The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy
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Title
The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy
Authors
Keywords
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Journal
Science Translational Medicine
Volume 13, Issue 596, Pages eabc0555
Publisher
American Association for the Advancement of Science (AAAS)
Online
2021-06-03
DOI
10.1126/scitranslmed.abc0555
References
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Related references
Note: Only part of the references are listed.- X‐linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies
- (2020) Bela R. Turk et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone
- (2019) Sarah A. Mosure et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Landscape of Hematopoietic Stem Cell Transplant and Gene Therapy for X-Linked Adrenoleukodystrophy
- (2019) Eric J. Mallack et al. Current Treatment Options in Neurology
- Impaired plasticity of macrophages in X-linked adrenoleukodystrophy
- (2018) Isabelle Weinhofer et al. BRAIN
- Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation
- (2018) Agatha Schlüter et al. BRAIN PATHOLOGY
- Survival and Functional Outcomes in Boys with Cerebral Adrenoleukodystrophy with and without Hematopoietic Stem Cell Transplantation
- (2018) Gerald V. Raymond et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Reduced cuprizone-induced cerebellar demyelination in mice with astrocyte-targeted production of IL-6 is associated with chronically activated, but less responsive microglia
- (2017) Filip Petković et al. JOURNAL OF NEUROIMMUNOLOGY
- Heat shock protein expression in cerebral X-linked adrenoleukodystrophy reveals astrocyte stress prior to myelin loss
- (2017) A. L. Görtz et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer’s disease
- (2016) Chengyu Zou et al. ACTA NEUROPATHOLOGICA
- Adrenoleukodystrophy – neuroendocrine pathogenesis and redefinition of natural history
- (2016) Stephan Kemp et al. Nature Reviews Endocrinology
- Pioglitazone after Ischemic Stroke or Transient Ischemic Attack
- (2016) Walter N. Kernan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis
- (2016) Laura Negrotto et al. JAMA Neurology
- C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man
- (2016) Malu-Clair van de Beek et al. PLoS One
- Astrocytes and mitochondria from adrenoleukodystrophy protein (ABCD1)-deficient mice reveal that the adrenoleukodystrophy-associated very long-chain fatty acids target several cellular energy-dependent functions
- (2015) Nicol Kruska et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Brain endothelial dysfunction in cerebral adrenoleukodystrophy
- (2015) Patricia L. Musolino et al. BRAIN
- Cerebral adrenoleukodystrophy: a demyelinating disease that leaves the door wide open: Figure 1
- (2015) Patrick Aubourg BRAIN
- Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy
- (2015) L Morató et al. CELL DEATH AND DIFFERENTIATION
- Pioglitazone inhibits the secretion of proinflammatory cytokines and chemokines in astrocytes stimulated with lipopolysaccharide
- (2015) Dong Qiu et al. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
- Abcd2 Is a Strong Modifier of the Metabolic Impairments in Peritoneal Macrophages of Abcd1-Deficient Mice
- (2014) Zahid Muneer et al. PLoS One
- Mitochondrial dysfunction and oxidative damage cooperatively fuel axonal degeneration in X-linked adrenoleukodystrophy
- (2013) Stéphane Fourcade et al. BIOCHIMIE
- Pathophysiology of X-linked adrenoleukodystrophy
- (2013) J. Berger et al. BIOCHIMIE
- Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy
- (2013) Laia Morató et al. BRAIN
- M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
- (2013) Veronique E Miron et al. NATURE NEUROSCIENCE
- Histone Deacetylase Inhibitor Upregulates Peroxisomal Fatty Acid Oxidation and Inhibits Apoptotic Cell Death in Abcd1-Deficient Glial Cells
- (2013) Jaspreet Singh et al. PLoS One
- X-linked adrenoleukodystrophy: Clinical, metabolic, genetic and pathophysiological aspects
- (2012) Stephan Kemp et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management
- (2012) Marc Engelen et al. Orphanet Journal of Rare Diseases
- A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis
- (2012) Luc Dupuis et al. PLoS One
- SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity
- (2012) Hongying Yang et al. PLoS One
- Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy
- (2011) Jone López-Erauskin et al. ANNALS OF NEUROLOGY
- Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy
- (2011) Agatha Schlüter et al. HUMAN MOLECULAR GENETICS
- The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys
- (2011) Christine R Swanson et al. Journal of Neuroinflammation
- Pathomechanisms Underlying X-Adrenoleukodystrophy: A Three-Hit Hypothesis
- (2010) Inderjit Singh et al. BRAIN PATHOLOGY
- Current and Future Pharmacological Treatment Strategies in X-Linked Adrenoleukodystrophy
- (2010) Johannes Berger et al. BRAIN PATHOLOGY
- The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy
- (2010) Rob Ofman et al. EMBO Molecular Medicine
- Gadofluorine M-enhanced MRI shows involvement of circumventricular organs in neuroinflammation
- (2010) Eva Wuerfel et al. Journal of Neuroinflammation
- PGC-1alpha Down-Regulation Affects the Antioxidant Response in Friedreich's Ataxia
- (2010) Daniele Marmolino et al. PLoS One
- Pioglitazone suppresses the lipopolysaccharide-induced production of inflammatory factors in mouse macrophages by inactivating NF-κB
- (2009) Caihui Ao et al. CELL BIOLOGY INTERNATIONAL
- Head trauma can initiate the onset of adreno-leukodystrophy
- (2009) Gerald V. Raymond et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?
- (2008) Florian S. Eichler et al. ANNALS OF NEUROLOGY
- The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters
- (2008) Carlo W. T. van Roermund et al. FASEB JOURNAL
- Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture
- (2008) S. Hein et al. HUMAN MOLECULAR GENETICS
- Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague–Dawley rats
- (2007) Randy L. Hunter et al. NEUROSCIENCE LETTERS
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