Inhibiting the inhibitors: evaluating agents targeting cancer immunosuppression

Strategies to Overcome Obstacles to Successful Immunotherapy of Melanoma

(2017) F. Pandolfi et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Human Circulating CD4+CD25highFoxp3+ Regulatory T Cells Kill Autologous CD8+ but Not CD4+ Responder Cells by Fas-Mediated Apoptosis

(2014) L. Strauss et al.   JOURNAL OF IMMUNOLOGY

Immune responses to malignancies

(2010) Theresa L. Whiteside   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanism of T Cell Tolerance Induced by Myeloid-Derived Suppressor Cells

(2010) S. Nagaraj et al.   JOURNAL OF IMMUNOLOGY

Clinical Use of Anti-CD25 Antibody Daclizumab to Enhance Immune Responses to Tumor Antigen Vaccination by Targeting Regulatory T cells

(2009) Andrew J. Rech et al.   Annals of the New York Academy of Sciences

Monoclonal Antibodies Targeting Vascular Endothelial Growth Factor

(2009) Jerry Y. Hsu et al.   BIODRUGS

Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion

(2009) R. Houot et al.   BLOOD

The Toll-like receptor 7/8 agonist resiquimod greatly increases the immunostimulatory capacity of human acute myeloid leukemia cells

(2009) Evelien L. J. M. Smits et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Triggering of Toll-like Receptor 4 Expressed on Human Head and Neck Squamous Cell Carcinoma Promotes Tumor Development and Protects the Tumor from Immune Attack

(2009) M. J. Szczepanski et al.   CANCER RESEARCH

Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy

(2009) E. Martinelli et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Effect of Granulocyte/Macrophage Colony-Stimulating Factor on Vaccination with an Allogeneic Whole-Cell Melanoma Vaccine

(2009) M. B. Faries et al.   CLINICAL CANCER RESEARCH

Immunostimulation Versus Immunosuppression after Multiple Vaccinations: the Woes of Therapeutic Vaccine Development

(2009) A. M.M. Eggermont   CLINICAL CANCER RESEARCH

Synergistic Enhancement of CD8+ T Cell-Mediated Tumor Vaccine Efficacy by an Anti-Transforming Growth Factor-  Monoclonal Antibody

(2009) M. Terabe et al.   CLINICAL CANCER RESEARCH

Partial CD4 Depletion Reduces Regulatory T Cells Induced by Multiple Vaccinations and Restores Therapeutic Efficacy

(2009) M. G. LaCelle et al.   CLINICAL CANCER RESEARCH

New Perspectives for Melanoma Immunotherapy: Role of IL-12

(2009) Claudia Cocco et al.   CURRENT MOLECULAR MEDICINE

Antigen choice in adoptive T-cell therapy of cancer

(2009) Rienk Offringa   CURRENT OPINION IN IMMUNOLOGY

IL-7 is superior to IL-2 forex vivoexpansion of tumour-specific CD4+T cells

(2009) Stefano Caserta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adenosine: An endogenous modulator of innate immune system with therapeutic potential

(2009) Vijay Kumar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Countering tumor-induced immunosuppression during immunotherapy for pancreatic cancer

(2009) Michael A Morse et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Ten years of rituximab in NHL

(2009) Matthew C Winter et al.   Expert Opinion On Drug Safety

A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells

(2009) Aixin Yu et al.   IMMUNITY

PD-1 signaling in primary T cells

(2009) James L. Riley   IMMUNOLOGICAL REVIEWS

PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells

(2009) Wenshi Wang et al.   INTERNATIONAL IMMUNOLOGY

The tumor-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans

(2009) Kellie A. Charles et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T Cells

(2009) David V. Liu et al.   JOURNAL OF IMMUNOTHERAPY

Molecular mechanisms of resistance to Rituximab and pharmacologic strategies for its circumvention

(2009) Claudia Stolz et al.   LEUKEMIA & LYMPHOMA

The biology of interleukin-2 efficacy in the treatment of patients with renal cell carcinoma

(2009) Antonio Romo de Vivar Chavez et al.   MEDICAL ONCOLOGY

Immunotherapeutic strategies in kidney cancer—when TKIs are not enough

(2009) Swethajit Biswas et al.   Nature Reviews Clinical Oncology

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival

(2009) D. Bogunovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene and chromosomal alterations in sporadic breast cancer: correlation with histopathological features and implications for genesis and progression

(2009) Hitoshi Tsuda   Breast Cancer

A clinical study assessing the tolerability and biological effects of infliximab, a TNF-α inhibitor, in patients with advanced cancer

(2008) E. R. Brown et al.   ANNALS OF ONCOLOGY

Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

(2008) M. A. Morse et al.   BLOOD

Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters

(2008) Lotte Engell-Noerregaard et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TGF-β: A Master of All T Cell Trades

(2008) Ming O. Li et al.   CELL

Sunitinib Reverses Type-1 Immune Suppression and Decreases T-Regulatory Cells in Renal Cell Carcinoma Patients

(2008) J. H. Finke et al.   CLINICAL CANCER RESEARCH

The role of vaccine therapy in the treatment of melanoma

(2008) Marko Lens   EXPERT OPINION ON BIOLOGICAL THERAPY

Signaling defects in anti-tumor T cells

(2008) Alan B. Frey et al.   IMMUNOLOGICAL REVIEWS

Twelve immunotherapy drugs that could cure cancers

(2008) Martin A. ‘Mac’ Cheever   IMMUNOLOGICAL REVIEWS

Role of TGF-β in the Induction of Foxp3 Expression and T Regulatory Cell Function

(2008) Ethan M. Shevach et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Next Generation of Immunotherapy for Melanoma

(2008) John M. Kirkwood et al.   JOURNAL OF CLINICAL ONCOLOGY

Adjuvant therapy of melanoma with interferon: lessons of the past decade

(2008) Paolo A Ascierto et al.   Journal of Translational Medicine

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE