Review
Pharmacology & Pharmacy
Stefania Ceruti
Summary: Progress in pain research has focused on the role of glial cells and purinergic receptors in pain modulation. Understanding the purinergic system's involvement in pain conditions may lead to the development of new and effective analgesics.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nan Yan, Shuai Wang, Haotian Gao, Jiaqi Chen, Jiahui Cao, Pengsheng Wei, Xue Li, Ying Yu, Yan Wang, Yalin Niu, Yijie Wang, Shuyuan Liu, Ge Jin
Summary: Aloe emodin, derived from aloe or rhubarb, has various therapeutic effects including anti-renal fibrosis, anti-atherosclerosis, anti-cancer, and neuroprotective effects in ischemic stroke. In this study, aloe emodin was found to improve motor coordination and attenuate visual recognition impairment in HD R6/1 transgenic mice. It achieved this by inhibiting the phosphorylation of CaMKII and TGF-beta 1/Smad signaling, downregulating mutant huntingtin protein levels, and inhibiting neuronal apoptosis. These findings suggest that aloe emodin may be a potential therapeutic option for HD.
Article
Neurosciences
Marc Espina, Nadia Di Franco, Martina Branas-Navarro, Irene Rodriguez Navarro, Veronica Brito, Laura Lopez-Molina, Carlos Costas-Insua, Manuel Guzman, Silvia Gines
Summary: Increasing evidence suggests that activation of the unfolded protein response (UPR) due to accumulation of misfolded proteins in the endoplasmic reticulum (ER stress) is a key factor in neurodegenerative diseases. In Huntington's disease (HD), disruption of ER-associated degradation pathway and loss of ER protein homeostasis leads to neuronal dysfunction and degeneration. The PERK signaling pathway, in particular, has been found to contribute to memory disturbances and synaptic plasticity deficiencies in HD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Eun Seon Pak, Lak Shin Jeong, Xiyan Hou, Sushil K. Tripathi, Jiyoun Lee, Hunjoo Ha
Summary: The synthesized dual-acting ligand LJ-4459, functioning as an A(2A)AR agonist and an A(3)AR antagonist, exhibits potential in preventing the progression of tubulointerstitial fibrosis. LJ-4459 showed improvements in kidney morphology, reductions in tubular injury markers, and attenuation of fibrosis. Additionally, LJ-4459 inhibited inflammation, oxidative stress, and macrophage infiltration in the obstructed kidney tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Shohei Nishimon, Noriaki Sakai, Seiji Nishino
Summary: Sleep deprivation has negative effects on health, productivity, and performance. This study found that sake yeast can effectively reduce wake time, enhance REM and NREM sleep, and may induce sleep through activation of the adenosine A(2A) receptor. Further research is needed to verify the role of adenosine in the pathophysiology of insomnia.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Melissa Talita Wiprich, Carla Denise Bonan
Summary: Huntington's disease is a devastating neurodegenerative disorder characterized by motor dysfunction, psychiatric disturbance, and cognitive decline. Purinergic signaling, particularly involving adenosine A(2A) receptors, plays a significant role in the pathophysiology of HD, offering potential pharmacological targets and biomarkers for this disorder.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Immunology
Deiziane V. S. Costa, Jae H. Shin, Sophia M. Goldbeck, David T. Bolick, Flavio S. Mesquita, Andrea V. Loureiro, Monica J. Rodrigues-Jesus, Gerly A. C. Brito, Cirle A. Warren
Summary: Increased risk of intestinal dysfunction has been reported in patients after Clostridioides difficile infection (CDI). Enteric glial cells (EGCs), a component of the enteric nervous system (ENS), contribute to gut homeostasis. Previous studies showed that adenosine receptors, A2A and A2B, modulate inflammation during CDI.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Thu Hang Lai, Susann Schroeder, Magali Toussaint, Sladjana Dukic-Stefanovic, Mathias Kranz, Friedrich-Alexander Ludwig, Steffen Fischer, Joerg Steinbach, Winnie Deuther-Conrad, Peter Brust, Rares-Petru Moldovan
Summary: This study demonstrated the metabolic stability and specific binding of two fluorinated analogs as PET tracers in the brains of mice, with in vivo PET/MRI studies in CD-1 mice showing high initial brain uptake and rapid clearance for both radiotracers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Brandon M. Fritz, Fuqin Yin, Brady K. Atwood
