Article
Health Care Sciences & Services
Chieh-Chen Wu, Md Mohaimenul Islam, An-Jen Lee, Chun-Hsien Su, Yung-Ching Weng, Chih-Yang Yeh, Hsun-Hua Lee, Ming-Chin Lin
Summary: This meta-analysis found that the use of statins is associated with a reduced risk of Parkinson's disease (PD), especially with long-term use. However, further randomized controlled trials are needed to confirm these findings.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Hayder M. M. Al-kuraishy, Ali I. I. Al-Gareeb, Athanasios Alexiou, Marios Papadakis, Abdulrahman A. A. Alsayegh, Najlaa Hamed Almohmadi, Hebatallah M. M. Saad, Gaber El-Saber Batiha
Summary: Parkinson's disease (PD) is the second most common neurodegenerative brain disease after Alzheimer's disease (AD). Statins are commonly used lipid-lowering agents for managing dyslipidemia and preventing cardiovascular diseases (CVD). There is a controversial point regarding the role of serum lipids in the development of PD. This review aims to clarify the precise role of statins in PD based on published studies.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)
Article
Business
Andreas Wagner, Denise Fischer-Kreer
Summary: This study contributes to the emerging trend of corporate carbon emission research by examining CEOs' responsibility in organizations' strategic decision-making. The findings reveal that a CEO's regulatory focus, be it promotion or prevention focus, is significantly related to corporate carbon emissions. The study enriches carbon emission research by focusing on the cognitive and motivational aspects of CEOs for effective carbon management.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2023)
Review
Cardiac & Cardiovascular Systems
Elena Olmastroni, Giulia Molari, Noemi De Beni, Ornella Colpani, Federica Galimberti, Marta Gazzotti, Alberto Zambon, Alberico L. Catapano, Manuela Casula
Summary: The meta-analysis found that statin use was associated with a decreased risk of dementia and Alzheimer's disease. There was no difference in dementia risk reduction between men and women. High-potency statins may be more effective in reducing dementia risk compared to low-potency statins.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Clinical Neurology
Nurit Omer, Nir Giladi, Tanya Gurevich, Anat Bar-Shira, Mali Gana-Weisz, Tal Glinka, Orly Goldstein, Meir Kestenbaum, Jesse M. Cedarbaum, Omar S. Mabrouk, Kyle B. Fraser, Julia C. Shirvan, Avi Orr-Urtreger, Anat Mirelman, Avner Thaler
Summary: This study investigated the association between GCase activity, PD phenotype, and prodromal PD probability in carriers of GBA gene mutations, finding that low GCase activity does not explain the clinical phenotype or risk for prodromal PD in this cohort.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Thi Thu Ha Nguyen, Agnes Fournier, Emeline Courtois, Fanny Artaud, Sylvie Escolano, Pascale Tubert-Bitter, Marie-Christine Boutron-Ruault, Isabelle Degaey, Emmanuel Roze, Marianne Canonico, Ismail Ahmed, Anne C. M. Thiebaut, Alexis Elbaz
Summary: This study examined the association between statin use and Parkinson's disease (PD) incidence using data from a cohort study of French women. The results showed that the use of lipophilic statins at least 5 years earlier was associated with a reduced incidence of PD in women, with a dose-response relationship for the mean daily dose.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Thi Thu Ha Nguyen, Agnes Fournier, Emeline Courtois, Fanny Artaud, Sylvie Escolano, Pascale Tubert-Bitter, Marie-Christine Boutron-Ruault, Isabelle Degaey, Emmanuel Roze, Marianne Canonico, Ismail Ahmed, Anne C. M. Thiebaut, Alexis Elbaz
Summary: This study examined the association between statin use and Parkinson's disease incidence in women. It found that the use of lipophilic statins at least 5 years earlier was associated with a reduced incidence of Parkinson's disease in women, with a dose-response relation for the mean daily dose.
