Discovery DMPK: changing paradigms in the eighties, nineties and noughties

Physiochemical drug properties associated with in vivo toxicological outcomes

(2008) Jason D. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The State of Innovation in Drug Development

(2008) I Kola   CLINICAL PHARMACOLOGY & THERAPEUTICS

Local Kinetics and Dynamics of Xenobiotics

(2008) Olavi Pelkonen et al.   CRITICAL REVIEWS IN TOXICOLOGY

Predicting the Volume of Distribution of Drugs in Humans

(2008) Xiaofan Sui et al.   CURRENT DRUG METABOLISM

What Does Systems Biology Mean for Drug Development?

(2008) Andre Schrattenholz et al.   CURRENT MEDICINAL CHEMISTRY

Potential Strategies for Minimizing Mechanism-Based Inhibition of Cytochrome P450 3A4

(2008) Shu-Feng Zhou   CURRENT PHARMACEUTICAL DESIGN

A Genomic “Roadmap” to “Better” Drugs

(2008) Guochun Liao et al.   DRUG METABOLISM REVIEWS

The Caco-2 cell monolayer: usefulness and limitations

(2008) Huadong Sun et al.   Expert Opinion on Drug Metabolism & Toxicology

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

Prediction of Distribution of Neutral, Acidic and Basic Structurally Diverse Compounds Between Blood and Brain by the Nonlinear Methodology

(2008) Huabei Zhang et al.   Medicinal Chemistry

Defining drug disposition determinants: a pharmacogenetic–pharmacokinetic strategy

(2008) David A. Katz et al.   NATURE REVIEWS DRUG DISCOVERY

The ontogeny of drug metabolism enzymes and implications for adverse drug events

(2008) Ronald N. Hines   PHARMACOLOGY & THERAPEUTICS

Snapshot PK: a rapid rodent in vivo preclinical screening approach

(2007) Bo Liu et al.   DRUG DISCOVERY TODAY

Prediction of Drug Tissue to Plasma Concentration Ratios Using a Measured Volume of Distribution in Combination With Lipophilicity

(2007) Rasmus Jansson et al.   JOURNAL OF PHARMACEUTICAL SCIENCES