Summary: The medial and lateral dorsal striatum play different roles in driving goal-directed and habitual/compulsive behaviors, respectively. Adenosine A(1) receptors in the dorsal striatum regulate excitatory glutamate transmission, potentially influencing striatally-mediated behaviors. The study found that activation of presynaptic A1Rs led to synaptic depression in both DLS and DMS, suggesting a potential role of A1Rs in neuropsychiatric diseases.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Daniel Guendel, Thu Hang Lai, Sladjana Dukic-Stefanovic, Rodrigo Teodoro, Winnie Deuther-Conrad, Magali Toussaint, Klaus Kopka, Rares-Petru Moldovan, Peter Boknik, Britt Hofmann, Ulrich Gergs, Joachim Neumann, Peter Brust
Summary: This study aims to investigate the potential use of the PET radiotracer [F-18]FLUDA for non-invasive assessment of A(2A)-AR as a marker for cardiac pathologies. The results show that [F-18]FLUDA exhibits high specific binding to A(2A)-AR and can be used for non-invasive diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lan -Ting Zhou, Dan Liu, Hui-Cong Kang, Lu Lu, He-Zhou Huang, Wen-Qing Ai, Yang Zhou, Man-Fei Deng, Hao Li, Zhi-Qiang Liu, Wei-Feng Zhang, Ya-Zhuo Hu, Zhi-Tao Han, Hong -Hong Zhang, Jian-Jun Jia, Avijite Kumer Sarkar, Saldin Sharaydeh, Jie Wang, Heng-Ye Man, Marcel Schilling, Lars Bertram, Youming Lu, Ziyuan Guo, Ling-Qiang Zhu
Summary: In this study, it was found that excessive expression of adenosine receptor 1 (A1R) in neurons is dependent on tau pathology and regulated posttranscriptionally by Mef2c via miR-133a-3p. Restoring the miR-133a-3p/A1R signal effectively improved synaptic and memory impairments in Alzheimer's disease (AD) mice. Additionally, neuronal A1R promoted the release of lipocalin 2 (Lcn2) and resulted in astrocyte activation. Silencing neuronal Lcn2 in AD mice ameliorated astrocyte activation and restored synaptic plasticity and learning/memory. These findings demonstrate the remodeling of neuron-glial cross-talk by tau pathology and suggest A1R as a potential therapeutic target for AD.
Review
Neurosciences
Ana Moreira-de-Sa, Vanessa S. Lourenco, Paula M. Canas, Rodrigo A. Cunha
Summary: Extracellular adenosine serves as a paracrine signal of cellular effort produced during increased metabolic activity or stress. Adenosine receptors, particularly A(2A) receptors, play a significant role in promoting physiological changes in brain function. Overactivation of A(2A) receptors may contribute to synaptic and neuronal damage, and could be an early indicator of brain disease progression.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Mafalda Campeao, Luciana Fernandes, Ines R. Pita, Cristina Lemos, Syed F. Ali, Felix Carvalho, Paulo Rodrigues-Santos, Carlos A. Fontes-Ribeiro, Edna Soares, Sofia D. Viana, Frederico C. Pereira
Summary: This study found that binge exposure to MDPV did not result in evident changes in behavior, neurochemistry, and glial cells compared to METH. Further profiling of MDPV's neuropharmacological profile at different time-points, regimens, and brain regions is needed.
Article
Pharmacology & Pharmacy
Kyoji Okita, Toshihiko Matsumoto, Daisuke Funada, Maki Murakami, Koichi Kato, Yoko Shigemoto, Noriko Sato, Hiroshi Matsuda
Summary: This study aims to assess the effect of the selective A2A receptor antagonist, istradefylline, on D2-type BPND in the striatum and neuroinflammation in the whole brain of individuals with methamphetamine use disorder. The hypotheses are that istradefylline will increase striatal D2-type BPND and attenuate neuroinflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Tristano Pancani, Michelle Day, Tatiana Tkatch, David L. L. Wokosin, Patricia Gonzalez-Rodriguez, Jyothisri Kondapalli, Zhong Xie, Yu Chen, Vahri Beaumont, D. James Surmeier
Summary: Using a mouse model of Huntington's disease, the authors found increased connectivity in the corticostriatal pathway due to deficient cholinergic transmission. Lowering mutant huntingtin specifically in striatal cholinergic interneurons normalized the connectivity, providing evidence for a key node in the network underlying corticostriatal pathophysiology in Huntington's disease.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Xavier Guitart, Jordi Bonaventura, William Rea, Marco Orru, Lucrezia Cellai, Ilaria Dettori, Felicita Pedata, Marc Brugarolas, Antonio Cortes, Vicent Casado, Ching-Pang Chang, Manikandan Narayanan, Yijuang Chern, Sergi Ferre
