Article
Neurosciences
Sara Bolivar, Esther Udina
Summary: Specificity in regeneration after peripheral nerve injuries is crucial for functional recovery. This study found that cutaneous mechanoreceptors regenerated faster than other neuron populations, followed by motoneurons and then proprioceptors. Additionally, all neuron types initially preferred to regenerate into the cutaneous branch, but in the long term, they mainly regenerated through their original branch. Furthermore, motoneurons had more collateral branches than proprioceptors, and myelinated neurons extended more regenerative sprouts in the cutaneous branch.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemical Research Methods
Qianru He, Fanhui Yu, Meng Cong, Yuhua Ji, Qi Zhang, Fei Ding
Summary: Peripheral nerve repair and functional recovery depend on the rate of nerve regeneration and the quality of target reinnervation. A quantitative proteomic technique was used to analyze the protein expression pattern between injured motor and sensory nerves, revealing 176 proteins with differential expressions. Functional categorization indicated that these differentially expressed proteins are linked to various molecular functions, which might play a crucial role in peripheral nerve regeneration.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Neurosciences
Qianru He, Zhenghang Cheng, Qiang Zhou, Fang Tong, Yan Li, Xinyang Zhou, Miaomei Yu, Yuhua Ji, Fei Ding
Summary: Functional reconstruction after peripheral nerve injury relies on the regeneration and re-innervation ability of sensory and motor axons. This study explores the cellular mechanisms of peripheral nerve-specific regeneration. It was found that sensory and motor fibroblasts have different effects on sensory and motor neurons, and the protein expression profiles of these fibroblasts are distinct. These findings provide potential directions for future research on peripheral nerve-specific regeneration.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Li-Kang Zhang, Jia-Hui Sun, Sheng Liu, Wen-Liang Zhang, Jian-Long Zou
Summary: In this study, we developed an in vitro model called SCWR to mimic the tissue-specific differences between motor and sensory nerve regeneration. The model demonstrated asymmetric regeneration of the ventral and dorsal roots in response to growth factors and exhibited motor and sensory Schwann cell phenotypes. Additionally, we identified a targeted effect of collagen VI on sensory nerve bundle formation and characterized the protein expression profiles associated with motor/sensory-specific nerve regeneration.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Imran, Ghulam Hussain, Arruje Hameed, Iqra Iftikhar, Muhammad Ibrahim, Rahat Asghar, Izzat Nisar, Tahir Farooq, Tanzila Khalid, Kanwal Rehman, Mohammed A. Assiri
Summary: This study screened the functional metabolites of Moringa oleifera and found that they play an important role in accelerated functional recovery after peripheral nerve injury. The extracts from Moringa showed potential in promoting the recovery of sensory and motor functions, as well as controlling oxidative stress and facilitating nerve regeneration. This study highlights the significance of Moringa as a sustainable source of nutritive metabolites and a valuable target for drug development.
