Article
Pharmacology & Pharmacy
Tao Wang, Yunran Zhang, Meiling Chi, Chen Zhao, Linlin Cao, Chutong Tian, K. Kamei, Ying Zheng, Qikun Jiang
Summary: Currently, the commercial fixed combination therapy for glaucoma has various problems, while the once-daily fixed-combination timolol-netarsudil-latanoprost ophthalmic solution (FC-TNL) offers great efficacy and patient compliance. By using a homologous salt engineering strategy and studying the drug morphology, the prepared FC-TNL demonstrated good stability, no influence on intraocular penetration, and potent effects on lowering intraocular pressure and protecting retinal ganglion cells.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Rosalia Moreddu, Nasim Mahmoodi, Panagiotis Kassanos, Daniele Vigolo, Paula M. Mendes, Ali K. Yetisen
Summary: Intraocular pressure is a crucial physiological parameter in ocular health, but its variability can lead to measurement errors. Developing portable solutions for continuous monitoring the IOP is a critical goal in ophthalmology.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Ophthalmology
Yangfan Yang, Xinyi Zhang, Zidong Chen, Yifan Wei, Qiaona Ye, Yanmei Fan, Neil Nathwani, Gus Gazzard, Minbin Yu
Summary: This study aimed to report the baseline characteristics and diurnal fluctuation of intraocular pressure (IOP) in a Chinese cohort of patients with glaucoma and ocular hypertension. The results showed that younger age, male gender, and thicker central corneal thickness were correlated with higher IOP in patients with primary open-angle glaucoma, while only thicker central corneal thickness was related to higher IOP in patients with ocular hypertension. Peak IOP occurred mostly in the early morning or late afternoon, and trough IOP occurred mostly in the early afternoon.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, Research & Experimental
Makoto Araie, Kazuhisa Sugiyama, Kenji Aso, Koji Kanemoto, Kalyani Kothapalli, Casey Kopczynski, Michelle Senchyna, David A. Hollander
Summary: Netarsudil ophthalmic solutions at concentrations of 0.01%, 0.02%, and 0.04% administered once daily in the evening demonstrated superiority to placebo in terms of hypotensive effectiveness at week 4, showing statistically significant reductions in mean diurnal IOP compared to the placebo group. Adverse events occurred in a concentration-dependent manner, with conjunctival hyperemia being the most frequently reported AE. Overall, netarsudil at the 0.02% concentration provided optimal efficacy and safety for Japanese patients with POAG or OHT.
ADVANCES IN THERAPY
(2021)
Article
Ophthalmology
Peizeng Yang, Chaokui Wang, Guannan Su, Su Pan, Yang Qin, Jun Zhang, Qingfeng Cao, Zhenyu Zhong, Chunjiang Zhou, Yao Wang, Aize Kijlstra
Summary: This study examined the prevalence, risk factors, and treatment outcomes of OHT/glaucoma in Chinese patients with VKH. Risk factors included poorer visual acuity, longer intervals between uveitis attacks and referral, more recurrent episodes, and posterior synechiae. Medical treatment and surgical interventions were effective in achieving normalized intraocular pressure in affected eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Wungrak Choi, Hyoung Won Bae, Hye Jung Shin, Eun Woo Kim, Chan Yun Kim, Min Kim, Gong Je Seong
Summary: This study developed two nomograms to predict a safety zone for intravitreal DEX implantation. These can be used to identify individuals who may be safely prescribed steroid treatments and for whom extra caution should be exercised.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Medicine, General & Internal
Michal Krzysztofik, Dorota Zygadlo, Paulina Trybek, Jakub Jarosz, Adam Zajac, Nicholas Rolnick, Michal Wilk
Summary: Resistance training may be harmful to patients with or at risk of glaucoma, thus combining it with blood flow restriction may be a solution. While BFR holds potential for improving fitness, there is limited research on its safety regarding ocular health.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Cynthia L. Pervan-Steel, Uttio Roy Chowdhury, Hemchand K. Sookdeo, Ralph A. Casale, Peter I. Dosa, Thurein M. Htoo, Michael P. Fautsch, Barbara M. Wirostko
Summary: The study characterized the ocular hypotensive and pharmacological properties of QLS-101, a novel ATP-sensitive potassium channel opening prodrug. Results showed that QLS-101 lowered intraocular pressure (IOP) in mice, with a sustained effect when administered topically. The conversion of QLS-101 to levcromakalim, its active form, was also confirmed.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Xinghuai Sun, Ke Yao, Qinghuai Liu, Hong Zhang, Xiaoli Xing, Aiwu Fang, Xuanchu Duan, Minbin Yu, Michelle Y. Chen, Jingyuan Yang, Margot L. Goodkin
Summary: This study evaluated the safety of using fixed-combination bimatoprost/timolol ophthalmic solution for the treatment of Chinese patients with open-angle glaucoma or ocular hypertension. The results showed that this treatment was safe and well-tolerated.
