Review
Polymer Science
Buket Bezgin Carbas, Emine Gul Cansu Ergun
Summary: This review provides an overview of the importance of poly(2,5-dithienyl-1-substituted-pyrrole) derivatives in electrochromic applications and categorizes and compares different derivatives. It includes different synthesis methods and the effects of substitutions on the electrochromic properties.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Physical
Chafai Boukentoucha, Ramzi Maadadi, Ali Benosmane, Ali Benboudiaf, Cherif Behloul, Abdelmadjid Kherrouba, Abdelmalek Bouraiou, Hocine Merazig
Summary: This work presents the synthesis, characterization, and theoretical study of new meso-substituted dipyrromethanes. The compounds were synthesized through a double Friedel-Crafts reaction using iodine as a catalyst. Various characterization techniques were employed to analyze the synthesized compounds, and the crystal structure of compound 2c was determined using single-crystal X-ray diffraction. The study also investigated the weak intermolecular interactions in the crystal packing and compared the experimental data with theoretical calculations.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Medicinal
Florian Galster, Timo Poestges, Walburga Hanekamp, Matthias Lehr
Summary: Amine oxidase copper containing 3 (AOC3) is an important enzyme that plays a potential role in the treatment of inflammation-related diseases by facilitating the transmigration of inflammatory cells from blood vessels to tissues. By modifying the functional groups of known AOC3 inhibitors, novel inhibitors can be obtained and further optimized through structural modifications.
ARCHIV DER PHARMAZIE
(2022)
Article
Biochemistry & Molecular Biology
Michal Abram, Marcin Jakubiec, Anna Rapacz, Szczepan Mogilski, Gniewomir Latacz, Bartlomiej Szulczyk, Malgorzata Szafarz, Katarzyna Socala, Dorota Nieoczym, Elzbieta Wyska, Piotr Wlaz, Rafal M. Kaminski, Krzysztof Kaminski
Summary: A series of water-soluble analogues of previously described anticonvulsants were characterized in vivo and in vitro, with compound 14 showing robust anticonvulsant, analgesic, and anti-inflammatory properties. The mechanism of action of compound 14 is believed to involve inhibition of sodium and calcium currents, as well as TRPV1 receptor antagonism. Overall, compound 14 exhibits potential for future preclinical development as a lead candidate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Electrochemistry
Ayhan Altun, Roxana-Mihaela Apetrei, Pinar Camurlu
Summary: Biosensing devices for urea detection have been extensively studied due to the importance of analyzing urea levels in biological fluids. The use of specific electrochemical methods and bio-materials have shown promising results for accurate urea detection, potentially playing a crucial role in clinical diagnostics.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Materials Science, Multidisciplinary
Emine Gul Cansu Ergun, Buket Bezgin Carbas
Summary: 2,5-dithienyl-N-substituted-pyrrole (SNS) derivatives are preferred for obtaining conducting polymers due to their low oxidation potential and ease of electrochemical polymerization. The SNS backbone can be substituted from the nitrogen atom on the pyrrole unit, allowing fine tuning of spectroelectrochemical properties. Copolymerization of SNS derivatives with 3,4-ethylenedioxythiophene (EDOT) enables further tuning or enhancement of the resulting copolymer. This review discusses the electrochemically synthesized conducting copolymers of SNS derivatives with EDOT, categorizing them based on N-substitutions and evaluating the effect of different substitutions and EDOT incorporation on the electrochromic properties. Electrochromic device applications of related copolymers are also discussed, providing insights for the design of new SNS derivatives for copolymerization.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Martin Breza
Summary: In this study, the structures and electron states of Ag complexes with dimethyl amino phenyl substituted phthalocyanine were optimized and analyzed using group theory. Two symmetry descent mechanisms were identified, highlighting the effects of pseudo-Jahn-Teller effect and vibronic interaction on polymerization reactions.
Article
Chemistry, Organic
Xinyi Wan, Haiwen Li, Shan Wang, Cunde Wang
Summary: A method mediated by acetic acid was developed for the synthesis of highly stereoselective tetrahydrothiopyranols. The method is characterized by cheap and readily available starting materials, simple operation, and mild reaction conditions.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Daniel S. Honeycutt, William F. Charbonneau, Alexander J. North, Sara L. Cobb, Derek Lohmann, Massoud J. Miri
Summary: Polyesters with furan groups have attracted attention due to the renewability of furan containing monomers. In this study, 11 diols were evaluated in polymerizations with the dimethyl ester of 2,5-furandicarboxylic acid, and 8 of them were found to be novel. The results showed that the glass transition temperatures of these polyesters could be controlled over a wide range by selecting specifically substituted diols.
