Article
Immunology
Maryam J. J. Tavaf, Azita Soltanmohammadi, Simin Zargarani, Esmaeil Yazdanpanah, Bizhan Sadighimoghaddam, Bahman Yousefi, Hamid R. R. Sameni, Dariush Haghmorad
Summary: This study utilized an EAE mouse model and found that low-dose and high-dose berberine can decrease the severity of EAE and alleviate its symptoms, possibly through increasing the number and function of Treg and Th2 cells, as well as its anti-inflammatory properties.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Dariush Haghmorad, Bahman Yousefi, Majid Eslami, Ali Rashidy-Pour, Mahdieh Tarahomi, Maryam Jadid Tavaf, Azita Soltanmohammadi, Simin Zargarani, Aleksandr Kamyshnyi, Valentyn Oksenych
Summary: This study investigated the efficacy of oral administration of Myelin Oligodendrocyte Glycoprotein (MOG) in the treatment of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS). The results showed that MOG administration, both before and after EAE induction, efficiently controlled EAE development by modulating T cell proliferation and reducing pro-inflammatory cytokines.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zahra Amiri, Shahla Jalili, Mahdieh Tarahomi, Majid Eslami, Esmaeil Yazdanpanah, Rasoul Baharlou, Seyed-Alireza Esmaeili, Bahman Yousefi, Dariush Haghmorad
Summary: This study investigates the potential benefits of Curcumin in treating experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). The findings reveal that Curcumin can slow disease development and alleviate symptoms in EAE through stimulating Treg and Th2 cell polarization, providing evidence for its therapeutic role in MS.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ana L. Vivinetto, Clara Castanares, Constanza Garcia-Keller, Cristian Falcon, Anabela Palandri, Victoria Rozes-Salvador, Juan I. Rojas, Liliana Patrucco, Clara Monferran, Liliana Cancela, Edgardo Cristiano, Ronald L. Schnaar, Ana Lis Moyano, Pablo H. H. Lopen
Summary: The activation of MAG triggers clearance of Glutamate and induces a protective antioxidant response, safeguarding oligodendrocytes and nearby neurons from damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Medicine, Research & Experimental
Iro Triantafyllakou, Nausicaa Clemente, Ravi Kumar Khetavat, Umberto Dianzani, Theodore Tselios
Summary: This study developed polymeric nanoparticles loaded with myelin peptide analogues to inhibit the development and progression of multiple sclerosis. The results showed that this therapeutic approach effectively reduced clinical scores and CNS inflammation, suggesting it as a promising alternative for treating multiple sclerosis by inducing tolerance against the disease.
MOLECULAR PHARMACEUTICS
(2022)
Article
Immunology
Yuanhua Cai, Jocelyn A. A. Schroeder, Weiqing Jing, Cody Gurski, Calvin B. B. Williams, Shaoyuan Wang, Bonnie N. N. Dittel, Qizhen Shi
Summary: Targeting MOG expression to platelets using genetic engineering can prevent the development of multiple sclerosis and reduce disease severity, showing promise as a potential treatment approach.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shishi Shen, Xi Cheng, Luyao Zhou, Yipeng Zhao, Hai Wang, Jie Zhang, Xiaobo Sun, Yuge Wang, Yaqing Shu, Yanteng Xu, Yu Tao, Mingqiang Li, Zhengqi Lu, Wei Cai, Guangjun Nie, Wei Qiu
Summary: This study developed neutrophil-derived nanovesicles (NNVs) to enhance the efficiency of myelin debris clearance in microglia for multiple sclerosis (MS) therapy. The results showed that NNVs treatment ameliorated lesional neuroinflammation and improved neurological functions and white matter integrity in a mouse model of MS. Additionally, NNVs treatment upregulated the expression of NRF2 in microglia and activated the transcription of RUBCN, leading to enhanced phagocytosis of myelin debris.
Review
Nanoscience & Nanotechnology
Prashant Sadanandan, Natalie L. Payne, Guizhi Sun, Anusha Ashokan, Siddaramana G. Gowd, Arsha Lal, Madathiparambil Kumaran Satheesh Kumar, Sreeranjini Pulakkat, Shantikumar Nair, Krishnakumar N. Menon, Claude C. A. Bernard, Manzoor Koyakutty
Summary: Targeting nano-conjugated autoantigens to tissue-resident macrophages in lymphoid organs can effectively suppress autoimmunity and restore self-tolerance.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Florent Salvador, Laure Deramoudt, Frederic Lepretre, Martin Figeac, Thomas Guerrier, Julie Boucher, Mathilde Bas, Nathalie Journiac, Anneli Peters, Lennart T. Mars, Helene Zephir
Summary: The key role of B cells in multiple sclerosis is supported by various factors, such as the presence of oligoclonal bands in the cerebrospinal fluid and the efficacy of B lymphocyte depletion. Using an EAE model, this study explores the clonality of B cell response targeting myelin oligodendrocyte glycoprotein (MOG) and demonstrates the pre-clinical mobilization of the MOG-specific B cell response within brain-draining cervical lymph nodes. The study also suggests that MOG antibodies are not a reliable biomarker for disease onset and progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Jordi Kuehne Escola, Cornelius Deuschl, Andreas Junker, Fabian Dusse, Refik Pul, Christoph Kleinschnitz, Martin Koehrmann, Benedikt Frank
Summary: We report a rare case of autoimmune disorder following COVID-19 vaccination, presenting with symptoms similar to bacterial meningomyelitis. The patient showed significant clinical improvement with appropriate treatment.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Neurosciences
James J. M. Cooper, Jessie J. Polanco, Darpan Saraswat, Jennifer J. Peirick, Anna Seidl, Yi Li, Dan Ma, Fraser J. Sim
Summary: The failure of remyelination in the human CNS is a major contributor to axonal injury and disease progression in multiple sclerosis (MS). Murine models show a high density of oligodendrocyte progenitor cells (OPCs) in areas of demyelination, suggesting that efficient OPC repopulation is necessary for successful remyelination. However, in this study, we found that OPC repopulation was low in large lesions and almost absent in small lesions in adult rabbits, suggesting that both lesion volume and species-specific mechanisms play a role in regulating OPC proliferation and remyelination.
Editorial Material
Medicine, General & Internal
Sohyeon Kim, Mi-Yeon Eun, Jae-Joon Lee, Hung Youl Seok
Summary: This study highlights the importance of recognizing the potential association between AHEM and MOGAD, especially when distinct MRI patterns are present.
Review
Clinical Neurology
Vanja Tepavcevi, Catherine Lubetzki
Summary: The failure of remyelination in multiple sclerosis (MS) is often characterized by low oligodendrocyte progenitor cell density. Stimulating this process may be crucial for achieving myelin regeneration.
Article
Biochemical Research Methods
Rina Aharoni, Renana Globerman, Raya Eilam, Ori Brenner, Ruth Arnon
Summary: By titrating the doses of MOG 35-55 peptide, MT H37Ra, and PTx during EAE induction, researchers were able to drastically reduce the amount of reagents used while maintaining similar disease manifestations, high disease incidence, and consistent disease course. This improved protocol may offer a more sensitive and cost-effective model for testing therapeutic modalities for MS.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Immunology
Shin-Young Na, Gurumoorthy Krishnamoorthy
Summary: The study demonstrates that ectopic expression of MOG in immune organs can induce MOG-specific tolerance and long-lasting protection, potentially serving as a therapeutic strategy for specific autoantigen-driven autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Clinical Neurology
Thomas Seifert-Held, Katharina Eberhard, Soren Christensen, Edith Hofer, Christian Enzinger, Gregory W. Albers, Maarten Lansberg
Summary: This study showed that the completeness of the Circle of Willis was not predictive of functional outcome in patients after stroke at 90 days. However, there were significant associations with patients' baseline National Institutes of Health Stroke Scale, age, and reperfusion status. The study suggests that a larger cohort of over 3000 patients may reveal a significant association between an incomplete Circle of Willis and functional outcome at 90 days.