OPHTHALMOLOGY AND THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Binze Han, Maomao Song, Liping Li, Xinghuai Sun, Yuan Lei
Summary: Despite various therapeutic methods for ocular hypertension and glaucoma, lowering intraocular pressure remains the most effective way to slow disease progression and prevent blindness. Only a couple of ocular hypotensive drugs act on the conventional outflow system, which is the main pathway for aqueous humor outflow and the major lesion site causing ocular hypertension.
Article
Chemistry, Multidisciplinary
Yousef Alqurashi, Mohamed Elsherif, Rosalia Moreddu, Magdalena Cieslak, Hemeth Dhaliwal, Khamis Essa, Haider Butt
Summary: Glaucoma is a leading cause of irreversible blindness, and intraocular pressure (IOP) is the most important biomarker for its diagnosis and monitoring. Current IOP monitoring techniques are invasive and inconvenient, while laser-processed contact lenses offer a potential solution for continuous and non-invasive monitoring of IOP variations.
APPLIED SCIENCES-BASEL
(2022)
Review
Pharmacology & Pharmacy
Phatsawee Jansook, Hay Marn Hnin, Thorsteinn Loftsson, Einar Stefansson
Summary: This article discusses the use of carbonic anhydrase inhibitors to lower intraocular pressure in patients with glaucoma, and explores the enhancement of drug solubility and permeability using cyclodextrin complexes. It also examines the development of drugs targeting specific CA isoenzymes in ocular tissues and the potential of pharmaceutical nanotechnology platforms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Nadia Toffoletto, Benilde Saramago, Ana Paula Serro
Summary: The increasing incidence of eye diseases in developed countries is attributed to aging population and changes in lifestyle. Drug-eluting ophthalmic lenses offer a non-invasive and patient-friendly approach for sustained drug delivery to the eye, showing promising results in the treatment of eye pathologies.
Article
Medicine, General & Internal
Silvia Mendez-Martinez, Teresa Martinez-Rincon, Manuel Subias, Luis E. Pablo, David Garcia-Herranz, Julian Garcia Feijoo, Irene Bravo-Osuna, Rocio Herrero-Vanrell, Elena Garcia-Martin, Maria J. Rodrigo
Summary: The study demonstrates that chronic ocular hypertension can accelerate the development of slowly progressive myopia in Long-Evans rat eyes, accompanied by an initial increase in eye structure and function that later reverses.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Tao Wang, Linlin Cao, Qikun Jiang, Tianhong Zhang
Summary: Glaucoma is a common cause of blindness, and topical medical therapy is the preferred treatment method. Fixed-combination therapeutics offer greater efficacy and safety compared to non-fixed combination agents and monotherapy. New trends in fixed combinations of medications may provide better control of intraocular pressure and treatment of glaucoma.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Alicia Arranz-Romera, Maria Hernandez, Patricia Checa-Casalengua, Alfredo Garcia-Layana, Irene T. Molina-Martinez, Sergio Recalde, Michael J. Young, Budd A. Tucker, Rocio Herrero-Vanrell, Patricia Fernandez-Robredo, Irene Bravo-Osuna
Summary: The study evaluated the sustained delivery effect of PLGA/VitE microspheres loaded with neurotrophic factors on the migration of retinal cells and the survival of RGCs, demonstrating a positive impact on RPE cell migration and high cell viability in vitro.
