Article
Oncology
Lifeng Feng, Muchun Li, Xinyang Hu, Yiling Li, Liyuan Zhu, Miaoqin Chen, Qi Wei, Wenxia Xu, Qiyin Zhou, Weikai Wang, Dingwei Chen, Xian Wang, Hongchuan Jin
Summary: Chemoresistance, previously seen as a stable outcome resulting from genetic changes, can also be unstable and reversible due to non-genetic alterations. The downregulation of ATF4 protein expression is associated with chemoresistance in gastric cancer cells, and its stabilization through inhibition of degradation can overcome resistance. ATF4 expression plays a crucial role in dynamic drug resistance, and interventions targeting its degradation pathway show promise in overcoming chemoresistance.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Andrea Baier, Ryszard Szyszka
Summary: Casein kinases are important factors in signaling pathways, inflammation, cancer, and neurological diseases, making them potential therapeutic targets. Recent studies have shown that the casein kinase 1 superfamily and CK2 play significant roles in the development of neurodegenerative pathologies. Overexpression of these kinases in the brain is closely related to neuronal and synaptic network functions. Therefore, the development of new substances for the treatment of these diseases is crucial.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Hematology
Maximilian Englert, Katja Aurbach, Isabelle C. Becker, Annika Gerber, Tobias Heib, Lou M. Wackerbarth, Charly Kusch, Kristina Mott, Gabriel H. M. Araujo, Ayesha A. Baig, Sebastian Duetting, Ulla G. Knaus, Christian Stigloher, Harald Schulze, Bernhard Nieswandt, Irina Pleines, Zoltan Nagy
Summary: The study found that genetic ablation of RhoB in mice results in microthrombocytopenia, impacting platelet function upon induction of the collagen/glycoprotein VI pathway. Furthermore, microtubule organization and dynamics are impaired in the absence of RhoB, contributing to the development of microthrombocytopenia through reduced levels of acetylated α-tubulin.
Article
Endocrinology & Metabolism
Hongzhou Guo, Di Zhang, Yewen Zhou, Longjie Sun, Changping Li, Xuan Luo, Jiali Liu, Sheng Cui
Summary: Our study showed that CK1 alpha is expressed in both germ cells and somatic cells of mouse testes and plays a crucial role in regulating testosterone synthesis and male reproduction. We found that conditional disruption of CK1 alpha in Leydig cells significantly reduced testosterone levels, affected testis development, sperm motility, and sperm morphology, and caused subfertility. Furthermore, we discovered that luteinizing hormone can upregulate CK1 alpha through a specific signaling pathway and that CK1 alpha can interact with and phosphorylate EGFR, leading to the activation of ERK1/2 and the promotion of testosterone synthesis.
Article
Cell Biology
Alaina H. Willet, Maya G. Igarashi, Jun-Song Chen, Rahul Bhattacharjee, Liping Ren, Sierra N. Cullati, Zachary C. Elmore, Rachel H. Roberts-Galbraith, Alyssa E. Johnson, Janel R. Beckley, Kathleen L. Gould
Summary: The F-BAR protein Imp2 is phosphorylated at 28 sites within its intrinsically disordered region, with casein kinase 1 (CK1) and Cdk1 being the major kinases involved. Phosphorylation plays a role in regulating Imp2 localization and function, with different kinases having distinct effects.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kuilong Huang, Zhihao Jia, Haoran Li, Ying Peng, Xiaochang Chen, Nanjian Luo, Tongxing Song, Yingqian Wang, Xin'e Shi, Shihuan Kuang, Gongshe Yang
Summary: FAM83A plays important roles in cancer and has a novel function in adipocyte differentiation. Inhibition of Fam83a results in reduced white adipose tissue mass, smaller adipocytes, and aggravated mitochondrial damage. Loss or knockdown of Fam83a in cultured adipocytes represses lipid droplet formation and downregulates lipogenic genes and proteins, leading to decreased mitochondrial ATP production and enhanced apoptosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Chen Shen, Anmada Nayak, Leif R. Neitzel, Amber A. Adams, Maya Silver-Isenstadt, Leah M. Sawyer, Hassina Benchabane, Huilan Wang, Nawat Bunnag, Bin Li, Daniel T. Wynn, Fan Yang, Marta Garcia-Contreras, Charles H. Williams, Sivanesan Dakshanamurthy, Charles C. Hong, Nagi G. Ayad, Anthony J. Capobianco, Yashi Ahmed, Ethan Lee, David J. Robbins
Summary: This study reveals how the Wnt ligand can enhance CRBN-dependent protein degradation and highlights the importance of CRBN in physiological Wnt signaling.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Abhishek Ankur Balmik, Shweta Kishor Sonawane, Subashchandrabose Chinnathambi
