Liquid Biopsy of Non-Plasma Body Fluids in Non-Small Cell Lung Cancer: Look Closer to the Tumor!

Current and future applications of liquid biopsy in nonsmall cell lung cancer from early to advanced stages

(2020) Nicolas Guibert et al.   European Respiratory Review

Extracellular vesicle-based EGFR genotyping in bronchoalveolar lavage fluid from treatment-naive non-small cell lung cancer patients

(2020) Jae Young Hur et al.   Translational Lung Cancer Research

Detection of promoter DNA methylation in urine and plasma aids the detection of non-small cell lung cancer

(2020) Bin Liu et al.   CLINICAL CANCER RESEARCH

Sputum Cell-Free DNA

(2020) Zheng Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Use of cytology centrifuged supernatants improves cost and turnaround time for targeted next generation sequencing

(2020) HamzaN. Gokozan et al.   DIAGNOSTIC CYTOPATHOLOGY

Gene Alterations in Paired Supernatants and Precipitates from Malignant Pleural Effusions of Non-Squamous Non-Small Cell Lung Cancer

(2020) Jianqiang Li et al.   Translational Oncology

Circulating tumour cells as a potential biomarker for lung cancer screening: a prospective cohort study

(2020) Charles-Hugo Marquette et al.   Lancet Respiratory Medicine

Differences in the genomic profiles of cell‐free DNA between plasma, sputum, urine, and tumor tissue in advanced NSCLC

(2019) Zhen Wu et al.   Cancer Medicine

Clinical Utility of Cerebrospinal Fluid Cell-Free DNA as Liquid Biopsy for Leptomeningeal Metastases in ALK-Rearranged NSCLC

(2019) Mei-Mei Zheng et al.   Journal of Thoracic Oncology

Liquid Biopsy Assay for Lung Carcinoma Using Centrifuged Supernatants from Fine Needle Aspiration Specimens

(2019) B Hannigan et al.   ANNALS OF ONCOLOGY

Comparison of cytocentrifugation supernatant fluid and formalin‐fixed paraffin‐embedded tissue for targeted next‐generation sequencing

(2019) Nafiseh Janaki et al.   CANCER CYTOPATHOLOGY

Prospective detection of mutations in cerebrospinal fluid, pleural effusion and ascites of advanced cancer patients to guide treatment decisions

(2019) Sergio Villatoro et al.   Molecular Oncology

Cytological-negative pleural effusion can be an alternative liquid biopsy media for detection of EGFR mutation in NSCLC patients

(2019) Zhengbo Song et al.   LUNG CANCER

Targeted sequencing of plasma cell-free DNA to predict response to PD1 inhibitors in advanced non-small cell lung cancer

(2019) Nicolas Guibert et al.   LUNG CANCER

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

(2019) Francesca Chemi et al.   NATURE MEDICINE

Detection of EGFR gene mutation status from pleural effusions and other body fluid specimens in patients with lung adenocarcinoma

(2019) Ping Zhang et al.   Thoracic Cancer

Evaluating the cerebrospinal fluid ctDNA detection by next-generation sequencing in the diagnosis of meningeal Carcinomatosis

(2019) Yue Zhao et al.   BMC Neurology

Unique genetic profiles from cerebrospinal fluid cell-free DNA in leptomeningeal metastases of EGFR-mutant non-small-cell lung cancer: a new medium of liquid biopsy

(2018) Y S Li et al.   ANNALS OF ONCOLOGY

Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA

(2018) Sarah B. Goldberg et al.   CLINICAL CANCER RESEARCH

False positive plasma genotyping due to clonal hematopoiesis

(2018) Yuebi Hu et al.   CLINICAL CANCER RESEARCH

Liquid biopsy of fine-needle aspiration supernatant for lung cancer genotyping

(2018) Nicolas Guibert et al.   LUNG CANCER

Salvaging the supernatant: next generation cytopathology for solid tumor mutation profiling

(2018) Sinchita Roy-Chowdhuri et al.   MODERN PATHOLOGY

Early stage NSCLC — challenges to implementing ctDNA-based screening and MRD detection

(2018) Christopher Abbosh et al.   Nature Reviews Clinical Oncology

Diagnostic value of microRNAs derived from exosomes in bronchoalveolar lavage fluid of early-stage lung adenocarcinoma: A pilot study

(2018) Ji Eun Kim et al.   Thoracic Cancer

Radial-probe endobronchial ultrasound outcomes in the investigation of peripheral pulmonary lesions - a New Zealand perspective

