROLOGY

Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

(2010) Laura Kapitzky et al.   Molecular Systems Biology

Translating cancer research into targeted therapeutics

(2010) J. S. de Bono et al.   NATURE

Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli

(2010) Manash S Chatterjee et al.   NATURE BIOTECHNOLOGY

Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity

(2010) Frédéric Chibon et al.   NATURE MEDICINE

Targeted cancer therapies

(2010) Saurabh Aggarwal   NATURE REVIEWS DRUG DISCOVERY

Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches

(2010) Jeanette Hellgren Kotaleski et al.   NATURE REVIEWS NEUROSCIENCE

Systems biology: opening new avenues in clinical research

(2010) F. Molina et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

PINT: Pathways INtegration Tool

(2010) Y.-T. Wang et al.   NUCLEIC ACIDS RESEARCH

Automated Network Analysis Identifies Core Pathways in Glioblastoma

(2010) Ethan Cerami et al.   PLoS One

Community Landscapes: An Integrative Approach to Determine Overlapping Network Module Hierarchy, Identify Key Nodes and Predict Network Dynamics

(2010) István A. Kovács et al.   PLoS One

Network synchronization landscape reveals compensatory structures, quantization, and the positive effect of negative interactions

(2010) T. Nishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revealing strengths and weaknesses of methods for gene network inference

(2010) D. Marbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Proteome in Balance

(2010) D. Hutt et al.   SCIENCE

Rules for Biologically Inspired Adaptive Network Design

(2010) A. Tero et al.   SCIENCE

Dopaminergic Network Differences in Human Impulsivity

(2010) J. W. Buckholtz et al.   SCIENCE

Structure and Dynamics of Ecological Networks

(2010) J. Bascompte   SCIENCE

"Complementing" Toll Signaling

(2010) J. C. Kagan   Science Signaling

Two Receptors, Two Kinases, and T Cell Lineage Determination

(2010) B. Alarcon et al.   Science Signaling

Predictive, preventive, personalized and participatory medicine: back to the future

(2010) Charles Auffray et al.   Genome Medicine

GeNGe: systematic generation of gene regulatory networks

(2009) Hendrik Hache et al.   BIOINFORMATICS

Modeling multi-cellular behavior in epidermal tissue homeostasis via finite state machines in multi-agent systems

(2009) T. Sutterlin et al.   BIOINFORMATICS

PerturbationAnalyzer: a tool for investigating the effects of concentration perturbation on protein interaction networks

(2009) F. Li et al.   BIOINFORMATICS

Perturbation Waves in Proteins and Protein Networks: Applications of Percolation and Game Theories in Signaling and Drug Design

(2009) Miklos Antal et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Can the whole be less than the sum of its parts? Pathway analysis in genome-scale metabolic networks using elementary flux patterns

(2009) C. Kaleta et al.   GENOME RESEARCH

Targeting the mTOR Signaling Network for Cancer Therapy

(2009) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

Neuronal Avalanches Imply Maximum Dynamic Range in Cortical Networks at Criticality

(2009) W. L. Shew et al.   JOURNAL OF NEUROSCIENCE

Quinine monotherapy for treating uncomplicated malaria in the era of artemisinin-based combination therapy: an appropriate public health policy?

(2009) Adoke Yeka et al.   LANCET INFECTIOUS DISEASES

Identifying responsive functional modules from protein-protein interaction network

(2009) Zikai Wu et al.   MOLECULES AND CELLS

Myopathy with statin–fibrate combination therapy: clinical considerations

(2009) Terry A. Jacobson   Nature Reviews Endocrinology

Complex brain networks: graph theoretical analysis of structural and functional systems

(2009) Ed Bullmore et al.   NATURE REVIEWS NEUROSCIENCE

Community detection in graphs

(2009) Santo Fortunato   PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS

The Increasing Complexity of the Cancer Stem Cell Paradigm

(2009) J. M. Rosen et al.   SCIENCE

Nontraditional Signaling Mechanisms of Lipoprotein Receptors

(2009) G. W. Rebeck   Science Signaling

The Complexity of Cell Signaling and the Need for a New Mechanics

(2009) W. S. Hlavacek et al.   Science Signaling

The Regulatory Logic of the NF- B Signaling System

(2009) E. O'Dea et al.   Cold Spring Harbor Perspectives in Biology

Broadband Criticality of Human Brain Network Synchronization

(2009) Manfred G. Kitzbichler et al.   PLoS Computational Biology

Quantitative analysis of robustness and fragility in biological networks based on feedback dynamics

(2008) Yung-Keun Kwon et al.   BIOINFORMATICS

Revealing Modular Architecture of Human Brain Structural Networks by Using Cortical Thickness from MRI

(2008) Zhang J. Chen et al.   CEREBRAL CORTEX

Integrating Computational and Biochemical Studies to Explore Mechanisms in NF-κB Signaling

(2008) Jeffrey D. Kearns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of Randomized Sampling for Analysis of Metabolic Networks

(2008) Jan Schellenberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploiting Complexity and the Robustness of Network Architecture for Drug Discovery

(2008) M. K. Hellerstein   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Temporal Perturbation of Tyrosine Phosphoproteome Dynamics Reveals the System-wide Regulatory Networks

(2008) Masaaki Oyama et al.   MOLECULAR & CELLULAR PROTEOMICS

High-order combination effects and biological robustness

(2008) Joseph Lehár et al.   Molecular Systems Biology

Finding multiple target optimal intervention in disease-related molecular network

(2008) Kun Yang et al.   Molecular Systems Biology

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

A modular approach for integrative analysis of large-scale gene-expression and drug-response data

(2008) Zoltán Kutalik et al.   NATURE BIOTECHNOLOGY

Learning biological networks: from modules to dynamics

(2008) Richard Bonneau   Nature Chemical Biology

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Self-organization and neuronal avalanches in networks of dissociated cortical neurons

(2008) V. Pasquale et al.   NEUROSCIENCE

Gene expression dynamics in the macrophage exhibit criticality

(2008) M. Nykter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA