标题
Modular pharmacology: the next paradigm in drug discovery
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume 7, Issue 8, Pages 667-677
出版商
Informa Healthcare
发表日期
2012-06-11
DOI
10.1517/17460441.2012.692673
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1
- (2011) Tomas Malinauskas et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Identifying and Characterizing Nodes Important to Community Structure Using the Spectrum of the Graph
- (2011) Yang Wang et al. PLoS One
- Network-Based Tools for the Identification of Novel Drug Targets
- (2011) I. J. Farkas et al. Science Signaling
- Allo-network drugs: harnessing allostery in cellular networks
- (2011) Ruth Nussinov et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- From protoplasmic theory to cellular systems biology: a 150-year reflection
- (2010) G. Rickey Welch et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- PathWave: discovering patterns of differentially regulated enzymes in metabolic pathways
- (2010) Gunnar Schramm et al. BIOINFORMATICS
- Biology-driven cancer drug development: back to the future
- (2010) Christopher J Lord et al. BMC BIOLOGY
- Pathway Analysis of Breast Cancer Genome-Wide Association Study Highlights Three Pathways and One Canonical Signaling Cascade
- (2010) Idan Menashe et al. CANCER RESEARCH
- Network Systems Biology for Drug Discovery
- (2010) D K Arrell et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Complementarity in biology
- (2010) Fulvio Mazzocchi EMBO REPORTS
- Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia
- (2010) A. Torkamani et al. GENOME RESEARCH
- An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer: Figure 1.
- (2010) Mark Asquith et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Pulmonary dendritic cells: thinking globally, acting locally: Figure 1.
- (2010) Troy D. Randall JOURNAL OF EXPERIMENTAL MEDICINE
- Combination therapy in multiple sclerosis
- (2010) Devon Conway et al. LANCET NEUROLOGY
- Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action
- (2010) Laura Kapitzky et al. Molecular Systems Biology
- Translating cancer research into targeted therapeutics
- (2010) J. S. de Bono et al. NATURE
- Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli
- (2010) Manash S Chatterjee et al. NATURE BIOTECHNOLOGY
- Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity
- (2010) Frédéric Chibon et al. NATURE MEDICINE
- Targeted cancer therapies
- (2010) Saurabh Aggarwal NATURE REVIEWS DRUG DISCOVERY
- Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches
- (2010) Jeanette Hellgren Kotaleski et al. NATURE REVIEWS NEUROSCIENCE
- Systems biology: opening new avenues in clinical research
- (2010) F. Molina et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- PINT: Pathways INtegration Tool
- (2010) Y.-T. Wang et al. NUCLEIC ACIDS RESEARCH
- Automated Network Analysis Identifies Core Pathways in Glioblastoma
- (2010) Ethan Cerami et al. PLoS One
- Community Landscapes: An Integrative Approach to Determine Overlapping Network Module Hierarchy, Identify Key Nodes and Predict Network Dynamics
- (2010) István A. Kovács et al. PLoS One
- Network synchronization landscape reveals compensatory structures, quantization, and the positive effect of negative interactions
- (2010) T. Nishikawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Revealing strengths and weaknesses of methods for gene network inference
- (2010) D. Marbach et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Proteome in Balance
- (2010) D. Hutt et al. SCIENCE
- Rules for Biologically Inspired Adaptive Network Design
- (2010) A. Tero et al. SCIENCE
- Dopaminergic Network Differences in Human Impulsivity
- (2010) J. W. Buckholtz et al. SCIENCE
- Structure and Dynamics of Ecological Networks
- (2010) J. Bascompte SCIENCE
- "Complementing" Toll Signaling
- (2010) J. C. Kagan Science Signaling
- Two Receptors, Two Kinases, and T Cell Lineage Determination
- (2010) B. Alarcon et al. Science Signaling
- Predictive, preventive, personalized and participatory medicine: back to the future
- (2010) Charles Auffray et al. Genome Medicine
- GeNGe: systematic generation of gene regulatory networks
- (2009) Hendrik Hache et al. BIOINFORMATICS
- Modeling multi-cellular behavior in epidermal tissue homeostasis via finite state machines in multi-agent systems
- (2009) T. Sutterlin et al. BIOINFORMATICS
- PerturbationAnalyzer: a tool for investigating the effects of concentration perturbation on protein interaction networks
- (2009) F. Li et al. BIOINFORMATICS
- Perturbation Waves in Proteins and Protein Networks: Applications of Percolation and Game Theories in Signaling and Drug Design
- (2009) Miklos Antal et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Can the whole be less than the sum of its parts? Pathway analysis in genome-scale metabolic networks using elementary flux patterns
- (2009) C. Kaleta et al. GENOME RESEARCH
- Targeting the mTOR Signaling Network for Cancer Therapy
- (2009) Funda Meric-Bernstam et al. JOURNAL OF CLINICAL ONCOLOGY
- Neuronal Avalanches Imply Maximum Dynamic Range in Cortical Networks at Criticality
- (2009) W. L. Shew et al. JOURNAL OF NEUROSCIENCE
- Quinine monotherapy for treating uncomplicated malaria in the era of artemisinin-based combination therapy: an appropriate public health policy?