STROKE AND VASCULAR NEUROLOGY
(2021)
Article
Clinical Neurology
Aarushi Rastogi, Robert Weissert, Sonu Menachem Maimonides Bhaskar
Summary: Leukoaraiosis severity in acute ischaemic stroke patients undergoing reperfusion therapy is significantly associated with poor 90-day functional outcome, 90-day mortality, and increased risk of symptomatic intracerebral haemorrhage after treatment. However, there is no significant association with haemorrhagic transformation and angiographic recanalization status.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Review
Clinical Neurology
Heinz Wiendl, Catharina C. Gross, Jan Bauer, Doron Merkler, Alexandre Prat, Roland Liblau
Summary: This review discusses how insights from rare neuroimmunological diseases can provide fundamental understanding of disease mechanisms that can be applied to more complex diseases, and how these insights can be relevant to the study of other neuroimmunological diseases.
NATURE REVIEWS NEUROLOGY
(2021)
Article
Clinical Neurology
Carles Gaig, Yaroslau Compta, Anna Heidbreder, Maria J. Marti, Maarten J. Titulaer, Yvette Crijnen, Birgit Hoegl, Jan Lewerenz, Maria Elena Erro, Juan Carlos Garcia-Monco, Pasquale Nigro, Nicola Tambasco, Maja Patalong-Ogiewa, Marcus Erdler, Stefan Macher, Evelyn Berger-Sieczkowski, Romana Hoeftberger, Christian Geis, Markus Hutterer, Angela Milan-Tomas, Antonio Martin-Bastida, Lydia Lopez Manzanares, Sonia Quintas, Guenter U. Hoeglinger, Nora Moehn, Florian Schoeberl, Franziska S. Thaler, Gian Maria Asioli, Federica Provini, Giuseppe Plazzi, Koldo Berganzo, Morten Blaabjerg, Norbert Brueggemann, Tarsis Farias, Chen Fei Ng, Caroline Giordana, Alejandro Herrero-San Martin, Lucio Huebra, Katya Kotschet, Herburg Liendl, Teresa Montojo, Carlos Morata, Jesus Perez Perez, Inmaculada Puertas, Thomas Seifert-Held, Caspar Seitz, Mateus Mistieri Simabukuro, Nieves Tellez, Javier Villacieros-Alvarez, Barbara Willekens, Lidia Sabater, Alex Iranzo, Joan Santamaria Cano, Josep Dalmau, Francesc Graus
Summary: Anti-IgLON5 disease is a neurological disorder characterized by a variety of movement disorders, with gait disturbances, generalized chorea, and dystonia being the most common. In addition to movement disorders, patients often experience sleep alterations, bulbar dysfunction, and cognitive impairment.
Article
Cell Biology
Laura Rodriguez-Pascau, Anna Vilalta, Marc Cerrada, Estefania Traver, Sonja Forss-Petter, Isabelle Weinhofer, Jan Bauer, Stephan Kemp, Guillem Pina, Silvia Pascual, Uwe Meya, Patricia L. Musolino, Johannes Berger, Marc Martinell, Pilar Pizcueta
Summary: Leriglitazone shows promising neuroprotective effects in X-ALD, reducing oxidative stress and toxicity in primary neurons and astrocytes. It also improves motor function, restores markers of oxidative stress and inflammation in spinal cord tissues, and decreases neurological disability in animal models of neuroinflammation.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Thomas Seifert-Held, Katharina Eberhard, Christian Lechner, Stefan Macher, Harald Hegen, Tobias Moser, Gregor Brecl Jacob, Gertraud Puttinger, Raffi Topakian, Michael Guger, Emrah Kacar, Lea Zoche, Desiree De Simoni, Andreas Seiser, Stefan Oberndorfer, Christoph Baumgartner, Walter Struhal, Friedrich Zimprich, Johann Sellner, Florian Deisenhammer, Christian Enzinger, Markus Reindl, Helmut Rauschka, Thomas Berger, Romana Hoeftberger
Summary: The study found that patients with different types of antibodies in autoimmune encephalitis show different dynamics in their recovery process, which has important implications for clinical trials. Some patients still have significant disabilities at 3 months after diagnosis, indicating the need for improving treatment options. Compared to patients in groups I and III, patients in group II with antibodies have better outcomes in their recovery process.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Aarushi Rastogi, Robert Weissert, Sonu M. M. Bhaskar
Summary: This systematic review suggests a potential prognostic role of brain atrophy in acute ischemic stroke (AIS). However, due to heterogeneity in brain atrophy assessment and reporting, quantitative analysis is not feasible. Future studies using standardized assessment are needed to clarify the association between brain atrophy and clinical and safety outcomes in AIS.
