Article
Chemistry, Physical
Tedjani Mohammed Laid, Khelef Abdelhamid, Laouini Salah Eddine, Bouafia Abderrhmane
Summary: In this study, Iron oxide nanoparticles (IONPs) were synthesized using a cost-effective and eco-friendly method, and the combined effect of different synthesis parameters on crystallite size was investigated. The experimental results showed a significant impact of the parameters and their interactions on crystallite size, leading to an optimal crystallite size under specific conditions. The biosynthesized IONPs were confirmed to have a rhombohedral structure and the promising performance of Response Surface Methodology (RSM) in optimizing the biosynthesis conditions was demonstrated.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Materials Science, Textiles
Prasanta K. Panda, Archana Gangwar, Amol G. Thite
Summary: This study prepared Nylon 6 nanofiber using needle-less wire electrospinning technique and evaluated the effects of operating variables on the fiber diameter. The results showed that polymer concentration, relative humidity, electrode distance, and applied voltage had significant effects on the fiber diameter. The optimized nanofiber membrane demonstrated high bacterial filtration efficiency against Staphylococcus Aureus bacteria, making it effective for face mask applications.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Chemistry, Multidisciplinary
Yuanyuan Shi, Chaopeng Li, Yizhe Huang
Summary: This study aims to suppress the resonance of a controllable mechanism welding robot end through dynamic modeling and experimental verification. A central composite design methodology is applied to optimize the suppression resonance using three variables: excitation source, rod stiffness, and damping. By considering the coupling effects and conducting combination optimization, the optimal control result of the end is obtained, leading to a significant reduction in peak amplitudes. The research provides an important technical basis for the dynamic design and resonance suppression control of controllable welding robot mechanisms.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Chemical
Ailton Guilherme Rissoni Toledo, Samir Prioto Tayar, Fabiana Antonia Arena, Assis Vicente Benedetti, Denise Bevilaqua
Summary: A response surface capable of high statistical confidence in describing copper extraction was obtained using a central composite factorial design. The study showed that the leaching of chalcopyrite is strongly influenced by the solution potential, and optimal conditions for maximizing copper extraction were identified.
MINERALS ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Muzamil Yaqub Want, Priya Yadav, Rakin Khan, Garima Chouhan, Mohammad Islamuddin, Sheka Yagub Aloyouni, Asoke P. Chattopadhyay, Suliman Yousef AlOmar, Farhat Afrin
Summary: The current therapeutic options for visceral leishmaniasis are limited, but gold nanoparticles show potential for antileishmanial activity, providing hope for treating visceral leishmaniasis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Husni Jakfar, Husni Husin, Komala Pontas, Rizalman Mamat, Mohd Rosdi Salleh, Mirna Zulrika
Summary: This research optimizes fermentation modification and papain enzymes for manufacturing virgin coconut oil. Through experimentation, it was observed that the addition of crude papain enzyme (CPE) and longer fermentation time increased the yield of virgin coconut oil. The optimal conditions for maximum yield and quality were obtained with a mass of crude papain enzyme of 993.5 mg and a fermentation time of 60 h.
FERMENTATION-BASEL
(2023)
Article
Engineering, Environmental
Jonas Bayuo, Mwemezi J. Rwiza, Kelvin Mark Mtei
Summary: In this study, a statistical experimental approach was applied to optimize the detoxification of mercury from a mono-component biosorption system using a novel hybrid granular activated carbon prepared from maize plant residues. The results showed that all the independent factors greatly influenced the removal efficiency and uptake capacity of mercury. The optimum experimental conditions were determined to be 30 minutes contact time, 0.5 g/L biosorbent dosage, and 15 mg/L initial mercury concentration, resulting in a removal efficiency of 96.7% and uptake capacity of 10.8 mg/g. Confirmatory laboratory experiments confirmed the accuracy of the quadratic models developed for predicting future cases. TEM and XRD analyses showed that the biosorbent successfully adsorbed mercury ions, suggesting its potential and applicability in treating water contaminants, especially heavy metals.
JOURNAL OF ENVIRONMENTAL HEALTH SCIENCE AND ENGINEERING
(2023)
Article
Construction & Building Technology
Stanferd Jenta Sanada, Mohamad Nur Hidayat Mat, Wong Ken Yinn, Siti Najiah Rosminahar
Summary: This study employs ANSYS Fluent 2022 R1 to visualize the airborne transmission of pathogens in indoor spaces under different environmental conditions. Five indoor parameters are studied, including wind velocity, air temperature, relative humidity, particle residence time, and physical distancing. Simulation-based experiments reveal the optimum indoor condition for reducing human-to-human airborne transmission. Higher relative humidity results in larger particle diameter, while lower humidity leads to particle shrinkage. Furthermore, longer distances between individuals result in lower particle deposition and prolonged exposure risk. This research is significant for enhancing safety and health judgement during a pandemic by identifying the optimal indoor conditions to minimize airborne transmission between individuals.
