Article
Engineering, Biomedical
Xianhao Dong, Siyang Liu, Yueyue Yang, Shan Gao, Wenlei Li, Jiasong Cao, Ye Wan, Ziqi Huang, Guanwei Fan, Quan Chen, Hongjun Wang, Meifeng Zhu, Deling Kong
Summary: Research on nerve conduits composed of oriented microfiber-bundle cores and randomly organized nanofiber sheaths has shed light on the regulatory role of microfiber orientation in promoting peripheral nerve regeneration, elucidating a cascade of biological responses and ultimately enhancing nerve regeneration outcomes.
Review
Biochemistry & Molecular Biology
Andrea Lavorato, Stefania Raimondo, Marina Boido, Luisa Muratori, Giorgia Durante, Fabio Cofano, Francesca Vincitorio, Salvatore Petrone, Paolo Titolo, Fulvio Tartara, Alessandro Vercelli, Diego Garbossa
Summary: The study discusses the features and applications of different types of mesenchymal stem cells in peripheral nerve regeneration after nerve injury. ADSCs are considered the most suitable MSCs for recovery from peripheral nerve lesions due to their excellent support and stimulation of axonal growth, remarkable paracrine activity, differentiation potential, low immunogenicity, and high survival rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Trevor Poitras, Douglas W. Zochodne
Summary: Common mechanisms of peripheral axon regeneration are recruited following diverse forms of damage to peripheral nerve axons. Supporting peripheral axon regrowth could be achieved through direct axon support or manipulation of the inflammatory milieu. Understanding the molecular barriers to regrowth and exploiting the downstream signaling pathways that impact neuron growth are promising approaches for promoting adult peripheral axon regeneration. This review emphasizes intrinsic aspects of adult peripheral axon regeneration and highlights several molecular barriers to regrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Papon Muangsanit, Victoria Roberton, Eleni Costa, James B. Phillips
Summary: Vascularisation is crucial for nerve tissue engineering to support long-term survival of implanted cells. Constructs containing endothelial cells have shown to promote axonal regeneration and vascularisation across peripheral nerve gaps.
ACTA BIOMATERIALIA
(2021)
Article
Biotechnology & Applied Microbiology
Lorena R. Lizarraga-Valderrama, Giulia Ronchi, Rinat Nigmatullin, Federica Fregnan, Pooja Basnett, Alexandra Paxinou, Stefano Geuna, Ipsita Roy
Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Wen Xue, Yunfan Kong, Rafay Abu, Pooja Roy, Sung-Ho Huh, Mitchell Kuss, Vikas Kumar, Bin Duan
Summary: Decellularized nerve hydrogels (dNHs) have shown promising effects on promoting Schwann cell proliferation and neurite outgrowth. The mechanics and components of the hydrogel contribute to its functionality, with laminin (LAM) and type V collagen (COLV) playing important roles. Additionally, by adding LAM and COLV to collagen hydrogels, gene expression of Schwann cells can be regulated, leading to improved spreading and neurite outgrowth. Furthermore, dNHs can be fabricated into paper-like, aligned nerve scaffolds for peripheral nerve injury treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Neurosciences
Yunsong Zhang, Yinying Shen, Li Zhao, Qian Zhao, Lili Zhao, Sheng Yi
Summary: Nerve injury-induced Schwann cell dedifferentiation promotes axon growth by creating a favorable microenvironment. Transcription factor BCL11A plays a crucial role in Schwann cell reprogramming during peripheral nerve regeneration. Silencing Bcl11a reduces Schwann cell viability, proliferation, migration rates, and debris clearance ability. Bcl11a deficiency leads to restricted axon elongation and myelin wrapping, resulting in failed recovery. Mechanistically, BCL11A regulates Schwann cell activity by binding to the Nr2f2 promoter and modulating Nr2f2 expression. In conclusion, BCL11A is essential for Schwann cell activation and peripheral nerve regeneration, making it a potential therapeutic target for peripheral nerve injury treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaxian Wang, Fuchao Zhang, Yunsong Zhang, Qi Shan, Wei Liu, Fengyuan Zhang, Feiyu Zhang, Sheng Yi
Summary: Research findings indicate that Btc plays essential roles in regulating Schwann cell migration and axon elongation, suggesting the potential application of Btc as a regenerative strategy for treating peripheral nerve injury.
MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Dong Keon Yon, Yong Jun Kim, Dong Choon Park, Su Young Jung, Sung Soo Kim, Joon Hyung Yeo, Jeongmin Lee, Jae Min Lee, Seung Geun Yeo
Summary: A literature review on the role of autophagy in peripheral nerve injury and regeneration was conducted. The review identified several factors, such as LC3II/I, PI3K, mTOR, Beclin-1, ATG3, ATG5, ATG7, ATG9, and ATG12, that are involved in the process of nerve degeneration and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Frederic A. A. Vallejo, Anthony Diaz, Emily L. L. Errante, Taylor Smartz, Aisha Khan, Risset Silvera, Adriana E. E. Brooks, Yee-Shuan Lee, Stephen Shelby Burks, Allan D. D. Levi
Summary: This study systematically evaluated the therapeutic use of Schwann cells (SC) in the repair of peripheral nerve injuries. The results showed that SCs have clear potential in improving morphological and functional outcomes in animal studies of long gap peripheral nerve injuries. However, the optimal nerve conduit or graft for delivering and retaining SCs for nerve regeneration has yet to be determined.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Article
Neurosciences
P. Komirishetty, K. Zubkow, A. Areti, H. Ong, D. W. Zochodne
Summary: The study found that local delivery of Rb1 siRNA can promote nerve regeneration at the outset, enhancing reinnervation of epidermal axons. Combining intrinsic Rb1 knockdown with exogenous insulin can significantly improve growth patterns of adult sensory neurons in vitro and enhance regeneration outcomes in vivo. Overall, the findings highlight the responsiveness of regrowing peripheral neurons to both intrinsic and exogenous approaches that improve their recovery, as well as a novel local approach to manipulate gene expression and outcome in regrowing axons.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Biotechnology & Applied Microbiology
Jue Ling, Chang He, Shuxuan Zhang, Yahong Zhao, Meifeng Zhu, Xiaoxuan Tang, Qiaoyuan Li, Liming Xu, Yumin Yang
Summary: This article provides an overview of evaluation methods used to study scaffold-based therapies for peripheral nerve injury (PNI) in experimental animal models, with particular focus on Schwann cell functions and axonal growth within the regenerated nerve.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Jingxin Zhang, Binjing Zhang, Jinglan Zhang, Weimin Lin, Shiwen Zhang
Summary: Magnesium as a suitable material for promoting peripheral nerve regeneration has both challenges and potentials, but there is currently limited research on this topic, requiring further exploration to address the shortcomings and challenges identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Xiaolan Li, Xiang Zhang, Ming Hao, Dongxu Wang, Ziping Jiang, Liqun Sun, Yongjian Gao, Ye Jin, Peng Lei, Yue Zhuo
Summary: This review summarizes the importance of collagen in peripheral nerve regeneration, focusing on its characteristics, role, and optimization methods. Collagen, as a biomaterial, plays a crucial role in peripheral nerve repair and can be further optimized by adjusting its structure and physical properties, as well as combining it with bioactive components.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemical Research Methods
Jennifer Pardieckt, Shelly Sakiyama-Elbert
CURRENT OPINION IN BIOTECHNOLOGY
(2018)
Article
Critical Care Medicine
Lyandysha V. Zholudeva, Nisha Iyer, Liang Qiang, Victoria M. Spruance, Margo L. Randelman, Nicholas W. White, Tatiana Bezdudnaya, Itzhak Fischer, Shelly E. Sakiyama-Elbert, Michael A. Lane
