Drug discovery and development: Biomarkers of neurotoxicity and neurodegeneration

Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study

(2017) Syed Z Imam et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models

(2017) Mariah L. Hoye et al.   JOURNAL OF NEUROSCIENCE

Changes in the sympathetic innervation of the gut in rotenone treated mice as possible early biomarker for Parkinson’s disease

(2016) Mike Arnhold et al.   CLINICAL AUTONOMIC RESEARCH

FDA drug labeling: rich resources to facilitate precision medicine, drug safety, and regulatory science

(2016) Hong Fang et al.   DRUG DISCOVERY TODAY

Distribution of miRNA expression across human tissues

(2016) Nicole Ludwig et al.   NUCLEIC ACIDS RESEARCH

A Minimally-invasive Blood-derived Biomarker of Oligodendrocyte Cell-loss in Multiple Sclerosis

(2016) John A. Olsen et al.   EBioMedicine

Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats

(2015) Xian-jian Huang et al.   JOURNAL OF NEUROTRAUMA

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Increased sociability and gene expression of oxytocin and its receptor in the brains of rats affected prenatally by valproic acid

(2015) Peter Štefánik et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward

(2015) Ruth A. Roberts et al.   TOXICOLOGICAL SCIENCES

Molecular mechanisms linking neuroinflammation and neurodegeneration in MS

(2014) Erik Ellwardt et al.   EXPERIMENTAL NEUROLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders

(2014) Stefania Mondello et al.   PARKINSONISM & RELATED DISORDERS

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

Reducing attrition in drug development: smart loading preclinical safety assessment

(2013) Ruth A. Roberts et al.   DRUG DISCOVERY TODAY

Acute Biomarkers of Traumatic Brain Injury: Relationship between Plasma Levels of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein

(2013) Ramon Diaz-Arrastia et al.   JOURNAL OF NEUROTRAUMA

In utero exposure to valproic acid and autism — A current review of clinical and animal studies

(2013) Florence I. Roullet et al.   NEUROTOXICOLOGY AND TERATOLOGY

Assessment of lesion pathology in a new animal model of MS by multiparametric MRI and DTI

(2011) Susann Boretius et al.   NEUROIMAGE