In vivo rat PK profiling in drug discovery: new challenges

Drug efficiency: a new concept to guide lead optimization programs towards the selection of better clinical candidates

(2010) Simone Braggio et al.   Expert Opinion on Drug Discovery

Use of intrinsic clearance for prediction of human hepatic clearance

(2010) Piyun Chao et al.   Expert Opinion on Drug Metabolism & Toxicology

Addressing Central Nervous System (CNS) Penetration in Drug Discovery: Basics and Implications of the Evolving New Concept

(2009) Andreas Reichel   CHEMISTRY & BIODIVERSITY

Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling

(2009) Bart A. Ploeger et al.   Drug Metabolism and Pharmacokinetics

Discovery DMPK: changing paradigms in the eighties, nineties and noughties

(2009) Scott Summerfield et al.   Expert Opinion on Drug Discovery

Role of membrane transporters in the safety profile of drugs

(2009) Edmund Jon Deoon Lee et al.   Expert Opinion on Drug Metabolism & Toxicology

Advances in the Integration of Drug Metabolism into the Lead Optimization Paradigm

(2009) Walter Korfmacher   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Separate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: comparison with the profile in non-cannulated mice

(2009) J. Kuze et al.   XENOBIOTICA

The State of Innovation in Drug Development

(2008) I Kola   CLINICAL PHARMACOLOGY & THERAPEUTICS

N-in-1 Dosing Pharmacokinetics in Drug Discovery: Experience, Theoretical and Practical Considerations

(2007) Kan He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetics in Drug Discovery

(2007) Ana Ruiz-Garcia et al.   JOURNAL OF PHARMACEUTICAL SCIENCES