Article
Chemistry, Physical
Mohd Mehkoom, S. M. Afzal, Shabbir Ahmad, Salman A. Khan
Summary: This study investigates the linear and nonlinear optical properties of a pyrazoline derivative and evaluates its potential applications in optical switching, optical communication, and optical data storage devices. The compound exhibits good nonlinear optical behavior and shows promise in these applications.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Electrochemistry
Gerardo Salinas, Angelica A. Villegas-Barron, Javier Tadeo-Leon, Bernardo A. Frontana-Uribe
Summary: N-substituted-2,5-dithienil-pyrroles have shown potential as a promising option for the synthesis of pi-conjugated polymers with excellent electrochromic properties. In this study, the chemical synthesis and electrochemical behavior of 4-(4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)benzyl)aniline (TPTBA) were investigated. The obtained film was characterized using electrochemical and spectroelectrochemical techniques. The resulting polyTPTBA exhibited a quasi-symmetrical reversible redox system, which can be attributed to the cross-linking of the polymer backbone facilitated by the presence of the aniline moiety. Spectroelectrochemical studies demonstrated a moderate and rapid electrochromic transition between the discharged and charged states, with a switching time of 2 seconds between colors at 430 nm and 800 nm.
ELECTROCHIMICA ACTA
(2023)
Article
Plant Sciences
Zhikun Yang, Jiahui Xu, Yumeng Bai, Zhao Wang, Liusheng Duan, Weiming Tan
Summary: The study found that compound S8 exhibited excellent promotion effects on plant growth, positively impacting the growth and development of Arabidopsis thaliana and rice. Molecular docking analysis showed that S8 had a tighter binding with the GID1 receptor, and its bioactivity displayed a clear negative association with the docking score values.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Chemistry, Organic
Chien-Chi Wu, Ram Ambre, Meng-Hsuan Lee, Jiun-Jie Shie
Summary: We present an efficient and mild tandem catalytic process for synthesizing functionalized pyrrole-3-carbaldehydes. This process involves a one-pot three-component reaction using 5-bromo-1,2,3-triazine, terminal alkynes, and primary amines, catalyzed by palladium for Sonogashira coupling, followed by annulation mediated by silver to access the multi-functionalized pyrrole-3-carbaldehydes.
Article
Chemistry, Medicinal
Jolanta Obniska, Malgorzata Gora, Anna Rapacz, Kinga Salat, Sabina Rybka, Michal Abram, Marcin Jakubiec, Krzysztof Kaminski
Summary: A library of new compounds were synthesized and tested for anticonvulsant and analgesic activities, with one compound showing promising results in both aspects. The potential mechanism of action for this compound involves its influence on neuronal sodium and calcium channels.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Applied
Xiaofeng Mo, Xiangdong Mo, Liping Lu, Mei Zhang, Tantan Yang, Irfan Majeed, Zhuo Zeng
Summary: A series of novel E, E/E, Z isomers based on 5-(2-cyano-3-ethoxy-3-oxoprop-1-en-1-yl)-1H-pyrrol-2-yl acrylic acid were synthesized, and their emission and temperature effects were compared. The different isomers exhibited varied luminous colors and aggregation-induced emission (AIE) properties. The E, E-OC2H5COOH loaded on filter paper could identify alkaline compounds, and the E, E-OC2H5COOH strips could selectively discriminate for n-/sec-/tert-butylamine by changing the fluorescence color. The configuration of double bonds could regulate fluorescence change and improve material properties.