Article
Pharmacology & Pharmacy
Deyanira Barbosa-Alfaro, Vanessa Andres-Guerrero, Ivan Fernandez-Bueno, Maria Teresa Garcia-Gutierrez, Esther Gil-Alegre, Irene Teresa Molina-Martinez, Jose Carlos Pastor-Jimeno, Rocio Herrero-Vanrell, Irene Bravo-Osuna
Summary: In this study, dexamethasone-loaded PLGA microspheres were successfully prepared and showed sustained release in vitro and good ocular tolerance in vivo. This provides a promising alternative for treating chronic diseases of the posterior segment of the eye.
Article
Pharmacology & Pharmacy
Jose Javier Lopez-Cano, A. Sigen, Vanessa Andres-Guerrero, Hongyun Tai, Irene Bravo-Osuna, Irene Teresa Molina-Martinez, Wenxin Wang, Rocio Herrero-Vanrell
Summary: This study aimed to develop a thermo-responsive-injectable hydrogel based on PLGA-PEG-PLGA to deliver neuroprotective agents to the retina over time. Two PLGA-PEG PLGA copolymers with different ratios were synthesized and characterized, and HyG-1 was selected for further studies and loaded with anti-inflammatory drugs and antioxidants. In vitro drug release and cytotoxicity studies were performed, showing sustained release of drugs and good tolerance in retinal cells. The developed hydrogels represent a novel biodegradable tool for treating neurodegenerative processes in the retina.
Article
Pharmacology & Pharmacy
Vanessa Andres-Guerrero, Irene Camacho-Bosca, Liseth Salazar-Quinones, Nestor Ventura-Abreu, Mercedes Molero-Senosiain, Samuel Hernandez-Ruiz, Guillermo Bernal-Sancho, Rocio Herrero-Vanrell, Julian Garcia-Feijoo
Summary: The local delivery of bevacizumab combined with sodium hyaluronate and a collagen matrix can improve the outcome of trabeculectomy by reducing inflammation and cell infiltration, and increasing the survival rate of filtering blebs.
Article
Biochemistry & Molecular Biology
Maria Jesus Rodrigo, David Garcia-Herranz, Manuel Subias, Teresa Martinez-Rincon, Silvia Mendez-Martinez, Irene Bravo-Osuna, Ana Carretero, Jesus Ruberte, Julian Garcia-Feijoo, Luis Emilio Pablo, Rocio Herrero-Vanrell, Elena Garcia-Martin
Summary: Comparing two prolonged animal models of glaucoma over 24 weeks, both showed progressive neuroretinal degeneration, with the Ms20/10 model exhibiting a more rapid increase in intraocular pressure and better preservation of ocular surface. Although differences were observed in structural and functional aspects between the two models, both have value for studying glaucoma pathology.