Article
Neurosciences
J. R. Nadeau, B. M. Arnold, J. M. Johnston, G. D. Muir, V. M. K. Verge
Summary: Brief electrical stimulation (ES) or acute intermittent hypoxia (AIH) treatment during surgical repair can enhance the regeneration of injured peripheral nerves by influencing the expression of regeneration-associated genes (RAG). These treatments lead to significant improvements in growth indicators and functional recovery, showing promising potential for non-invasive therapies in nerve regeneration.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Surgery
Jonathan I. Leckenby, Miranda A. Chacon, David Milek, Jeff W. Lichtman, Adriaan O. Grobbelaar
Summary: Two-stage free functional muscle transfers for long-standing facial palsy can have unpredictable results. This study investigated the impact of axonal count in autologous grafts on functional outcomes and found that higher axonal count resulted in a higher percentage of regeneration across neurorrhaphies.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Clinical Neurology
Sophie-Charlotte Fabig, Dilara Kersebaum, Josephine Lassen, Manon Sendel, Swantje Jendral, Alexandra Muntean, Ralf Baron, Philipp Huellemann
Summary: The study aimed to establish an objective neurophysiological test protocol to assess the somatosensory nervous system, finding functional loss in patients with polyneuropathy through the application of various stimuli. Despite technical challenges, preliminary patient data appear promising for potential future clinical applications.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Sofia Meyer Zu Reckendorf, Diana Moser, Anna Blechschmidt, Venkata Neeha Joga, Daniela Sinske, Jutta Hegler, Stefanie Deininger, Alberto Catanese, Sabine Vettorazzi, Gregor Antoniadis, Tobias Boeckers, Bernd Knoell
Summary: In postmitotic neurons, PTEN inhibition is crucial for successful axon regeneration in the central nervous system, but its influence in peripheral neurons is less understood. This study demonstrates that conditional PTEN deletion in mouse facial motoneurons not only induces morphological and physiological changes, but also promotes facial nerve regeneration and recovery after injury, highlighting the dual function of PTEN in neuronal function impairment and axon regeneration.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Xijie Zhou, Jian Du, Liming Qing, Thomas Mee, Xiang Xu, Zhuoran Wang, Cynthia Xu, Xiaofeng Jia
Summary: This study suggests that a combination of ChAT and CGRP is the most reliable method for distinguishing motor and sensory nerve fibers. The mean gray value method was found to be the most accurate for quantifying the expression of nerve markers in immunofluorescence images.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Applied
Yulin Wang, Ya Li, Zhongbing Huang, Bing Yang, Ning Mu, Zhaopu Yang, Min Deng, Xiaoming Liao, Guangfu Yin, Yu Nie, Tunan Chen, Hua Ma
Summary: By constructing gene vectors and nerve scaffolds, successful localized delivery of c-Jun plasmids and upregulation of nerve growth factor expression were achieved, promoting nerve regeneration and functional recovery.
CARBOHYDRATE POLYMERS
(2022)
Article
Immunology
Jiawei Xu, Jinkun Wen, Lanya Fu, Liqiang Liao, Ying Zou, Jiaqi Zhang, Junyao Deng, Haowen Zhang, Jingmin Liu, Xianghai Wang, Daming Zuo, Jiasong Guo
Summary: The depletion of RhoA in macrophages has a negative impact on Wallerian degeneration and nerve regeneration, mainly due to impaired migration and phagocytosis of macrophages resulting from disrupted RhoA/ROCK/MLCK pathway. Since previous research has shown that RhoA inhibition in neurons promotes axonal regeneration, the study highlights the importance of considering cellular specificity of RhoA-targeted drugs in future applications for treating peripheral nerve injuries.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Clinical Neurology
Widya Adidharma, Alexander N. Khouri, Jennifer C. Lee, Kathryn Vanderboll, Theodore A. Kung, Paul S. Cederna, Stephen W. P. Kemp
Summary: Sensory afferent fibers, a crucial component of motor nerves, play a significant role in proprioception and motor control. After peripheral nerve injury, these fibers can reinnervate muscle, even unrelated ones, allowing for cross-innervation. This has important clinical applications in peripheral nerve repair, sensory protection, and prosthetic sensorimotor control.
Article
Engineering, Biomedical
Qingqing Lu, Feng Zhang, Weinan Cheng, Xiang Gao, Zhaozhao Ding, Xiaoyi Zhang, Qiang Lu, David L. Kaplan
Summary: The study utilized modular assembly for fabricating nerve conduits with multifunctional guidance cues, which promoted cell proliferation and growth factor secretion, and demonstrated improved nerve regeneration in both cell and animal experiments for rat sciatic nerve defects.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Yutong Wu, Ying Wang, Zhe Fu, Huiling Sun, Yixiang Liu, Chao Li, Yinglei Wang, Naixin Liu, Yubing Huang, Saige Yin, Kun Guo, Chengan Feng, Jing Tang, Li He, Ying Yang, Xinwang Yang
Summary: Epidermal nerve fiber regeneration and sensory function are impaired in skin wounds of diabetic patients. In this study, localized treatment with the drug candidate RL-QN15 accelerated wound healing in diabetic mice and rats. RL-QN15 also enhanced nerve density, axonal plasticity, and plantar sensitivity in diabetic animals. The therapeutic effects of RL-QN15 were associated with the activation of the PI3K/Akt signaling pathway. This study provides a foundation for the development of RL-QN15 peptide-based therapeutics for diabetic skin wounds.