JOURNAL OF NEUROTRAUMA
(2018)
Article
Orthopedics
Stephen W. Linderman, Hua Shen, Susumu Yoneda, Rohith Jayaram, Michael L. Tanes, Shelly E. Sakiyama-Elbert, Younan Xia, Stavros Thomopoulos, Richard H. Gelberman
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Review
Neurosciences
Lyandysha V. Zholudeva, Liang Qiang, Vitaliy Marchenko, Kimberly J. Dougherty, Shelly E. Sakiyama-Elbert, Michael A. Lane
TRENDS IN NEUROSCIENCES
(2018)
Article
Multidisciplinary Sciences
Hua Shen, Rohith Jayaram, Susumu Yoneda, Stephen W. Linderman, Shelly E. Sakiyama-Elbert, Younan Xia, Richard H. Gelberman, Stavros Thomopoulos
SCIENTIFIC REPORTS
(2018)
Review
Anatomy & Morphology
Nicholas White, Shelly E. Sakiyama-Elbert
DEVELOPMENTAL DYNAMICS
(2019)
Review
Neurosciences
Ze Zhong Wang, Shelly E. Sakiyama-Elbert
EXPERIMENTAL NEUROLOGY
(2019)
Review
Neurosciences
Thomas Wilems, Sangamithra Vardhan, Siliang Wu, Shelly Sakiyama-Elbert
BRAIN RESEARCH BULLETIN
(2019)
Article
Biochemical Research Methods
Jessica C. Butts, Nisha Iyer, Nick White, Russell Thompson, Shelly Sakiyama-Elbert, Todd C. McDevitt
Correction
Biochemical Research Methods
Jessica C. Butts, Nisha Iyer, Nick White, Russell Thompson, Shelly Sakiyama-Elbert, Todd C. McDevitt
Article
Neurosciences
Lia M. Bonacci, Scott Bressler, Jasmine A. C. Kwasa, Abigail L. Noyce, Barbara G. Shinn-Cunningham
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Cell & Tissue Engineering
Jennifer Pardieck, Manwal Harb, Shelly Sakiyama-Elbert
Summary: Researchers have developed an induction protocol using mouse embryonic stem cells (mESCs) and specific growth factors to derive V0 interneurons (INs) from pluripotent sources. The final protocol yielded the highest percentage of cells expressing V0 IN markers, providing an important tool for further studies.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Neurosciences
E. Kate Webb, J. Arthur Etter, Jasmine A. Kwasa
Summary: Neuroscience tools for physiological data collection introduce racial bias by excluding individuals based on phenotypic differences. We urge researchers to challenge racism in their scientific work and propose procedures to prevent biased data.
NATURE NEUROSCIENCE
(2022)
Article
Psychology, Experimental
Abigail L. Noyce, Jasmine A. C. Kwasa, Barbara G. Shinn-Cunningham
Summary: Attention prioritizes certain information across sensory modalities, influencing how information is represented and processed in the brain. It is not limited to visual tasks, but also plays a role in auditory perception.
WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE
(2023)
Article
Psychology, Clinical
Daniel E. E. Bradford, Angelica DeFalco, Emily R. R. Perkins, Ivan Carbajal, Jasmine Kwasa, Fallon R. R. Goodman, Felicia Jackson, Lietsel N. S. Richardson, Nina Woodley, Lindsay Neuberger, Jennifer A. A. Sandoval, Helen J. J. Huang, Keanan J. J. Joyner
Summary: Research using psychophysiological methods has potential for improving clinical assessment, identifying risk factors, and informing treatment. However, the unique methodological features of existing approaches limit inclusive research participation and result in exclusion of Black participants. Reflection and input from a wider range of affected individuals are needed to develop and refine new technologies.
CLINICAL PSYCHOLOGICAL SCIENCE
(2022)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)