MOVEMENT DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Jackie Bosch, Eva M. Lonn, Hyejung Jung, Jun Zhu, Lisheng Liu, Patricio Lopez-Jaramillo, Prem Pais, Denis Xavier, Rafael Diaz, Gilles Dagenais, Antonio Dans, Alvaro Avezum, Leopoldo S. Piegas, Alexander Parkhomenko, Kati Keltai, Matyas Keltai, Karen Sliwa, Claus Held, Ronald J. G. Peters, Basil S. Lewis, Petr Jansky, Khalid Yusoff, Kamlesh Khunti, William D. Toff, Christopher M. Reid, John Varigos, Philip Joseph, Lawrence A. Leiter, Salim Yusuf
Summary: Rosuvastatin significantly reduced major adverse cardiovascular events in participants with intermediate cardiovascular risk compared to placebo. The benefits of rosuvastatin continued to increase during post-trial observation period, while blood pressure lowering did not affect the overall study outcomes.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Jackie Bosch, Eva M. Lonn, Hyejung Jung, Jun Zhu, Lisheng Liu, Patricio Lopez-Jaramillo, Prem Pais, Denis Xavier, Rafael Diaz, Gilles Dagenais, Antonio Dans, Alvaro Avezum, Leopoldo S. Piegas, Alexander Parkhomenko, Kati Keltai, Matyas Keltai, Karen Sliwa, Claus Held, Ronald J. G. Peters, Basil S. Lewis, Petr Jansky, Khalid Yusoff, Kamlesh Khunti, William D. Toff, Christopher M. Reid, John Varigos, Philip Joseph, Lawrence A. Leiter, Salim Yusuf
Summary: Rosuvastatin (10 mg daily) reduced major adverse cardiovascular events by 24% compared to placebo in participants at intermediate cardiovascular risk. The benefits of rosuvastatin continued to accrue for at least 3 years after cessation of treatment, indicating a legacy effect.
EUROPEAN HEART JOURNAL
(2021)
Article
Business, Finance
Alba Halili, Jean-Pierre Fenech, Silvio Contessi
Summary: The study found that an increase in banks' holdings of credit derivatives leads to higher systemic risk, which has important policy implications for regulators and market participants.
FINANCE RESEARCH LETTERS
(2021)
Review
Clinical Neurology
Rebecca J. Solch, Julia O. Aigbogun, Andrew G. Voyiadjis, Grant M. Talkington, Revonda M. Darensbourg, Keith M. Pickett, Sarah R. Perez, Demetrius M. Maraganore, Samantha O'Connell
Summary: The Mediterranean diet may reduce the risk of Alzheimer's disease and Parkinson's disease by modulating the gut microbiota. Existing studies have shown an association between adherence to the Mediterranean diet and a lower risk of developing these neurodegenerative diseases, but more research is needed to establish a causal relationship.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Morten Malmborg, Michelle D. S. Schmiegelow, Thomas Gerds, Morten Schou, Caroline Kistorp, Christian Torp-Pedersen, Gunnar Gislason
Summary: This study demonstrates that primary prevention with statins can reduce the risk of cardiovascular events or death in low-risk patients with T2D, with the greatest benefit seen in elderly patients and those with high adherence to statin treatment.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Chandini Raina MacIntyre, Abrar Ahmad Chughtai, Arpita Das, Bayzidur Rahman, Aye M. Moa, Chieh H. Gan, Timothy C. Tan
Summary: The study found a significantly higher rate of laboratory-confirmed influenza among statin users who were not vaccinated. However, there was no significant difference in influenza vaccine effectiveness between statin users and non-users after vaccination. Statin users had a significantly higher risk of influenza, suggesting that they should be vaccinated against influenza.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
Chieh-Li Yen, Pei-Chun Fan, Ming-Shyan Lin, Cheng-Chia Lee, Kun-Hua Tu, Chao-Yu Chen, Ching-Chung Hsiao, Hsiang-Hao Hsu, Ya-Chung Tian, Chih-Hsiang Chang
Summary: This study found that among advanced CKD patients, the use of fenofibrate and statins can reduce the risk of cardiovascular death, while fenofibrate can also reduce the incidence of permanent dialysis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Anne J. Strikwerda, Lisanne J. Dommershuijsen, M. Kamran Ikram, Trudy Voortman
Summary: The Mediterranean diet and the 'Prudent' dietary pattern may be associated with the risk of Parkinson's disease, while no associations were found for the Dutch diet quality score and other dietary patterns. Further research is needed to investigate the effects of different dietary patterns on PD risk.
