More than just a filler - the role of hyaluronan for skin homeostasis

Hyaluronan uptake by adult human skin fibroblasts in vitro

(2015) MA Croce et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Hyperglycemia, intracellular hyaluronan synthesis, cyclin D3 and autophagy

(2014) Aimin Wang et al.   Autophagy

Low Molecular Weight Hyaluronic Acid Increases the Self-Defense of Skin Epithelium by Induction of  -Defensin 2 via TLR2 and TLR4

(2014) S. Gariboldi et al.   JOURNAL OF IMMUNOLOGY

Artificial extracellular matrix composed of collagen I and highly sulfated hyaluronan interferes with TGFβ1 signaling and prevents TGFβ1-induced myofibroblast differentiation

(2013) Anja van der Smissen et al.   Acta Biomaterialia

Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat

(2013) H. Siiskonen et al.   EXPERIMENTAL CELL RESEARCH

Altered expression of hyaluronan synthase and hyaluronidase mRNA may affect hyaluronic acid distribution in keloid disease compared with normal skin

(2013) Gary P. Sidgwick et al.   EXPERIMENTAL DERMATOLOGY

Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan SynthasesHas1–3Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling

(2013) Leena Rauhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan Synthase 1 (HAS1) Requires Higher Cellular UDP-GlcNAc Concentration than HAS2 and HAS3

(2013) Kirsi Rilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-10 regulates the fetal hyaluronan-rich extracellular matrix via a STAT3-dependent mechanism

(2013) Alice King et al.   JOURNAL OF SURGICAL RESEARCH

Prevention of Anti-microbial Peptide LL-37-Induced Apoptosis and ATP Release in the Urinary Bladder by a Modified Glycosaminoglycan

(2013) Won Yong Lee et al.   PLoS One

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

(2013) H. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artificial extracellular matrices composed of collagen I and high-sulfated hyaluronan promote phenotypic and functional modulation of human pro-inflammatory M1 macrophages

(2012) Sandra Franz et al.   Acta Biomaterialia

Long Pentraxin 3/Tumor Necrosis Factor-Stimulated Gene-6 Interaction

(2012) Daria Leali et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The anti-ageing potential of a new jasmonic acid derivative (LR2412): in vitro evaluation using reconstructed epidermis episkin™

(2012) Jean F. Michelet et al.   EXPERIMENTAL DERMATOLOGY

Hyaluronan in cytosol--Microinjection-based probing of its existence and suggested functions

(2012) H. Siiskonen et al.   GLYCOBIOLOGY

Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling

(2012) Sanna Pasonen-Seppänen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Engineering a clinically-useful matrix for cell therapy

(2012) Glenn D. Prestwich   Organogenesis

Hyaluronan minimizes effects of UV irradiation on human keratinocytes

(2011) Martina Hašová et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Bioactive tetrapeptide GEKG boosts extracellular matrix formation: in vitro and in vivo molecular and clinical proof

(2011) Mike Farwick et al.   EXPERIMENTAL DERMATOLOGY

Hyaluronan matrices in pathobiological processes

(2011) Aimin Wang et al.   FEBS Journal

Transcriptional and post-translational regulation of hyaluronan synthesis

(2011) Raija H. Tammi et al.   FEBS Journal

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium

(2011) Kirsi Rilla et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Collagen Fragments Inhibit Hyaluronan Synthesis in Skin Fibroblasts in Response to Ultraviolet B (UVB)

(2011) Katharina Röck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic UVR Causes Increased Immunostaining of CD44 and Accumulation of Hyaluronan in Mouse Epidermis

(2011) Hanna Siiskonen et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Melanoma Cells Control HA Synthesis in Peritumoral Fibroblasts via PDGF-AA and PDGF-CC: Impact on Melanoma Cell Proliferation

(2011) Anja Willenberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Enhanced Inflammation and Accelerated Wound Closure Following Tetraphorbol Ester Application or Full-Thickness Wounding in Mice Lacking Hyaluronan Synthases Has1 and Has3

(2011) Judith A. Mack et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regenerative potential of glycosaminoglycans for skin and bone

(2011) Juliane Salbach et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Implication of the oligomeric state of the N-terminal PTX3 domain in cumulus matrix assembly

(2011) Elena Ievoli et al.   MATRIX BIOLOGY

Effect of Cross-Linking Reagents for Hyaluronic Acid Hydrogel Dermal Fillers on Tissue Augmentation and Regeneration

(2010) Junseok Yeom et al.   BIOCONJUGATE CHEMISTRY

4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors

(2010) M. Edward et al.   BRITISH JOURNAL OF DERMATOLOGY

RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53

(2010) Sindy Sohr et al.   CELL CYCLE

The initial and subsequent inflammatory events during calcium oxalate lithiasis

(2010) John W.M. Yuen et al.   CLINICA CHIMICA ACTA

Suppression of hyaluronan synthase 2 expression reflects the atrophogenic potential of glucocorticoids

