Minicircle DNA vectors for gene therapy: advances and applications

Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution

(2014) Kvar C. L. Black et al.   ACS Nano

Fabrication of Corona-Free Nanoparticles with Tunable Hydrophobicity

(2014) Daniel F. Moyano et al.   ACS Nano

Nucleic acid delivery with microbubbles and ultrasound

(2014) Joshua J. Rychak et al.   ADVANCED DRUG DELIVERY REVIEWS

Liposomal siRNA nanocarriers for cancer therapy

(2014) Bulent Ozpolat et al.   ADVANCED DRUG DELIVERY REVIEWS

Bacteriophage recombination systems and biotechnical applications

(2014) Nafiseh Nafissi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Targeted Decationized Polyplexes for Cell Specific Gene Delivery

(2014) Luís Novo et al.   BIOCONJUGATE CHEMISTRY

The role of autophagy in the neurotoxicity of cationic PAMAM dendrimers

(2014) Shaofei Wang et al.   BIOMATERIALS

Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors

(2014) Zhishen Ge et al.   BIOMATERIALS

Inorganic nanoparticles for therapeutic delivery: Trials, tribulations and promise

(2014) Gulen Yesilbag Tonga et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology

(2014) Natalay Kouprina et al.   Expert Opinion on Drug Delivery

Treatment of phenylketonuria using minicircle-based naked-DNA gene transfer to murine liver

(2014) Hiu Man Viecelli et al.   HEPATOLOGY

Comparison of active, passive and magnetic targeting to tumors of multifunctional paclitaxel/SPIO-loaded nanoparticles for tumor imaging and therapy

(2014) Nathalie Schleich et al.   JOURNAL OF CONTROLLED RELEASE

Current advances in the fabrication of microneedles for transdermal delivery

(2014) Sunaina Indermun et al.   JOURNAL OF CONTROLLED RELEASE

Insight into nanoparticle cellular uptake and intracellular targeting

(2014) Basit Yameen et al.   JOURNAL OF CONTROLLED RELEASE

Poly(2-ethyl-2-oxazoline)–PLA-g–PEI amphiphilic triblock micelles for co-delivery of minicircle DNA and chemotherapeutics

(2014) Vítor M. Gaspar et al.   JOURNAL OF CONTROLLED RELEASE

New Applications for Phage Integrases

(2014) Paul C.M. Fogg et al.   JOURNAL OF MOLECULAR BIOLOGY

Preclinical study on combined chemo- and nonviral gene therapy for sensitization of melanoma using a human TNF-alpha expressing MIDGE DNA vector

(2014) Dennis Kobelt et al.   Molecular Oncology

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

(2014) Sutapa Barua et al.   Nano Today

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

(2014) Samir Mitragotri et al.   NATURE REVIEWS DRUG DISCOVERY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Genetic use restriction technologies: a review

(2014) Luca Lombardo   PLANT BIOTECHNOLOGY JOURNAL

All Roads Lead to Induced Pluripotent Stem Cells: The Technologies of iPSC Generation

(2014) Kejin Hu   STEM CELLS AND DEVELOPMENT

On the dual effect of glucose during production of pBAD/AraC-based minicircles

(2014) Michaela Simcikova et al.   VACCINE

Induced Pluripotent Stem Cells in Regenerative Medicine and Disease Modeling

(2014) Graham Walmsley et al.   Current Stem Cell Research & Therapy

Micro-minicircle Gene Therapy: Implications of Size on Fermentation, Complexation, Shearing Resistance, and Expression

(2014) Sofia Stenler et al.   Molecular Therapy-Nucleic Acids

Development of Poly(β-amino ester)-Based Biodegradable Nanoparticles for Nonviral Delivery of Minicircle DNA

(2013) Michael Keeney et al.   ACS Nano

Physical energy for drug delivery; poration, concentration and activation

(2013) Shanmugamurthy Lakshmanan et al.   ADVANCED DRUG DELIVERY REVIEWS

Sensitive Detection of Peptide–Minicircle DNA Interactions by Surface Plasmon Resonance

(2013) Vítor M. Gaspar et al.   ANALYTICAL CHEMISTRY

The Use of the Cre/loxP System to Study Oxidative Stress in Tissue-Specific Manganese Superoxide Dismutase Knockout Models