Letter
Immunology
Xinling Wang, Wei Xu, Gaowei Hu, Shuai Xia, Zhiping Sun, Zezhong Liu, Youhua Xie, Rong Zhang, Shibo Jiang, Lu Lu
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Letter
Cell Biology
Shuai Xia, Jasper Fuk-Woo Chan, Lijue Wang, Fanke Jiao, Kenn Ka-Heng Chik, Hin Chu, Qiaoshuai Lan, Wei Xu, Qian Wang, Chao Wang, Kwok-Yung Yuen, Lu Lu, Shibo Jiang
Article
Chemistry, Medicinal
Wei Xu, Zhe Cong, Qianyu Duan, Qian Wang, Shan Su, Rui Wang, Lu Lu, Jing Xue, Shibo Jiang
Summary: A protein-based, long-acting HIV fusion inhibitor called FLT was designed and constructed, which binds with human serum albumin in a reversible manner to prolong the half-life of the HIV fusion inhibitor T1144. FLT showed high efficiency in inhibiting HIV infection and is considered a promising candidate for a new protein-based anti-HIV drug.
Article
Biochemistry & Molecular Biology
Shuwen Liu, Yuanyuan Chen, Tianming Du, Wencong Zhao, Xuejing Liu, Heng Zhang, Qing Yuan, Liang Gao, Yuhui Dong, Xueyun Gao, Yong Gong, Peng Cao
Summary: In cyanobacteria and algae, flavodoxin (Fld) acts as an electron carrier during photosynthesis under stress conditions. This study presents the crystal structures of apo-Fld from Synechococcus sp. PCC 7942, revealing a potential dimer-monomer transition mechanism. The dimer serves as a standby state to stabilize itself, while the monomer is ready to bind FMN. Additionally, a docking model of the cyanobacterial Fld-FNR complex is proposed, highlighting the interactions between Fld and FNR.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Shuwen Liu, Qiulong Gao, Kaiming Hou, Zhangpeng Li, Jinqing Wang, Shengrong Yang
Summary: From the standpoint of fusion of solid and liquid lubrication, solvent-free MXene nanofluids were synthesized and demonstrated excellent friction-reduction and anti-wear properties even under high velocity, elevated temperature, and heavy load conditions.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Food Science & Technology
Tian Lan, Jiaqi Wang, Shihan Bao, Qinyu Zhao, Xiangyu Sun, Yulin Fang, Tingting Ma, Shuwen Liu
Summary: This review systematically examines the relationship between fruit and vegetable juice (FVJ) processing and its nutrition and function in the past 10 years, highlighting the impact of processing technology on the nutrient and functional components of FVJ, and providing new perspectives for future studies.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Computer Science, Artificial Intelligence
Yun Zhu, Chengjian Gong, Shuwen Liu, Zhiyue Yu, Hanzeng Shao, Gaohang Yu
Summary: This paper proposes a multi-channel weighted truncated WSNM model based on the WSNM optimization framework for RGB colour image denoising. The proposed model is significantly improved by the optimization methods of superposition and truncation. It is also generalized to the tensor space and employed for the infrared imaging target detection based on the spatial-temporal tensor model for the first time. The efficiency and accuracy of the algorithm are verified through extensive experiments on real infrared data.
IET IMAGE PROCESSING
(2023)
Article
Virology
Chao Wang, Qing Li, Lujia Sun, Xinling Wang, Huan Wang, Wenpeng Zhang, Jiahui Li, Yang Liu, Lu Lu, Shibo Jiang
Summary: Researchers developed a novel dual-target inhibitor by integrating a small-molecule HIV-1 inhibitor with an artificial peptide. This inhibitor showed improved activity against multiple drug-resistant HIV-1 strains.
Article
Chemistry, Multidisciplinary
Abdullah Khamis Ali Al Saidi, Adibehalsadat Ghazanfari, Shuwen Liu, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Dejun Zhao, Ying Liu, So Hyeon Yang, Dong Wook Hwang, Ji-ung Yang, Ji Ae Park, Jae Chang Jung, Sung-Wook Nam, Yongmin Chang, Gang Ho Lee
Summary: Ultrasmall platinum nanoparticles (Pt-NPs) coated with three types of hydrophilic and biocompatible polymers were successfully synthesized using a one-pot polyol method. The polymer-coated Pt-NPs showed excellent stability and low cellular toxicity. They also exhibited stronger X-ray attenuation power compared to a commercial iodine contrast agent, indicating their potential as computed tomography contrast agents.