(2018) William R. Good et al.   INTERNAL MEDICINE JOURNAL

Exosomal RNA-profiling of pleural effusions identifies adenocarcinoma patients through elevated miR-200 and LCN2 expression

(2018) Per Hydbring et al.   LUNG CANCER

Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab

(2018) David R. Gandara et al.   NATURE MEDICINE

Liquid biopsy using the supernatant of a pleural effusion for EGFR genotyping in pulmonary adenocarcinoma patients: a comparison between cell-free DNA and extracellular vesicle-derived DNA

(2018) Jong Sik Lee et al.   BMC CANCER

Molecular biomarkers for lung adenocarcinoma

(2017) Olivier Calvayrac et al.   EUROPEAN RESPIRATORY JOURNAL

Liquid biopsy: a step forward towards precision medicine in urologic malignancies

(2017) Ashley Di Meo et al.   Molecular Cancer

Cell-Free DNA from Ascites and Pleural Effusions: Molecular Insights into Genomic Aberrations and Disease Biology

(2017) Hatim Husain et al.   MOLECULAR CANCER THERAPEUTICS

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

(2017) Aaron M. Goodman et al.   MOLECULAR CANCER THERAPEUTICS

Dynamic circulating tumor DNA quantificaton for the individualization of non-small-cell lung cancer patients treatment

(2017) Mariano Provencio et al.   Oncotarget

Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum

(2016) Alicia Hulbert et al.   CLINICAL CANCER RESEARCH

Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid

(2016) Elena I. Pentsova et al.   JOURNAL OF CLINICAL ONCOLOGY

Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non–Small-Cell Lung Cancer

(2016) Geoffrey R. Oxnard et al.   JOURNAL OF CLINICAL ONCOLOGY

DNA hypermethylation analysis in sputum of asymptomatic subjects at risk for lung cancer participating in the NELSON trial: argument for maximum screening interval of 2 years

(2016) A Jasmijn Hubers et al.   JOURNAL OF CLINICAL PATHOLOGY

Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC

(2016) Phil A.J. Crosbie et al.   Journal of Thoracic Oncology

A Highly Sensitive and Quantitative Test Platform for Detection of NSCLC EGFR Mutations in Urine and Plasma

(2016) Karen L. Reckamp et al.   Journal of Thoracic Oncology

Molecular analysis of peripheral non-squamous non-small cell lung cancer sampled by radial EBUS

(2016) Florian Guisier et al.   RESPIROLOGY

Early Intervention in Lung Cancers With Rapid Plasma Genotyping forEGFRandKRASMutations—Reply

(2016) Adrian G. Sacher et al.   JAMA Oncology

DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach

(2015) A J Hubers et al.   BRITISH JOURNAL OF CANCER

Epidermal growth factor receptor mutation status in cell-free DNA supernatant of bronchial washings and brushings

(2015) Akihiko Kawahara et al.   CANCER CYTOPATHOLOGY

Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

(2015) Yuxuan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

(2015) Leticia De Mattos-Arruda et al.   Nature Communications

Noninvasive Saliva-basedEGFRGene Mutation Detection in Patients with Lung Cancer

(2014) Fang Wei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA

(2014) G. R. Oxnard et al.   CLINICAL CANCER RESEARCH

Sensitive Detection of EGFR Mutations in Cerebrospinal Fluid from Lung Adenocarcinoma Patients with Brain Metastases

(2014) Haihong Yang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

EGFR mutations detected on cytology samples by a centralized laboratory reliably predict response to gefitinib in non-small cell lung carcinoma patients

(2013) Umberto Malapelle et al.   CANCER CYTOPATHOLOGY

Mutational analysis of cytocentrifugation supernatant fluid from pancreatic solid mass lesions

(2013) Sydney D. Finkelstein et al.   DIAGNOSTIC CYTOPATHOLOGY

Development of transcriptomic biomarker signature in human saliva to detect lung cancer

(2012) Lei Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genotyping Performance between Saliva and Blood-Derived Genomic DNAs on the DMET Array: A Comparison

(2012) Yueshan Hu et al.   PLoS One

SHOX2 DNA Methylation is a Biomarker for the diagnosis of lung cancer based on bronchial aspirates

(2010) Bernd Schmidt et al.   BMC CANCER

Radial probe endobronchial ultrasound for the diagnosis of peripheral lung cancer: systematic review and meta-analysis

(2010) D. P. Steinfort et al.   EUROPEAN RESPIRATORY JOURNAL