NEUROBIOLOGY OF DISEASE
(2016)
Review
Neurosciences
Felicita Pedata, Ilaria Dettori, Elisabetta Coppi, Alessia Melani, Irene Fusco, Renato Corradetti, Anna Maria Pugliese
Article
Chemistry, Medicinal
Daniela Poli, Matteo Falsini, Flavia Varano, Marco Betti, Katia Varani, Fabrizio Vincenzi, Anna Maria Pugliese, Felicita Pedata, Diego Dal Ben, Ajiroghene Thomas, Ilaria Palchetti, Francesca Bettazzi, Daniela Catarzi, Vittoria Colotta
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Geriatrics & Gerontology
Daniele Lana, Filippo Ugolini, Alessia Melani, Daniele Nosi, Felicita Pedata, Maria Grazia Giovannini
EXPERIMENTAL GERONTOLOGY
(2017)
Editorial Material
Biochemistry & Molecular Biology
Felicita Pedata
PURINERGIC SIGNALLING
(2017)
Article
Pharmacology & Pharmacy
Irene Fusco, Filippo Ugolini, Daniele Lana, Elisabetta Coppi, Ilaria Dettori, Lisa Gaviano, Daniele Nosi, Federica Cherchi, Felicita Pedata, Maria G. Giovannini, Anna M. Pugliese
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Ilaria Dettori, Lisa Gaviano, Alessia Melani, Laura Lucarini, Mariaconcetta Durante, Emanuela Masini, Felicita Pedata
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Anesthesiology
Elisabetta Coppi, Federica Cherchi, Irene Fusco, Paola Failli, Alessia Vona, Ilaria Dettori, Lisa Gaviano, Elena Lucarini, Kenneth A. Jacobson, Dilip K. Tosh, Daniela Salvemini, Carla Ghelardini, Felicita Pedata, Lorenzo Di Cesare Mannelli, Anna Maria Pugliese
Article
Neurosciences
Irene Fusco, Federica Cherchi, Daniela Catarzi, Vittoria Colotta, Flavia Varano, Felicita Pedata, Anna Maria Pugliese, Elisabetta Coppi
BRAIN RESEARCH BULLETIN
(2019)
Article
Anesthesiology
Elena Lucarini, Elisabetta Coppi, Laura Micheli, Carmen Parisio, Alessia Vona, Federica Cherchi, Anna M. Pugliese, Felicita Pedata, Paola Failli, Seph Palomino, Jared Wahl, Tally M. Largent-Milnes, Todd W. Vanderah, Dilip K. Tosh, Kenneth A. Jacobson, Daniela Salvemini, Carla Ghelardini, Lorenzo Di Cesare Mannelli
Article
Pharmacology & Pharmacy
Elisabetta Coppi, Federica Cherchi, Irene Fusco, Ilaria Dettori, Lisa Gaviano, Giada Magni, Daniela Catarzi, Vittoria Colotta, Flavia Varano, Francesca Rossi, Caterina Bernacchioni, Chiara Donati, Paola Bruni, Felicita Pedata, Francesca Cencetti, Anna Maria Pugliese
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Elisabetta Coppi, Federica Cherchi, Erica Sarchielli, Irene Fusco, Giulia Guarnieri, Pasquale Gallina, Renato Corradetti, Felicita Pedata, Gabriella B. Vannelli, Anna Maria Pugliese, Annamaria Morelli
Summary: This study characterized cholinergic effects in human NBM neurons, showing that acetylcholine can modulate ion channels by enhancing K currents, reducing Na currents, and activating different receptors. Spontaneous acetylcholine release from neuroblasts in the human fetal NBM may play a key role in brain development.
JOURNAL OF NEUROCHEMISTRY
(2021)
Proceedings Paper
Engineering, Biomedical
Giada Magni, Martina Banchelli, Federica Cherchi, Elisabetta Coppi, Marco Fraccalvieri, Anna Maria Pugliese, Felicita Pedata, Antongiulio Mangia, Stefano Gasperini, Francesco S. Pavone, Duccio Rossi Degl'Innocenti, Lorenzo Targetti, Roberto Pini, Paolo Matteini, Francesca Rossi
MEDICAL LASER APPLICATIONS AND LASER-TISSUE INTERACTIONS IX
(2019)
Proceedings Paper
Biophysics
Giada Magni, Federica Cherchi, Elisabetta Coppi, Marco Fraccalvieri, Francesca Tatini, Irene Fusco, Roberto Pini, Anna Maria Pugliese, Felicita Pedata, Antongiulio Mangia, Stefano Gasperini, Francesco S. Pavone, Duccio Rossi Degl'Innocenti, Cristina Tripodi, Domenico Alfier, Lorenzo Targetti, Francesca Rossi
MECHANISMS OF PHOTOBIOMODULATION THERAPY XIV
(2019)
Proceedings Paper
Engineering, Biomedical
Giada Magni, Francesca Rossi, Francesca Tatini, Roberto Pini, Elisabetta Coppi, Federica Cherchi, Irene Fusco, Anna Maria Pugliese, Felicita Pedata, Marco Fraccalvieri, Stefano Gasperini, Francesco S. Pavone, Cristina Tripodi, Domenico Alfieri, Lorenzo Targetti
MECHANISMS OF PHOTOBIOMODULATION THERAPY XIII
(2018)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