Summary: The study shows that HDAC6's ZnF UBP domain can modulate Tau phosphorylation, actin cytoskeleton organization, neurite extension, and ApoE nuclear localization. Additionally, it plays a role in increasing tubulin localization in the microtubule organizing center. The ZnF domain of HDAC6 is involved in various regulatory functions in neurodegenerative diseases beyond its classical role in aggresome formation.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Pharmacology & Pharmacy
Laura Meier, Bernd Martin Gahr, Aileen Roth, Adrian Gihring, Stefan Kirschner, Clemens Woitaske-Proske, Joana Baier, Christian Peifer, Steffen Just, Uwe Knippschild
Summary: The CK1 family plays a role in various physiological processes by regulating different signaling pathways. Mutations or dysregulation of CK1 can lead to the development of cancer, neurodegenerative diseases, and inflammation. CK1 isoform specific small molecule inhibitors, such as IWP-based small molecules, show promise in therapeutic applications.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aileen Roth, Annabelle Sander, Marleen Silke Oswald, Fabian Gaertner, Uwe Knippschild, Joachim Bischof
Summary: This study analyzed the phosphorylation of tau proteins by CK1 delta in Alzheimer's disease. Through in vitro experiments and mass spectrometry, ten potential phosphorylation sites were identified, with five of them associated with Alzheimer's disease. Further analysis confirmed the specific phosphorylation sites and demonstrated the potential role of CK1 delta in tau aggregation. These findings highlight the potential of CK1 delta as a promising target for Alzheimer's disease treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
Alexander Hirschhaeuser, Marianne van Cann, Sven Bogdan
Summary: CK1 alpha regulates the stability of WAVE by phosphorylating it, protecting it from premature degradation and promoting its function in vivo. Loss of CK1 alpha function phenocopies depletion of WAVE, indicating the importance of CK1 alpha in regulating cell motility. Pharmacologic inhibition of CK1 alpha leads to ubiquitin-dependent degradation of WAVE.
JOURNAL OF CELL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Zeng Tao-Ling, Wang Hong-Rui
Summary: As a special member of the Rho family, RhoB has unique biological activities and plays a distinctive role in tumorigenesis. It is tightly regulated compared to other family members. Although RhoB has been reported as a tumor suppressor, it can also promote the development of certain types of tumors, and the underlying molecular mechanisms are still unclear.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Cell Biology
Bing Zhong, Zexue Zhao, Xi Jiang
Summary: RP1-59D14.5 acts as a tumor suppressor in prostate cancer (PCa) by activating the Hippo pathway through regulating the miR-147a/LATS1/2 and HUR/CK1/beta TrCP pathways, thus inhibiting the proliferation, migration, and invasion of PCa cells.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Daniela Marzoll, Fidel E. Serrano, Anton Shostak, Carolin Schunke, Axel C. R. Diernfellner, Michael Brunner
Summary: This study reveals that CK1, FRQ, and PERs form equivalent timing modules in circadian clocks, regulating rhythmicity through phosphorylation. The slow phosphorylation kinetics depend on site-specific recruitment, interaction between disordered segments and CK1, and CK1 autoinhibition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Plant Sciences
Lu Peng, Juan He, Huan Yao, Qin Yu, Qian Zhang, Kexuan Li, Yaling Huang, Li Chen, Xufeng Li, Yi Yang, Xiaoyi Li
Summary: It is found that CARK3 plays a regulatory role in plant development and drought tolerance through interaction with ADF4.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Medicine, Research & Experimental
Emilie Bousquet Mur, Sara Bernardo, Laura Papon, Maicol Mancini, Eric Fabbrizio, Marion Goussard, Irene Ferrer, Anais Giry, Xavier Quantin, Jean-Louis Pujol, Olivier Calvayrac, Herwig P. Moll, Yael Glasson, Nelly Pirot, Andrei Turtoi, Marta Canamero, Kwok-Kin Wong, Yosef Yarden, Emilio Casanova, Jean-Charles Soria, Jacques Colinge, Christian W. Siebel, Julien Mazieres, Gilles Favre, Luis Paz-Ares, Antonio Maraver
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Editorial Material
Medicine, Research & Experimental
Nicolas Guibert, Anne Pradines, Gilles Favre, Julien Mazieres
