Review
Biochemistry & Molecular Biology
Petra Pavel, Stefan Blunder, Verena Moosbrugger-Martinz, Peter M. Elias, Sandrine Dubrac
Summary: Atopic dermatitis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Alterations of the epidermal barrier and lipid abnormalities play crucial roles in the development and inflammation of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tubanur Cetinarslan, Lisa Kuemper, Regina Foelster-Holst
Summary: Atopic dermatitis is a common and chronic inflammatory skin disease with various clinical presentations. The etiopathogenesis of AD involves structural and immunological epidermal barrier defect, imbalance of the skin microbiome, genetic background, and environmental factors. Therapeutic options targeting these pathways, such as topical steroids and biological therapies, have gained importance in the treatment of AD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Dermatology
Folke Hueppop, Stephan Deahnhardt-Pfeiffer, Regina Foelster-Holst
Summary: Nummular and classical atopic dermatitis have differences and similarities in children, including age of onset, localization, distribution, and morphology of the eczema. Keratosis pilaris is more severe in children with nummular atopic dermatitis. Both disease groups show reduced hydration, increased transepidermal water loss, and reduced intercellular lipid lamellae in lesional skin areas.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Medicine, General & Internal
Anna Debinska, Hanna Danielewicz, Barbara Sozanska
Summary: The risk variants of HRNR and FLG2 genes are associated with atopic eczema, allergic sensitization, and susceptibility to the complex phenotype-asthma plus eczema. These effects may be modulated by gene-gene interactions, and these genetic variants can also be considered as predictive biomarkers for eczema-associated asthma.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nahoko Zeze, Makiko Kido-Nakahara, Gaku Tsuji, Eriko Maehara, Yuki Sato, Sawako Sakai, Kei Fujishima, Akiko Hashimoto-Hachiya, Masutaka Furue, Takeshi Nakahara
Summary: Atopic dermatitis is a skin disorder characterized by inflammation, barrier disruption, and intense itch. This study investigates the involvement of the extracellular signal-regulated kinase (ERK) pathway in the pathogenesis of atopic dermatitis. The results suggest that the ERK pathway plays a role in the development of atopic dermatitis and may be a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Allergy
Jessica W. Hui-Beckman, Elena Goleva, Evgeny Berdyshev, Donald Y. M. Leung
Summary: Atopic dermatitis (AD) and food allergy (FA) are closely related and one-third of AD children develop concomitant FA. Epithelial barrier dysfunction is important in both diseases. Genetic factors such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms are associated with increased risk. In addition, several environmental exposures lead to reduced filaggrin and contribute to skin barrier dysfunction. Staphylococcus aureus colonization appears to contribute to AD and FA as well as activating the type 2 immune response. Comprehensive multiomic studies have identified distinct atopic endotypes with unique characteristics, providing an opportunity for improved diagnosis and prevention of atopy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Hyang Jeon, Geunyeong Kim, Ayesha Kashif, Min Hwa Hong, Ji-Sook Lee, Yujin Hong, Beom Seok Park, Eun Ju Yang, In Sik Kim
Summary: Atopic dermatitis is a chronic disease characterized by skin inflammation and barrier dysfunction, with house dust mites being key allergens. A study on Der p 38, a novel mite allergen, has shown that it triggers atopic dermatitis by reducing skin barrier proteins and increasing inflammatory cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Dermatology
Thomas Luger, Masayuki Amagai, Brigitte Dreno, Marie-Ange Dagnelie, Wilson Liao, Kenji Kabashima, Tamara Schikowski, Ehrhardt Proksch, Peter M. Elias, Michel Simon, Eric Simpson, Erin Grinich, Matthias Schmuth
Summary: AD is a chronic inflammatory skin disorder characterized by eczematous and pruritic skin lesions, with increasing prevalence worldwide in recent decades. Studies have shown that genetic defects affecting structural proteins of the skin barrier, as well as exposure to environmental allergens and pollutants, contribute to the development of AD. Research on epidermal barrier function, inflammation, lipid metabolism, and bacterial communities is crucial for understanding the complex etiology of AD and developing new therapies.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Biology
Regina Foelster-Holst, Rahel Reimer, Claudia Neumann, Erhardt Proksch, Elke Rodriguez, Stephan Weidinger, Mohamad Goldust, Eckhard Hanisch, Stephan Daehnhardt-Pfeiffer, Sandra Freitag-Wolf
Summary: Atopic dermatitis and prurigo nodularis are two chronic skin diseases characterized by impaired skin barrier and disturbed water balance. Basic barrier repair is crucial for the treatment of both conditions.
Article
Allergy
Michelle F. Huffaker, Kanika Kanchan, Henry T. Bahnson, Ingo Ruczinski, Gautam Shankar, Donald Y. M. Leung, Carolyn Baloh, George Du Toit, Gideon Lack, Gerald T. Nepom, Rasika A. Mathias
Summary: This study found that deleterious variation in the epidermal differentiation complex (EDC) is associated with the severity of atopic dermatitis (AD) and the risk of peanut allergy (PA). Specifically, variations in the FLG gene are significantly associated with AD severity and the risk of PA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
Minke M. F. van Mierlo, Luba M. Pardo, Karin B. Fieten, Tim J. van den Broek, Frank H. J. Schuren, Michel van Geel, Suzanne G. M. A. Pasmans
Summary: This study found that filaggrin gene (FLG) mutations have a significant effect on the overall microbiome composition in children with difficult-to-treat atopic dermatitis (AD), but have a minor role in specific microbiomes.