(2013) John C. Marecki et al.   ANTIOXIDANTS & REDOX SIGNALING

Ethical and Legal Issues Arising in Research on Inducing Human Germ Cells from Pluripotent Stem Cells

(2013) Tetsuya Ishii et al.   Cell Stem Cell

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

Short Hairpin RNA Gene Silencing of Prolyl Hydroxylase-2 with a Minicircle Vector Improves Neovascularization of Hindlimb Ischemia

(2013) Maarten A. Lijkwan et al.   HUMAN GENE THERAPY

Rapid quantification of supercoiled plasmid deoxyribonucleic acid using a monolithic ion exchanger

(2013) Élia Mota et al.   JOURNAL OF CHROMATOGRAPHY A

Recent progress of cell-penetrating peptides as new carriers for intracellular cargo delivery

(2013) Feihu Wang et al.   JOURNAL OF CONTROLLED RELEASE

In Vivo Electroporation of Minicircle DNA as a Novel Method of Vaccine Delivery To Enhance HIV-1-Specific Immune Responses

(2013) Q. Wang et al.   JOURNAL OF VIROLOGY

Small fluorescent nanoparticles at the nano–bio interface

(2013) Li Shang et al.   Materials Today

Minicircle DNA is Superior to Plasmid DNA in Eliciting Antigen-specific CD8+ T-cell Responses

(2013) Wynette M Dietz et al.   MOLECULAR THERAPY

Biofunctionalized nanoparticles with pH-responsive and cell penetrating blocks for gene delivery

(2013) V M Gaspar et al.   NANOTECHNOLOGY

Development and Validation of Non-Integrative, Self-Limited, and Replicating Minicircles for Safe Reporter Gene Imaging of Cell-Based Therapies

(2013) John A. Ronald et al.   PLoS One

Surface modification of inorganic nanoparticles for development of organic–inorganic nanocomposites—A review

(2013) Sarita Kango et al.   PROGRESS IN POLYMER SCIENCE

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

(2013) P. L. Rodriguez et al.   SCIENCE

Marker-free plasmids for biotechnological applications – implications and perspectives

(2013) Pedro H. Oliveira et al.   TRENDS IN BIOTECHNOLOGY

Baculovirus Nuclear Import: Open, Nuclear Pore Complex (NPC) Sesame

(2013) Shelly Au et al.   Viruses-Basel

Improved Minicircle DNA Biosynthesis for Gene Therapy Applications

(2013) Vítor M. Gaspar et al.   Human Gene Therapy Methods

Magnetic nanoparticle drug delivery systems for targeting tumor

(2013) Vicky V. Mody et al.   Applied Nanoscience

Devices for overcoming biological barriers: The use of physical forces to disrupt the barriers

(2012) Samir Mitragotri   ADVANCED DRUG DELIVERY REVIEWS

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Surface engineering of inorganic nanoparticles for imaging and therapy

(2012) Jutaek Nam et al.   ADVANCED DRUG DELIVERY REVIEWS

Evaluating metabolic stress and plasmid stability in plasmid DNA production by Escherichia coli

(2012) Filomena Silva et al.   BIOTECHNOLOGY ADVANCES

Therapeutic Applications of the PhiC31 Integrase System

(2012) Christopher L. Chavez et al.   CURRENT GENE THERAPY

Effective healing of diabetic skin wounds by using nonviral gene therapy based on minicircle vascular endothelial growth factor DNA and a cationic dendrimer

(2012) Min J. Kwon et al.   JOURNAL OF GENE MEDICINE

Performance of High Quality Minicircle DNA for In Vitro and In Vivo Gene Transfer

(2012) Dennis Kobelt et al.   MOLECULAR BIOTECHNOLOGY

Minicircle DNA Vectors Achieve Sustained Expression Reflected by Active Chromatin and Transcriptional Level

(2012) Lia E. Gracey Maniar et al.   MOLECULAR THERAPY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant

(2012) Pin Gao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Co-delivery of small interfering RNA and plasmid DNA using a polymeric vector incorporating endosomolytic oligomeric sulfonamide

(2011) Han Chang Kang et al.   BIOMATERIALS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

(2011) Kanjiro Miyata et al.   CHEMICAL SOCIETY REVIEWS

Double Knockdown of Prolyl Hydroxylase and Factor-Inhibiting Hypoxia-Inducible Factor With Nonviral Minicircle Gene Therapy Enhances Stem Cell Mobilization and Angiogenesis After Myocardial Infarction

