Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Cell Biology
Yu-Jeong Ahn, Hyun-Joo Shin, Eun-Ae Jeong, Hyeong-Seok An, Jong-Youl Lee, Hye-Min Jang, Kyung-Eun Kim, Jaewoong Lee, Meong-Cheol Shin, Gu-Seob Roh
Summary: Exendin-4 (Ex-4) pretreatment showed neuroprotective effects in a mouse model of kainic acid (KA)-induced seizures, reversing the reduction of GLP-1R expression and attenuating seizure score, hippocampal neuronal death, and neuroinflammation. It also significantly reduced hippocampal lipocalin-2 protein levels and alleviated blood-brain barrier leakage, while stimulating the expression of phosphorylated cyclic adenosine monophosphate response element-binding protein (p-CREB). These findings suggest that Ex-4 pretreatment may protect against KA-induced neuronal damage by regulating GLP-1R/CREB-mediated signaling pathways.
Article
Biochemistry & Molecular Biology
Hyun Joo Shin, Eun Ae Jeong, Jong Youl Lee, Hyeong Seok An, Hye Min Jang, Yu Jeong Ahn, Jaewoong Lee, Kyung Eun Kim, Gu Seob Roh
Summary: The deficiency of LCN2 reduces neuronal cell death, BBB leakage, iron overload, and oxidative stress in KA-induced hippocampal cell death, and inhibits related neuroinflammatory responses, indicating a significant role of LCN2 in this process.
Review
Biochemistry & Molecular Biology
Marta D'Amora, Alessandro Galgani, Maria Marchese, Francesco Tantussi, Ugo Faraguna, Francesco De Angelis, Filippo Sean Giorgi
Summary: This article explores the potential of using Zebrafish as a model for epilepsy research. Zebrafish provide a simplified and cost-effective alternative to traditional rodent models for studying the pathophysiology and drug treatments of epilepsy. They can be easily genetically modified to mimic specific forms of human epilepsy and have been successfully induced to have seizures using various chemical agents. This research highlights the state-of-the-art and potential new applications of Zebrafish in understanding the mechanisms of epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Jigao Feng, Zheng Hao, Xian Zhang, Mingxia Li, Wuzhao Zhong, Caicai Zhang, Ali Gharawi, Sara T. Alrashood, Haseeb A. Khan
Summary: This study showed that the anti-hyperthyroid drug thiamazole (TZ) increased the frequency and severity of KA-induced epileptic seizures in mice. The findings suggest a caution when administering anti-hyperthyroid drugs in epileptic seizures.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ming -Shang Pai, Kaw-Chen Wang, Kun-Chieh Yeh, Su-Jane Wang
Summary: The study found that chlorogenic acid can protect rats from kainic acid-induced neurotoxicity and seizures by reducing glutamate levels and maintaining mitochondrial balance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Aoife Campbell, Gareth Morris, Janosch P. Heller, Elena Langa, Elizabeth Brindley, Jesper Worm, Mads Aaboe Jensen, Meghan T. Miller, David C. Henshall, Cristina R. Reschke
Summary: This study demonstrates that targeting microRNA-134 may have therapeutic applications for the treatment of seizures in children. Reduction of microRNA-134 levels in the immature brain can delay and lessen acute seizures, as well as reduce neuronal death in the hippocampus.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
N. H. Harbin, D. J. Lustberg, C. Hurst, J. Pare, K. M. Crotty, A. L. Waters, S. M. Yeligar, Y. Smith, N. T. Seyfried, D. Weinshenker, J. R. Hepler
Summary: RGS14 is a protein that plays a multifunctional role in the hippocampus, suppressing excessive signaling and plasticity in neurons and protecting against seizure activity and pathology. It is upregulated following seizure activity to support mitochondrial function and prevent oxidative stress.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Jennifer M. Walters, Eung Chang Kim, Jiaren Zhang, Han Gil Jeong, Archit Bajaj, Brian C. Baculis, Gregory C. Tracy, Baher Ibrahim, Catherine A. Christian-Hinman, Daniel A. Llano, Graham R. Huesmann, Hee Jung Chung
Summary: This study is the first to demonstrate that the drug TC-2153 has inhibitory effects on hippocampal excitability and seizure severity in both sexes. TC-2153 can reduce seizure severity and decrease overall hippocampal excitability.
Article
Biochemistry & Molecular Biology
Ting-Yang Hsieh, Yi Chang, Su-Jane Wang
Summary: This study found that piperine can protect hippocampal neurons against excitotoxicity induced by kainic acid by modulating the nerve growth factor signaling pathway.
Article
Neurosciences
Cathryn A. Cutia, Leanna K. Leverton, Xiyu Ge, Rana Youssef, Lori T. Raetzman, Catherine A. Christian-Hinman
Summary: Clinical evidence suggests that there are differential outcomes of comorbid conditions in patients with temporal lobe epilepsy (TLE) based on the lateralization of the seizure focus. This study evaluated the effects of targeting left or right dorsal hippocampus in a model of TLE, and found that it produced different outcomes in granule cell dispersion, body weight gain, and reproductive endocrine dysfunction in female mice. The findings suggest that lateralization of the epileptogenic insult may contribute to similar reproductive endocrine outcomes.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Yeonggwang Hwang, Hyoung-Chun Kim, Eun-Joo Shin
Summary: Repeated exposure to MCLR enhances KA-induced seizures and neurodegeneration in the hippocampus by increasing membrane GluK2 expression and enhancing oxidative stress and neuroinflammation.