ENERGY AND BUILDINGS
(2023)
Article
Immunology
Joao Guilherme Lino da Silva, Ana Alice Maia Goncalves, Liliam Teixeira Oliveira, Giani Martins Garcia, Mauricio Azevedo Batista, Ludmila Zanandreis de Mendonca, Kelvinson Fernandes Viana, Rita de Cassia Oliveira Sant'Ana, Otoni Alves de Oliveira Melo Junior, Denise Silveira-Lemos, Walderez Ornelas Dutra, Olindo Assis Martins-Filho, Alexsandro Sobreira Galdino, Sandra Aparecida Lima de Moura, Vanessa Carla Furtado Mosqueira, Rodolfo Cordeiro Giunchetti
Summary: Recent studies suggest that antigens in microparticles can enhance the immunogenicity of antiLeishmania vaccines. This study investigates the in situ effect of chitosan-coated poly(D,L-lactic) acid submicrometric particles (SMP) as adjuvants and analyzes their inflammatory profile and toxicity. The results show that SMPs promote cell recruitment without tissue damage and stimulate early innate immune responses. They also demonstrate reduced NK cell count and impaired T and B cell subsets in mice vaccinated with SMPs encapsulating Leishmania braziliensis antigen.
Article
Energy & Fuels
B. Thangagiri, A. Sakthivel, K. Jeyasubramanian, S. Seenivasan, J. Dhaveethu Raja
Summary: This study explored the optimization of Pb(II) adsorption from synthetic wastewater using engineered biochar derived from waste biomass (fallen neem leaves). The efficacy of neem biochar (NBC) was investigated by varying adsorption parameters such as pH, Pb(II) concentration, and contact time using a central composite design (CCD). Response surface methodology was employed to optimize the adsorption parameters to achieve a maximum adsorption efficiency of 98.54%. Experimental data were compared with optimized results, and Langmuir adsorption isotherm and pseudo-second-order kinetics were found to be involved in the adsorption process.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Biotechnology & Applied Microbiology
Gayatriben B. Patel, Kamlesh R. Shah, Toral Shindhal, Parita Rakholiya, Sunita Varjani
Summary: Actinomycete strains were isolated from cottonseed soap-stock and analyzed for enzyme production. The strain Nocardiopsis alba was identified as the best lipase producer. By optimizing process parameters, the study found conditions for maximum lipase production, offering potential environmental and socio-economic benefits.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Environmental Sciences
Payal Mazumder, P. M. Akhil, Jyoti, Meena Khwairakpam, Umesh Mishra, Ajay S. Kalamdhad
Summary: The study investigated the impact of different composts on soil nutrient quality and engineering properties, finding that compost at 15-45% proportions enhanced soil nutrient value, with VWC showing the most efficient results in improving soil quality within 60 days.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Environmental Sciences
Hossein Khaleghi, Neamatollah Jaafarzadeh, Hossein Esmaeili, Bahman Ramavandi
Summary: In this study, Alginate@ Fe3O4/Bentonite nanocomposite was effectively used to eliminate formaldehyde from wastewater, with high removal efficiency and good recyclability. Isotherm and kinetic studies showed that the removal process follows the Langmuir isotherm and quasi-first-order kinetic models, with a maximum uptake capacity of 50.25 mg/g. The nanocomposite also exhibited exothermic and spontaneous formaldehyde uptake behavior, with a slight decrease in adsorption efficiency after six reuse cycles. Interference ion studies showed low interaction with formaldehyde, except for nitrate ion.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Computer Science, Interdisciplinary Applications
Camila Aparecida Diniz, Yohan Mendez, Fabricio Alves de Almeida, Sebastiao Simoes da Cunha Jr, G. F. Gomes
Summary: Many studies only consider ply stacking sequence as the design variable for determining optimal ply drop-off locations. This study aimed to find the most significant design variables relative to drop-off locations, utilizing a statistical approach with design of experiments. The findings showed that not all design factors influence response variability, with strain and natural frequency response variables demonstrating high significance.