Article
Clinical Neurology
Robert Weissert, Therese Hugosson, Axel Petzold
Summary: The transient thickening of the macular retinal nerve fibre layer (RNFL) in optic neuritis (ON) may be explained by the up-regulation of neurofilament (Nf) protein expression in the retinal ganglion cells.
NEURO-OPHTHALMOLOGY
(2022)
Article
Clinical Neurology
Thomas Grueter, Franziska E. Moellers, Anja Tietz, Justina Dargvainiene, Nico Melzer, Anna Heidbreder, Christine Strippel, Andrea Kraft, Romana Hoeftberger, Florian Schoeberl, Franziska S. Thaler, Jonathan Wickel, Ha-Yeun Chung, Frank Seifert, Marlene Tschernatsch, Michael Nagel, Jan Lewerenz, Sven Jarius, Brigitte C. Wildemann, Lucie de Azevedo, Fedor Heidenreich, Raphaela Heusgen, Ulrich Hofstadt-van Oy, Andreas Linsa, Jannis Justus Maass, Til Menge, Marius Ringelstein, David J. Pedrosa, Josef Schill, Thomas Seifert-Held, Caspar Seitz, Silke Tonner, Christian Urbanek, Simone Zittel, Robert Markewitz, Mirjam Korporal-Kuhnke, Thomas Schmitter, Carsten Finke, Norbert Brueggemann, Corinna Bien, Ingo Kleiter, Ralf Gold, Klaus-Peter Wandinger, Gregor Kuhlenbaeumer, Frank Leypoldt, Ilya Ayzenberg
Summary: In a study of a large group of anti-IgLON5 disease patients, Gruter et al. found that early inflammatory CSF changes, subacute relapses, and HLA-DRB1*10:01 were associated with higher autoantibody levels, supporting the autoimmune nature of the disease. They also found that immunotherapy is effective if initiated early, before major neurodegeneration occurs.
Editorial Material
Clinical Neurology
Robert Weissert
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Marlene Tahedl, Seth M. Levine, Robert Weissert, Zacharias Kohl, De-Hyung Lee, Ralf A. Linker, Jens Schwarzbach
Summary: This study found that the functional networks of patients with multiple sclerosis (MS) change during remission, with significant alterations related to the cerebellar network. These changes may be associated with learning processes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Bastian Weiss, Alexander Pichler, Anna Damulina, Arabella Buchmann, Sonja Hochmeister, Thomas Seifert-Held, Christian Enzinger, Juan-Jose Archelos, Michael Khalil
Summary: This study evaluated the clinical significance of quantitative kappa free light chains (k-FLC) in patients with an isolated band in the cerebrospinal fluid (CSF). The results showed that positive k-FLC can indicate the possibility of neuroinflammatory diseases in patients with an isolated band in isoelectric focusing (IEF). Therefore, measuring k-FLC can provide support in the diagnosis of neurological diseases.
Editorial Material
Public, Environmental & Occupational Health
Sonu M. M. Bhaskar, Alma Nurtazina, Shikha Mittoo, Maciej Banach, Robert Weissert
FRONTIERS IN PUBLIC HEALTH
(2022)
Meeting Abstract
Clinical Neurology
S. Wilfling, B. Tsoneva, P. Forras, O. Hsam, K. Klein, N. Deininger, R. Weissert, C. Wendl, R. Linker, U. Hehr, Z. Kohl
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Slaven Pikija, Alexander B. Kunz, Raffaele Nardone, Christian Enzinger, Johannes A. R. Pfaff, Eugen Trinka, Thomas Seifert-Held, Johann Sellner
Summary: This study retrospectively analyzed spontaneous spinal cord infarction (SCI) patients in two tertiary care centers in Austria, with a total of 88 cases. The study found that the characteristics of spontaneous SCI included a median age of 65.5 years, anterior spinal artery infarction being the most common syndrome, and differences in etiology and diagnostic certainty between the two centers. The article also emphasized the importance of establishing standards for pre- and in-hospital care to improve treatment outcomes.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)