Article
Ophthalmology
J. J. Lopez-Cano, M. A. Gonzalez-Cela-Casamayor, V Andres-Guerrero, R. Herrero-Vanrell, J. M. Benitez-Del-Castillo, I. T. Molina-Martinez
Summary: This study investigated the effects of different osmolarities and ophthalmic therapeutic substances in human corneal epithelial cells and mouse macrophages. Results showed that Betaine, L-Carnitine, and Taurine can improve cell survival, while Hyaluronic acid is the most effective polymer in preventing cell death.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marc Labetoulle, Jose Manuel Benitez-del-Castillo, Stefano Barabino, Rocio Herrero Vanrell, Philippe Daull, Jean-Sebastien Garrigue, Maurizio Rolando
Summary: This review describes the main categories of ingredients in tear substitutes and their effects on the ocular surface. It also provides insights into how to select the appropriate tear substitute formulations based on the predominant causes of dry eye disease (DED).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Marco Brugnera, Marta Vicario-de-la-Torre, Vanessa Andres-Guerrero, Irene Bravo-Osuna, Irene Teresa Molina-Martinez, Rocio Herrero-Vanrell
Summary: This paper discusses the development and validation of a rapid method for the quantification of two neuroprotective agents in biodegradable PLGA microspheres. The method allows for the simultaneous determination of the two agents and has potential value in the treatment of glaucoma.
Article
Biochemistry & Molecular Biology
Maria Jesus Rodrigo, Manuel Subias, Alberto Montolio, Silvia Mendez-Martinez, Teresa Martinez-Rincon, Lorena Arias, David Garcia-Herranz, Irene Bravo-Osuna, Julian Garcia-Feijoo, Luis Pablo, Jose Cegonino, Rocio Herrero-Vanrell, Ana Carretero, Jesus Ruberte, Elena Garcia-Martin, Amaya Perez del Palomar
Summary: This study monitors vitreous parainflammation in two animal models of glaucoma, comparing both healthy controls and sexes over six months. Computational analysis characterizes in vivo the hyperreflective opacities, identified histologically as hyalocyte-like Iba-1+ (microglial marker) cells. Glaucomatous eyes showed greater intensity and number of vitreous opacities as well as dynamic fluctuations in the percentage of activated cells (50-250 microns(2)) vs. non-activated cells (10-50 microns(2)), isolated cells (10 microns(2)) and complexes (>250 microns(2)).
Article
Ophthalmology
Assumpta Peral, Jesus Mateo, Carmen O. Dominguez-Godinez, Gonzalo Carracedo, Jose Antonio Gomez, Almudena Crooke, Jesus Pintor
Summary: This study tested the efficacy of using siRNAs to silence HIF-1 alpha and demonstrated that it can effectively stop neovascularization. The results showed that siRNA targeting HIF-1 alpha can reduce the generation of new blood vessels in a corneal burn model.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Miriam Ana Gonzalez-Cela-Casamayor, Jose Javier Lopez-Cano, Irene Bravo-Osuna, Vanessa Andres-Guerrero, Marta Vicario-de-la-Torre, Manuel Guzman-Navarro, Jose Manuel Benitez-del-Castillo, Rocio Herrero-Vanrell, Irene Teresa Molina-Martinez
Summary: Glaucoma, a chronic irreversible neuropathy affecting the retina and optic nerve, is a major cause of blindness worldwide. Elevated intraocular pressure is a modifiable risk factor, and antihypertensive formulations are commonly used for treatment. However, frequent instillation of these formulations can lead to dry eye disease. In this study, liposome formulations loaded with brimonidine or travoprost, enriched with osmoprotective compounds, were developed. These formulations exhibited suitable physicochemical characteristics and encapsulation efficiency for ocular surface administration. They also showed good tolerability and osmoprotective activity in cell cultures. In animal experiments, the liposomal formulations demonstrated faster and longer-lasting reduction of intraocular pressure compared to commercial control products. Overall, the liposomal formulations combined with osmoprotective agents present a promising platform for the treatment of glaucoma and protection of the ocular surface.
Article
Ophthalmology
Elena Diz-Arias, Elena Fernandez-Jimenez, Assumpta Peral, Jose A. Gomez-Pedrero
Summary: This study analyzed the instrumental factors related to Meibomian gland contrast and assessed whether the equations used to compute contrast impact the ability to identify abnormal individuals. The results showed that Meibomian gland contrast is a useful biomarker of disease related to the glands, and contrast measurement should be determined using contrast-enhanced images. However, the method used to compute contrast did not influence the results.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)