Article
Neurosciences
Lise Heylen, Duc-Hung Pham, Ann-Sofie De Meulemeester, Eric Samarut, Adrianna Skiba, Danielle Copmans, Youcef Kazwiny, Pieter Vanden Berghe, Peter A. M. de Witte, Aleksandra Siekierska
Summary: Zebrafish present a novel model for epilepsy research, offering unique insights for studying epileptogenic processes in vivo and suitable for high-throughput AED screening and rapid genetic investigations.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Allison E. E. Tipton, Yasmin Cruz Del Angel, Kathryn Hixson, Jessica Carlsen, Dana Strode, Nicolas Busquet, Michael H. H. Mesches, Marco I. I. Gonzalez, Eleonora Napoli, Shelley J. J. Russek, Amy R. R. Brooks-Kayal
Summary: Neuronal STAT3 signaling inhibition improves outcomes in temporal lobe epilepsy, preventing seizure progression and cognitive co-morbidities, and rescuing pathogenic changes in gene expression.
ANNALS OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tzu-Yu Lin, Chih-Yu Hung, Kuan-Ming Chiu, Ming-Yi Lee, Cheng-Wei Lu, Su-Jane Wang
Summary: Neferine pretreatment showed positive effects in increasing seizure latency, reducing seizure scores, preventing glutamate elevation and neuronal loss, as well as decreasing neuroinflammation in rats with KA-induced seizures, indicating its potential as a therapeutic option in epilepsy treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Nicola Maggio, Efrat Shavit Stein, Menahem Segal
Article
Neurosciences
Marina Ben Shimon, Maximilian Lenz, Benno Ikenberg, Denise Becker, Efrat Shavit Stein, Joab Chapman, David Tanne, Chaim G. Pick, Ilan Blatt, Miri Neufeld, Andreas Vlachos, Nicola Maggio
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Article
Multidisciplinary Sciences
Efrat Shavit Stein, Zeev Itsekson-Hayosh, Anna Aronovich, Yair Reisner, Doron Bushi, Chaim G. Pick, David Tanne, Joab Chapman, Andreas Vlachos, Nicola Maggio
SCIENTIFIC REPORTS
(2015)
Article
Neurosciences
Nicola Maggio, Zeev Itsekson, Dan Dominissini, Ilan Blatt, Ninette Amariglio, Gideon Rechavi, David Tanne, Joab Chapman
EXPERIMENTAL NEUROLOGY
(2013)
Article
Neurosciences
Andreas Strehl, Maximilian Lenz, Zeev Itsekson-Hayosh, Denise Becker, Joab Chapman, Thomas Deller, Nicola Maggio, Andreas Vlachos
EXPERIMENTAL NEUROLOGY
(2014)
Article
Neurosciences
Nicola Maggio, Zeev Itsekson, Benno Ikenberg, Andreas Strehl, Andreas Vlachos, Ilan Blatt, David Tanne, Joab Chapman
Article
Immunology
Aviva Katzav, Assaf Menachem, Nicola Maggio, Lea Pollak, Chaim G. Pick, Joab Chapman
JOURNAL OF AUTOIMMUNITY
(2014)
Article
Medicine, Research & Experimental
Aline Winkelmann, Nicola Maggio, Joanna Eller, Guersel Caliskan, Marcus Semtner, Ute Haeussler, Rene Juettner, Tamar Dugladze, Birthe Smolinsky, Sarah Kowalczyk, Ewa Chronowska, Guenter Schwarz, Fritz G. Rathjen, Gideon Rechavi, Carola A. Haas, Akos Kulik, Tengis Gloveli, Uwe Heinemann, Jochen C. Meier
JOURNAL OF CLINICAL INVESTIGATION
(2014)
Article
Biochemistry & Molecular Biology
Zeev Itzekson, Nicola Maggio, Anat Milman, Efrat Shavit, Chaim G. Pick, Joab Chapman
JOURNAL OF MOLECULAR NEUROSCIENCE
(2014)
Article
Biochemistry & Molecular Biology
Doron Bushi, Joab Chapman, Aviva Katzav, Efrat Shavit-Stein, Noa Molshatzki, Nicola Maggio, David Tanne
JOURNAL OF MOLECULAR NEUROSCIENCE
(2013)
Article
Neurosciences
Giovanni Cirillo, Anna Maria Colangelo, Miluscia Berbenni, Vita Maria Ippolito, Ciro De Luca, Francesco Verdesca, Leonilde Savarese, Lilia Alberghina, Nicola Maggio, Michele Papa
MOLECULAR NEUROBIOLOGY
(2015)
Article
Neurosciences
Nicola Maggio, Carlo Cavaliere, Michele Papa, Ilan Blatt, Joab Chapman, Menahem Segal
NEUROBIOLOGY OF DISEASE
(2013)
Article
Neurosciences
Denise Becker, Benno Ikenberg, Sabine Schiener, Nicola Maggio, Andreas Vlachos
Review
Neurosciences
N. Maggio, A. Vlachos
Article
Neurosciences
Nicola Maggio, Efrat Shavit-Stein, Amir Dori, Ilan Blatt, Joab Chapman
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2013)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)