M S-MEDECINE SCIENCES
(2020)
Article
Immunology
Chloe Laplagne, Sarah Meddour, Sarah Figarol, Marie Michelas, Olivier Calvayrac, Gilles Favre, Camille Laurent, Jean-Jacques Fournie, Stephanie Cabantous, Mary Poupot
FRONTIERS IN IMMUNOLOGY
(2020)
Meeting Abstract
Oncology
J-S. Frenel, F. Dalenc, B. Pistilli, T. de la Motte Rouge, C. Levy, M-A. Mouret-Reynier, A-C. Hardy-Bessard, N. Bonichon-Lamichhane, C. Greilsamer, V. Delecroix, S. Nguyen, F. Berger, S. Everhard, J. Lemonnier, D. Loirat, C. Callens, A. Pradines, T. Bachelot, S. Delaloge, F. C. Bidard
ANNALS OF ONCOLOGY
(2020)
Meeting Abstract
Oncology
J. L. Lacaze, C. Chira, G. Glemarec, R. Aziza, E. De Maio, F. Izar, E. Jouve, C. Massabeau, A. Pradines, G. Selmes, M. Ung, S. Zerdoud, F. Dalenc
ANNALS OF ONCOLOGY
(2020)
Article
Oncology
Sandra Ortiz-Cuaran, Laura Mezquita, Aurelie Swalduz, Mihalea Aldea, Julien Mazieres, Camille Leonce, Cecile Jovelet, Anne Pradines, Virginie Avrillon, Washington R. Chumbi Flores, Ludovic Lacroix, Yohann Loriot, Virginie Westeel, Maud Ngo-Camus, Claire Tissot, Christine Raynaud, Radj Gervais, Etienne Brain, Isabelle Monnet, Etienne Giroux Leprieur, Caroline Caramella, Celine Mahier-Ait Oukhatar, Natalie Hoog-Labouret, Frank de Kievit, Karen Howarth, Clive Morris, Emma Green, Luc Friboulet, Sylvie Chabaud, Jean-Francois Guichou, Maurice Perol, Benjamin Besse, Jean-Yves Blay, Pierre Saintigny, David Planchard
CLINICAL CANCER RESEARCH
(2020)
Review
Cell Biology
Lucile Durin, Anne Pradines, Celine Basset, Bryan Ulrich, Laura Keller, Vincent Dongay, Gilles Favre, Julien Mazieres, Nicolas Guibert
Article
Pathology
Cathy Quelen, David Grand, Emeline Sarot, Laurence Brugieres, David Sibon, Anne Pradines, Camille Laurent, Pierre Brousset, Laurence Lamant
Summary: In ALK-positive anaplastic large-cell lymphomas, real-time quantitative PCR can identify high-risk patients, but the current technique designed for patients with the most common NPM1-ALK translocation has reproducibility issues among different laboratories.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Review
Oncology
Bryan Ulrich, Anne Pradines, Julien Mazieres, Nicolas Guibert
Summary: Circulating tumor DNA is a novel biomarker that shows potential in predicting cancer relapse and guiding adjuvant therapies. In patients with localized disease, ctDNA kinetics is considered a highly sensitive and specific marker for relapse. Further research is needed to explore the full potential of ctDNA as a tool for personalized treatment in non-small-cell lung cancer.
Article
Oncology
Jean-Louis Lacaze, Richard Aziza, Ciprian Chira, Eleonora De Maio, Francoise Izar, Eva Jouve, Carole Massabeau, Anne Pradines, Gabrielle Selmes, Mony Ung, Slimane Zerdoud, Florence Dalenc
Summary: Oligometastatic breast cancer (OMBC) lacks a standardized treatment strategy, with limited information provided by existing literature. Research on OMBC biological characteristics suggests a focus on circulating tumor cell counts, as well as development of studies on microRNAs, circulating tumor DNA, and genomic alterations.
Review
Oncology
Celia Delahaye, Sarah Figarol, Anne Pradines, Gilles Favre, Julien Mazieres, Olivier Calvayrac
Summary: The article discusses the benefits and limitations of more effective treatments for lung cancer patients, as well as the emergence of resistance. It emphasizes the importance of understanding the mechanisms underlying DTP survival for developing therapeutic strategies.
Meeting Abstract
Oncology
Anne Pradines, Celine Callens, Aurelia Doussine, Ivan Bieche, Jerome Lemonnier, Marjorie Mauduit, Thomas Bachelot, Florence Dalenc, Alain Lortholary, Barbara Pistilli, Thibault De la Motte Rouge, Renaud Sabatier, Jean-Marc Ferrero, Sylvain Ladoire, Frederique Berger, Francois-Clement Bidard
Meeting Abstract
Oncology
Francois Clement Bidard, Celine Callens, Florence Dalenc, Barbara Pistilli, Thibault De La Motte Rouge, Florian Clatot, Veronique D'hondt, Luis Teixeira, Helene Vegas, Sibille Everhard, Jerome Lemonnier, Ivan Bieche, Anne Pradines, Jean FranCois Paitel, Dominique Spaeth, Isabelle Moullet, Jean-Yves Pierga, Frederique Berger, Anne-Claire Hardy-Bessard, Thomas Bachelot
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Vincent Nicolai, Julia Gilhodes, Jean Louis Lacaze, Mony Ung, Eleonora De Maio, Raphaelle Duprez-Paumier, Charlotte Vaysse, Thomas Filleron, Eva Jouve, Gabrielles Selmes, Camille Franchet, Carole Massabeau, Cyprian Chira, Francoise Izar, Henri Roche, Anne Pradines, Florence Dalenc