Article
Biochemistry & Molecular Biology
Suzanne D. Lanooij, Ulrich L. M. Eisel, Wilhelmus H. I. M. Drinkenburg, Eddy A. van der Zee, Martien J. H. Kas
Summary: This article provides an overview of deficits in the social and cognitive domain in psychiatric and neurological disorders and explores the extensive neurobiological basis underlying the relationship between these two domains. By mapping rodent brain regions involved in social and/or cognitive functions, it is shown that the majority of cognitive brain regions are also involved in the social domain. This neuroanatomical overlap has an evolutionary basis and aligns with the functional interactions between cognitive and social processes. Therefore, the social domain should receive more focus as an important treatment target and/or biomarker, especially considering the limited treatment strategies for these disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Giuseppe Locatelli, Filipa Marques-Ferreira, Antonis Katsoulas, Vasileia Kalaitzaki, Martin Krueger, Barbara Ingold-Heppner, Sabrina Walthert, Roman Sankowski, Olivia Prazeres da Costa, Amalia Dolga, Magdalena Huber, Maike Gold, Carsten Culmsee, Ari Waisman, Ingo Bechmann, Vladislava Milchevskaya, Marco Prinz, Achim Tresch, Burkhard Becher, Thorsten Buch
Summary: Research suggests that insulin-like growth factor 1 (IGF-1) signaling is not necessary for the function and survival of mature oligodendrocytes (ODCs) in the central nervous system (CNS). Lack of IGF-1 receptor in ODCs does not affect ODC survival and myelin status in toxin-induced and autoimmune demyelination models. Surprisingly, the absence of IGF-1 receptor in ODCs protects against clinical neuroinflammation in the autoimmune demyelination model.
Article
Biochemistry & Molecular Biology
Asmaa Oun, Emmy Hoeksema, Ahmed Soliman, Famke Brouwer, Fabiola Garcia-Reyes, Henderikus Pots, Marina Trombetta-Lima, Arjan Kortholt, Amalia M. Dolga
Summary: Dysfunction of the immune system and mitochondrial metabolism is associated with Parkinson's disease (PD) pathology. Mutations and increased kinase activity of leucine-rich repeat kinase 2 (LRRK2) are linked to both idiopathic and familial PD. However, the function of LRRK2 in immune cells under inflammatory conditions is contradictory.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel
Summary: TNF signaling plays a crucial role in cellular homeostasis, and its activation of TNFR1 and TNFR2 can determine cell death or survival. It regulates important biological functions such as inflammation, neuronal activity, and tissue regeneration. Modulating TNF-TNFRs signaling can potentially be used for the treatment of neurodegenerative diseases, but conflicting findings have been reported. This study investigates the therapeutic effects of sequential modulation of TNFR1 and TNFR2 signaling in an experimental mouse model of autoimmune encephalomyelitis (EAE).
JOURNAL OF NEUROINFLAMMATION
(2023)
Correction
Cell Biology
Wei Han, Eva-Maria Meissner, Stefanie Neunteibl, Madeline Guenther, Joerg Kahnt, Amalia Dolga, Cuicui Xie, Nikolaus Plesnila, Changlian Zhu, Klas Blomgren, Carsten Culmsee
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Wei Han, Eva-Maria Meissner, Stefanie Neunteibl, Madeline Gunther, Joerg Kahnt, Amalia Dolga, Cuicui Xie, Nikolaus Plesnila, Changlian Zhu, Klas Blomgren, Carsten Culmsee
Summary: Neural stem and progenitor cell (NSPC) transplants provide neuroprotection by releasing a protective secretome, containing heat-stable proteins, that promote neuronal survival in acute brain injury models.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Gwenda F. Vasse, Sara Russo, Andrei Barcaru, Asmaa A. A. Oun, Amalia M. Dolga, Patrick van Rijn, Marcel Kwiatkowski, Natalia Govorukhina, Rainer Bischoff, Barbro N. Melgert
Summary: Idiopathic pulmonary fibrosis is a progressive lung disease that causes scarring and loss of lung function. Macrophages respond to altered morphological and mechanical properties of the extracellular matrix in fibrosis and can change their expression and activity of metabolism-related proteins. These findings suggest important interactions between macrophages and their surroundings in the repair or fibrosis of lung tissue.