- (2009) Adoke Yeka et al. LANCET INFECTIOUS DISEASES
- Identifying responsive functional modules from protein-protein interaction network
- (2009) Zikai Wu et al. MOLECULES AND CELLS
- Myopathy with statin–fibrate combination therapy: clinical considerations
- (2009) Terry A. Jacobson Nature Reviews Endocrinology
- Complex brain networks: graph theoretical analysis of structural and functional systems
- (2009) Ed Bullmore et al. NATURE REVIEWS NEUROSCIENCE
- Community detection in graphs
- (2009) Santo Fortunato PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS
- The Increasing Complexity of the Cancer Stem Cell Paradigm
- (2009) J. M. Rosen et al. SCIENCE
- Nontraditional Signaling Mechanisms of Lipoprotein Receptors
- (2009) G. W. Rebeck Science Signaling
- The Complexity of Cell Signaling and the Need for a New Mechanics
- (2009) W. S. Hlavacek et al. Science Signaling
- The Regulatory Logic of the NF- B Signaling System
- (2009) E. O'Dea et al. Cold Spring Harbor Perspectives in Biology
- Broadband Criticality of Human Brain Network Synchronization
- (2009) Manfred G. Kitzbichler et al. PLoS Computational Biology
- Quantitative analysis of robustness and fragility in biological networks based on feedback dynamics
- (2008) Yung-Keun Kwon et al. BIOINFORMATICS
- Revealing Modular Architecture of Human Brain Structural Networks by Using Cortical Thickness from MRI
- (2008) Zhang J. Chen et al. CEREBRAL CORTEX
- Integrating Computational and Biochemical Studies to Explore Mechanisms in NF-κB Signaling
- (2008) Jeffrey D. Kearns et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Use of Randomized Sampling for Analysis of Metabolic Networks
- (2008) Jan Schellenberger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exploiting Complexity and the Robustness of Network Architecture for Drug Discovery
- (2008) M. K. Hellerstein JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Temporal Perturbation of Tyrosine Phosphoproteome Dynamics Reveals the System-wide Regulatory Networks
- (2008) Masaaki Oyama et al. MOLECULAR & CELLULAR PROTEOMICS
- High-order combination effects and biological robustness
- (2008) Joseph Lehár et al. Molecular Systems Biology
- Finding multiple target optimal intervention in disease-related molecular network
- (2008) Kun Yang et al. Molecular Systems Biology
- Variations in DNA elucidate molecular networks that cause disease
- (2008) Yanqing Chen et al. NATURE
- A modular approach for integrative analysis of large-scale gene-expression and drug-response data
- (2008) Zoltán Kutalik et al. NATURE BIOTECHNOLOGY
- Learning biological networks: from modules to dynamics
- (2008) Richard Bonneau Nature Chemical Biology
- Network pharmacology: the next paradigm in drug discovery
- (2008) Andrew L Hopkins Nature Chemical Biology
- Self-organization and neuronal avalanches in networks of dissociated cortical neurons
- (2008) V. Pasquale et al. NEUROSCIENCE
- Gene expression dynamics in the macrophage exhibit criticality
- (2008) M. Nykter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search