Article
Chemistry, Multidisciplinary
Hyeyeon Moon, Minseon Lee, Soonjo Kwon
Summary: This study examines whether electrical stimulation enhances the osteogenic differentiation of mouse clonal mesenchymal stem cells (cMSCs). Results show that electrical stimulation increases intracellular calcium concentration, which in turn promotes bone formation. These findings have important implications for the treatment of bone healing.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Francisco Sadras, Teneale A. Stewart, Melanie Robitaille, Amelia A. Peters, Priyakshi Kalita-de Croft, Patsy S. Soon, Jodi M. Saunus, Sunil R. Lakhani, Sarah J. Roberts-Thomson, Gregory R. Monteith
Summary: The role of calcium signalling pathways in inducing CAF phenotype has not been fully explored. A CAF model was generated by stimulating normal human mammary fibroblast cells with TGF beta 1, leading to altered calcium influx pathways. Upregulation of VGCCs Ca(V)1.2 and Ca(V)3.2 was observed in both the model and patient-derived breast CAFs, and inhibiting these channels impaired CAF activation. Targeting calcium signalling in breast CAFs could have a therapeutic potential.
Article
Biochemistry & Molecular Biology
Sreerag Othayoth Vasu, Hanoch Kaphzan
Summary: Transcranial direct current stimulation (tDCS) is a technique that modulates spontaneous neurotransmitter release by regulating calcium channels in axon terminals, primarily through P/Q and N-type calcium channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Antoine Folcher, Dmitri Gordienko, Oksana Iamshanova, Alexandre Bokhobza, George Shapovalov, Dheeraj Kannancheri-Puthooru, Pascal Mariot, Laurent Allart, Emilie Desruelles, Corentin Spriet, Raquel Diez, Thibauld Oullier, Severine Marionneau-Lambot, Lucie Brisson, Sandra Geraci, Hathaichanok Impheng, V'yacheslav Lehen'kyi, Aurelien Haustrate, Adriana Mihalache, Pierre Gosset, Stephanie Chadet, Stephanie Retif, Maryline Laube, Julien Sobilo, Stephanie Lerondel, Giulia Villari, Guido Serini, Alessandra Fiorio Pla, Sebastien Roger, Gaelle Fromont-Hankard, Mustafa Djamgoz, Philippe Clezardin, Arnaud Monteil, Natalia Prevarskaya
Summary: There is increasing evidence that ion channels play a crucial role in the invasiveness and metastasis of cancer cells. However, the molecular mechanisms of ion signaling in promoting cancer behavior are not well understood, and the complex remodeling during metastasis remains to be explored. This study demonstrates that metastatic prostate cancer cells develop a specific Na+/Ca2+ signaling, which is essential for persistent invasion. The Na+ leak channel, NALCN, is identified as a major initiator and regulator of Ca2+ oscillations required for the formation of invadopodia. The signaling cascade involving NALCN, ion transport proteins, and proto-oncogene Src kinase promotes actin remodeling, secretion of proteolytic enzymes, and enhances cancer cell invasive potential and metastatic lesions in vivo.
Article
Food Science & Technology
Gary Ro-Lin Chang, Min-Yu Tu, Yu-Hsuan Chen, Ku-Yi Chang, Chien-Fu Chen, Jen-Chieh Lai, Yu-Tang Tung, Hsiao-Ling Chen, Hueng-Chuen Fan, Chuan-Mu Chen
Summary: KFP-1 is a novel calcium-binding peptide derived from kefir, which enhances calcium influx in intestinal cells through TRPV6 calcium channels. The peptide shows potential as a functional nutraceutical additive for promoting calcium uptake.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Cell Biology
Sreerag Othayoth Vasu, Hanoch Kaphzan
Summary: Research indicates that weak subthreshold electrical fields can modify the conductance of voltage-dependent sodium channels in axon terminals, enhancing their membrane polarization and affecting synaptic functioning. Analytical modeling is employed to explain how modifications in sodium currents enhance axon terminal polarization.