SCIENTIFIC REPORTS
(2023)
Review
Physiology
Tong Zhang, Minh D. A. Luu, Amalia M. M. Dolga, Ulrich L. M. Eisel, Martina Schmidt
Summary: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent neurodegenerative disorders worldwide, impacting millions of people's life expectancy and quality. Recent research suggests overlapping mechanisms may underlie AD and PD, with novel cell death mechanisms, such as parthanatos, netosis, lysosome-dependent cell death, senescence, and ferroptosis, being modulated by cAMP signaling via PKA and Epac. This review focuses on the overlapping mechanisms between AD and PD, specifically in relation to cAMP signaling and the pharmacology of cAMP signaling pathways.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tingting Chen, Nad'a Majernikova, Alejandro Marmolejo-Garza, Marina Trombetta-Lima, Angelica Maria Sabogal-Guaqueta, Yuequ Zhang, Ruth ten Kate, Minte Zuidema, Patty P. M. F. A. Mulder, Wilfred den Dunnen, Reinoud Gosens, Elisabeth Verpoorte, Carsten Culmsee, Ulrich L. M. Eisel, Amalia M. Dolga
Summary: Transplanting exogenous mitochondria into neuronal cells can protect cells from ferroptotic cell death by reducing lipid peroxidation and mitochondrial superoxide production. The function of mitochondrial complexes is crucial for the neuroprotective effects of exogenous mitochondria.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Neurosciences
Suzanne D. Lanooij, W. H. I. M. Drinkenburg, U. L. M. Eisel, E. A. van der Zee, Martien J. H. Kas
Summary: Social factors are linked to the risk of developing Alzheimer's Disease. Social housing conditions have a significant effect on amyloid plaques and microglia, particularly in certain genotypes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Zeyana M. Al-Dahmani, Mojgan Hadian, Angel J. Ruiz-Moreno, Sabogal-Guaqueta Angelica Maria, Fernando A. Batista, Ran Zhang, Yang Luo, Afsaneh Sadremomtaz, Robin van der Straat, Mette Spoor, Amalia M. Dolga, Frank J. Dekker, S. S. Alexander Domling, Harry van Goor, Matthew R. Groves
Summary: A small molecule activator of human TST, identified through screening, increases TST activity and may have therapeutic benefits for diabetes and obesity. Two distinct isomers and an allosteric mode of activation are required for full activation. Molecular docking and dynamics suggest an allosteric site for the activator's binding, and increased TST activity enhances mitochondrial respiration.
Article
Biochemistry & Molecular Biology
Tong Zhang, Nshunge Musheshe, Christina H. J. T. M. van der Veen, Helmut W. Kessels, Amalia Dolga, Peter De Deyn, Ulrich Eisel, Martina Schmidt
Summary: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of amyloid beta (A beta) and hyperphosphorylated tau in the brain. Recent studies have shown that memory retrieval is impaired in the early stage of AD. This study aimed to investigate the expression of proteins associated with Epac2-mediated memory in hippocampal postmortem samples of AD patients and experimental AD model mice.
Article
Multidisciplinary Sciences
Natalia Orti-Casan, Ate S. S. Boerema, Karina Kopke, Amber Ebskamp, Jan Keijser, Yuequ Zhang, Tingting Chen, Amalia M. M. Dolga, Kerensa Broersen, Roman Fischer, Klaus Pfizenmaier, Roland E. E. Kontermann, Ulrich L. M. Eisel
Summary: Tumor necrosis factor alpha (TNF-α) has been recognized as a therapeutic target for inflammatory and neurodegenerative diseases. In this study, the TNFR1-specific antagonist Atrosimab was found to attenuate cognitive impairments, reduce neuroinflammation, and neuronal cell death in an acute neurodegenerative mouse model. These results suggest that Atrosimab may be a promising candidate for the treatment of neurodegenerative diseases.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
