A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative Retinal Pathologies
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative Retinal Pathologies
Authors
Keywords
-
Journal
Pharmaceuticals
Volume 14, Issue 1, Pages 50
Publisher
MDPI AG
Online
2021-01-12
DOI
10.3390/ph14010050
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Simultaneous co-delivery of neuroprotective drugs from multi-loaded PLGA microspheres for the treatment of glaucoma
- (2019) A. Arranz-Romera et al. JOURNAL OF CONTROLLED RELEASE
- Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation
- (2019) Mária Szatmári-Tóth et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Combination therapy and co-delivery strategies to optimize treatment of posterior segment neurodegenerative diseases
- (2019) Alicia Arranz-Romera et al. DRUG DISCOVERY TODAY
- Undertreatment of Neovascular Age-Related Macular Degeneration after 10 Years of Anti-Vascular Endothelial Growth Factor Therapy in the Real World: The Need for A Change of Mindset
- (2019) Jordi Monés et al. OPHTHALMOLOGICA
- Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization
- (2019) Maria Hernandez et al. Molecular Therapy-Methods & Clinical Development
- Microspheres as intraocular therapeutic tools in chronic diseases of the optic nerve and retina
- (2018) Irene Bravo-Osuna et al. ADVANCED DRUG DELIVERY REVIEWS
- Cellular regeneration strategies for macular degeneration: past, present and future
- (2018) Valeria Chichagova et al. EYE
- Six month delivery of GDNF from PLGA/vitamin E biodegradable microspheres after intravitreal injection in rabbits
- (2017) Cristina García-Caballero et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Current drug and molecular therapies for the treatment of atrophic age-related macular degeneration: phase I to phase III clinical development
- (2017) Huiling Li et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells
- (2017) Yanyan Li et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Dual Antagonism of PDGF and VEGF in Neovascular Age-Related Macular Degeneration
- (2017) Glenn J. Jaffe et al. OPHTHALMOLOGY
- Prevalence of Age-Related Macular Degeneration in Europe
- (2017) Johanna M. Colijn et al. OPHTHALMOLOGY
- Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis
- (2017) Seth R Flaxman et al. Lancet Global Health
- Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery
- (2017) Laura Garcia-Garcia et al. Molecular Therapy-Nucleic Acids
- Co-delivery of chemotherapeutics and proteins for synergistic therapy
- (2016) Chaoliang He et al. ADVANCED DRUG DELIVERY REVIEWS
- Single- and repeated-dose toxicity study of bevacizumab, ranibizumab, and aflibercept in ARPE-19 cells under normal and oxidative stress conditions
- (2016) Manuel Saenz-de-Viteri et al. BIOCHEMICAL PHARMACOLOGY
- Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo
- (2016) Daniel Santos et al. BRAIN RESEARCH
- Pharmaceutical microscale and nanoscale approaches for efficient treatment of ocular diseases
- (2016) I. Bravo-Osuna et al. Drug Delivery and Translational Research
- Functional regeneration of the transected recurrent laryngeal nerve using a collagen scaffold loaded with laminin and laminin-binding BDNF and GDNF
- (2016) Baoxin Wang et al. Scientific Reports
- Progression of Retinal Pigment Epithelial Atrophy in Antiangiogenic Therapy of Neovascular Age-Related Macular Degeneration
- (2015) Christopher Schütze et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Low blood and vitreal BDNF, LXA4 and altered Th1/Th2 cytokine balance are potential risk factors for diabetic retinopathy
- (2015) Kuppan Kaviarasan et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Sodium iodate induced retinal degeneration: new insights from an old model
- (2015) DavidR Hinton et al. Neural Regeneration Research
- Anti-vascular endothelial growth factor therapies in ophthalmology: current use, controversies and the future
- (2014) Tsong Qiang Kwong et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Effects of aflibercept on primary RPE cells: toxicity, wound healing, uptake and phagocytosis
- (2014) Alexa Klettner et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Safety evaluation of poly(lactic-co-glycolic acid)/poly(lactic-acid) microspheres through intravitreal injection in rabbits
- (2014) Xianfang Rong et al. International Journal of Nanomedicine