Review
Biology
Sebastian Lucio Filelfi, Alberto Onorato, Bianca Brix, Nandu Goswami
Summary: Lymphatic senescence is associated with changes in lymphatic muscles and nerve fibers, dysfunction of lymphatic endothelial cell membrane, alterations in lymphatic pump, acute inflammation responses, and immune function. Further research on the impact of aging on the lymphatic vasculature is necessary to develop innovative clinical diagnostic and treatment modalities, and to reduce morbidity associated with lymphatic system diseases.
Article
Multidisciplinary Sciences
Lauren F. Sestito, Kim H. T. To, Matthew T. Cribb, Paul A. Archer, Susan N. Thomas, J. Brandon Dixon
Summary: Formulating S-(-)-Bay K8644 (BayK) within lymph-draining nanoparticles (NPs) can improve lymphatic vessel function and reduce side effects. In a mouse model of lymphedema, treatment with BayK formulated in lymph-draining NPs improves pumping pressure and tissue remodeling associated with the pathology.
Review
Biochemistry & Molecular Biology
Noushin Ahmadpour, Meher Kantroo, Jillian L. Stobart
Summary: Astrocytes play crucial roles in the brain by modulating microdomain calcium events, which are diverse and complex in nature. These events are regulated by different signaling mechanisms and can impact synaptic activity, blood flow, and even behaviors. Rapid microdomain calcium events in astrocytes are linked to local neuronal circuit activity, highlighting their importance in brain function.
Article
Biochemistry & Molecular Biology
Yi Feng, Shaon Borosha, Anamika Ratri, Eun Bee Lee, Huizhen Wang, Timothy A. Fields, William H. Kinsey, Jay L. Vivian, M. A. Karim Rumi, Patrick E. Fields
Summary: Erythropoietin (EPO) signaling regulates calcium influx through TRPC2 and TRPC6 proteins in erythropoiesis. This study reveals that DOT1L regulates TRPC6 gene expression in erythroid progenitor cells, and loss of DOT1L leads to accelerated calcium influx through TRPC2 and detrimental effects on HPCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Andrew T. Landau, Pojeong Park, J. David Wong-Campos, He Tian, Adam E. Cohen, Bernardo L. Sabatini
Summary: This study reveals that back-propagating action potentials (bAPs) fail to evoke calcium influx in specific dendritic branches of mouse cortical layer 2/3 pyramidal cells, despite evoking it in sister branches. The branch-specific compartmentalization of bAP-dependent calcium signals may provide a mechanism for neurons to diversify synaptic tuning across the dendritic tree.
Article
Biochemistry & Molecular Biology
Hyocheol Bae, Woonghee Lee, Jisoo Song, Taeyeon Hong, Myung Hyun Kim, Jiyeon Ham, Gwonhwa Song, Whasun Lim
Summary: The study found that polydatin can suppress the progression of colon cancer, induce anti-cancer effects by modifying cell cycle distribution and causing mitochondrial dysfunction. It can also overcome drug resistance by inhibiting signaling pathways and enhancing chemosensitivity, potentially serving as an innovative medicinal drug for colon cancer treatment.
Article
Mathematics, Applied
Hardik Joshi, Brajesh Kumar Jha
Summary: In this paper, a calcium dynamics model is proposed to study cellular activities and calcium homeostasis by considering the exchange of calcium flux between intracellular and extracellular sources. A generalized two-dimensional reaction-diffusion model is formulated and analyzed for different ranges of calcium flux. The model is solved using the fractional integral transform and special functions, and the existence and uniqueness of the proposed model are discussed. The obtained results are graphically presented to illustrate the significance of calcium flux and validate the effectiveness of the method.
COMPUTERS & MATHEMATICS WITH APPLICATIONS
(2023)
Article
Immunology
Chung-Chi Yang, Yen-Ling Hung, Hsin-Ju Li, Ya-Fan Lin, Su-Jane Wang, Der-Chen Chang, Chi-Ming Pu, Chi-Feng Hung
Summary: Quercetin has anti-inflammatory and anti-itching effects by reducing histamine-induced calcium influx via the TRPV1 channel and influencing H4 receptors, providing a molecular mechanism for its anti-itching, anti-inflammatory, and unpleasant sensations properties.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Boqiang Shen, Juan Hao, Yanying Lin, Xingchen Li, Xiao Yang, Ting Huang, Jiaqi Wang, Yuanyuan Jia, Jingyi Zhou, Jianliu Wang
Summary: This study revealed a significant relationship between serum calcium level and clinicopathological characteristics of endometrial cancer (EC). Estrogen-induced extracellular calcium influx might be involved in the regulation of autophagy and mitochondrial-related pathways, and affects mitochondrial ROS and lysosomal activity.