(2010) Marco Averbeck et al.   EXPERIMENTAL DERMATOLOGY

HA modulation of epidermal morphogenesis in an organotypic keratinocyte-fibroblast co-culture model

(2010) Hua Gu et al.   EXPERIMENTAL DERMATOLOGY

Regenerative medicine in dermatology: biomaterials, tissue engineering, stem cells, gene transfer and beyond

(2010) Christina Dieckmann et al.   EXPERIMENTAL DERMATOLOGY

Hyaluronan Synthesis Mediates the Fibrotic Response of Keratocytes to Transforming Growth Factor β

(2010) Naxin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and Ubiquitination

(2010) Eugenia Karousou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis

(2010) TG Tzellos et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Characterization of hyaluronan and TSG-6 in skin scarring: differential distribution in keloid scars, normal scars and unscarred skin

(2010) KT Tan et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

High-fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin

(2010) Takumi Yamane et al.   MOLECULAR NUTRITION & FOOD RESEARCH

CD19, a Response Regulator of B Lymphocytes, Regulates Wound Healing through Hyaluronan-Induced TLR4 Signaling

(2009) Yohei Iwata et al.   AMERICAN JOURNAL OF PATHOLOGY

Enhanced Deposition of Low-Molecular-Weight Hyaluronan in Lungs of Cigarette Smoke–Exposed Mice

(2009) Ken R. Bracke et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

(2009) Anne Kultti et al.   EXPERIMENTAL CELL RESEARCH

Extrinsic ageing in the human skin is associated with alterations in the expression of hyaluronic acid and its metabolizing enzymes

(2009) T. G. Tzellos et al.   EXPERIMENTAL DERMATOLOGY

Immunological functions of hyaluronan and its receptors in the lymphatics

(2009) David G. Jackson   IMMUNOLOGICAL REVIEWS

Cyclin D3 Mediates Synthesis of a Hyaluronan Matrix That Is Adhesive for Monocytes in Mesangial Cells Stimulated to Divide in Hyperglycemic Medium

(2009) Juan Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Hyaluronan Synthase 2 Gene by Convergence in Cyclic AMP Response Element-binding Protein and Retinoid Acid Receptor Signaling

(2009) Katri M. Makkonen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Hyaluronan Synthase Activity in Cellular Membrane Fractions

(2009) Davide Vigetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dermal Hyaluronan Is Rapidly Reduced by Topical Treatment with Glucocorticoids

(2009) Carl Gebhardt et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inhibition of HA Synthase 3 mRNA Expression, with a Phosphodiesterase 3 Inhibitor, Blocks Lung Injury in a Septic Ventilated Rat Model

(2009) Hicham Mrabat et al.   LUNG

Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy

(2009) H. Jarvelainen et al.   PHARMACOLOGICAL REVIEWS

Interaction of Wingless Protein (Wnt), Transforming Growth Factor-β1, and Hyaluronan Production in Fetal and Postnatal Fibroblasts

(2009) Antoine L. Carre et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Design of graded biomimetic osteochondral composite scaffolds

(2008) Anna Tampieri et al.   BIOMATERIALS

Hyaluronan in skin: aspects of aging and its pharmacologic modulation

(2008) Robert Stern et al.   CLINICS IN DERMATOLOGY

Chemically-Modified HA for Therapy and Regenerative Medicine

(2008) Glenn Prestwich et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Understanding, Avoiding, and Managing Dermal Filler Complications

(2008) JOEL L. COHEN   DERMATOLOGIC SURGERY

Imaging and tracking of single hyaluronan molecules diffusing in solution

(2008) Tim Kaminski et al.   GLYCOCONJUGATE JOURNAL

Hyaluronan Accumulation Is Elevated in Cultures of Low Density Lipoprotein Receptor-deficient Cells and Is Altered by Manipulation of Cell Cholesterol Content

(2008) Sana W. Sakr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan Facilitates Transforming Growth Factor-β1-mediated Fibroblast Proliferation

(2008) Soma Meran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation

(2008) Vasantha Atmuri et al.   MATRIX BIOLOGY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Hyaluronan: A constitutive regulator of chemoresistance and malignancy in cancer cells

(2008) Bryan P. Toole et al.   SEMINARS IN CANCER BIOLOGY

Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation

(2008) Ashley Gordon et al.   WOUND REPAIR AND REGENERATION

Differential effects of hyaluronan and its fragments on fibroblasts: Relation to wound healing

(2008) Maha David-Raoudi et al.   WOUND REPAIR AND REGENERATION

Biomimetic materials for tissue engineering

(2007) Peter X. Ma   ADVANCED DRUG DELIVERY REVIEWS

Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4

(2007) Verena Voelcker et al.   EXPERIMENTAL DERMATOLOGY