ENGINEERING COMPUTATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Reza Shokoohi, Mohammad Khazaei, Kazem Godini, Ghasem Azarian, Zahra Latifi, Leila Javadimanesh, Hassan Zolghadr Nasab
Summary: In this study, Mn3O4 nanoparticles were synthesized and characterized, the conditions for MB decolorization process were optimized using RSM, achieving a maximum decolorization rate of 86.71%. Experimental results indicate that the synergistic effects of Mn3O4 and PMS enhance the catalytic performance for MB decolorization.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Pooja Mittal, Harsh Vardhan, Gufran Ajmal, Gunjan Vasant Bonde, Ramit Kapoor, Ashu Mittal, Brahmeshwar Mishra
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2019)
Article
Pharmacology & Pharmacy
Kanchan Bharti, Pooja Mittal, Brahmeshwar Mishra
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Sandeep Kumar Reddy Adena, Mansi Upadhyay, Harsh Vardhan, Brahmeshwar Mishra
Article
Biotechnology & Applied Microbiology
Gufran Ajmal, Gunjan Vasant Bonde, Sathish Thokala, Pooja Mittal, Gayasuddin Khan, Juhi Singh, Vivek Kumar Pandey, Brahmeshwar Mishra
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2019)
Article
Materials Science, Biomaterials
Mansi Upadhyay, Sandeep Kumar Reddy Adena, Harsh Vardhan, Sarita K. Yadav, Brahmeshwar Mishra
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Review
Oncology
Manikanta Murahari, Vikas Singh, Pramila Chaubey, Vasanti Suvarna
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2020)
Article
Biophysics
Gunjan Vasant Bonde, Gufran Ajmal, Sarita Kumari Yadav, Pooja Mittal, Juhi Singh, Bharati V. Bakde, Brahmeshwar Mishra
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Review
Pharmacology & Pharmacy
Manish Kumar, Abhishek Jha, Madhu, Brahmeshwar Mishra
EXPERT OPINION ON DRUG DELIVERY
(2020)
Review
Pharmacology & Pharmacy
D. R. Madhukiran, Abhishek Jha, Manish Kumar, Gufran Ajmal, Gunjan Vasant Bonde, Brahmeshwar Mishra
Summary: Electrospinning is a convenient method for fabricating nanofibers, with great potential in delivering drugs or therapeutic molecules to wound sites, especially in the treatment of diabetic foot ulcers. This review discusses the evolution of electrospinning techniques, various types of electrospun nanofibers used for DFU or chronic diabetic wounds, challenges in nanofiber preparation, and methods for evaluating their efficacy in diabetic wound healing. Expert opinions suggest that electrospinning-based nanofibers are safe, effective, and multifunctional for managing DFUs.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Pharmacology & Pharmacy
Mohana Das, Manish Kumar, Abhishek Jha, D. R. Madhukiran, Kanchan Bharti, Shomedeep Mondal, Brahmeshwar Mishra
Summary: Coronaviruses are a group of RNA viruses that primarily infect the respiratory system. Recent outbreaks of Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses have highlighted the urgent need for new screening models to identify potential drugs against COVID-19. The global spread of the SARS-CoV-2 virus has led to a massive pandemic with no successful treatment currently available.
CURRENT DRUG TARGETS
(2021)
Review
Immunology
Mohammad Z. Ahmad, Javed Ahmad, Mohammed Y. Alasmary, Basel A. Abdel-Wahab, Musarrat H. Warsi, Anzarul Haque, Pramila Chaubey
Summary: The advancements in cancer therapeutics have seen a recent surge in the use of liposomes, particularly cationic liposomes, as a promising vaccine delivery platform for cancer immunotherapy. Physicochemical characteristics of liposomes and their components play a significant role in modulating the immune response, making them effective in promoting cancer immunotherapy.
Article
Instruments & Instrumentation
Pratiksha Prabhu, Trinette Fernandes, Pramila Chaubey, Parvinder Kaur, Shridhar Narayanan, Ramya Vk, Sujata P. Sawarkar
Summary: Tuberculosis is a potentially fatal contagious disease and osteoarticular TB treatment using standard regimen of anti-tubercular drugs faces challenges such as poor patient compliance, long treatment period, and toxicity. Nanotherapeutics, specifically polymeric nanoparticles, offer an ideal approach for targeting macrophages containing mycobacteria. By conjugating nanoparticles with ligands, such as mannose, uptake by macrophages can be improved. Incorporating these nanoparticles into an in situ gelling system shows promise in improving drug release and localization in the intra-articular cavity.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Manish Kumar, Abhishek Jha, Kanchan Bharti, Gourav Parmar, Brahmeshwar Mishra
Summary: Inflammatory lung disorders, such as chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis, are a growing global health concern. The current therapeutic strategies and drugs used to manage these disorders face limitations. This review discusses the potential of lipid-based pulmonary nanomedicine as a platform to overcome these limitations and ensure targeted drug delivery with minimal side effects.
Article
Pharmacology & Pharmacy
Kanchan Bharti, Deepika Deepika, Manish Kumar, Abhishek Jha, Vinod Tiwari, Vikas Kumar, Brahmeshwar Mishra
Summary: In this study, polymers were screened to produce a stable amorphous solid dispersion (ASD) of a poorly water-soluble drug Riluzole (RLZ). Polyacrylic acid (PAA) was selected due to its strong drug-polymer interaction and wetting property. Experimental data and a physiologically based pharmacokinetic (PBPK) model showed that the RLZ:PAA ASD significantly enhanced drug concentration in the brain, suggesting improved biopharmaceutical performance and therapeutic efficacy.
Review
Multidisciplinary Sciences
Ashutosh Gupta, Shiran Shetty, Srinivas Mutalik, H. Raghu Chandrashekar, K. Nandakumar, Elizabeth Mary Mathew, Abhishek Jha, Brahmeshwar Mishra, Siddheesh Rajpurohit, Gundawar Ravi, Moumita Saha, Sudheer Moorkoth
Summary: This article introduces the background and treatment methods of peptic ulcer disease, with a focus on the challenges of H. pylori infection treatment and the current limitations. The article discusses novel formulation strategies such as extended-release drug delivery systems and nanoformulations to overcome the current bioavailability challenges, and proposes an innovative strategy to improve H. pylori eradication efficiency.