FRONTIERS IN MEDICINE
(2022)
Letter
Dermatology
Yuko Matsumoto-Okazaki, Junko Yamane, Kentaro Kajiya
JOURNAL OF DERMATOLOGICAL SCIENCE
(2015)
Article
Nutrition & Dietetics
Kaedeko Fukada, Mika Kajiya-Sawane, Yuko Matsumoto, Tatsuya Hasegawa, Yukitaka Fukaya, Kentaro Kajiya
NUTRITION RESEARCH
(2016)
Editorial Material
Dermatology
Kentaro Kajiya, Mika Kajiya-Sawane, Takayuki Ono, Katsujiro Sato
JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
Yusuke Hara, Toyonobu Yamashita, Kumiko Kikuchi, Yoshihide Kubo, Chika Katagiri, Kentaro Kajiya, Souichi Saeki
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Letter
Dermatology
Yuzo Yoshida, Kentaro Kajiya, Jiro Kishimoto, Michael Detmar
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Letter
Dermatology
Kentaro Kajiya, Ryoma Bise, Catharina Commerford, Imari Sato, Toyonobu Yamashita, Michael Detmar
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Letter
Oncology
Takako Shibata, Kentaro Kajiya, Kiyoshi Sato, Jisun Yoon, Hee Young Kang
PIGMENT CELL & MELANOMA RESEARCH
(2018)
Letter
Peripheral Vascular Disease
Kaedeko Fukada, Kentaro Kajiya
Article
Multidisciplinary Sciences
Yasuhiro Yoshimatsu, Shiori Kimuro, Joris Pauty, Kazuki Takagaki, Sanae Nomiyama, Akihiko Inagawa, Kentaro Maeda, Katarzyna A. Podyma-Inoue, Kentaro Kajiya, Yukiko T. Matsunaga, Tetsuro Watabe
Article
Peripheral Vascular Disease
Mika Sawane, Yuki Ogura, Ayano Nakamura, Hitomi Otaka, Hiroyasu Kidoya, Katsujiro Sato, Nobuyuki Takakura, Kentaro Kajiya
Summary: The study found that appropriate stiffness induces vascular maturation and upregulated APJ expression, while overexpression of APJ promotes the formation of large vessels, potentially providing a novel mechanism for preventing human skin aging.
Article
Dermatology
Moe Tsutsumi, Saito Sakaguchi, Kazuki Takagaki, Jeremy Cheret, Ralf Paus, Kentaro Kajiya
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Ilaria Piccini, Jeremy Cheret, Moe Tsutsumi, Saito Sakaguchi, Leslie Ponce, Luis Almeida, Wolfgang Funk, Maximilian Kueckelhaus, Kentaro Kajiya, Ralf Paus, Marta Bertolini
Summary: Recent research has found that epidermal Merkel cells (MCs) not only have mechanotransduction function for light-touch sensory stimuli, but also are thermosensitive, suggesting a physiological role beyond mechanosensation. Functional olfactory receptors, specifically OR2AT4, were found to be expressed by epidermal MCs in healthy human skin, similar to neighboring keratinocytes. Stimulation of OR2AT4 by topical application of the synthetic odorant Sandalore significantly increased Piccolo protein expression in MCs, indicating increased vesicle trafficking and recycling, and reduced nerve growth factor (NGF) immunoreactivity within MCs, potentially suggesting increased neurotrophin release upon OR2AT4 activation. Further investigation is needed to explore whether these newly discovered properties of MCs are dysregulated in specific skin disorders and if they can be targeted therapeutically to maintain/promote skin health.
EXPERIMENTAL DERMATOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Kentaro Kajiya
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2016)
Article
Ophthalmology
Yuko Maruyama, Kazuichi Maruyama, Yukinari Kato, Kentaro Kajiya, Satoru Moritoh, Kotaro Yamamoto, Yuko Matsumoto, Mika Sawane, Dontscho Kerjaschki, Toru Nakazawa, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2014)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)