Review
Medicine, General & Internal
Anna Debinska
Summary: Atopic dermatitis is a common chronic, inflammatory skin disorder with a complex etiology and diverse clinical manifestations. Skin barrier dysfunction and immunological abnormalities play critical roles in its pathogenesis. New therapeutic approaches targeting specific pathophysiological pathways are being developed, emphasizing the regulation of skin barrier-related molecules.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Liu Tang, Xiaoqin Cao, Xiaolei Li, Hong Ding
Summary: The study showed that topical application of conjugated linoleic acid (CLA) significantly improved skin lesions, itching, and inflammation in a murine model of AD. CLA modulated skin barrier function and inflammation response, providing protective effects against AD lesional skin.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Peter Olah, Eszter Szlavicz, Marcus Kuchner, Jana Nemmer, Patrick Zeeuwen, Alain Lefevre-Utile, Nanna Fyhrquist, Stefanie Prast-Nielsen, Tiina Skoog, Angela Serra, Elke Rodriguez, Ulrike Raap, Stephan Meller, Rolland Gyulai, Philippe Hupe, Juha Kere, Francesca Levi-Schaffer, Sophia Tsoka, Helen Alexander, Frank O. Nestle, Jens M. Schroeder, Stephan Weidinger, Ellen van den Bogaard, Vassili Soumelis, Dario Greco, Jonathan Barker, Antti Lauerma, Annamari Ranki, Bjorn Andersson, Harri Alenius, Bernhard Homey
Summary: This study investigates the relationship between FLG gene mutations and atopic dermatitis (AD), revealing that FLG mutations lead to skin barrier dysfunction and water imbalance, as well as enhanced inflammatory response and T-cell proliferation. Staphylococcus aureus dominates the microbial communities in AD patients, and changes in microbial composition can be observed when comparing healthy individuals or non-lesional skin.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Letter
Allergy
Heidi Schaarschmidt, David Ellinghaus, Elke Rodriguez, Anja Kretschmer, Hansjoerg Baurecht, Simone Lipinski, Ulf Meyer-Hoffert, Juergen Harder, Wolfgang Lieb, Natalija Novak, Regina Foelster-Holst, Jorge Esparza-Gordillo, Ingo Marenholz, Franz Ruschendorf, Norbert Hubner, Eva Reischl, Melanie Waldenberger, Christian Gieger, Thomas Illig, Michael Kabesch, Xue-Jun Zhang, Feng-Li Xiao, Young-Ae Lee, Andre Franke, Stephan Weidinger
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2015)
Article
Dermatology
Lisa Redelfs, Jan Fischer, Clemens Weber, Zhihong Wu, Ulf Meyer-Hoffert
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Sascha Jung, Jan Fischer, Bjoern Spudy, Tim Kerkow, Frank D. Soennichsen, Li Xue, Alexandre M. J. J. Bonvin, Peter Goettig, Viktor Magdolen, Ulf Meyer-Hoffert, Joachim Groetzinger
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Review
Biochemistry & Molecular Biology
Magdalena Kalinska, Ulf Meyer-Hoffert, Tomasz Kantyka, Jan Potempa
Article
Biochemistry & Molecular Biology
Karolina Plaza, Magdalena Kalinska, Oliwia Bochenska, Ulf Meyer-Hoffert, Zhihong Wu, Jan Fischer, Katherine Falkowski, Laura Sasiadek, Ewa Bielecka, Barbara Potempa, Andrzej Kozik, Jan Potempa, Tomasz Kantyka
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Dermatology
Jan Fischer, Zhihong Wu, Tomasz Kantyka, Maria Sperrhacke, Olga Dimitrieva, Yulia Koblyakova, Kerstin Ahrens, Nina Graumann, Hansjoerg Baurecht, Karina Reiss, Jens-Michael Schroder, Ehrhardt Proksch, Ulf Meyer-Hoffert
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2014)
Article
Dermatology
Maria Sperrhacke, Jan Fischer, Zhihong Wu, Sarah Kluender, Radislav Sedlacek, Jens-Michael Schroeder, Ulf Meyer-Hoffert, Karina Reiss
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2014)
Article
Dermatology
Regine Glaeser, Karsten Becker, Christof von Eiff, Ulf Meyer-Hoffert, Juergen Harder
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2014)
Article
Dermatology
Zhihong Wu, Yuanyuan Wu, Jan Fischer, Joachim Bartels, Jens-Michael Schroeder, Ulf Meyer-Hoffert
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Meeting Abstract
Dermatology
Z. Wu, J. Fischer, J. Yan, J. Schroeder, U. Meyer-Hoffert
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Dermatology
Clemens Weber, Jan Fischer, Lisa Redelfs, Franziska Rademacher, Juergen Harder, Stephan Weidinger, Zhihong Wu, Ulf Meyer-Hoffert
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2017)
Meeting Abstract
Dermatology
Z. Wu, R. Siebert, J. Schroeder, U. Meyer-Hoffert
EXPERIMENTAL DERMATOLOGY
(2017)
Meeting Abstract
Dermatology
E. Rodriguez, J. Manz, B. S. Petersen, H. Baurecht, G. Mayr, J. Harder, U. Meyer-Hoffert, A. Franke, A. ElSharawy, S. Weidinger
EXPERIMENTAL DERMATOLOGY
(2015)
Meeting Abstract
Dermatology
L. Redelfs, J. Fischer, C. Weber, U. Meyer-Hoffert
EXPERIMENTAL DERMATOLOGY
(2014)
Meeting Abstract
Dermatology
D. Mercier, T. Latendorf, R. Foelster-Holst, J. M. Schroeder, U. Meyer-Hoffert
EXPERIMENTAL DERMATOLOGY
(2014)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)