Review
Cell Biology
Haifeng Zeng, Shaoshen Guo, Xuancheng Ren, Zhenkun Wu, Shuwen Liu, Xingang Yao
Summary: Extracellular vesicles, including ectosomes and exosomes, have emerged as promising natural carriers for drug delivery. Exosomes, which are 30-100 nm in diameter and possess a lipid bilayer, have high biocompatibility, stability, and low immunogenicity, making them desirable for cargo delivery. Loading cargo into exosomes, however, remains challenging despite various strategies developed. This review provides an overview of current cargo delivery strategies using exosomes and summarizes recent approaches for loading small-molecule, nucleic acid, and protein drugs into exosomes, offering insights for more efficient drug delivery.
Article
Geography
Han Zhang, Bing-Bing Zhou, Shuwen Liu, Guohua Hu, Xing Meng, Xiaojuan Liu, Hong Shi, Yukun Gao, Haiyan Hou, Xia Li
Summary: With the patient-mobility policy and intercity transportation in China, interprovincial patient mobility has become important, but its impact on high-quality healthcare delivery is still unknown. This study analyzed the accessibility of township-level divisions to tertiary hospitals in various patient-mobility scenarios considering different transportation systems. The results showed that high-speed rail had the largest influence on high-quality healthcare utilization, while air transport was insignificant. High-speed rail can promote equitable distribution of healthcare, reducing the Gini index and urban-rural disparity in accessibility.
Article
Chemistry, Physical
Xiaonan Miao, Zhangpeng Li, Shuwen Liu, Kaiming Hou, Jinqing Wang, Shengrong Yang
Summary: This study presents a simple method to strengthen the mechanical properties and enhance the abrasion durability of MXene-based films through ionic bridging. The metal ions bridged with the surface groups of MXene and GO nanosheets to form ion-strengthened films, which significantly improved their mechanical properties and service life. The resulting MXene/GO nanocomposite films exhibit excellent lubricity and durability, making them promising lubricants in precision mechanical devices, MEMS/NEMS, etc.
APPLIED SURFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ling Xu, Chao Wang, Wei Xu, Lixiao Xing, Jie Zhou, Jing Pu, Mingming Fu, Lu Lu, Shibo Jiang, Qian Wang
Summary: By replacing the PEG linker in EK1C4 with a short peptide, we designed and synthesized a dePEGylated lipopeptide, EKL1C, which showed potent inhibitory activity against coronaviruses, including SARS-CoV-2, and HIV-1. This indicates that HR1 may serve as a common target for the development of broad-spectrum viral fusion inhibitors, and EKL1C has potential clinical application as a therapeutic or preventive agent against coronavirus, HIV-1, and other class I enveloped viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaojie Su, Ziqi Huang, Wei Xu, Qian Wang, Lixiao Xing, Lu Lu, Shibo Jiang, Shuai Xia
Summary: The peptide-based pan-coronavirus fusion inhibitor EK1 is showing promising clinical application prospects against SARS-CoV-2 and its variants. By conjugating EK1 with the human immunoglobulin G Fc-binding peptide (IBP), the engineered peptide IBP-EK1 demonstrates broad-spectrum inhibitory activity against various coronaviruses with improved in vivo half-life. It also shows synergistic effects when combined with monoclonal neutralizing antibodies, suggesting its potential as a long-acting, broad-spectrum antiviral agent against COVID-19 and future highly pathogenic coronaviruses.
Article
Geosciences, Multidisciplinary
Guozheng Sun, Yalu Hu, Shuwen Liu, Sanzhong Li, Jinghao Fu, Lei Gao
Summary: Diverse Neoarchean granitoid assemblages, dominated by late Neoarchean sodic diorite-TTGs (DTTGs) and sanukitoids, are prevalent in the Hengshan terrane of the North China Craton. These sanukitoids show Mg-rich chemical features and are the only high-K granitoids found in the region. The late Neoarchean DTTGs and sanukitoids were formed around 2486-2537 Ma and are characterized by high Mg# values, enriched light rare earth elements, and heterogeneous zircon Lu-Hf and whole-rock Sm-Nd isotopic components, indicating their derivation from interactions between mantle peridotite and subduction-related materials. The occurrence of late Neoarchean high-Mg magmatism in the Hengshan terrane is closely related to warm oceanic slab subduction in the active continental margin during the end of the Archean.
GEOLOGICAL SOCIETY OF AMERICA BULLETIN
(2023)