(2011) M. Huang et al.   CIRCULATION

Nanoparticle mediated delivery of pure P53 supercoiled plasmid DNA for gene therapy

(2011) Vítor M. Gaspar et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers

(2011) Claudia Scholz et al.   JOURNAL OF CONTROLLED RELEASE

Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver

(2011) Orestis Argyros et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles

(2011) Marco P. Monopoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanomedicine(s) under the Microscope

(2011) Ruth Duncan et al.   MOLECULAR PHARMACEUTICS

Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

(2011) Tore-Geir Iversen et al.   Nano Today

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Methods for making induced pluripotent stem cells: reprogramming à la carte

(2011) Federico González et al.   NATURE REVIEWS GENETICS

DNA Nuclear Targeting Sequences for Non-Viral Gene Delivery

(2011) Ethlinn V. B. van Gaal et al.   PHARMACEUTICAL RESEARCH

Transgene excision in pollen using a codon optimized serine resolvase CinH-RS2 site-specific recombination system

(2011) Hong S. Moon et al.   PLANT MOLECULAR BIOLOGY

Minicircle-oriP-IFNγ: A Novel Targeted Gene Therapeutic System for EBV Positive Human Nasopharyngeal Carcinoma

(2011) Yufang Zuo et al.   PLoS One

Overcoming in vivo barriers to targeted nanodelivery

(2011) Adrian Chrastina et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA

(2010) Peter C. DeMuth et al.   ADVANCED MATERIALS

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted minicircle DNA delivery using folate–poly(ethylene glycol)–polyethylenimine as non-viral carrier

(2010) Chao Zhang et al.   BIOMATERIALS

Plasmid DNA fermentation strain and process-specific effects on vector yield, quality, and transgene expression

(2010) Aaron E. Carnes et al.   BIOTECHNOLOGY AND BIOENGINEERING

Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

(2010) Jacob H. Hanna et al.   CELL

Transfection of shRNA-encoding Minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells

(2010) N Zhao et al.   GENE THERAPY

Progress and prospects: nuclear import of nonviral vectors

(2010) A P Lam et al.   GENE THERAPY

Induced pluripotency: history, mechanisms, and applications

(2010) M. Stadtfeld et al.   GENES & DEVELOPMENT

Minicircle DNA-based Gene Therapy Coupled With Immune Modulation Permits Long-term Expression of α-L-Iduronidase in Mice With Mucopolysaccharidosis Type I

(2010) Mark J Osborn et al.   MOLECULAR THERAPY

A robust system for production of minicircle DNA vectors

(2010) Mark A Kay et al.   NATURE BIOTECHNOLOGY

A nonviral minicircle vector for deriving human iPS cells

(2010) Fangjun Jia et al.   NATURE METHODS

Hydrodynamic Gene Delivery and Its Applications in Pharmaceutical Research

(2010) Barbara Bonamassa et al.   PHARMACEUTICAL RESEARCH

Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process

(2009) Hidetaka Akita et al.   BIOMATERIALS

Progress and Prospects: The design and production of plasmid vectors

(2009) D R Gill et al.   GENE THERAPY

An optimized extended DNA kappa B site that enhances plasmid DNA nuclear import and gene expression

(2009) Cristine Gonçalves et al.   JOURNAL OF GENE MEDICINE

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Minicircle-DNA production by site specific recombination and protein-DNA interaction chromatography

(2008) Peter Mayrhofer et al.   JOURNAL OF GENE MEDICINE

Silencing of Episomal Transgene Expression in Liver by Plasmid Bacterial Backbone DNA Is Independent of CpG Methylation

(2008) Zhi-Ying Chen et al.   MOLECULAR THERAPY

Nuclear delivery of NFκB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging

(2008) Gilles Breuzard et al.   NUCLEIC ACIDS RESEARCH

Sonoporation of the Minicircle-VEGF165 for Wound Healing of Diabetic Mice

(2008) C. S. Yoon et al.   PHARMACEUTICAL RESEARCH

Efficient expression of vascular endothelial growth factor using minicircle DNA for angiogenic gene therapy

(2007) Chien-Wen Chang et al.   JOURNAL OF CONTROLLED RELEASE