Targeting human inducible regulatory T cells (Tr1) in patients with cancer: blocking of adenosine–prostaglandin E2cooperation

Human Circulating CD4+CD25highFoxp3+ Regulatory T Cells Kill Autologous CD8+ but Not CD4+ Responder Cells by Fas-Mediated Apoptosis

(2014) L. Strauss et al.   JOURNAL OF IMMUNOLOGY

Receptor desensitization and blockade of the suppressive effects of prostaglandin E2 and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes

(2010) Yunyun Su et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD73: A Novel Target for Cancer Immunotherapy

(2010) B. Zhang   CANCER RESEARCH

Inhibiting the inhibitors: evaluating agents targeting cancer immunosuppression

(2010) Theresa L Whiteside   EXPERT OPINION ON BIOLOGICAL THERAPY

Regulatory T cells in tumor immunity

(2010) Hiroyoshi Nishikawa et al.   INTERNATIONAL JOURNAL OF CANCER

Immune responses to malignancies

(2010) Theresa L. Whiteside   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Adenosine and Prostaglandin E2Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells

(2010) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Roles of Adenylyl Cyclase VII in Regulating the Immune Responses in Mice

(2010) B. Duan et al.   JOURNAL OF IMMUNOLOGY

Much Ado about Adenosine: Adenosine Synthesis and Function in Regulatory T Cell Biology

(2010) P. B. Ernst et al.   JOURNAL OF IMMUNOLOGY

Regulatory (FoxP3+) T-cell Tumor Infiltration Is a Favorable Prognostic Factor in Advanced Colon Cancer Patients Undergoing Chemo or Chemoimmunotherapy

(2010) Pierpaolo Correale et al.   JOURNAL OF IMMUNOTHERAPY

Reciprocal granzyme/perforin-mediated death of human regulatory and responder T cells is regulated by interleukin-2 (IL-2)

(2010) Malgorzata Czystowska et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

FOXP3 Expression Is Upregulated in CD4+T Cells in Progressive HIV-1 Infection and Is a Marker of Disease Severity

(2010) Melinda S. Suchard et al.   PLoS One

The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent

(2009) Xiujun Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

GD3, an Overexpressed Tumor-Derived Ganglioside, Mediates the Apoptosis of Activated but not Resting T Cells

(2009) G. Sa et al.   CANCER RESEARCH

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer

(2009) M. Mandapathil et al.   CLINICAL CANCER RESEARCH

Increased Frequency and Suppression by Regulatory T Cells in Patients with Acute Myelogenous Leukemia

(2009) M. J. Szczepanski et al.   CLINICAL CANCER RESEARCH

Regulatory T cells and inhibitory cytokines in autoimmunity

(2009) Maria Bettini et al.   CURRENT OPINION IN IMMUNOLOGY

Adenylyl cyclases as innovative therapeutic goals

(2009) Barbara Pavan et al.   DRUG DISCOVERY TODAY

Dynamics of peripheral tolerance and immune regulation mediated by Treg

(2009) Shimon Sakaguchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+Regulatory T Cells

(2009) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression

(2009) Magis Mandapathil et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Fas Signal Promotes Lung Cancer Growth by Recruiting Myeloid-Derived Suppressor Cells via Cancer Cell-Derived PGE2

(2009) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

(2008) M. A. Morse et al.   BLOOD

Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells

(2008) M Sitkovsky et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP–PKA signaling and immunosuppression

(2008) Yunyun Su et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease

(2008) C. Bergmann et al.   CLINICAL CANCER RESEARCH

Hypoxia-Adenosinergic Immunosuppression: Tumor Protection by T Regulatory Cells and Cancerous Tissue Hypoxia

(2008) M. V. Sitkovsky et al.   CLINICAL CANCER RESEARCH

Sunitinib Reverses Type-1 Immune Suppression and Decreases T-Regulatory Cells in Renal Cell Carcinoma Patients

(2008) J. H. Finke et al.   CLINICAL CANCER RESEARCH

Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8+ T cells

(2008) Naoko Imai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

(2008) Paul Salama et al.   JOURNAL OF CLINICAL ONCOLOGY

Cyclooxygenase-2 Induces Genomic Instability, BCL2 Expression, Doxorubicin Resistance, and Altered Cancer-Initiating Cell Phenotype in MCF7 Breast Cancer Cells

(2008) Balraj Singh et al.   JOURNAL OF SURGICAL RESEARCH

Improved Survival of Patients With Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial

(2008) C. Fakhry et al.   JNCI-Journal of the National Cancer Institute

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

The role of CD26/dipeptidyl peptidase IV in cancer

(2007) Pamela et al.   Frontiers in Bioscience-Landmark