- Three-Year Outcomes of Individualized Ranibizumab Treatment in Patients with Diabetic Macular Edema
- (2014) Ursula Schmidt-Erfurth et al. OPHTHALMOLOGY
- The potential of using biodegradable microspheres in retinal diseases and other intraocular pathologies
- (2014) Rocío Herrero-Vanrell et al. PROGRESS IN RETINAL AND EYE RESEARCH
- EXACERBATION OF CHOROIDAL AND RETINAL PIGMENT EPITHELIAL ATROPHY AFTER ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
- (2014) Mei Young et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Mechanism of Retinal Pigment Epithelium Tear Formation Following Intravitreal Anti–Vascular Endothelial Growth Factor Therapy Revealed by Spectral-Domain Optical Coherence Tomography
- (2013) Aaron Nagiel et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: An insight into the role of glial cells in retinal repair
- (2013) Anna Machalińska et al. EXPERIMENTAL EYE RESEARCH
- Mechanisms of age-related macular degeneration and therapeutic opportunities
- (2013) Menno van Lookeren Campagne et al. JOURNAL OF PATHOLOGY
- Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial
- (2013) Usha Chakravarthy et al. LANCET
- Seven new loci associated with age-related macular degeneration
- (2013) Lars G Fritsche et al. NATURE GENETICS
- Long-term Outcomes in Patients with Retinal Vein Occlusion Treated with Ranibizumab
- (2013) Peter A. Campochiaro et al. OPHTHALMOLOGY
- Preservation of biological activity of glial cell line-derived neurotrophic factor (GDNF) after microencapsulation and sterilization by gamma irradiation
- (2012) P. Checa-Casalengua et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- One-Year Outcomes of the DA VINCI Study of VEGF Trap-Eye in Eyes with Diabetic Macular Edema
- (2012) Diana V. Do et al. OPHTHALMOLOGY
- Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration
- (2012) Daniel F. Martin et al. OPHTHALMOLOGY
- RETINAL PIGMENT EPITHELIAL ATROPHY IN PATIENTS WITH EXUDATIVE AGE-RELATED MACULAR DEGENERATION UNDERGOING ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY
- (2012) Noemi Lois et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure
- (2011) Patricia Checa-Casalengua et al. JOURNAL OF CONTROLLED RELEASE
- Protein Instability and Immunogenicity: Roadblocks to Clinical Application of Injectable Protein Delivery Systems for Sustained Release
- (2011) Wim Jiskoot et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Mature Peripheral RPE Cells Have an Intrinsic Capacity to Proliferate; A Potential Regulatory Mechanism for Age-Related Cell Loss
- (2011) Ioannis Kokkinopoulos et al. PLoS One
- Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration
- (2011) K. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Abdominal obesity and other risk factors largely explain the high CRP in Indigenous Australians relative to the general population, but not gender differences: a cross-sectional study
- (2010) Allison M Hodge et al. BMC PUBLIC HEALTH
- PEDF in Angiogenic Eye Diseases
- (2010) J. Tombran-Tink CURRENT MOLECULAR MEDICINE
- Delivery of Therapeutic Proteins
- (2010) Dipak S. Pisal et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way
- (2009) Peter Carmeliet et al. Nature Reviews Clinical Oncology
- Development of Laser-Induced Choroidal Neovascularization in Rats after Retinal Damage by Sodium Iodate Injection
- (2009) Alfredo García-Layana et al. OPHTHALMIC RESEARCH
- Introduction: Understanding the Role of Angiogenesis and Antiangiogenic Agents in Age-Related Macular Degeneration
- (2009) Susan B. Bressler OPHTHALMOLOGY
- Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: Implications for glaucoma
- (2009) A. Lambiase et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antioxidant effects of vitamins C and E, multivitamin-mineral complex and flavonoids in a model of retinal oxidative stress: The ApoE-deficient mouse
- (2008) Luis M. Sádaba et al. EXPERIMENTAL EYE RESEARCH
- Controlled release carrier of BSA made by W/O/W emulsion method containing PLGA and hydroxyapatite
- (2008) Mei Ling Ho et al. JOURNAL OF CONTROLLED RELEASE
- Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors
- (2008) Magali Saint-Geniez et al. PLoS One
- Therapeutic monoclonal antibodies in ophthalmology
- (2008) Eduardo B. Rodrigues et al. PROGRESS IN RETINAL AND EYE RESEARCH
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started