Article
Engineering, Biomedical
Aouod Agenor, Lucas Dvoracek, Ann Leu, Daniel A. Hunter, Piyaraj Newton, Ying Yan, Philip J. Johnson, Susan E. Mackinnon, Amy M. Moore, Matthew D. Wood
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2017)
Article
Clinical Neurology
Scott J. Farber, Gwendolyn M. Hoben, Daniel A. Hunter, Ying Yan, Philip J. Johnson, Susan E. Mackinnon, Matthew D. Wood
Article
Anesthesiology
Scott J. Farber, Maryam Saheb-Al-Zamani, Lawrence Zieske, Osvaldo Laurido-Soto, Amit Bery, Daniel Hunter, Philip Johnson, Susan E. Mackinnon
ANESTHESIA AND ANALGESIA
(2013)
Article
Biotechnology & Applied Microbiology
Yuewei Wu-Fienberg, Amy M. Moore, Laura M. Marquardt, Piyaraj Newton, Philip J. Johnson, Susan E. Mackinnon, Shelly E. Sakiyama-Elbert, Matthew D. Wood
BIOTECHNOLOGY AND BIOENGINEERING
(2014)
Article
Surgery
P. J. Johnson, M. D. Wood, A. M. Moore, S. E. Mackinnon
EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
(2013)
Article
Neurosciences
Maryam Saheb-Al-Zamani, Ying Yan, Scott J. Farber, Daniel A. Hunter, Piyaraj Newton, Matthew D. Wood, Sheila A. Stewart, Philip J. Johnson, Susan E. Mackinnon
EXPERIMENTAL NEUROLOGY
(2013)
Article
Orthopedics
Scott J. Farber, Simone W. Glaus, Amy M. Moore, Daniel A. Hunter, Susan E. Mackinnon, Philip J. Johnson
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2013)
Article
Biochemical Research Methods
Amy M. Moore, Gregory H. Borschel, Katherine A. Santosa, Eric R. Flagg, Alice Y. Tong, Rahul Kasukurthi, Piyaraj Newton, Ying Yan, Daniel A. Hunter, Philip J. Johnson, Susan E. Mackinnon
JOURNAL OF NEUROSCIENCE METHODS
(2012)
Article
Clinical Neurology
Katherine B. Santosa, Nithya J. Jesuraj, Andreu Viader, Matthew MacEwan, Piyaraj Newton, Daniel A. Hunter, Susan E. Mackinnon, Philip J. Johnson
Article
Clinical Neurology
Nithya J. Jesuraj, Katherine B. Santosa, Matthew R. Macewan, Amy M. Moore, Rahul Kasukurthi, Wilson Z. Ray, Eric R. Flagg, Daniel A. Hunter, Gregory H. Borschel, Philip J. Johnson, Susan E. Mackinnon, Shelly E. Sakiyama-Elbert
Article
Surgery
Ying Yan, Matthew R. MacEwan, Daniel A. Hunter, Scott Farber, Piyaraj Newton, Thomas H. Tung, Susan E. Mackinnon, Philip J. Johnson
PLASTIC AND RECONSTRUCTIVE SURGERY
(2013)
Article
Surgery
Theodore A. Kung, Nicholas B. Langhals, David C. Martin, Philip J. Johnson, Paul S. Cederna, Melanie G. Urbanchek
PLASTIC AND RECONSTRUCTIVE SURGERY
(2014)
Article
Physiology
James P. Hummel, Martin L. Mayse, Steve Dimmer, Philip J. Johnson
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Respiratory System
Arschang Valipour, Martin L. Mayse, Alexander D. Peterson, Philip J. Johnson, Kristina T. Rouw, Sherwin Asadi, James P. Hummel
Article
Respiratory System
Martin L. Mayse, Holly S. Norman, Alexander D. Peterson, Kristina T. Rouw, Philip J. Johnson
RESPIRATORY RESEARCH
(2020)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
